LOCUS       NM_004473               3492 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens forkhead box E1 (FOXE1), mRNA.
ACCESSION   NM_004473 NM_012185
VERSION     NM_004473.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3492)
  AUTHORS   Pires,C., Saramago,A., Moura,M.M., Li,J., Donato,S., Marques,I.J.,
            Belo,H., Machado,A.C., Cabrera,R., Grunewald,T.G.P., Leite,V. and
            Cavaco,B.M.
  TITLE     Identification of Germline FOXE1 and Somatic MAPK Pathway Gene
            Alterations in Patients with Malignant Struma Ovarii, Cleft Palate
            and Thyroid Cancer
  JOURNAL   Int J Mol Sci 25 (4), 1966 (2024)
   PUBMED   38396644
  REMARK    GeneRIF: Identification of Germline FOXE1 and Somatic MAPK Pathway
            Gene Alterations in Patients with Malignant Struma Ovarii, Cleft
            Palate and Thyroid Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3492)
  AUTHORS   Liu,M., Zhang,G., Wang,Z., Liu,X., He,K., Luo,R., Duan,Q., Bai,R.,
            Wang,Y., Du,W., Zheng,Y. and Shao,Y.
  TITLE     FOXE1 Contributes to the Development of Psoriasis by Regulating
            WNT5A
  JOURNAL   J Invest Dermatol 143 (12), 2366-2377 (2023)
   PUBMED   37394057
  REMARK    GeneRIF: FOXE1 Contributes to the Development of Psoriasis by
            Regulating WNT5A.
REFERENCE   3  (bases 1 to 3492)
  AUTHORS   Liu,X., Chen,L., Wen,F., Zheng,S. and Ge,W.
  TITLE     The high expression of FOXE1 in colorectal cancer predicts a
            promising prognosis: a retrospective study
  JOURNAL   Clin Exp Med 23 (7), 3995-4001 (2023)
   PUBMED   37278933
  REMARK    GeneRIF: The high expression of FOXE1 in colorectal cancer predicts
            a promising prognosis: a retrospective study.
            Erratum:[Clin Exp Med. 2023 Dec;23(8):5479-5480. doi:
            10.1007/s10238-023-01160-8.. PMID: 37597038]
REFERENCE   4  (bases 1 to 3492)
  AUTHORS   Zamboni,M., Strimpakos,G., Poggiogalle,E., Donini,L.M. and
            Civitareale,D.
  TITLE     Adipocyte signaling affects thyroid-specific gene expression via
            down-regulation of TTF-2/FOXE1
  JOURNAL   J Mol Endocrinol 70 (1), e220129 (2022)
   PUBMED   36347053
  REMARK    GeneRIF: Adipocyte signaling affects thyroid-specific gene
            expression via down-regulation of TTF-2/FOXE1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3492)
  AUTHORS   Macchia,P.E., Mattei,M.G., Lapi,P., Fenzi,G. and Di Lauro,R.
  TITLE     Cloning, chromosomal localization and identification of
            polymorphisms in the human thyroid transcription factor 2 gene
            (TITF2)
  JOURNAL   Biochimie 81 (5), 433-440 (1999)
   PUBMED   10403172
REFERENCE   6  (bases 1 to 3492)
  AUTHORS   Clifton-Bligh,R.J., Wentworth,J.M., Heinz,P., Crisp,M.S., John,R.,
            Lazarus,J.H., Ludgate,M. and Chatterjee,V.K.
  TITLE     Mutation of the gene encoding human TTF-2 associated with thyroid
            agenesis, cleft palate and choanal atresia
  JOURNAL   Nat Genet 19 (4), 399-401 (1998)
   PUBMED   9697705
REFERENCE   7  (bases 1 to 3492)
  AUTHORS   Zannini,M., Avantaggiato,V., Biffali,E., Arnone,M.I., Sato,K.,
            Pischetola,M., Taylor,B.A., Phillips,S.J., Simeone,A. and Di
            Lauro,R.
