LOCUS       NM_014947               5225 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens forkhead box J3 (FOXJ3), transcript variant 1, mRNA.
ACCESSION   NM_014947 XM_378181
VERSION     NM_014947.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5225)
  AUTHORS   Seo,Y., Lee,J., Kim,J., Shim,S. and Jang,S.W.
  TITLE     FOXJ3 Regulates Cell Proliferation and Motility Through Modulating
            Snail Expression in Breast Cancer Cells
  JOURNAL   Anticancer Res 43 (7), 2995-3001 (2023)
   PUBMED   37351974
  REMARK    GeneRIF: FOXJ3 Regulates Cell Proliferation and Motility Through
            Modulating Snail Expression in Breast Cancer Cells.
REFERENCE   2  (bases 1 to 5225)
  AUTHORS   Yong,W., Deng,S., Tan,Y. and Li,S.
  TITLE     Circular RNA circSLC8A1 inhibits the proliferation and invasion of
            non-small cell lung cancer cells through targeting the miR-106b-5p
            /FOXJ3 axis
  JOURNAL   Cell Cycle 20 (24), 2597-2606 (2021)
   PUBMED   34724864
  REMARK    GeneRIF: Circular RNA circSLC8A1 inhibits the proliferation and
            invasion of non-small cell lung cancer cells through targeting the
            miR-106b-5p /FOXJ3 axis.
REFERENCE   3  (bases 1 to 5225)
  AUTHORS   Huang,G., Ma,J. and Zhang,L.
  TITLE     Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges
            microRNA-107 in Colorectal Carcinoma Cells and Tissues and
            Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene
  JOURNAL   Med Sci Monit 26, e920623 (2020)
   PUBMED   32305992
  REMARK    GeneRIF: Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges
            microRNA-107 in Colorectal Carcinoma Cells and Tissues and
            Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5225)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 5225)
  AUTHORS   Zhang,J.Y., Su,X.P., Li,Y.N. and Guo,Y.H.
  TITLE     MicroRNA-425-5p promotes the development of prostate cancer via
            targeting forkhead box J3
  JOURNAL   Eur Rev Med Pharmacol Sci 23 (2), 547-554 (2019)
   PUBMED   30720162
  REMARK    GeneRIF: The found the stimulation effects of miR-425-5p on
            prostate cancer (PCa) cell behaviors were fulfilled through
            directly regulating the expression of FOXJ3, which validated FOXJ3
            as a functional target of miR-425-5p in PCa.
REFERENCE   6  (bases 1 to 5225)
  AUTHORS   Jolma,A., Yan,J., Whitington,T., Toivonen,J., Nitta,K.R.,
            Rastas,P., Morgunova,E., Enge,M., Taipale,M., Wei,G., Palin,K.,
            Vaquerizas,J.M., Vincentelli,R., Luscombe,N.M., Hughes,T.R.,
            Lemaire,P., Ukkonen,E., Kivioja,T. and Taipale,J.
  TITLE     DNA-binding specificities of human transcription factors
  JOURNAL   Cell 152 (1-2), 327-339 (2013)
   PUBMED   23332764
REFERENCE   7  (bases 1 to 5225)
  AUTHORS   Grant,G.D., Gamsby,J., Martyanov,V., Brooks,L. 3rd, George,L.K.,
            Mahoney,J.M., Loros,J.J., Dunlap,J.C. and Whitfield,M.L.
  TITLE     Live-cell monitoring of periodic gene expression in synchronous
            human cells identifies Forkhead genes involved in cell cycle
            control
  JOURNAL   Mol Biol Cell 23 (16), 3079-3093 (2012)
   PUBMED   22740631
  REMARK    GeneRIF: FOXJ3 is identified as a novel cell cycle reguulator that
            may regulate a network of zinc finger proteins.
REFERENCE   8  (bases 1 to 5225)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 5225)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   10 (bases 1 to 5225)
  AUTHORS   Nakayama,M., Kikuno,R. and Ohara,O.
  TITLE     Protein-protein interactions between large proteins: two-hybrid
            screening using a functionally classified library composed of long
            cDNAs
  JOURNAL   Genome Res 12 (11), 1773-1784 (2002)
   PUBMED   12421765
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC096540.2, BC063298.1, AK027075.1 and BC151828.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014947.4.
