LOCUS       NM_005250               4930 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens forkhead box L1 (FOXL1), mRNA.
ACCESSION   NM_005250
VERSION     NM_005250.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4930)
  AUTHORS   Abdelfatah,N., Mostafa,A.A., French,C.R., Doucette,L.P., Penney,C.,
            Lucas,M.B., Griffin,A., Booth,V., Rowley,C., Besaw,J.E.,
            Tranebjaerg,L., Rendtorff,N.D., Hodgkinson,K.A., Little,L.A.,
            Agrawal,S., Parnes,L., Batten,T., Moore,S., Hu,P., Pater,J.A.,
            Houston,J., Galutira,D., Benteau,T., MacDonald,C., French,D.,
            O'Rielly,D.D., Stanton,S.G. and Young,T.L.
  TITLE     A pathogenic deletion in Forkhead Box L1 (FOXL1) identifies the
            first otosclerosis (OTSC) gene
  JOURNAL   Hum Genet 141 (3-4), 965-979 (2022)
   PUBMED   34633540
  REMARK    GeneRIF: A pathogenic deletion in Forkhead Box L1 (FOXL1)
            identifies the first otosclerosis (OTSC) gene.
REFERENCE   2  (bases 1 to 4930)
  AUTHORS   Elaidy,N.F., Harb,O.A., Mohamed,A.M., Hemeda,R., Taha,H.F.,
            Samir,A., Elsayed,A.M., Osman,G. and Hendawy,E.I.E.
  TITLE     Prognostic Significances of NEDD-9 and FOXL-1 Expression in
            Intestinal Type Gastric Carcinoma: an Immunohistochemical Study
  JOURNAL   J Gastrointest Cancer 52 (2), 728-737 (2021)
   PUBMED   32794109
  REMARK    GeneRIF: Prognostic Significances of NEDD-9 and FOXL-1 Expression
            in Intestinal Type Gastric Carcinoma: an Immunohistochemical Study.
REFERENCE   3  (bases 1 to 4930)
  AUTHORS   Jin,J., Wang,L., Liu,X., Long,Z., Zhou,Y., Huang,H. and Wang,Y.
  TITLE     NTF4 stimulates the progression of gastric cancer via regulating
            FOXL1
  JOURNAL   J BUON 26 (2), 499-505 (2021)
   PUBMED   34076998
  REMARK    GeneRIF: NTF4 stimulates the progression of gastric cancer via
            regulating FOXL1.
REFERENCE   4  (bases 1 to 4930)
  AUTHORS   Miyashita,N., Horie,M., Suzuki,H.I., Saito,M., Mikami,Y., Okuda,K.,
            Boucher,R.C., Suzukawa,M., Hebisawa,A., Saito,A. and Nagase,T.
  TITLE     FOXL1 Regulates Lung Fibroblast Function via Multiple Mechanisms
  JOURNAL   Am J Respir Cell Mol Biol 63 (6), 831-842 (2020)
   PUBMED   32946266
  REMARK    GeneRIF: FOXL1 Regulates Lung Fibroblast Function via Multiple
            Mechanisms.
REFERENCE   5  (bases 1 to 4930)
  AUTHORS   Shi,D., Zhang,K., Li,G. and Zhao,Y.
  TITLE     MiR-1471 protects the aggravation of non-small-cell lung carcinoma
            by targeting FOXL1
  JOURNAL   Biofactors 46 (5), 734-742 (2020)
   PUBMED   33045131
  REMARK    GeneRIF: MiR-1471 protects the aggravation of non-small-cell lung
            carcinoma by targeting FOXL1.
            Erratum:[Biofactors. 2023 Jan;49(1):187. doi: 10.1002/biof.1790..
            PMID: 34787347]
REFERENCE   6  (bases 1 to 4930)
  AUTHORS   Kim,M.S., Hur,S.Y., Yoo,N.J. and Lee,S.H.
  TITLE     Mutational analysis of FOXL2 codon 134 in granulosa cell tumour of
            ovary and other human cancers
  JOURNAL   J Pathol 221 (2), 147-152 (2010)
   PUBMED   20198651
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 4930)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   8  (bases 1 to 4930)
  AUTHORS   Ferrell,R.E., Kimak,M.A., Lawrence,E.C. and Finegold,D.N.
