LOCUS       NM_004514               5243 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens forkhead box K2 (FOXK2), mRNA.
ACCESSION   NM_004514 XM_942705 XM_946279 XM_946280 XM_946281
VERSION     NM_004514.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5243)
  AUTHORS   Yu,Y., Cao,W.M., Cheng,F., Shi,Z., Han,L., Yi,J., da Silva,E.M.,
            Dopeso,H., Chen,H., Yang,J., Wang,X., Zhang,C. and Zhang,H.
  TITLE     FOXK2 amplification promotes breast cancer development and
            chemoresistance
  JOURNAL   Cancer Lett 597, 217074 (2024)
   PUBMED   38901667
  REMARK    GeneRIF: FOXK2 amplification promotes breast cancer development and
            chemoresistance.
REFERENCE   2  (bases 1 to 5243)
  AUTHORS   El-Mergawy,R., Chafin,L., Ovando-Ricardez,J.A., Rosas,L., Tsai,M.,
            Rojas,M., Mora,A.L. and Mallampalli,R.K.
  TITLE     FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for ubiquitin
            mediated degradation modulates mitochondrial respiration
  JOURNAL   J Biol Chem 300 (6), 107359 (2024)
   PUBMED   38735474
  REMARK    GeneRIF: FOXK2 targeting by the SCF-E3 ligase subunit FBXO24 for
            ubiquitin mediated degradation modulates mitochondrial respiration.
REFERENCE   3  (bases 1 to 5243)
  AUTHORS   Liu,X., Tang,N., Liu,Y., Fu,J., Zhao,Y., Wang,H., Wang,H. and Hu,Z.
  TITLE     FOXK2 regulates PFKFB3 in promoting glycolysis and tumorigenesis in
            multiple myeloma
  JOURNAL   Leuk Res 132, 107343 (2023)
   PUBMED   37356282
  REMARK    GeneRIF: FOXK2 regulates PFKFB3 in promoting glycolysis and
            tumorigenesis in multiple myeloma.
REFERENCE   4  (bases 1 to 5243)
  AUTHORS   Zheng,J., Yan,X., Lu,T., Song,W., Li,Y., Liang,J., Zhang,J.,
            Cai,J., Sui,X., Xiao,J., Chen,H., Chen,G., Zhang,Q., Liu,Y.,
            Yang,Y., Zheng,K. and Pan,Z.
  TITLE     CircFOXK2 promotes hepatocellular carcinoma progression and leads
            to a poor clinical prognosis via regulating the Warburg effect
  JOURNAL   J Exp Clin Cancer Res 42 (1), 63 (2023)
   PUBMED   36922872
  REMARK    GeneRIF: CircFOXK2 promotes hepatocellular carcinoma progression
            and leads to a poor clinical prognosis via regulating the Warburg
            effect.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5243)
  AUTHORS   Li,Y., Chen,J., Wang,B., Xu,Z., Wu,C., Ma,J., Song,Q., Geng,Q.,
            Yu,J., Pei,H. and Yao,Y.
  TITLE     FOXK2 affects cancer cell response to chemotherapy by promoting
            nucleotide de novo synthesis
  JOURNAL   Drug Resist Updat 67, 100926 (2023)
   PUBMED   36682222
  REMARK    GeneRIF: FOXK2 affects cancer cell response to chemotherapy by
            promoting nucleotide de novo synthesis.
REFERENCE   6  (bases 1 to 5243)
  AUTHORS   Liu,P.P., Chen,Y.C., Li,C., Hsieh,Y.H., Chen,S.W., Chen,S.H.,
            Jeng,W.Y. and Chuang,W.J.
  TITLE     Solution structure of the DNA-binding domain of interleukin
            enhancer binding factor 1 (FOXK1a)
  JOURNAL   Proteins 49 (4), 543-553 (2002)
   PUBMED   12402362
REFERENCE   7  (bases 1 to 5243)
  AUTHORS   Nirula,A., Moore,D.J. and Gaynor,R.B.
  TITLE     Constitutive binding of the transcription factor interleukin-2
            (IL-2) enhancer binding factor to the IL-2 promoter
  JOURNAL   J Biol Chem 272 (12), 7736-7745 (1997)
   PUBMED   9065434
REFERENCE   8  (bases 1 to 5243)
  AUTHORS   Li,C., Lusis,A.J., Sparkes,R., Nirula,A. and Gaynor,R.
  TITLE     Characterization and chromosomal mapping of the gene encoding the
            cellular DNA binding protein ILF
  JOURNAL   Genomics 13 (3), 665-671 (1992)
   PUBMED   1339390
REFERENCE   9  (bases 1 to 5243)
  AUTHORS   Li,C., Lai,C.F., Sigman,D.S. and Gaynor,R.B.