            
            Transcript Variant: This variant (1) and variants 2 and 3 encode
            the same isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063298.1, SRR1803612.198306.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361346.6/ ENSP00000354620.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AC096540.2         134115-134117       c
            4-678               BC063298.1         1-675
            679-1698            AK027075.1         754-1773
            1699-2673           BC063298.1         1694-2668
            2674-4111           BC151828.1         2640-4077
            4112-5225           BC063298.1         4107-5220
FEATURES             Location/Qualifiers
     source          1..5225
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..5225
                     /gene="FOXJ3"
                     /note="forkhead box J3"
                     /db_xref="GeneID:22887"
                     /db_xref="HGNC:HGNC:29178"
                     /db_xref="MIM:616035"
     exon            1..177
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            178..238
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..2063
                     /gene="FOXJ3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     forkhead box protein J3"
                     /codon_start=1
                     /product="forkhead box protein J3 isoform 1"
                     /protein_id="NP_055762.3"
                     /db_xref="CCDS:CCDS30689.1"
                     /db_xref="GeneID:22887"
                     /db_xref="HGNC:HGNC:29178"
                     /db_xref="MIM:616035"
                     /translation="MGLYGQACPSVTSLRMTSELESSLTSMDWLPQLTMRAAIQKSDA
                     TQNAHGTGISKKNALLDPNTTLDQEEVQQHKDGKPPYSYASLITFAINSSPKKKMTLS
                     EIYQWICDNFPYYREAGSGWKNSIRHNLSLNKCFLKVPRSKDDPGKGSYWAIDTNPKE
                     DVLPTRPKKRARSVERASTPYSIDSDSLGMECIISGSASPTLAINTVTNKVTLYNTDQ
                     DGSDSPRSSLNNSLSDQSLASVNLNSVGSVHSYTPVTSHPESVSQSLTPQQQPQYNLP
                     ERDKQLLFSEYNFEDLSASFRSLYKSVFEQSLSQQGLMNIPSESSQQSHTSCTYQHSP
                     SSTVSTHPHSNQSSLSNSHGSGLNTTGSNSVAQVSLSHPQMHTQPSPHPPHRPHGLPQ
                     HPQRSPHPAPHPQQHSQLQSPHPQHPSPHQHIQHHPNHQHQTLTHQAPPPPQQVSCNS
                     GVSNDWYATLDMLKESCRIASSVNWSDVDLSQFQGLMESMRQADLKNWSLDQVQFADL
                     CSSLNQFFTQTGLIHSQSNVQQNVCHGAMHPTKPSQHIGTGNLYIDSRQNLPPSVMPP
                     PGYPHIPQALSTPGTTMAGHHRAMNQQHMMPSQAFQMRRSLPPDDIQDDFDWDSIV"
     exon            239..563
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            564..638
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            639..722
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            723..824
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            825..953
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1128
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1545
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1647
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1648..1839
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1947
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     exon            1948..5225
                     /gene="FOXJ3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5202..5207
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXJ3"
