LOCUS       NM_001452               2451 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box F2 (FOXF2), mRNA.
ACCESSION   NM_001452
VERSION     NM_001452.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2451)
  AUTHORS   Zhong,B.H., Ma,Y.T., Sun,J., Tang,J.T. and Dong,M.
  TITLE     Transcription factor FOXF2 promotes the development and progression
            of pancreatic cancer by targeting MSI2
  JOURNAL   Oncol Rep 52 (1) (2024)
   PUBMED   38847273
  REMARK    GeneRIF: Transcription factor FOXF2 promotes the development and
            progression of pancreatic cancer by targeting MSI2.
REFERENCE   2  (bases 1 to 2451)
  AUTHORS   Jia,D., Zhou,Z., Kwon,O.J., Zhang,L., Wei,X., Zhang,Y., Yi,M.,
            Roudier,M.P., Regier,M.C., Dumpit,R., Nelson,P.S., Headley,M.,
            True,L., Lin,D.W., Morrissey,C., Creighton,C.J. and Xin,L.
  TITLE     Stromal FOXF2 suppresses prostate cancer progression and metastasis
            by enhancing antitumor immunity
  JOURNAL   Nat Commun 13 (1), 6828 (2022)
   PUBMED   36369237
  REMARK    GeneRIF: Stromal FOXF2 suppresses prostate cancer progression and
            metastasis by enhancing antitumor immunity.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2451)
  AUTHORS   Ryu,J.R., Ahuja,S., Arnold,C.R., Potts,K.G., Mishra,A., Yang,Q.,
            Sargurupremraj,M., Mahoney,D.J., Seshadri,S., Debette,S. and
            Childs,S.J.
  TITLE     Stroke-associated intergenic variants modulate a human FOXF2
            transcriptional enhancer
  JOURNAL   Proc Natl Acad Sci U S A 119 (35), e2121333119 (2022)
   PUBMED   35994645
  REMARK    GeneRIF: Stroke-associated intergenic variants modulate a human
            FOXF2 transcriptional enhancer.
REFERENCE   4  (bases 1 to 2451)
  AUTHORS   Zhang,X., Zhang,R., Hou,C., He,R., Wang,Q.S., Zhou,T.H., Li,X.Q.,
            Zhai,Q.L. and Feng,Y.M.
  TITLE     FOXF2 oppositely regulates stemness in luminal and basal-like
            breast cancer cells through the Wnt/beta-catenin pathway
  JOURNAL   J Biol Chem 298 (7), 102082 (2022)
   PUBMED   35660418
  REMARK    GeneRIF: FOXF2 oppositely regulates stemness in luminal and
            basal-like breast cancer cells through the Wnt/beta-catenin
            pathway.
REFERENCE   5  (bases 1 to 2451)
  AUTHORS   Li,T., Huang,S., Yan,W., Zhang,Y. and Guo,Q.
  TITLE     FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis of
            Colorectal Cancer
  JOURNAL   Technol Cancer Res Treat 21, 15330338221118717 (2022)
   PUBMED   35929169
  REMARK    GeneRIF: FOXF2 Regulates PRUNE2 Transcription in the Pathogenesis
            of Colorectal Cancer.
REFERENCE   6  (bases 1 to 2451)
  AUTHORS   Blixt,A., Mahlapuu,M., Bjursell,C., Darnfors,C., Johannesson,T.,
            Enerback,S. and Carlsson,P.
  TITLE     The two-exon gene of the human forkhead transcription factor
            FREAC-2 (FKHL6) is located at 6p25.3
  JOURNAL   Genomics 53 (3), 387-390 (1998)
   PUBMED   9799607
REFERENCE   7  (bases 1 to 2451)
  AUTHORS   Hellqvist,M., Mahlapuu,M., Blixt,A., Enerback,S. and Carlsson,P.
  TITLE     The human forkhead protein FREAC-2 contains two functionally
            redundant activation domains and interacts with TBP and TFIIB
  JOURNAL   J Biol Chem 273 (36), 23335-23343 (1998)
   PUBMED   9722567
REFERENCE   8  (bases 1 to 2451)
  AUTHORS   Hellqvist,M., Mahlapuu,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Differential activation of lung-specific genes by two forkhead
            proteins, FREAC-1 and FREAC-2
  JOURNAL   J Biol Chem 271 (8), 4482-4490 (1996)
   PUBMED   8626802
REFERENCE   9  (bases 1 to 2451)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
REFERENCE   10 (bases 1 to 2451)
  AUTHORS   Murphy,D.B., Wiese,S., Burfeind,P., Schmundt,D., Mattei,M.G.,
            Schulz-Schaeffer,W. and Thies,U.
