LOCUS       NM_018416               5524 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens forkhead box J2 (FOXJ2), mRNA.
ACCESSION   NM_018416
VERSION     NM_018416.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5524)
  AUTHORS   Wang,C.P., Yu,Y.Z., Zhao,H., Xie,L.J., Wang,Q.T., Wang,Y. and Mu,Q.
  TITLE     MicroRNA-454-5p promotes breast cancer progression by inducing
            epithelial-mesenchymal transition via targeting the
            FoxJ2/E-cadherin axis
  JOURNAL   Oncol Rep 46 (1) (2021)
   PUBMED   33982790
  REMARK    GeneRIF: MicroRNA4545p promotes breast cancer progression by
            inducing epithelialmesenchymal transition via targeting the
            FoxJ2/Ecadherin axis.
REFERENCE   2  (bases 1 to 5524)
  AUTHORS   Li,Y., Zhu,X., Liu,C., Han,Q., Chen,X., Liu,Y., Yin,Y., He,A. and
            Xia,F.
  TITLE     Low FOXJ2 expression is associated with unfavorable postoperative
            prognosis of patients with epithelial ovarian cancer
  JOURNAL   Medicine (Baltimore) 100 (10), e24759 (2021)
   PUBMED   33725831
  REMARK    GeneRIF: Low FOXJ2 expression is associated with unfavorable
            postoperative prognosis of patients with epithelial ovarian cancer.
REFERENCE   3  (bases 1 to 5524)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5524)
  AUTHORS   Zhang,H., Tang,Q.F., Sun,M.Y., Zhang,C.Y., Zhu,J.Y., Shen,Y.L.,
            Zhao,B., Shao,Z.Y., Zhang,L.J. and Zhang,H.
  TITLE     ARHGAP9 suppresses the migration and invasion of hepatocellular
            carcinoma cells through up-regulating FOXJ2/E-cadherin
  JOURNAL   Cell Death Dis 9 (9), 916 (2018)
   PUBMED   30206221
  REMARK    GeneRIF: The data clearly show that ARHGAP9/FOXJ2 inhibit cell
            migration and invasion during hepatocellular carcinoma development
            via inducing the transcription of CDH1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5524)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 5524)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   7  (bases 1 to 5524)
  AUTHORS   Ferrell,R.E., Kimak,M.A., Lawrence,E.C. and Finegold,D.N.
  TITLE     Candidate gene analysis in primary lymphedema
  JOURNAL   Lymphat Res Biol 6 (2), 69-76 (2008)
   PUBMED   18564921
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 5524)
  AUTHORS   Gomez-Ferreria,M.A. and Rey-Campos,J.
  TITLE     Functional domains of FOXJ2
  JOURNAL   J Mol Biol 329 (4), 631-644 (2003)
   PUBMED   12787665
REFERENCE   9  (bases 1 to 5524)
  AUTHORS   Perez-Sanchez,C., Arias-de-la-Fuente,C., Gomez-Ferreria,M.A.,
            Granadino,B. and Rey-Campos,J.
  TITLE     FHX.L and FHX.S, two isoforms of the human fork-head factor FHX
            (FOXJ2) with differential activity
  JOURNAL   J Mol Biol 301 (4), 795-806 (2000)
   PUBMED   10966786
REFERENCE   10 (bases 1 to 5524)
  AUTHORS   Perez-Sanchez,C., Gomez-Ferreria,M.A., de La Fuente,C.A.,
            Granadino,B., Velasco,G., Esteban-Gamboa,A. and Rey-Campos,J.