  TITLE     TTF-2, a new forkhead protein, shows a temporal expression in the
            developing thyroid which is consistent with a role in controlling
            the onset of differentiation
  JOURNAL   EMBO J 16 (11), 3185-3197 (1997)
   PUBMED   9214635
  REMARK    Erratum:[EMBO J 2001 Apr 17;20(8):2108]
REFERENCE   8  (bases 1 to 3492)
  AUTHORS   Chadwick,B.P., Obermayr,F. and Frischauf,A.M.
  TITLE     FKHL15, a new human member of the forkhead gene family located on
            chromosome 9q22
  JOURNAL   Genomics 41 (3), 390-396 (1997)
   PUBMED   9169137
REFERENCE   9  (bases 1 to 3492)
  AUTHORS   Wiese,S., Emmerich,D., Schroder,B., Murphy,D.B., Grzeschik,K.H.,
            Van Kessel,A.G. and Thies,U.
  TITLE     The novel human HNF-3/fork head-like 5 gene: chromosomal
            localization and expression pattern
  JOURNAL   DNA Cell Biol 16 (2), 165-171 (1997)
   PUBMED   9052737
REFERENCE   10 (bases 1 to 3492)
  AUTHORS   Bamforth,J.S., Hughes,I.A., Lazarus,J.H., Weaver,C.M. and
            Harper,P.S.
  TITLE     Congenital hypothyroidism, spiky hair, and cleft palate
  JOURNAL   J Med Genet 26 (1), 49-51 (1989)
   PUBMED   2918525
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL499604.9 and U89995.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_004473.3.
            
            Summary: This intronless gene encodes a protein that belongs to the
            forkhead family of transcription factors. Members of this family
            contain a conserved 100-amino acid DNA-binding 'forkhead' domain.
            The encoded protein functions as a thyroid transcription factor
            that plays a role in thyroid morphogenesis. Mutations in this gene
            are associated with the Bamforth-Lazarus syndrome, and with
            susceptibility to nonmedullary thyroid cancer-4. [provided by
            RefSeq, Nov 2016].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U89995.2, DRR138513.469772.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000375123.5/ ENSP00000364265.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL499604.9         71510-71538
            30-45               U89995.2           1-16
            46-559              AL499604.9         71555-72068
            560-1075            U89995.2           531-1046
            1076-2076           AL499604.9         72585-73585
            2077-3479           U89995.2           2057-3459
            3480-3480           AL499604.9         74989-74989
            3481-3490           U89995.2           3461-3470
            3491-3492           AL499604.9         75000-75001
FEATURES             Location/Qualifiers
     source          1..3492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q22.33"
     gene            1..3492
                     /gene="FOXE1"
                     /gene_synonym="BAMLAZ; FKHL15; FOXE2; HFKH4; HFKL5; NMTC4;
                     TITF2; TTF-2; TTF2"
                     /note="forkhead box E1"
                     /db_xref="GeneID:2304"
                     /db_xref="HGNC:HGNC:3806"
                     /db_xref="MIM:602617"
     exon            1..3492
                     /gene="FOXE1"