  TITLE     Candidate gene analysis in primary lymphedema
  JOURNAL   Lymphat Res Biol 6 (2), 69-76 (2008)
   PUBMED   18564921
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4930)
  AUTHORS   Fang,J., Dagenais,S.L., Erickson,R.P., Arlt,M.F., Glynn,M.W.,
            Gorski,J.L., Seaver,L.H. and Glover,T.W.
  TITLE     Mutations in FOXC2 (MFH-1), a forkhead family transcription factor,
            are responsible for the hereditary lymphedema-distichiasis syndrome
  JOURNAL   Am J Hum Genet 67 (6), 1382-1388 (2000)
   PUBMED   11078474
REFERENCE   10 (bases 1 to 4930)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC100027.1, AC009108.10 and
            BM675371.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 27, 2019 this sequence version replaced NM_005250.2.
            
            Summary: This gene encodes a member of the forkhead/winged
            helix-box (FOX) family of transcription factors. FOX transcription
            factors are characterized by a distinct DNA-binding forkhead domain
            and play critical roles in the regulation of multiple processes
            including metabolism, cell proliferation and gene expression during
            ontogenesis. [provided by RefSeq, Nov 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC100027.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000320241.5/ ENSP00000326272.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-844               BC100027.1         41-884
            845-2624            AC009108.10        62664-64443         c
            2625-3150           BM675371.1         18-543              c
            3151-4930           AC009108.10        60358-62137         c
FEATURES             Location/Qualifiers
     source          1..4930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..4930
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /note="forkhead box L1"
                     /db_xref="GeneID:2300"
                     /db_xref="HGNC:HGNC:3817"
                     /db_xref="MIM:603252"
     exon            1..4930
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /inference="alignment:Splign:2.1.0"
     CDS             176..1213
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /note="forkhead-like 11; forkhead-related protein FKHL11;
                     forkhead-related transcription factor 7"
                     /codon_start=1
                     /product="forkhead box protein L1"
                     /protein_id="NP_005241.1"
                     /db_xref="CCDS:CCDS10959.1"
                     /db_xref="GeneID:2300"
                     /db_xref="HGNC:HGNC:3817"
                     /db_xref="MIM:603252"
                     /translation="MSHLFDPRLPALAASPMLYLYGPERPGLPLAFAPAAALAASGRA
                     ETPQKPPYSYIALIAMAIQDAPEQRVTLNGIYQFIMDRFPFYHDNRQGWQNSIRHNLS
                     LNDCFVKVPREKGRPGKGSYWTLDPRCLDMFENGNYRRRKRKPKPGPGAPEAKRPRAE
                     THQRSAEAQPEAGSGAGGSGPAISRLQAAPAGPSPLLDGPSPPAPLHWPGTASPNEDA
                     GDAAQGAAAVAVGQAARTGDGPGSPLRPASRSSPKSSDKSKSFSIDSILAGKQGQKPP
                     SGDELLGGAKPGPGGRLGASLLAASSSLRPPFNASLMLDPHVQGGFYQLGIPFLSYFP
                     LQVPDTVLHFQ"
     regulatory      3122..3127
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /note="hexamer: AATAAA"
     polyA_site      3143
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /note="major polyA site"
     regulatory      3585..3590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /note="hexamer: CATAAA"