                     /note="hexamer: AATAAA"
     polyA_site      5225
                     /gene="FOXJ3"
                     /note="major polyA site"
ORIGIN      
        1 agtagttccg ggtgcgcggc cccggatgtt ggctgctctt gctgccgccg ccgctctcgg
       61 ggctgctcgg ggcctcgacc gctcgcagta ggcaccgttg ggacctttcc cgggggggcg
      121 gagacgcacg gagcggccgg gggctcggcc gggccgtccc ggcctgcgca gcctgagatt
      181 ctctttgtgg ccagatgggt ttgtatggac aggcttgtcc atctgtaact tcattaagga
      241 tgacatctga actggagagc agcctaacgt ctatggactg gttaccacag ctcaccatga
      301 gagcagccat ccaaaaatct gatgctacac aaaatgcaca tggaacagga atttctaaga
      361 agaatgcact ccttgaccca aatacaactc tggaccagga agaagtccaa cagcacaaag
      421 atgggaaacc tccatacagt tatgccagcc tcattacatt tgcaattaat agctcaccca
      481 aaaagaaaat gactttaagt gaaatttatc agtggatttg tgataacttc ccatattata
      541 gagaggctgg cagtggttgg aagaattcca tacgacataa tctgtcattg aacaaatgtt
      601 tccttaaagt gcctcgatct aaggatgacc ctggaaaggg gtcctactgg gcaatagaca
      661 ccaatccgaa ggaagatgtg ctgcctactc ggccaaagaa gagggcacga tctgtagaac
      721 gggcctcaac tccatatagc atagattcag attctttggg aatggagtgt attatttcgg
      781 gaagtgcctc tccaactctg gcaatcaaca ctgtgactaa caaagtaaca ttgtataaca
      841 ctgatcagga tggtagtgat agcccacgca gtagccttaa caacagtctc tcagaccaga
      901 gtttggcatc tgttaatttg aacagtgttg gaagtgtgca tagttataca ccggtgacaa
      961 gccatccaga atcagtctct caatcattaa ctcctcagca gcaaccacag tacaaccttc
     1021 cagaaagaga caagcaacta cttttctcag aatataattt tgaagatctt agtgcctcat
     1081 ttcggagcct ttataagtca gtttttgagc agtcacttag tcaacaaggt ttgatgaaca
     1141 tcccttctga atcttcccag cagtcccaca cttcatgtac ctatcagcac tctcccagca
     1201 gtacagtgag cactcaccca cacagcaacc aaagcagcct gtccaacagt catggcagtg
     1261 gcctcaacac cacaggcagt aattcggttg cacaggtctc actgtctcac ccccagatgc
     1321 acacacagcc atctccacat cctccccatc gaccgcatgg tttaccgcag catccgcagc
     1381 gttccccaca cccagcacca cacccacagc aacacagcca gctccagtcc cctcaccccc
     1441 agcatccctc tccacatcaa cacatacagc accatccgaa ccatcagcat cagacgttaa
     1501 cacatcaggc acccccaccc ccacaacagg tatcctgtaa ttctggtgtt tcaaatgatt
     1561 ggtatgcgac acttgatatg ctaaaagaaa gctgtcgaat tgccagcagt gttaattggt
     1621 cagatgtaga cctttcacag tttcaaggtc tgatggagag tatgagacag gcagatctca
     1681 agaactggtc tttagaccag gttcagtttg ccgatctttg ttcttctctt aatcagttct
     1741 ttacacaaac tggccttata cattcacaga gtaatgttca acaaaatgtt tgtcatggtg
     1801 ccatgcatcc aacaaaacct tcccaacaca ttggaacagg aaatttgtac atagattcta
     1861 ggcaaaatct ccctccttca gtgatgccac cccctggtta tcctcatatc ccacaggcac
     1921 tcagcactcc aggaacaacg atggcaggcc atcacagagc catgaaccag cagcacatga
     1981 tgccttccca agccttccag atgcggcgtt ccctgcctcc agatgacatc caggatgact
     2041 ttgattggga ttcaattgtg tagggcttgt ttctgcaaga caccagaccc taacgttacc
     2101 tttctgtgca gtgaagggaa aggtttaaga gaatccagtt gagaaaacaa acttgctaat
     2161 cactttacca atgttatcaa aattactttt gaagacaatc agaaggattt tagctggata
     2221 acttactgct tttatctgac ccaagcaagt actacatgtt tgtctccctg ccagctgccc
     2281 tatgtagctc ctaactgttg tgtgatttgg acggcttttt gcatatttgt gtcagtttga
     2341 tgttaaccac aagtgccaga ctgatttttc agacggagcc tattttgctg caagcagttt
     2401 atataaagat acatatgtgt aaatatatgt acaaaaatta ctgaaaggct tcagtttttt
     2461 ctaattggat tattatgtct tgaaagttat tgtcagtttt tattccttgt taggctattt
     2521 tctgcaggat gcttttaact gatgtaggaa actgaaagga aatagatttt ttccaaaacc