  TITLE     Cloning of a cellular factor, interleukin binding factor, that
            binds to NFAT-like motifs in the human immunodeficiency virus long
            terminal repeat
  JOURNAL   Proc Natl Acad Sci U S A 88 (17), 7739-7743 (1991)
   PUBMED   1909027
REFERENCE   10 (bases 1 to 5243)
  AUTHORS   Durand,D.B., Shaw,J.P., Bush,M.R., Replogle,R.E., Belagaje,R. and
            Crabtree,G.R.
  TITLE     Characterization of antigen receptor response elements within the
            interleukin-2 enhancer
  JOURNAL   Mol Cell Biol 8 (4), 1715-1724 (1988)
   PUBMED   3260003
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124287.10, U58196.1 and
            AC124283.11.
            
            On Nov 23, 2018 this sequence version replaced NM_004514.3.
            
            Summary: The protein encoded by this gene contains a fork head DNA
            binding domain. This protein can bind to the purine-rich motifs of
            the HIV long terminal repeat (LTR), and to the similar purine-rich
            motif in the interleukin 2 (IL2) promoter. It may be involved in
            the regulation of viral and cellular promoter elements. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.107086.1,
                                           SRR1803613.198923.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335255.10/ ENSP00000335677.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               AC124287.10        142309-142884
            577-2685            U58196.1           602-2710
            2686-5243           AC124283.11        92442-94999
FEATURES             Location/Qualifiers
     source          1..5243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..5243
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /note="forkhead box K2"
                     /db_xref="GeneID:3607"
                     /db_xref="HGNC:HGNC:6036"
                     /db_xref="MIM:147685"
     exon            1..576
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             158..2140
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /note="cellular transcription factor ILF-1; FOXK1;
                     interleukin enhancer-binding factor 1; G/T-mismatch
                     specific binding protein"
                     /codon_start=1
                     /product="forkhead box protein K2"
                     /protein_id="NP_004505.2"
                     /db_xref="CCDS:CCDS11813.1"
                     /db_xref="GeneID:3607"
                     /db_xref="HGNC:HGNC:6036"
                     /db_xref="MIM:147685"
                     /translation="MAAAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGRE
                     FEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFTPPGGGGHGGAAPELPPAQ
                     PRPDAGGDFYLRCLGKNGVFVDGVFQRRGAPPLQLPRVCTFRFPSTNIKITFTALSSE
                     KREKQEASESPVKAVQPHISPLTINIPDTMAHLISPLPSPTGTISAANSCPSSPRGAG
                     SSGYKVGRVMPSDLNLMADNSQPENEKEASGGDSPKDDSKPPYSYAQLIVQAITMAPD
                     KQLTLNGIYTHITKNYPYYRTADKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRI
                     DPASESKLIEQAFRKRRPRGVPCFRTPLGPLSSRSAPASPNHAGVLSAHSSGAQTPES
                     LSREGSPAPLEPEPGAAQPKLAVIQEARFAQSAPGSPLSSQPVLITVQRQLPQAIKPV
                     TYTVATPVTTSTSQPPVVQTVHVVHQIPAVSVTSVAGLAPANTYTVSGQAVVTPAAVL
                     APPKAEAQENGDHREVKVKVEPIPAIGHATLGTASRIIQTAQTTPVQTVTIVQQAPLG
                     QHQLPIKTVTQNGTHVASVPTAVHGQVNNAAASPLHMLATHASASASLPTKRHNGDQP
                     EQPELKRIKTEDGEGIVIALSVDTPPAAVREKGVQN"
     exon            577..771
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     exon            772..919
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     exon            920..1066