     polyA_site      3612
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
     regulatory      4267..4272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /note="hexamer: AATAGA"
     polyA_site      4288
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
     regulatory      4843..4848
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /note="hexamer: AATAAA"
     polyA_site      4870
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
     regulatory      4905..4910
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
                     /note="hexamer: AATAAA"
     polyA_site      4930
                     /gene="FOXL1"
                     /gene_synonym="FKH6; FKHL11; FREAC7; OTSC11"
ORIGIN      
        1 aacattttta aagccatgaa gaagggacag agcacggagc ggccggggag agcggcagag
       61 ccagaggcag aggcacggct ggctccccgg gagggccctt gcggcgcggg gcgcagtgcc
      121 taggccgccc gggtctcctg cgttgcgggg agcgcagcgc aggctctcgc ttgccatgag
      181 tcacctcttc gatccccggc tgcctgccct ggccgcctcg cccatgctgt atctgtacgg
      241 tcccgagaga cccggcctcc ctctggcctt cgcccccgcg gctgctctag ctgcctcggg
      301 ccgggccgag accccgcaga agcctcccta cagctacatc gcgctcatcg ccatggcgat
      361 ccaggacgcg cccgagcaga gggtcacgct caacggcatc taccagttca tcatggaccg
      421 cttccccttc taccacgaca accggcaggg ctggcagaac agcatccgcc acaacctctc
      481 gctcaacgac tgcttcgtca aggtgccccg cgagaaaggg cggccgggca agggcagcta
      541 ctggacgctg gacccccgct gcctggacat gtttgagaac ggcaactacc ggcgccggaa
      601 gaggaagccc aagccgggcc ccggggcccc ggaggccaag aggccccgcg ccgagacgca
      661 ccagcgcagc gcggaggcgc agccggaggc ggggagcggg gcagggggct cgggccccgc
      721 aatctcccgc ctgcaggcag cgcccgcggg cccctcgccc ctcctggacg gcccctctcc
      781 gccggcgccc ctccactggc cggggaccgc gtccccgaac gaggacgctg gtgacgctgc
      841 ccagggcgca gcggccgtgg cggtcggcca ggcagcgcgc acaggggacg gcccggggtc
      901 ccctctgcgc cccgcctccc gcagctctcc gaagagctcc gacaagtcca agagcttcag
      961 catagacagc atcctggcgg gaaagcaggg ccagaagccg ccttcagggg acgaactcct
     1021 agggggtgcc aagcctgggc ccggcggccg tctgggtgcc tcgctcctgg ccgcctcctc
     1081 cagcctccgt ccgcctttca acgcttccct gatgctcgac ccgcatgtcc agggcggctt
     1141 ttaccagctc gggatcccct tcctctctta tttccccctg caggttcccg acacggtact
     1201 ccacttccag taaagcaaac aatggcacgg ttcttctccc ggcccagcct gagcctccgc
     1261 tgagcgaaag gccacagctc ccaccggcgg aggattttaa aatgatcttt gcctgggtcg
     1321 gcctgtgggt tcagggaagt gttaccaacc attgcgcgca ggtgggcgcg ctcgcctgcc
     1381 ttctccgaag caaacttttc ccagcaactg ggagcagcta cggagactta aaagatcccc
     1441 gcggggtcgt gggcaccgca cgtgggccct gcagggacct ccaccgcggg agattccttg
     1501 acgtttgacc tgtctaatgg agtgtggtct tcagccgccc accgcaggtc ctgcgagtcc
     1561 cgggcatgca agggcccgca gaccacccaa ggcaggcctt acaggtgcag ttgaggtcct
     1621 ttcgaccggg gacccccgta tgaccgtcgc ctgcttcgct gttgccgtgt ggctcaggcc
     1681 ttggttttga gcccatctgg gtggtgggtg gtcacagctg ggtttgttcc tgacttgaag
     1741 ttgtggaggt gccgggggtg accccgggtt ttcaggtttt ctgagagatg tagggcccga
     1801 tgaggattta tgaccaatgt tcagctatag aagctgataa ccacccagag caataacact
     1861 tttattttaa acagagactt tttctcttaa tttctttctg ggtagtaaaa agaacatgtt
     1921 tcattctttg cataaatact tgactctaag cattgacctt tgaaaacgct tgtattaaca
     1981 atttttatta agaaagtgca ctctatataa catcttcttg cattacgata gctcattagc
     2041 caatacacat gcagctatgt aagccacaac agcagacgtc ctatcctttt gcttttgttt
     2101 ttaagggatc aaaatatttc aagggatacc atgaggaagg gtgtgagggg aaggggatat