  TITLE     FHX, a novel fork head factor with a dual DNA binding specificity
  JOURNAL   J Biol Chem 275 (17), 12909-12916 (2000)
   PUBMED   10777590
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC006511.5, BC032608.1, AL161978.1, AF155132.1 and CB243304.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018416.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.222474.1,
                                           SRR1803611.23969.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000162391.8/ ENSP00000162391.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC006511.5         97657-97703         c
            48-3275             BC032608.1         13-3240
            3276-4432           AL161978.1         773-1929
            4433-4563           AF155132.1         3791-3921
            4564-5505           AL161978.1         2062-3003
            5506-5524           CB243304.1         23-41               c
FEATURES             Location/Qualifiers
     source          1..5524
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..5524
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /note="forkhead box J2"
                     /db_xref="GeneID:55810"
                     /db_xref="HGNC:HGNC:24818"
                     /db_xref="MIM:619162"
     exon            1..1118
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1465
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     CDS             1133..2857
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /note="fork head homologous X; FOXJ2 forkhead factor"
                     /codon_start=1
                     /product="forkhead box protein J2"
                     /protein_id="NP_060886.1"
                     /db_xref="CCDS:CCDS8587.1"
                     /db_xref="GeneID:55810"
                     /db_xref="HGNC:HGNC:24818"
                     /db_xref="MIM:619162"
                     /translation="MASDLESSLTSIDWLPQLTLRATIEKLGSASQAGPPGSSRKCSP
                     GSPTDPNATLSKDEAAVHQDGKPRYSYATLITYAINSSPAKKMTLSEIYRWICDNFPY
                     YKNAGIGWKNSIRHNLSLNKCFRKVPRPRDDPGKGSYWTIDTCPDISRKRRHPPDDDL
                     SQDSPEQEASKSPRGGVAGSGEASLPPEGNPQMSLQSPTSIASYSQGTGSVDGGAVAA
                     GASGRESAEGPPPLYNTNHDFKFSYSEINFQDLSWSFRNLYKSMLEKSSSSSQHGFSS
                     LLGDIPPSNNYYMYQQQQPPPPQQQQQQQQPPQPPPQQSQPQQQQAPAQGPSAVGGAP
                     PLHTPSTDGCTPPGGKQAGAEGYGPPPVMAMHPPPLQHGGYHPHQHHPHSHPAQQPPP
                     PQPQAQGQAPINNTGFAFPSDWCSNIDSLKESFKMVNRLNWSSIEQSQFSELMESLRQ
                     AEQKNWTLDQHHIANLCDSLNHFLTQTGHVPPQGGTHRPPAPARIADSCALTSGKQES
                     AMSQVNSYGHPQAPHLYPGPSPMYPIPTQDSAGYNRPAHHMVPRPSVPPPGANEEIPD
                     DFDWDLIT"
     exon            1466..1540
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            1541..1609
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1750
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..1949
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            1950..2357
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2459
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            2460..2669
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2768
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     exon            2769..5524
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5492..5497
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /note="hexamer: AATAAA"
     polyA_site      5524
                     /gene="FOXJ2"
                     /gene_synonym="FHX"