  TITLE     Human brain factor 1, a new member of the fork head gene family
  JOURNAL   Genomics 21 (3), 551-557 (1994)
   PUBMED   7959731
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034346.31, U13220.1 and
            CA448136.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 9, 2018 this sequence version replaced NM_001452.1.
            
            Summary: FOXF2 encodes forkhead box F2, one of many human
            homologues of the Drosophila melanogaster transcription factor
            forkhead. FOXF2 is expressed in lung and placenta, and has been
            shown to transcriptionally activate several lung-specific genes.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U13220.1, ERR279863.5368.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645481.2/ ENSP00000496415.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AL034346.31        33054-33311
            259-2445            U13220.1           1-2187
            2446-2451           CA448136.1         19-24               c
FEATURES             Location/Qualifiers
     source          1..2451
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.3"
     gene            1..2451
                     /gene="FOXF2"
                     /gene_synonym="FKHL6; FREAC-2; FREAC2"
                     /note="forkhead box F2"
                     /db_xref="GeneID:2295"
                     /db_xref="HGNC:HGNC:3810"
                     /db_xref="MIM:603250"
     exon            1..1543
                     /gene="FOXF2"
                     /gene_synonym="FKHL6; FREAC-2; FREAC2"
                     /inference="alignment:Splign:2.1.0"
     CDS             373..1707
                     /gene="FOXF2"
                     /gene_synonym="FKHL6; FREAC-2; FREAC2"
                     /note="forkhead-like 6; forkhead-related activator 2;
                     forkhead-related protein FKHL6; forkhead-related
                     transcription factor 2"
                     /codon_start=1
                     /product="forkhead box protein F2"
                     /protein_id="NP_001443.1"
                     /db_xref="CCDS:CCDS4472.1"
                     /db_xref="GeneID:2295"
                     /db_xref="HGNC:HGNC:3810"
                     /db_xref="MIM:603250"
                     /translation="MTTEGGPPPAPLRRACSPVPGALQAALMSPPPAAAAAAAAAPET
                     TSSSSSSSSASCASSSSSSNSASAPSAACKSAGGGGAGAGSGGAKKASSGLRRPEKPP
                     YSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVRHNLSLNECFIK
                     LPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYHRVVSGLGFGA
                     SLLPQGFDFQAPPSAPLGCHSQGGYGGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHM
                     SPNPGSTYMASCPVPAGPGGVGAAGGGGGGDYGPDSSSSPVPSSPAMASAIECHSPYT
                     SPAAHWSSPGASPYLKQPPALTPSSNPAASAGLHSSMSSYSLEQSYLHQNAREDLSVG
                     LPRYQHHSTPVCDRKDFVLNFNGISSFHPSASGSYYHHHHQSVCQDIKPCVM"
     exon            1544..2451
                     /gene="FOXF2"
                     /gene_synonym="FKHL6; FREAC-2; FREAC2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2428..2433
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXF2"
                     /gene_synonym="FKHL6; FREAC-2; FREAC2"
                     /note="hexamer: AATAAA"
