LOCUS       NM_001451               3520 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens forkhead box F1 (FOXF1), mRNA.
ACCESSION   NM_001451
VERSION     NM_001451.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3520)
  AUTHORS   Peng,K., Xia,R.P., Zhao,F., Xiao,Y., Ma,T.D., Li,M., Feng,Y. and
            Zhou,C.G.
  TITLE     ALKBH5 facilitates the progression of infantile hemangioma by
            increasing FOXF1 expression in a m6A-YTHDF2 dependent manner to
            activate HK-2 signaling
  JOURNAL   Mol Cell Biochem 479 (11), 3153-3166 (2024)
   PUBMED   38306011
  REMARK    GeneRIF: ALKBH5 facilitates the progression of infantile hemangioma
            by increasing FOXF1 expression in a m[6]A-YTHDF2 dependent manner
            to activate HK-2 signaling.
REFERENCE   2  (bases 1 to 3520)
  AUTHORS   Chen,J.H., Ye,L., Zhu,S.L., Yang,Y. and Xu,N.
  TITLE     DNMT1-Mediated the Downregulation of FOXF1 Promotes High
            Glucose-induced Podocyte Damage by Regulating the miR-342-3p/E2F1
            Axis
  JOURNAL   Cell Biochem Biophys 82 (3), 2957-2975 (2024)
   PUBMED   39014186
  REMARK    GeneRIF: DNMT1-Mediated the Downregulation of FOXF1 Promotes High
            Glucose-induced Podocyte Damage by Regulating the miR-342-3p/E2F1
            Axis.
REFERENCE   3  (bases 1 to 3520)
  AUTHORS   Wang,G., Wen,B., Guo,M., Li,E., Zhang,Y., Whitsett,J.A., Kalin,T.V.
            and Kalinichenko,V.V.
  TITLE     Identification of endothelial and mesenchymal FOXF1 enhancers
            involved in alveolar capillary dysplasia
  JOURNAL   Nat Commun 15 (1), 5233 (2024)
   PUBMED   38898031
  REMARK    GeneRIF: Identification of endothelial and mesenchymal FOXF1
            enhancers involved in alveolar capillary dysplasia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3520)
  AUTHORS   Bian,F., Goda,C., Wang,G., Lan,Y.W., Deng,Z., Gao,W., Acharya,A.,
            Reza,A.A., Gomez-Arroyo,J., Merjaneh,N., Ren,X., Goveia,J.,
            Carmeliet,P., Kalinichenko,V.V. and Kalin,T.V.
  TITLE     FOXF1 promotes tumor vessel normalization and prevents lung cancer
            progression through FZD4
  JOURNAL   EMBO Mol Med 16 (5), 1063-1090 (2024)
   PUBMED   38589650
  REMARK    GeneRIF: FOXF1 promotes tumor vessel normalization and prevents
            lung cancer progression through FZD4.
REFERENCE   5  (bases 1 to 3520)
  AUTHORS   Guan,X., Liang,J., Xiang,Y., Li,T. and Zhong,X.
  TITLE     BARX1 repressed FOXF1 expression and activated Wnt/beta-catenin
            signaling pathway to drive lung adenocarcinoma
  JOURNAL   Int J Biol Macromol 261 (Pt 2), 129717 (2024)
   PUBMED   38290639
  REMARK    GeneRIF: BARX1 repressed FOXF1 expression and activated
            Wnt/beta-catenin signaling pathway to drive lung adenocarcinoma.
REFERENCE   6  (bases 1 to 3520)
  AUTHORS   Hellqvist,M., Mahlapuu,M., Blixt,A., Enerback,S. and Carlsson,P.
  TITLE     The human forkhead protein FREAC-2 contains two functionally
            redundant activation domains and interacts with TBP and TFIIB
  JOURNAL   J Biol Chem 273 (36), 23335-23343 (1998)
   PUBMED   9722567
REFERENCE   7  (bases 1 to 3520)
  AUTHORS   Hellqvist,M., Mahlapuu,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Differential activation of lung-specific genes by two forkhead
            proteins, FREAC-1 and FREAC-2
  JOURNAL   J Biol Chem 271 (8), 4482-4490 (1996)
   PUBMED   8626802
REFERENCE   8  (bases 1 to 3520)
  AUTHORS   Larsson,C., Hellqvist,M., Pierrou,S., White,I., Enerback,S. and
            Carlsson,P.
  TITLE     Chromosomal localization of six human forkhead genes, freac-1
            (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8
            (FKHL12)
  JOURNAL   Genomics 30 (3), 464-469 (1995)
   PUBMED   8825632
REFERENCE   9  (bases 1 to 3520)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
REFERENCE   10 (bases 1 to 3520)
  AUTHORS   Murphy,D.B., Wiese,S., Burfeind,P., Schmundt,D., Mattei,M.G.,
            Schulz-Schaeffer,W. and Thies,U.