                     /note="major polyA site"
ORIGIN      
        1 gcagcggagc cgagccgagc ccgagcccgc gccgagccct gacactgtct gcccgccttc
       61 tggctccccg ggagcccaga ctggtcggag cccgagcggt ggcagcgcgg ggagccccac
      121 gcgccgaagg gagcggaccc gacaggacgg ccctagagga ggtgctgccg ccacagtagc
      181 agggaccgga gtctcgagcc gcggcctccc ggaccgtgct gcccaggcca gctcagggac
      241 agccgggagt acgaaagccc caccctctgg ggcaccccgg gagcggaggc gggagcgggg
      301 acgcgagcaa cctctccccc tgttggagag aaaagaccct taccactcgg gtgagggaaa
      361 gaagagaccc ctggagggga cgcctctctc ctgcctagag gcgaggaaga cccctgtact
      421 ggccggggag gagaccccca gaagtggaaa gaagggagct ttccgtaggg aagcagagtg
      481 agaccaccct agcgcgcccc cgcccctcca aacacacact ctcaacagtt caggactttg
      541 gaggcaaaga gagacggggc tgtgcctgtg gagtaggcac cctcggccca ccactattca
      601 caggagacag gagtccttac gttcagaagc cactccaggg aaagaagagg aatcggcttt
      661 cagccttctg gagaggggaa gacctccccc tcaacttcct cgtgcctaga cagtggaacg
      721 gggtggagcc cctccgctcc tatctccagc agacagaaag agccctccac ctcagaaaga
      781 tccagtttgg gggggagggg aactccccca agggggagga gacaactcct ggttgggaga
      841 ggctcctccc ctcctccccc gggtaacaag cagggtgtgg ggggtgtgcc accttcccca
      901 agtaggacct ccttctcctc cccctccccc tcctccaacc ttgactcctc atcctcaggg
      961 gacccagttc ccctcaccaa cttgggaggc tcagcctcgt ccaggaagag ccactgagga
     1021 tgagagccgt cacctgcctc tgaagagggg aatccctcca accccaaact ccagtaccag
     1081 gtggttccct ccctttgccg gaggaacctt ggagacagaa cccagaagta ccatggcttc
     1141 tgacctagag agtagcctca cctccataga ctggctcccc cagctgaccc tccgagctac
     1201 cattgagaag cttggaagtg cctcccaggc tgggcctccc gggagcagcc gcaagtgttc
     1261 accagggtca cccacagatc ctaatgccac cctgagcaaa gacgaggcag cagtgcacca
     1321 ggacggcaag ccacgataca gctatgccac tctcatcacc tatgccatca actcctctcc
     1381 agccaagaag atgaccctca gcgagattta ccgctggatc tgtgataact tcccctatta
     1441 caagaatgct ggcattggtt ggaagaattc aatacggcac aacctttctc tcaacaagtg
     1501 tttccggaag gtgcccagac ctcgggatga ccctgggaag ggttcctatt ggacaattga
     1561 cacctgccct gacatttccc gaaagagaag acaccctcca gatgatgatc tgtcccaaga
     1621 ctcaccagaa caggaggcaa gcaagagccc acggggaggc gttgcaggga gtggagaagc
     1681 ctcactgcct cctgagggga atccgcagat gtcacttcag agccccacat ctatagccag
     1741 ctacagccag ggcacaggat ctgtggatgg tggagcagtg gcagcagggg cttcaggccg
     1801 agaaagtgct gagggtcccc ctcccctcta taacaccaac catgacttta aattctccta
     1861 ctcagagatc aactttcagg atctaagctg gtccttccgc aacctctata agtccatgct
     1921 ggagaagtcc tcttcctcct ctcagcacgg cttttcttct ctcctggggg acatcccacc
     1981 ctcgaacaac tactacatgt atcagcagca gcagccaccg ccacctcaac agcagcagca
     2041 gcagcagcag ccgccacagc cacctcccca gcagtcccag ccacagcagc agcaggcacc
     2101 tgcccagggc ccctcagctg tagggggtgc tcctccactg cacaccccaa gcacagatgg
     2161 ttgtacccca ccagggggaa agcaagctgg ggcggaaggc tatgggcctc cccctgtaat
     2221 ggccatgcat ccacccccgc tgcagcatgg aggctaccac cctcatcagc accatcccca
     2281 ctcccaccct gcccagcagc caccacctcc acagccacag gcacaaggcc aggctcccat
     2341 caacaacact ggctttgcct ttccttctga ctggtgctct aatattgact ctttaaagga
     2401 aagcttcaag atggtgaatc ggctcaattg gtccagcatt gagcagtcac aattctcaga
     2461 actgatggag agtctacgac aggcagagca gaagaactgg accctcgacc agcatcacat
     2521 tgccaatctg tgtgactccc tcaaccactt ccttactcag actggtcacg tgccccctca
     2581 agggggtacc caccgcccac cagcccctgc ccgtattgct gactcctgtg ccctcaccag
     2641 tggcaaacag gagtcagcca tgagccaagt gaactcttat gggcacccac aagctcccca
     2701 cctctaccct ggcccatcac caatgtaccc aatccccacc caggactcag caggatacaa