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1260
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1436
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1733
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1943
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1944..5243
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3013..3018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /note="hexamer: AGTAAA"
     polyA_site      3031
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /note="major polyA site"
     regulatory      5219..5224
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
                     /note="hexamer: AATAAA"
     polyA_site      5243
                     /gene="FOXK2"
                     /gene_synonym="ILF; ILF-1; ILF1; nGTBP"
ORIGIN      
        1 gcccctcgcc gccgctcgct cgctcgccgg ccggcggcct ccgctcggcc ccctccctca
       61 gctccggtgc gcggcggccg acgacccgcg cggcctgggc ctcggcccgc gccaccggcg
      121 cccgcgcgga gcggcccggg ggccctcacg caggcccatg gcggcggccg cggcggcgct
      181 ctcgggcgcg ggcacgccac ccgcgggcgg cggggccggg ggcggcgggg ccgggggcgg
      241 cgggtccccg ccgggcggct gggccgtggc gcgcctggag ggccgcgagt tcgagtatct
      301 gatgaagaag cgctcggtga ccatcggccg caactcgtcg cagggctcgg tggacgtgag
      361 catgggccac tcgagcttca tctcccggcg ccacctcgag atcttcacgc ccccgggcgg
      421 cggcggccat ggcggggccg ctccggagct gccgcccgcg cagcccaggc ccgacgccgg
      481 cggcgacttc tacctgcgct gcttgggcaa gaacggggta ttcgtggacg gcgtgttcca
      541 gaggcgcggg gcgccgccgc tgcagctgcc gcgcgtgtgc acattcaggt tcccgagcac
      601 aaacatcaag ataacgttca ctgccctgtc cagcgagaag agagagaagc aggaggcgtc
      661 tgagtctcca gtgaaggccg tacagccaca catctcgccc ctgaccatca acattccaga
      721 caccatggcc cacctcatca gccctctgcc ctcccccacg ggaaccatca gcgctgcaaa
      781 ctcctgcccc tccagccccc ggggagcggg gtcttcaggg tacaaggtgg gccgagtgat
      841 gccatctgac ctcaatttaa tggctgacaa ctcacagcct gaaaatgaaa aggaagcttc
      901 aggtggagac agcccgaagg atgattcaaa gccgccttac tcctacgcgc agctgatagt
      961 tcaggcgatt acgatggctc ccgacaaaca gctcaccctg aacgggattt atacacacat
     1021 cactaaaaat tatccctact acaggactgc ggacaagggc tggcagaatt caattcgcca
     1081 caatctctct ctgaatcgtt atttcatcaa agtgccgcgt tcccaggaag aaccaggcaa
     1141 aggctcgttc tggaggatag acccagcctc tgaaagcaaa ttaatagaac aggcttttag
     1201 gaaacgacgg cctaggggcg tgccctgctt tagaacccct ctgggaccgc tctcttctag
     1261 gagtgcccca gcctctccca atcacgcggg agtgctgtct gctcactcta gtggcgccca
     1321 gacccctgag agcctgtcga gggaaggttc gccggccccc ctggagcctg agcctggcgc
     1381 tgcacagccc aaactcgctg tcatccagga agcccggttt gcccagagcg ccccagggtc
     1441 acctctgtcc agtcagccag tcttaatcac cgtccagcgg cagctaccac aggccatcaa
     1501 gcctgtcacc tacactgtgg ccaccccagt gaccacctcg acctcccagc cacccgtcgt
     1561 gcagacggtt cacgtcgtcc accagatccc agcggtgtcg gtcaccagtg tggccggact
     1621 ggccccagcg aacacgtaca ctgtctctgg acaagctgtg gtcaccccgg cagccgtgct
     1681 ggcccctcct aaggcagagg cccaggagaa tggagaccac agggaagtca aagtgaaagt
     1741 agagcctatt cccgccattg gccacgccac gctcggcact gccagccgga tcattcagac
     1801 ggcacagacc accccggtcc agacggtgac catagtacaa caggcacctc taggtcaaca
     1861 ccagctacca ataaaaactg taacacaaaa cggcactcac gtggcatcag tccccactgc
     1921 ggtccacggc caggtgaaca atgccgcggc gagtcctttg cacatgttgg caacacacgc
     1981 atccgcatcg gcctccctgc ccacaaagcg ccacaacggt gaccagccgg agcagccgga
     2041 gctgaagcgg atcaagacag aagacggcga gggcatcgtc attgccctga gcgtggacac
     2101 gccaccggca gccgtaaggg aaaagggtgt ccagaactag cgaccgggag agcttttctt
     2161 taacgatatc aactctgtgg tgccaaaagg agacgcggcc tcccgccagc actcgggggt
     2221 gcagggccct gtggttggac ttcacctctc agcactgaaa acccaaaacc cagctggcct