                     /gene_synonym="BAMLAZ; FKHL15; FOXE2; HFKH4; HFKL5; NMTC4;
                     TITF2; TTF-2; TTF2"
                     /inference="alignment:Splign:2.1.0"
     CDS             690..1811
                     /gene="FOXE1"
                     /gene_synonym="BAMLAZ; FKHL15; FOXE2; HFKH4; HFKL5; NMTC4;
                     TITF2; TTF-2; TTF2"
                     /note="forkhead, drosophila, homolog-like 15; forkhead box
                     protein E2; HNF-3/fork head-like protein 5; thyroid
                     transcription factor 2; forkhead-related protein FKHL15"
                     /codon_start=1
                     /product="forkhead box protein E1"
                     /protein_id="NP_004464.2"
                     /db_xref="CCDS:CCDS35078.1"
                     /db_xref="GeneID:2304"
                     /db_xref="HGNC:HGNC:3806"
                     /db_xref="MIM:602617"
                     /translation="MTAESGPPPPQPEVLATVKEERGETAAGAGVPGEATGRGAGGRR
                     RKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIR
                     HNLTLNDCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAY
                     MHDAAAAAAAAAAAAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASP
                     GPCRVFGLVPERPLSPELGPAPSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSA
                     YAAAYAGPDGAYPQGAGSAIFAAAGRLAGPASPPAGGSSGGVETTVDFYGRTSPGQFG
                     ALGACYNPGGQLGGASAGAYHARHAAAYPGGIDRFVSAM"
     regulatory      3203..3208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXE1"
                     /gene_synonym="BAMLAZ; FKHL15; FOXE2; HFKH4; HFKL5; NMTC4;
                     TITF2; TTF-2; TTF2"
                     /note="hexamer: AATAAA"
     polyA_site      3225
                     /gene="FOXE1"
                     /gene_synonym="BAMLAZ; FKHL15; FOXE2; HFKH4; HFKL5; NMTC4;
                     TITF2; TTF-2; TTF2"
                     /note="major polyA site"
     regulatory      3472..3477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXE1"
                     /gene_synonym="BAMLAZ; FKHL15; FOXE2; HFKH4; HFKL5; NMTC4;
                     TITF2; TTF-2; TTF2"
                     /note="hexamer: AATAAA"
     polyA_site      3492
                     /gene="FOXE1"
                     /gene_synonym="BAMLAZ; FKHL15; FOXE2; HFKH4; HFKL5; NMTC4;
                     TITF2; TTF-2; TTF2"
ORIGIN      
        1 gagccggtcc ggtgtgtgca ggggagcgcc tcgccagcgg tccgcagggc tggagaccca
       61 cgccgtggag aggaccagcc tcaggtcgcc ccgcctgggc ccgcgccccg acctcgctgc
      121 ccccgcctcg cctctctgcc cgtggcgctt acggccacct tggcctcggg ggcagggcat
      181 gggcggcccc cgccagatcg cccagcgcca gtactaactg ccctcgctct ggccttcgag
      241 cccgaagcct cttctgcgcg cacaacctag gcagtaatcc taaactagcg ggcaccacag
      301 accagctgca gccaccccaa cccagggatc acttccggac ccctcgaccg cccggcacca
      361 gcgcgcaagg gacccttcag ccggagacca gagtccagtc ccggtcacga ggccaccgcc
      421 gctgcccgcc tcgagaagca ccacgcgggc tgagccgtcg gctagcgggt cactcccgag
      481 cctctgtctg caccgcgcca gccccagacc acggacgctg agcctccagc gcgtgccagc
      541 ctgggccgct gggctctcgg ggccagcccg cgacgatccc ctgagctctc cgcagaaggg
      601 ccgagcgtcc gttccgggga cgccaggccc gcccccgccc cccgacagcc gcggggatcc
