LOCUS       NM_003923               2017 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens forkhead box H1 (FOXH1), mRNA.
ACCESSION   NM_003923
VERSION     NM_003923.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2017)
  AUTHORS   Pluta,R., Aragon,E., Prescott,N.A., Ruiz,L., Mees,R.A.,
            Baginski,B., Flood,J.R., Martin-Malpartida,P., Massague,J.,
            David,Y. and Macias,M.J.
  TITLE     Molecular basis for DNA recognition by the maternal pioneer
            transcription factor FoxH1
  JOURNAL   Nat Commun 13 (1), 7279 (2022)
   PUBMED   36435807
  REMARK    GeneRIF: Molecular basis for DNA recognition by the maternal
            pioneer transcription factor FoxH1.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2017)
  AUTHORS   Ouyang,X., Feng,L., Yao,L., Zhang,J., Xiao,Y., Liu,G., Zhang,G. and
            Wang,Z.
  TITLE     A comprehensive analysis of FOX family in HCC and experimental
            evidence to support the oncogenic role of FOXH1
  JOURNAL   Aging (Albany NY) 14 (5), 2268-2286 (2022)
   PUBMED   35255005
  REMARK    GeneRIF: A comprehensive analysis of FOX family in HCC and
            experimental evidence to support the oncogenic role of FOXH1.
REFERENCE   3  (bases 1 to 2017)
  AUTHORS   Zhou,W., Chen,L., Jiang,B., Sun,Y., Li,M., Wu,H., Zhang,N., Sun,X.
            and Qin,S.
  TITLE     Large-scale whole-exome sequencing association study identifies
            FOXH1 gene and sphingolipid metabolism pathway influencing major
            depressive disorder
  JOURNAL   CNS Neurosci Ther 27 (11), 1425-1428 (2021)
   PUBMED   34633764
  REMARK    GeneRIF: Large-scale whole-exome sequencing association study
            identifies FOXH1 gene and sphingolipid metabolism pathway
            influencing major depressive disorder.
REFERENCE   4  (bases 1 to 2017)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2017)
  AUTHORS   Wei,W., Li,B., Li,F., Sun,K., Jiang,X. and Xu,R.
  TITLE     Identification of FOXH1 mutations in patients with sporadic
            conotruncal heart defect
  JOURNAL   Clin Genet 97 (4), 576-585 (2020)
   PUBMED   32003456
  REMARK    GeneRIF: Identification of FOXH1 mutations in patients with
            sporadic conotruncal heart defect.
REFERENCE   6  (bases 1 to 2017)
  AUTHORS   Liu,B., Dou,C.L., Prabhu,L. and Lai,E.
  TITLE     FAST-2 is a mammalian winged-helix protein which mediates
            transforming growth factor beta signals
  JOURNAL   Mol Cell Biol 19 (1), 424-430 (1999)
   PUBMED   9858566
REFERENCE   7  (bases 1 to 2017)
  AUTHORS   Zhou,S., Zawel,L., Lengauer,C., Kinzler,K.W. and Vogelstein,B.
  TITLE     Characterization of human FAST-1, a TGF beta and activin signal
            transducer
  JOURNAL   Mol Cell 2 (1), 121-127 (1998)
   PUBMED   9702198
REFERENCE   8  (bases 1 to 2017)
  AUTHORS   Liu,F., Pouponnot,C. and Massague,J.
  TITLE     Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible
            transcriptional complexes
  JOURNAL   Genes Dev 11 (23), 3157-3167 (1997)
   PUBMED   9389648
REFERENCE   9  (bases 1 to 2017)
  AUTHORS   Chen,X., Weisberg,E., Fridmacher,V., Watanabe,M., Naco,G. and
            Whitman,M.
  TITLE     Smad4 and FAST-1 in the assembly of activin-responsive factor
  JOURNAL   Nature 389 (6646), 85-89 (1997)
   PUBMED   9288972
REFERENCE   10 (bases 1 to 2017)
  AUTHORS   Tekendo-Ngongang,C., Muenke,M. and Kruszka,P.
  TITLE     Holoprosencephaly Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF076292.1, AC084125.9,
            CX782591.1 and BE550635.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_003923.2.
