LOCUS       NM_207426               3264 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens forkhead box I2 (FOXI2), mRNA.
ACCESSION   NM_207426
VERSION     NM_207426.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3264)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   2  (bases 1 to 3264)
  AUTHORS   Wijchers,P.J., Hoekman,M.F., Burbach,J.P. and Smidt,M.P.
  TITLE     Cloning and analysis of the murine Foxi2 transcription factor
  JOURNAL   Biochim Biophys Acta 1731 (2), 133-138 (2005)
   PUBMED   16289364
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL391005.9.
            
            On May 17, 2019 this sequence version replaced NM_207426.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments and PMID: 16289364.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK128865.1, BC137297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000388920.5/ ENSP00000373572.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AL391005.9         159742-159830
            90-600              AL391005.9         159831-160341
            601-3264            AL391005.9         161077-163740
FEATURES             Location/Qualifiers
     source          1..3264
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.2"
     gene            1..3264
                     /gene="FOXI2"
                     /note="forkhead box I2"
                     /db_xref="GeneID:399823"
                     /db_xref="HGNC:HGNC:32448"
                     /db_xref="MIM:617202"
     exon            1..600
                     /gene="FOXI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1046
                     /gene="FOXI2"
                     /note="homolog of mouse Foxi2"
                     /codon_start=1
                     /product="forkhead box protein I2"
                     /protein_id="NP_997309.2"
                     /db_xref="CCDS:CCDS7655.2"
                     /db_xref="GeneID:399823"
                     /db_xref="HGNC:HGNC:32448"
                     /db_xref="MIM:617202"
                     /translation="MATYCDDLGPSSAPPGQAQATAHPPGYEPGDLGAVGGGPLLWVN
                     APALSPKSYASGPGPAPPYAAPSYGAPGPLLGAPGGLAGADLAWLSLSGQQELLRLVR
                     PPYSYSALIAMAIQSAPLRKLTLSQIYQYVAGNFPFYKRSKAGWQNSIRHNLSLNDCF
                     KKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRKRRAEASAAVRSGARSVGGAEAP
                     ALEPPSAACLDLQASPSPSAPEAATCFSGFASAMSALAGGLGTFPGGLAGDFSFGRRP
                     PTVATHAPQTLNPSPGFAPGHQTAAAGFRLSHLLYSREGTEV"
     exon            601..3264
                     /gene="FOXI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3244..3249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXI2"
                     /note="hexamer: AATAAA"
     polyA_site      3264
                     /gene="FOXI2"
                     /note="major polyA site"
ORIGIN      
        1 gcacccgggc gctgctggcg gccaagctgg atgggtcgcc agtgagtttc ggtgcggcac
       61 cgctggccca ggcccgggcg cggctggaca tggccaccta ctgcgacgac ctgggcccct
      121 cctcggcccc gcccggccag gcccaggcca ccgcgcaccc cccgggctat gagccagggg
      181 atctgggcgc ggtgggcggg ggccccctcc tgtgggtgaa cgcgccagcg ctcagcccca
      241 agtcctacgc ttcgggtccc gggcctgcgc cgccctacgc ggccccgagc tacggggctc
      301 ccggcccgct cctcggcgcc ccgggcggcc tggcgggcgc cgacctcgcc tggctgagcc
      361 tctccggcca gcaggagctg ctgaggctgg tgcggccgcc ctactcctac tcggcgctca
      421 tcgccatggc catccagagc gcgccgctgc ggaagctgac gctcagccag atctaccagt