     2761 tcgcccagca caccatatgg tccctcggcc atcagtgcca cctcctggtg ccaatgagga
     2821 gatccctgat gacttcgact gggacttgat cacttagtgc atcacagagt gtggacatca
     2881 gcccagggcc gcgtggtgaa atctggcagt ggggaaagag caaccccagc ccgtcccttc
     2941 cccccgtctg tatatagaca tatatcctct ttttgttctt tctctgtcag agaagccact
     3001 gcaagatgct gccgaagata accctctctt tcctgcctca ttcttctctc ttccttcctg
     3061 ttttttccta gttcttttat tattattctt atattattat tattattatt ggttatatac
     3121 tgtccatagt ctcctgtccc tacatcatgg atcatgtcca ccttttgcta atttaaaatc
     3181 atcaggctgg aagatgaagc catgatagct acagagaaag gttttagact ccagtttacc
     3241 tttctcttgg agaaactcaa tgctaatccc accttttggc cctaaattgt tttttgttcc
     3301 catcagtttc aggccaggac tggagaggcc acattaccaa gtagaaaggg tctgaaacat
     3361 tacttggcag ccaagaattt ggaggtttta aaatggtgct aattctgtcc tctgaggtct
     3421 tccttgtccc tttatacctt caatccttac ttctgccagt ctgtatttcc tatcaagggt
     3481 gaaagtgatg atggtggtgc aggagggtga caataaaatc ctagtggaat tggagaccat
     3541 tggaagggat ggaatataag tcagtgtgaa actgagtata cactgccatg ttacatcagt
     3601 gtccattggc ttgttttgag cctgttctct aagaagatag gattggtttt agcccaaact
     3661 ctgcttctat ggtagggcat gaggacaact attcagcatg gttttagctt cttggagatg
     3721 attccaactt aactattttg gctttttaaa cataattttc tctgaaaatt aattgtggct
     3781 cttatttgca tttacgaatg atcttcccat ccctttttcc cattcagcaa atattagttt
     3841 gtcctccttt aattgtttgc ccaaatcttc cacccatctt ttttcttccc tcattttctg
     3901 ggattctcaa gaaagaaaaa gtaacccatt atcactctga gtttcgtcgt gccctgagac
     3961 atgatgggaa tctcattccc acctctcata gcagagccaa acctttagtg ttggtggtag
     4021 gaggatgggg agaggaaaaa agagctggca aagaaatgga tagggaatat tttagttctt
     4081 taaatatata ggcagatgct tctcttggaa tccagatcat ctggctgaag cttttgcaag
     4141 taggctttga ggggtgaagg agattggtgg aggagagtaa ataatctaga ggcaagagtt
     4201 cagtgagggc caagggggac ccccagaaaa aggtatggag ctaactcatc tcttttacaa
     4261 ggggtggcca tgacttactg ttgcaaagta ctcagtgtat atttaatgtt gattgttgaa
     4321 ttttagttac gagagggaag aacaatttta cttctgtcct tatttcactt gctgaaaagc
     4381 tgtgggacaa aatgtatgga atagacaagg ccactttctt tgtgatttct gcttttcatg
     4441 catattattt tatttaccca taatttccaa gaggtttggc gttccgctct cctgcttttt
     4501 tctttcatcc acccctttcc tttttttgga agggggttat atatgagagt tcattgaaga
     4561 agtccagtga ggctgaagta aaggggcaag atagggcagt taactaaaga gcactttatt
     4621 tctttgaagc ctttctaaga aagaaatggg ggtgcgagtg gcttgaatct cccatgatgt
     4681 tggagggcac ttagtggggt tgaagtatga cataatattt cccattgggg aaaggagaat
     4741 ttctcttaga gggtggcaaa atgcctttgc ccagtgtccc tattttaggc atcttttcct
     4801 tccttattcc ttccagtcag ggtgtgtcct atacaaaact tcccatcagt tctcctcaat
     4861 attccccatt tgtaaatgat cacttctctt ttctaaaccc ttttcctgtt cagatccata
     4921 caggatttgc aagggtagga tcatacatgc aaatgcccct tgttcatctg tgtcttctgc
     4981 aaactagtct catgaagaat tctggcgtgc agccagggta gctgaagttt gggtctggga
     5041 ctggagattg gccattaggc ctcctgagat tccagctccc ttccaccaag cccagtcttg
     5101 ctacgtggca cagggcaaac ctgactccct ttgggcctca gtttcccctc cccttcatga
     5161 aatgaaaaga atactacttt ttcttgttgg tctagcattg ctggacacaa agtgtagtca
     5221 ttattgttgt attgggtgat gtgtgcaaaa ctgcagaagc tcactgccta taagaggaaa
     5281 taagagagaa agtggaggag agggacaaaa ggagtaatta tttggtatag atccacccat
     5341 cccaaccttt ctctcctcag tccctgctcc tcatgtttct ggtttggtga gtcctttgtg
     5401 ccaccaccca taatgctttg cattgctgca tcctgggaag ggggtatatg gtctcacaag
     5461 ttgttgtcat tgtttttttg catgctttct taataaaaaa aaaaaaagaa tgtttacagt
     5521 ttta
//