            
            Summary: FOXH1 encodes a human homolog of Xenopus forkhead activin
            signal transducer-1. FOXH1 protein binds SMAD2 and activates an
            activin response element via binding the DNA motif
            TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF076292.1, CX165012.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2149876
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000377317.5/ ENSP00000366534.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1210              AF076292.1         487-1696
            1211-1211           AC084125.9         154534-154534
            1212-1376           CX782591.1         618-782
            1377-1697           BE550635.1         11-331              c
            1698-2017           AC084125.9         155021-155340
FEATURES             Location/Qualifiers
     source          1..2017
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..2017
                     /gene="FOXH1"
                     /gene_synonym="FAST-1; FAST1"
                     /note="forkhead box H1"
                     /db_xref="GeneID:8928"
                     /db_xref="HGNC:HGNC:3814"
                     /db_xref="MIM:603621"
     exon            1..267
                     /gene="FOXH1"
                     /gene_synonym="FAST-1; FAST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1191
                     /gene="FOXH1"
                     /gene_synonym="FAST-1; FAST1"
                     /note="TGF-beta/activin signal transducer; forkhead
                     activin signal transducer-1; fast-2; hFAST-1; forkhead
                     activin signal transducer 2"
                     /codon_start=1
                     /product="forkhead box protein H1"
                     /protein_id="NP_003914.1"
                     /db_xref="CCDS:CCDS6428.1"
                     /db_xref="GeneID:8928"
                     /db_xref="HGNC:HGNC:3814"
                     /db_xref="MIM:603621"
                     /translation="MGPCSGSRLGPPEAESPSQPPKRRKKRYLRHDKPPYTYLAMIAL
                     VIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKDPAKPQ
                     AKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDLGPYVLHGRPYRPPSPP
                     PPPSEGFSIKSLLGGSGEGAPWPGLAPQSSPVPAGTGNSGEEAVPTPPLPSSERPLWP
                     LCPLPGPTRVEGETVQGGAIGPSTLSPEPRAWPLHLLQGTAVPGGRSSGGHRASLWGQ
                     LPTSYLPIYTPNVVMPLAPPPTSCPQCPSTSPAYWGVAPETRGPPGLLCDLDALFQGV
                     PPNKSIYDVWVSHPRDLAAPGPGWLLSWCSL"
     exon            268..372
                     /gene="FOXH1"
                     /gene_synonym="FAST-1; FAST1"
                     /inference="alignment:Splign:2.1.0"
     exon            373..2017
                     /gene="FOXH1"
                     /gene_synonym="FAST-1; FAST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1673..1678
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXH1"
                     /gene_synonym="FAST-1; FAST1"
                     /note="hexamer: AGTAAA"
     polyA_site      1697
                     /gene="FOXH1"
                     /gene_synonym="FAST-1; FAST1"
                     /note="major polyA site"
ORIGIN      
        1 cggcctcagg tcccggccct gccttctaca ctgccccacc gccctgcacc ctccacccgg
       61 ccaggcccct gcccacgctg tctaccgtcc cgcatggggc cctgcagcgg ctcccgcctg
      121 gggcccccag aggcagagtc gccctcccag ccccctaaga ggaggaagaa gaggtacctg
      181 cgacatgaca agccccccta cacctacttg gccatgatcg ccttggtgat tcaggccgct
      241 ccctcccgca gactgaagct ggcccagatc atccgtcagg tccaggccgt gttccccttc
      301 ttcagggaag actacgaggg ctggaaagac tccattcgcc acaacctttc ctccaaccga
      361 tgcttccgca aggtgcccaa ggaccctgca aagccccagg ccaagggcaa cttctgggcg
      421 gtcgacgtga gcctgatccc agctgaggcg ctccggctgc agaacaccgc cctgtgccgg
      481 cgctggcaga acggaggtgc gcgtggagcc ttcgccaagg acctgggccc ctacgtgctg
      541 cacggccggc cataccggcc gcccagtccc ccgccaccac ccagtgaggg cttcagcatc
      601 aagtccctgc taggagggtc cggggagggg gcaccctggc cggggctagc tccacagagc
      661 agcccagttc ctgcaggcac agggaacagt ggggaggagg cggtgcccac cccacccctt
      721 ccctcttctg agaggcctct gtggcccctc tgcccccttc ctggccccac gagagtggag
      781 ggggagactg tgcagggggg agccatcggg ccctcaaccc tctccccaga gcctagggcc
      841 tggcctctcc acttactgca gggcaccgca gttcctgggg gacggtccag cgggggacac
      901 agggcctccc tctgggggca gctgcccacc tcctacttgc ctatctacac tcccaatgtg
      961 gtaatgccct tggcaccacc acccacctcc tgtccccagt gtccgtcaac cagccctgcc
     1021 tactgggggg tggcccctga aacccgaggg cccccagggc tgctctgcga tctagacgcc
     1081 ctcttccaag gggtgccacc caacaaaagc atctacgacg tttgggtcag ccaccctcgg
     1141 gacctggcgg cccctggccc aggctggctg ctctcctggt gcagcctgtg aggctcttaa
     1201 gacaggggcc actcctccct cccgctccca cccccacctt gttgacaggg agccaaggcg
     1261 aggcggctgt ctgcgaccac agcagcctcg aaacaccagg cagcagcctt gctgggagtc
     1321 cacggtgttt attgggccac cccacgcatg gccgtggccc agctgggcac aaccctcacc
     1381 ctggtctgtc atgcctgttt ttcctacact cagcggcaaa gctgcaggag cagggctgag
     1441 cctggaatag cccttcctag tcccctcttc tcagcccact acccatccat cagtcaccag
     1501 ccgtcacctc ccctcccgtg ctccaggctg ggggagggag agcccagtgg tggatccagc
     1561 ctgaagtcct gccctctctc atctgtctgg aaaggaggta gcaccttttt cgggaaacgg
     1621 gttagggagt aaagactgca ccctacatgg tcctggtggt gggggggata acagtaaagg
     1681 aatttgcaac gttttaatgc catgcctgat ttttgggtca ggagtggtga cttgggtaac
     1741 cacttggcgg gggggcctgg gattccctgc tgtgtgccgt gataacagca aatggtgata
     1801 aggagaaagc caagacctgt ggcctgatgc agggctgggg gcggggggtg atcacttcag
     1861 caggcacaac acacttcact ggctgcggag gtggaggggt gactctggga gctcaggggc
     1921 aatggatcca aagaggctag ggagcttgtg ccctgggaga cggggtacag ggactttact
     1981 accgcctctg ccagcagaga cctggcctga gacccca
//