     polyA_site      2447
                     /gene="FOXF2"
                     /gene_synonym="FKHL6; FREAC-2; FREAC2"
                     /note="major polyA site"
ORIGIN      
        1 agagcgagga gcgctcctga agggagacgt cgggctcgtc cccggggtcc aggccgcggt
       61 cccactcgcg ggcgcagtcg cccggcgccg gccgctcggc cccgcggcct gggaggccgt
      121 tgcgcaaggc agggcccgcg gctcggggag ggatgcgccg ggcgttgcct cccgcccgcc
      181 gccgccgccg ccgccagaag ccccagagga gctgagggag gcgacgccga agcgctggcc
      241 cggagtggcc acggctgcag cccgggcggc gggctagggc gctcgcaggg cttctgggcc
      301 gaccccgctc cggcgcctcc gcttcccgcc cggggcccgc cctcgcggcc cggcctcgct
      361 cccgggtccc agatgaccac cgagggcggg ccgccgccgg ccccgctccg ccgcgcgtgc
      421 agcccggtcc ccggcgcgct ccaggccgcc ctgatgagcc cgccgcccgc cgccgccgcc
      481 gccgccgccg ccgccccgga gaccacctcc tcctcctcgt cgtcgtcctc cgcctcctgc
      541 gcctcgtcct cgtcctcctc caattcggcc agcgccccct cggctgcctg caagagcgcg
      601 ggcggcggcg gcgcgggcgc cgggagcggg ggcgccaaga aggcgagctc ggggctgcgg
      661 cggcccgaga agccgcccta ctcgtacatc gcgctcatcg tcatggccat ccagagctcg
      721 cccagcaagc gcctgacgct cagcgagatc taccagttcc tgcaggcgcg cttccccttc
      781 ttccgcggcg cctaccaggg ctggaagaac tcggtgcgcc acaatctctc gctcaacgag
      841 tgcttcatca agctgcctaa gggcctcggg cggcccggca agggccacta ctggaccatc
      901 gacccggcca gcgagttcat gttcgaggag ggctcgttcc gccgccggcc gcgcggcttc
      961 aggcggaagt gccaggcgct caagcccatg taccaccgcg tggtgagcgg cttgggcttc
     1021 ggggcgtcgc tgctgcccca gggcttcgac ttccaggcgc ccccgtcggc gccgctcggc
     1081 tgccacagcc agggcggcta cggcggcctc gacatgatgc ccgcgggcta cgacgccggc
     1141 gcgggcgccc ccagccacgc gcaccctcac caccaccacc accaccacgt cccgcacatg
     1201 tcgcccaacc cgggttccac ctacatggcc agctgcccgg tgcccgcggg acccgggggc
     1261 gtcggtgcgg ccgggggcgg cggcggcggc gactacgggc cggacagcag cagcagcccg
     1321 gtaccctcgt ccccggccat ggcgagcgcc atcgaatgcc actcgcccta cacgagccct
     1381 gcggcgcact ggagctcgcc tggcgcctcg ccttacctca agcagccgcc tgccctgacg
     1441 cccagcagca accccgccgc ctcggcaggc ctgcactcca gcatgtcctc ctactcgctg
     1501 gagcagagct acttgcacca gaacgctcgc gaggacctct cagtgggact gccccgttac
     1561 cagcatcact ctactccagt gtgtgacaga aaagatttcg tcctcaactt caatgggatt
     1621 tcttctttcc atccctcagc tagcgggtcg tattatcacc atcaccacca gagcgtctgt
     1681 caggatatta agccctgcgt catgtgaacg gaaagaggcc aagcgatggc cgctctctcc
     1741 tctcccctcc tcagaggggg cagatagaaa ctgggacgga ttcaagtcac atgcacgcgg
     1801 atagcagtaa gccacacacc tgccacttag ccagaatgcc caggatcgcg ttggtcactg
     1861 ttatttgcct actgctggaa gaaggacaac cgctggcaag gtagcgttcc ccaatctgaa
     1921 tacctgcagg ctcccacatg agggagaggg cagactcagg tgggaagatg tgccatgcgt
     1981 aaggcatcaa cgtgtatctg tgggatcttc gttgccttca gtaatcaggg tgtgaaaaaa
     2041 gcagacaagt tgtgtgtgtg tgtgtgtgtc taagaaaact tgtgtgcttt tcaaaaaggc
     2101 agtgctaagc acaagatttc aagaaagcct cttcttgttg cctagctgag tgggagagtc
     2161 attttcccca gacactacat ttggatacag gtgccaaaga acattattaa ggaattattt
     2221 agaaacaatg tgtctagttt aagaaagtgg ttttcagtat tgtgacaata caacgttttt
     2281 acaaggttgt tttctaccac catattttaa agatattttt atgaccgtgt atactcacac
     2341 tttgcttgta ttttaaaagg aggatatatt tgcacttatg tatactttta cagtttgcca
     2401 aaatattttg ttgtaaaatt ttttttcaat aaaatgtata taacaaatag t
//