      481 acgtggctgg taacttccct ttctacaagc gcagcaaggc gggctggcag aactccatcc
      541 gccacaacct gtcgctcaac gactgcttca agaaggtgcc ccgcgacgag gacgacccag
      601 gtaaaggcaa ttactggacc ctggacccca actgcgagaa gatgtttgac aacgggaact
      661 tccgaaggaa gaggaagagg agagctgaag ccagcgcggc cgtgcgctcg ggagccagga
      721 gcgtgggagg ggccgaggcg ccagcgctgg agcccccgag cgcggcttgc ctggacctgc
      781 aggcctcgcc ctctccatcc gcacccgagg ccgccacctg cttctccggt ttcgcttctg
      841 ctatgagcgc tctggctggc ggccttggca ccttccccgg gggcctggcg ggcgactttt
      901 ctttcgggag gcggccaccg acagtcgcca cccacgctcc ccagaccctt aacccctccc
      961 ctggcttcgc ccctggccac cagaccgcgg ccgccggctt ccgcctcagt cacctcctct
     1021 acagccggga agggaccgaa gtttgaaggg aggctggagg ctagccgggt gcgggtccag
     1081 aggtgctgag ctcaggcctc cggtttcccc tggtgacagc cccacgtgtt ggcgttgaag
     1141 gccttggtgc cctgggagga agcgcagagc cgggggcggc tcggccagca gggagctggg
     1201 ctgagcggct cttgggcttt ggggtgggtg gcccttctgc tgtgcacccc tcacccaggc
     1261 gaccttcgga acctccctgc tctgcctcta agtccagccg ccctgggcgt ctagaacctg
     1321 tgctctcgag ggatttgcct tgaaggggcg gcgggtcggc cctcagctcc agcgttttcc
     1381 aaggaggctg gctgactcca aagagcctta gagcagatgg gaagaaggtg ggctgccaga
     1441 gcggcccagg tggtgggggc cctttccacc tccacccagc ttggcccacc tggctcaggg
     1501 ccttcccttc tgcttcaggg aagctgccgc aggggctggg ggacagagct caggagcagc
     1561 tgcagtgggc tccaggtggg ccaggagcct gcagtgaggg gatctgagac agttggcatt
     1621 gggtcctgtg taaggaaggt cttgctaatg gttggaactg ctggtggtgg gagggagaag
     1681 cactgcgtgg gcagaaagcg cccttgggat accagctccc ttccctgtca ctcagccctg
     1741 gtccttgatg acccccctct aggacaaggc aactccccag ggccccgcca ccactgacca
     1801 caggagcggt gcccagcacc caggagttcc ccaagggtcc aggtttgtgc cacccacacc
     1861 cacactcaca cccacactca cacccacact cacacccaca cccacaccca cacccacact
     1921 cacactcaca ctcacaccca cactcacacc cacactcaca cccacaccca cacccacact
     1981 cacacacact cacacccaca cccacactca cacccacaca cactcacacc cacacacacc
     2041 cacactcata ctcacactca cacccacact cacaccacac ccacactcac actgacaccc
     2101 acactcacac ccacactcac actgacaccc acactcacac ccacactcat actcacactc
     2161 acacccacac tcacactcac acccacactc acaccacact cacacccaca cacacccaca
     2221 ctcatactca cacccacacc cacactcata ctcacacacc cacacccaca cccacaccca
     2281 cacccacacc cacacccaca ctcacacagg ctcatggaag gccacacttg ttttggtctc
     2341 tttcccctcc aaacccacag tttgagccaa agctgtgcgt gtgttcagag ctcctgaaca
     2401 gcagcctcct gtgtaaattg aaccctgccc cacccagttc cttcttaggg atggtatctt
     2461 tgtgaaggac aaggagcccc cagtcactgg gaagaggaat tttttggcct ctgtactcct
     2521 tagaggacct aagtgcccca gtcagatgcc ctgagtcttt gtggcatctg ggactccctg
     2581 gagatggaga cgttggtggg gggggggtac ccaccttgtt gttgatgggg gtacctatct
     2641 tccctgcatt ttgggggagg gtgggagggg tccttcccag gaagagagtg gagacaggtt
     2701 actgttactt tggagtggga caggctggtt tagcaatcct aagccccagc cacgcaggta
     2761 ttcctgatct gcctgcaggg cccctcactg cagctgccac cagtgctgga aatgagagca
     2821 gggctcctga ctgtccctag agctgactca tcatggccct gctgaagagt gaggtgtgtg
     2881 tgtgtgtgtg cgtgtgtgcg taagacagag agggagggag aaggaaggag gcgggggaac
     2941 atggagagaa ggagccagga gttgggataa acctggccct ggtcatatgt ttcatcagca
     3001 gtggctccta actccacgtg ccatctctgc tgctgccctc cacaagcagg tgagcagagt
     3061 gccagttgtg ttgaaggtga tgatgtcgcc taactaaact cacaaccaac ccgcaatctc
     3121 tcttgggggg acactcccca taagcaatac aattaaagaa gaccaggaaa ggaaaataaa
     3181 ttccttagct tatacattta aaaagtatcc cttgaaccta ttttaataga atgaaatgct
     3241 aaaaataaag accaatataa cata
//