  TITLE     Human brain factor 1, a new member of the fork head gene family
  JOURNAL   Genomics 21 (3), 551-557 (1994)
   PUBMED   7959731
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB011539.1, BC089442.1,
            CA438612.1 and AC009108.10.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001451.2.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which is characterized by a distinct forkhead domain.  The
            specific function of this gene has not yet been determined;
            however, it may play a role in the regulation of pulmonary genes as
            well as embryonic development. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314167.1, U13219.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262426.6/ ENSP00000262426.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB011539.1         1-11
            12-2359             BC089442.1         1-2348
            2360-2481           BC089442.1         2350-2471
            2482-2562           CA438612.1         18-98               c
            2563-3520           AC009108.10        128414-129371       c
FEATURES             Location/Qualifiers
     source          1..3520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16q24.1"
     gene            1..3520
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="forkhead box F1"
                     /db_xref="GeneID:2294"
                     /db_xref="HGNC:HGNC:3809"
                     /db_xref="MIM:601089"
     exon            1..1022
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1183
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="forkhead-related activator 1; Forkhead, drosophila,
                     homolog-like 5; FREAC-1; forkhead-related protein FKHL5;
                     forkhead-related transcription factor 1"
                     /codon_start=1
                     /product="forkhead box protein F1"
                     /protein_id="NP_001442.2"
                     /db_xref="CCDS:CCDS10957.2"
                     /db_xref="GeneID:2294"
                     /db_xref="HGNC:HGNC:3809"
                     /db_xref="MIM:601089"
                     /translation="MSSAPEKQQPPHGGGGGGGGGGGAAMDPASSGPSKAKKTNAGIR
                     RPEKPPYSYIALIVMAIQSSPTKRLTLSEIYQFLQSRFPFFRGSYQGWKNSVRHNLSL
                     NECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFRRKCQALKPMYSMMNG
                     LGFNHLPDTYGFQGSAGGLSCPPNSLALEGGLGMMNGHLPGNVDGMALPSHSVPHLPS
                     NGGHSYMGGCGGAAAGEYPHHDSSVPASPLLPTGAGGVMEPHAVYSGSAAAWPPSASA
                     ALNSGASYIKQQPLSPCNPAANPLSGSLSTHSLEQPYLHQNSHNAPAELQGIPRYHSQ
                     SPSMCDRKEFVFSFNAMASSSMHSAGGGSYYHQQVTYQDIKPCVM"
     exon            1023..3520
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2427..2432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="hexamer: TATAAA"
     polyA_site      2447
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="major polyA site"
     regulatory      2489..2494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="hexamer: AATAAA"
     polyA_site      2511
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="major polyA site"
     regulatory      2540..2545
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="hexamer: AATAAA"
     polyA_site      2562
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="major polyA site"
     regulatory      2733..2738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="hexamer: AGTAAA"
     polyA_site      2754
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
     regulatory      3045..3050
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="hexamer: TATAAA"
     polyA_site      3067
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
     regulatory      3485..3490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
                     /note="hexamer: AATAAA"
     polyA_site      3520
                     /gene="FOXF1"
                     /gene_synonym="ACDMPV; FKHL5; FREAC1"
ORIGIN      
        1 gcagagcagc ggcggcagcg gcggcggcgg cagcagccac ccgatgtctt cggcgcccga
       61 gaagcagcag ccaccgcacg gcggcggcgg cggcggcggc gggggaggcg gcgcggccat
      121 ggaccccgcg tcgtccggcc cgtccaaggc caagaagacc aacgccggca tccggcgccc