     2161 gccttggaca atgtcagagt tttgatttcc atgttttttc aagatccagg cttggtggtc
     2221 gctatatttt tcagaaacag ataatgaaag actacattta atttaaaaag ttgggtgaaa
     2281 caaccaaaag cagatgcaga gagagagagg gatgaatgcg ggggaagaat aaggggacgt
     2341 gctggtgtcc gctggaaggg gcctctctgg gccccagagg acctgaggtt tgatggcagg
     2401 aatctcccag acactcctgg cccccgcacc ccctgcagcc gcccgctctt ccctcccagc
     2461 cctgccaggc aggcctggag gctgatacta aatcaaaacc ttaaagaggt gactggcagt
     2521 ctggggaggg gagaagaggt ctgcaacgaa aatctaatta agaacattga gatgttcaca
     2581 accaagttca gcttgcagct tccggggaaa tgcaaccgac ctctatgcca tctctagctg
     2641 ggtaatcttc gaggccctga aatgcaattt tctgaacctc taagtcactt ttattttatg
     2701 tcatgtgata aagacacaag tagtcacgca ctattggaaa taggttggga gggaggtctt
     2761 taagatcgct tttaaaatag tttccaggac ttgtctaaaa atgatgacaa actttgaatc
     2821 cagagggcct gttggtcaat gtgttggaaa ggacatttca ggccggcaga gtaattggat
     2881 aattcacagg catagaggtg acttttggaa aattcattct cctatccatg ctgaaccagg
     2941 cttccacgac tgggttctac ccaggccagt gggaagactc tgggaaactt caggccagcc
     3001 ttgattggaa gaacttccag gaggagccat tgctgagatc caggctcact gtgattcact
     3061 gaaaatgtag cgaaagggct gtcactggat attttgctat cccaaactct cagcctctgt
     3121 gaataaagtt gttttttcat taacctctca gtgactggtt cagtggatta ctggagggaa
     3181 ataaacaaac agtgtaataa gaaagaggag actgggatta tatctgggag tcgtgttagc
     3241 atctcaggag gctctggctt ctgaggggta aacacacaga tggaggggaa ggagtggaga
     3301 ggatgccggg cccaggaagc tgcctccata tcagaaagca cgatgagtta attctgccgt
     3361 attgaatcgg tttttaatct ttcctttttc ttttttgtgt ttgtatgtta tcttgggagg
     3421 ttttgttaat ttgtgatggc tatgttttga agaagcaaat aatttgatac tgcagtttta
     3481 aaagggtcgt attttaaagt tactattcca aaaagtattg tacgaatgtt acttttatga
     3541 cacagaaaaa atgcagatgt atccactttg tgtgtttata catgcataaa gagaaattct
     3601 atttaatccc aacttttgtc tggtttagaa aagctaagac aagtggatac tgaggtcgtt
     3661 tttatgtaat ctatataatt gcatgtgtat tccttcctcc tgaaccaaaa agaggaggtt
     3721 tgggtcttac caatccgaat agctgttcta ttgatccata tttaatcgtt ggctcaaaat
     3781 tatggctcaa taaggtcaat agtttctgct cttaattaaa acaaaatctc agctataatt
     3841 agggtgagcc agaagcaagc ttatcattgt actcttaggc aatctgaagg aatacctctc
     3901 tgctctcatc taaacaaagg gaacagatct gtcttctgta aatgatcttt ggttcaagcc
     3961 ctgattacac acacacacaa acaaataccc acacacatat gagtgcactg atcataatga
     4021 ggatatggca ggcacatgtt tgataacaaa gtgtgtatac atatgtacac gtttatatat
     4081 atgtatatac atatatatac atgaatgtgt aggggtgtgt gtgtgtattt gttctgtgta
     4141 catgaatgct cataaatgta tcttttttga atatacctga gactcagatc aagtactgag
     4201 tcctttcact ttaacccaag tattgatact atttgaaaga ttttgttttt ctatatagtt
     4261 tttaaaaata gataataatt tctatatagc tttaatagtt ttgtttctct atgtagtatg
     4321 aaccagggat aactttattg ttctgtgtta gtatagtgaa actgacagat tttatttaaa
     4381 catcgcggaa gacacccgct ttgagaactt ttccctccgt tcacaaggac agagaacttt
     4441 acaaaggact cttgctctgc ctggcctcat ctagttgctg gcttttctag aaacaaacgg
     4501 cctcctgggc ctccagtgaa ccataagagt tttgagaacc tgaataggac cttcttagcc
     4561 attttcagat ttaattgtgc ccgtttgaat ggtggtcttc accatttcac tcaaagtggt
     4621 gagtgtatgc ccgtgtgtat gttaaagaat tagccacata taattattgt tacagctgaa
     4681 agccagagcc agcctgccca gaccctggca ggttaatgtt aacatcacaa aggtaggtga
     4741 cgtttccagt aaccagctgc acccaggagt gagaaaataa ggggagagcc atgattttgt
     4801 gcacttcctg gcttcatggt ggatggagtc ttgtttccat gaaataaagg ttgtttcata
     4861 gaatgaaaaa cataaatgat aaaaagcaaa gtttgtccat taaaaataaa aagcgtgagt
     4921 ttgtggaaaa
//