     2281 taacactcct taaagacaga agtcacactt gaacaaaacc cacacacaac aaaacctgat
     2341 ttgggagacg gtgtctccac tgagcacctg ctgggctgag cttctaccta cgagtgaaac
     2401 tctgtcctcc cgcgaggacc aggcatcgct gtgtgaggac ggcacggcca gcgcctgctg
     2461 tgagtgggtc tcccaagact aggcctcagg acgcgggggg agccatcccc gccgccctca
     2521 caggacccac caggcagcgg agacatgtgg aattagagta ttttgaggtg tcctttcttt
     2581 acaaaataat ggggtcttgg gcatttcaca tcactccatt tctactgaga ctttcagaat
     2641 cacacaggcc ctttccgtgg atttcatttg gggcaaagaa acaacgtagt tttgtttttg
     2701 ttttcagcct atggaatgat ttccttttgt ctgtcttgtt caagttcaga cgaagctact
     2761 ctggcatctg cacatttccg tgttacagca gctgcctgat gaattttatc cacctccatt
     2821 tcagcatgtg gctcgcgtgg acaggtggac ggacgctgtg gccgcatgga accttgagaa
     2881 cccagggacg agccagtgcc gggaaggaac tgccgggact caccgagctg cacttaactg
     2941 ttctctttct ggctattttt tgttgtttgt ttctttgtgt tgactttgtc cctggcaaaa
     3001 ttttccactc tgagtaaaac aagtctccta agtattgtgt atgtttaaaa cgacagaacc
     3061 atttctactt catttggaaa aagattcagt cttttatcac aggccctttt gaaactcaga
     3121 tcccaggtct ctccgtggta tgtttgtatt tggggtgtcc ctccggctct aggcggcctc
     3181 tgacctgctg tctactcccc accttcggtg agcggccgcc atggtggagc agggtccgag
     3241 ccacgtcctg cagggcacgt ctggggcatt tcctgttttg tggtaggaaa tgtccctgac
     3301 ctttcagaac cgaacccaat cctgaggctg actcctctac ggaaaatgag gacaggacgg
     3361 gggtgaggga atgagagtgg gaggtccctg cacctcctcg cccggctcct caggaagaaa
     3421 accgctggcc cttcccgagt gtgccggccg agggccgagg gccgtgcaca tggggagagg
     3481 gcgtcagcct gatggctgag cttttaaatg tcatcatcat aacattattt atttaaatgt
     3541 agttattttg gtatttaatt tttttttaga gaggaaaaaa cctgtatttt cctggtggga
     3601 tgaaataggg atgaaatggc tcagaatggt atatttaggc aattttaaaa catttattat
     3661 ttacataaag accaaatatg atgaatctgt tccgtgaatt gtgtcggccc tcagcatggg
     3721 gctggggcag cgtcactgcg gtgacgccca ttgaaaggta tgaaatgact gcacactagc
     3781 tggattatca ctcagccgtt taagaaataa aagcaaaacc atcacgtgac tgagaccgtg
     3841 tgtgtgaccg cagcaaagcg cagcgtgtgg atggatcaga gcccctcggt gcagctgtct
     3901 gcatcttcca agcactttac agataccttg gaatgtatat ttttgtcttc ttactcagaa
     3961 ggtttgcagt ttgtaaaata atcaggattc tgctctgtcc tgtgtgtggg gtcagctccc
     4021 tccacagagg gctccagctc tgttggtcac agctgatggg gttctctgat tgataggaga
     4081 cgagctcttg agctctaagg aacagtgagg tcgccggtgg ggagcttggc tgggacacca
     4141 agcaaatgca tcgtatgtcc ccttggagac gtttttatgc agctgtgtat gttactatcc
     4201 agaaggagtc gggggtagac tttcccgtgt aagctcagtc cataaactgg ttacttctga
     4261 tcctggaacg tggacttcac atgataggtc tggatctgtt tctgttggga tcacaggtaa
     4321 ggaaaatgtc cattcaaatg gtaaagaagg gaggagggtg tttttttttt ttttttttgc
     4381 cgtaggcacc attctgcatc ttgaacccag actgaagtgt gcctctcaca gatggaaggt
     4441 gcacacgctc ctgtctcctc ctcactctgc cacgttcact tggctttttc attggtacct
     4501 aggaatttaa gaatatcgaa gcgagagcag taacaaacca tagatgagca gactcccaca
     4561 ccgggttttc ttgcccgtct ttaaggcact gtttctaaat tttgaactta gctctgaatc
     4621 cccaagaact tgagcacagc aagggttgct gagctgctgt cgccgcagcc ctggcccctg
     4681 gtgctggagc tgcagcacct ttgggagagg tcctgcgtcg tcctcagctg cgtcgctgtg
     4741 aactcccgct ctccactgtg ttcctcagtg tctgcttttc aggaagtctg ctgtgacctt
     4801 tgcccaactt ctgagctcct cagggactag gaacaatttc agtagctttg ccctgaacca
     4861 aacgagaaaa caaaagggaa ctcccgtatg acccacgtca cgtggtgcac tcagagtgtg
     4921 tgcggcatga tcctcggttg ctcctcctct cactttagta gagtacgcgg tggacagctg
     4981 atctccttca gtcgtctacc cacttccgtc attgtcctcc gctagaataa cagagtagtt
     5041 ggtagtcatg gccagaaggg gggtgggggc agtgtgagga cttggggttt ctgtgctgtg
     5101 tgacacaagg agataagtga caatcttgaa gtcctaactt ccactattct agaaagtata
     5161 gtggtgattt gtgtgcaaag atttgaagtt ttaaaaaagt accaagttcc tgaaattcaa
     5221 taaaatattt ttattaattt taa
//