      181 ggagaagccg ccctattcct acatcgcgct catcgtcatg gccatccaga gttcacccac
      241 caagcgcctg acgctgagcg agatctacca gttcctgcag agccgcttcc ccttcttccg
      301 gggctcctac cagggctgga agaactccgt gcgccacaac ctctcgctca acgagtgctt
      361 catcaagcta cccaagggcc ttgggcggcc cggcaagggc cactactgga ccatcgaccc
      421 ggccagcgag ttcatgttcg aggagggctc ctttcggcgg cggccgcgcg gcttccgaag
      481 gaaatgccag gcgctcaagc ccatgtacag catgatgaac gggctcggct tcaaccacct
      541 cccggacacc tacggcttcc agggctcggc cggcggcctc tcgtgcccgc ccaacagcct
      601 ggcgctggag ggcggcctgg gcatgatgaa cggccacttg ccgggcaacg tggacggcat
      661 ggccctgccc agccactcgg tgccccacct gccttccaac ggcggccact cgtacatggg
      721 cggctgcggc ggcgcggcgg ccggcgagta cccgcaccac gacagctcgg tgcccgcctc
      781 cccgctgctg cccaccggcg ccggtggggt catggagccg cacgccgtct actcgggctc
      841 ggcggcggcc tggccgccct cggcgtccgc ggcgctcaac agcggcgcct cttatatcaa
      901 gcagcagccc ctgtccccct gtaaccccgc ggccaacccc ctgtccggca gcctctccac
      961 gcactccctg gagcagccgt atctgcacca gaacagccac aacgccccag ccgagctgca
     1021 aggcatcccg cggtatcact cgcagtcgcc cagcatgtgt gaccgaaagg agtttgtctt
     1081 ctctttcaac gccatggcgt cctcttccat gcactcggcc ggcgggggct cctactacca
     1141 ccagcaggtc acctaccaag acatcaagcc ttgcgtgatg tgaggctgcc gccgcaggcc
     1201 ctcctggtgc aggcaggcgg gtcacaggga ccctggaccg gcacaagaaa ctgctttctt
     1261 ctcgaggtat aaccgtcggc agaagaaaag ggttccacct ctccccaacc ggagtttttg
     1321 gcaaggagtc cccaatgcaa agacacagcg ctgcggttgg cacctccttc ctcactcctt
     1381 caaaattgtt aagaaatgtt agtggtgggt ctgatctgac tgcagccatc ggtaaataaa
     1441 agtttttgat cctgttgaac ccgcctgaga cggtgctgtg caggggaaag cccccgcacc
     1501 cacacaggaa ttctgctgag gtcccccctc cttccggcca atggcagaag tgggggaaaa
     1561 tttttagaag aaaagcaaac atgtgagacc aatcattatc aaatactttt attttttggt
     1621 tgagtattta tctttttatt ttttattttt tttttgaaag aatgtcttgg aatgcgcaag
     1681 tctcccttta gagccgtctt ttgcagggag cgggaagtga caagagctca gatctccctc
     1741 ccgatctccc tccccacctc cgaagtctcc tccgtggacc acaggtggat ctttgtgcga
     1801 acaacttgca tttcggaagc cactgtccgt ctttaaacag aaagtcaaag gagccacgaa
     1861 gcaagcggcc gtccgggcgt ccgcctccgt ccccttccat gttcctcctc ttccttcgct
     1921 tcagcctctt ctgttatgtt ttgtcttgaa ttttatttag actttttcag tgggtatttt
     1981 tctgtctccc aacctctact gtaaactttc tggtccgaga acgagccgaa cacagcgcga
     2041 cgcagggact aggacggccc ggtgaccgcg cggattcagg attgcgggga cgcagaaagg
     2101 ttaaggcact tttaaaaact atagcaaggc tcctgtttat ttattctact ttctttccct
     2161 aataatcaaa acaccgcgta ggctcctccg tttatcagta ttaatggtgt aactttgttg
     2221 gcaatatttg ccgtgtagaa ttttttttag atatccattg taaatttgaa acaaagaccg
     2281 atctgtgtaa aaacaaattt ccatatgttt tatataaata tatatataat atgaaggact
     2341 accctccttt tttttttttg tattttggct gctagagtgc agcatttgtg acacgtattt
     2401 gaaatttgaa atttccttct gcactgtata aaaggaccat ttgaggatgt tttgcctttt
     2461 gtgtattttt tcctaaaaaa agaacaaaaa taaaaatgta taacatttgt acatggcctt
     2521 taaaattgta tcaactagaa ataaaattgc atgagtattt tattgggact gagattgtag
     2581 aataccttcc agactcccaa agatagaggg gggaaaaaag aaaaaacagg ctttggatct
     2641 ctagacgctt aaaaatttac aatctgggtg attctgagta cttttttctt ttttggcaaa
     2701 tcctcctctt ttcactcttc attccacttt gaagtaaacg ctggacaaga ggaactattt
     2761 ttcttggctt ctgtttttta agaagagccc tttgcccctc taaatgtcat tgatcgtttt
     2821 aaagaaataa acttttaaag aacactatag acctccttcc cctagggaac accaattaaa
     2881 ccatatatgt gcacatacat atggatatac atatatatgt atatacatat atgtacatat
     2941 atgtatacgt gtccatgtac ataatatata tttttttgcc actacaagac caatgagagt
     3001 tttactttgg gtttccgact ttcttgttct cttgctgtag ctgttataaa tcgtgaatca
     3061 actttaaggt ttttttgtag ttgttggttt gtcttgtttt gttttggctt tttggtgcct
     3121 tgttcttggt tttccccgat agaaaatcaa gcaaaatcta aatgaggcaa aagggcgctt
     3181 ggtgggccag gtgacaggca cctttccaat cctgtaacat ttatctccta agtcacagtt
     3241 cgtcctctct gggggaaaaa tattttttaa cacttgtacc ttccactgac caccctcttt
     3301 ctattccagt tcccggctac cgagaaaaac aaacacagta agtcacattg ttggtgcggt
     3361 ccttccagac ccaccgcagt gtcttgcgtc gtggggtcgt gagtctctga acctggttct
     3421 tctcagagtt gacattttgg acgtgggggt aatttctccg gtgctctgtt acatcaaaat
     3481 tatcaataaa ctcgcctggg caattagtgt ccccaactaa
//