     2581 cagttcccct tatttaatct tttttagaaa tgtgggtaat gaattctatc taataagtca
     2641 aggaaaccag aatttgacac actccaacaa tccgaagggg catgttgctc ctgagcagca
     2701 tgaagaactg accaaattgg ttttgatgct tgggggatca tagagtattt atgtctgctt
     2761 ttctaaatct gcattataat agctctaaaa tttgttgatt ggtaagaaat tgggcattgc
     2821 ttggctcttt aaacacatca gtgcttccac attcacctat gtatttatta ttcaaaagtg
     2881 tcattttaat atttattgct accttctgtg aatgcttagc tcctgtcggg ttcattaagg
     2941 agaaatgtgt ctgaaagcac agaactatta ttattttttt ctttttttga gatggagtct
     3001 tgccctgttg cccaggctgg agtgcagtgg cacgatctcg gctcactgca acctccgcct
     3061 cccgggttca agcaattctc ctgcctcagc ctcccgagta gctgggagtg caggtgcaca
     3121 ccgccatgcc tggctgattt tttgtatttt agtagagatg gggtttcacc atgttgcctg
     3181 ggctggttgc aaactcttga gctcaggcag tctgcctgcc tcagcctcct agagtgctgg
     3241 gattacagac atgagccact gcgcctggcc cagcgttact tttcttgata agaatttaca
     3301 gataagacac tcagagagac attgtgtcat tctctatcat cactcctttt accatgtgaa
     3361 tagatttctc tgtcttggca ttcttgctga ttcagactta ttagttaaat cggatttttc
     3421 tggaatttga atcagatttc atttgggcaa caacagcagg gcagggtttc taaagcaggt
     3481 ttccccactc atctaggttg tcttgaaagg aggatagagc cacttacagt tttatttgct
     3541 tcagtgttta atgtagatat tatgtggcct gctgtttctg ttgtcttgta tgtctgtgta
     3601 tgcatgacat ttggtccctt tctttgaaat gcagcccctc ttacgggttt tttagtggtg
     3661 gtggtttgtt ttgtttcata tcatatcaca gtttgcatgg actgattatc ttagttttat
     3721 gataaaacta gaagaaatga gggttttttt ttaatgaata gattttgaat tgattcttta
     3781 gaccccccaa aaagtgtcag ttctaatggg gaaatatatt ccatcaagtc aaagagtaat
     3841 aactgctcac tagttgcttt ttagcatctc tggtcttatc agccatgcta aatcacttta
     3901 attagcctta gtgattctat ggttgagtaa tctctacttg aactaaacaa acatcttttg
     3961 tttctgtgtg tgtgtgctgt gtgtgagagt gtgcgcgcgc gtgtgtgtgt gtgtgtttta
     4021 atggagtgtt gccttgaatg aatcactggg aagccagcca tggtaagggc tggtgaggtt
     4081 ggggagaaag gaagagcttt atgtttctct gttgtttgga ccctacttgg catgaaaaag
     4141 gaagctcagt tccagcccct tggatcaacg aaaatcagag gattctggaa aggcagccaa
     4201 cttgcgcctc ttagaaggat cagaggcaag atgagatggc agcctgcaga gtaaatgctt
     4261 gaaaaaagag gggtgatttt caatggtttg cttaagtcac tgttttctag acaccaaaat
     4321 agctgttttg aaactgtttt aattgcttgg gtagcaatgt gcactttaaa caatttggat
     4381 attggaatgc agtctcatac tgagtgattt gagtagaacc actgatgatg attttataaa
     4441 ttgtgtgaag cgaatttccc atttggcaat catttactga tttgcagtga tgaatatttt
     4501 tatgagaatt taaacttagc aagaatggcc atggaggcaa agccttcacc cagacccatc
     4561 ccactctcct gtgatccagg tggtccagga gcccaggaca ggccttttct gtgggccctg
     4621 gccagacagg gttacctggt gaggtgcaga gagtccctct agtggccatt ttgtatggta
     4681 gttgctaatg cagaacaagt tctgtcttgg gcttaaattg actgaagact ttagggggaa
     4741 agaatagtaa atgcatgtaa acaaatgggg acactctgtt caggagaata atccgactgg
     4801 catttgtggc agtttttgaa atgtaaatgt attcatgtgt gttcttgtaa atacgtgtcg
     4861 ctcagatgtc ctttgaagtg ggagggaatc aatccgggga taatttcaaa tggaatagag
     4921 tattttgata ttgttcattc agagggtgat gtgtacatat ctatattgta tatatgtgat
     4981 gaaaatgcat tggctttttg tgcagataca acctgctctc tgtactgctg ttggacagtc
     5041 agtgttttaa tgtttctaca gttttgctat tgcacgattt catattttgc ctctatgatg
     5101 aacggcaacc attatttgta actgtttagt gctgtaaaga aatattccaa gtgtcattag
     5161 gattgttgct gccagaactg atatgcatga atggcactta aaataaatat attatgttaa
     5221 ctcta
//