      661 agagcccggg ggtgcgggac gcccgcgcca tgactgccga gagcgggccg ccgccgccgc
      721 agccggaggt gctggctacc gtgaaggaag agcgcggcga gacggcagca ggggccgggg
      781 tcccagggga ggccacgggc cgcggggcgg gcgggcggcg ccgcaagcgc cccctgcagc
      841 gcgggaagcc gccctacagc tacatcgcgc tcatcgccat ggccatcgcg cacgcgcccg
      901 agcgccgcct cacgctgggc ggcatctaca agttcatcac cgagcgcttc cccttctacc
      961 gcgacaaccc caaaaagtgg cagaacagca tccgccacaa cctcacactc aacgactgct
     1021 tcctcaagat cccgcgcgag gccggccgcc cgggtaaggg caactactgg gcgcttgacc
     1081 ccaacgcgga ggacatgttc gagagcggca gcttcctgcg ccgccgcaag cgcttcaagc
     1141 gctcggacct ctccacctac ccggcttaca tgcacgacgc ggcggctgcc gcagccgccg
     1201 ccgccgccgc cgccgccgcc gccgccatct tcccaggcgc ggtgcccgcc gcgcgccccc
     1261 cctacccggg cgccgtctat gcaggctacg cgccgccgtc gctggccgcg ccgcctccag
     1321 tctactaccc cgcggcgtcg cccggccctt gccgcgtctt cggcctggtt cctgagcggc
     1381 cgctcagccc agagctgggg cccgcaccgt cggggcccgg cggctcttgc gcctttgcct
     1441 ccgccggcgc ccccgctacc accaccggct accagcccgc aggctgcacc ggggcccggc
     1501 cggccaaccc ctccgcctat gcggctgcct acgcgggccc cgacggcgcg tacccgcagg
     1561 gcgccggcag tgcgatcttt gccgctgctg gccgcctggc gggacccgct tcgcccccag
     1621 cgggcggcag cagtggcggc gtggagacca cggtggactt ctacgggcgc acgtcgcccg
     1681 gccagttcgg agcgctggga gcctgctaca accctggcgg gcagctcgga ggggccagtg
     1741 caggcgccta ccatgctcgc catgctgccg cttatcccgg tgggatagat cggttcgtgt
     1801 ccgccatgtg agccagcgta gggacgaaaa ctcatagaca catcggctgt tcacacgttc
     1861 cccgcaatct gagaacgaac aggaatggag agaggactca actgggaccc acgtggaaaa
     1921 gaccgagcag gccacagagg ctcggtctcc ccgcgcacag cgtaggcacc cggtgtactc
     1981 tgtaaacggg aggaggtggg gcgaggcagc cagagccctt ggactggcac agggaccctc
     2041 gatggagcga agccctcaaa cgggatgctt tctggtattc tatcggggag ggtccttggc
     2101 ggtaaccaga gggcagcgta gtgtcaacac cagagaccag gatccaaatt gtggggaatc
     2161 agtttcagcc ttccatgtgc tgccggaact cgggcctttt tacgcggttc gtcctctagt
     2221 gcctttaact gcgttactac aataaaaggc tgcggcagcg cctttcttct taaagtgagg
     2281 aggacaaatt tgcaaaagaa ataggctttt cttctttttt aaattggaga aatctctgct
     2341 ctggttgacc tgggctggtt ttccctgtct ctgagaactt gagacctagc tccgagttga
     2401 actgtgcgtc agcactccag tcccatcacc tgaaccttca gtctccccca tctgttacac
     2461 tagagggctg caggactcta tccaccgccc ccgggttatc attcagggcc ccatcatctt
     2521 ggatgctgcc ctgcgtattt ggcagcaatg gtgggccacc cagggcctct gagtagccac
     2581 ccaaagccta gccgctgttc tagggaacgg aaaagagttc atggccaagc gtctaaccta
     2641 aagtcccagg attggctcca ggcagcaatt atatcataac ttattgaact tttgagcagg
     2701 acgtgctggt aatttcatgg ctgttactgc ccagtcataa atctgctttt ccattataag
     2761 gcagagagaa gtacattcgt tcatttgtcc actgtttctt gtcatcacgc agccctggac
     2821 ccaaagggtg aactaaagtt taaggagatg agaggattca aggagcccgt tggtgacgcc
     2881 tttcagtagc tggggagggc tcttccatcc ccagcacccc ctgctacacc tcagcagcct
     2941 cccccatgca aaaaggaaag agaaaaatta agttagggca gtcagtaaag tgagctttag
     3001 aaagaaactg gaattttaac ttcattttgt atcttgctta agtagcaggc tcactaaaat
     3061 tagagaaagt ccaataactc tccccctttc ccttgagaaa tctttaagtt tcgattctgg
     3121 agcaaaaact ttcagcatta aatatttcag aggctccatt cacagctttc agataaactg
     3181 gagtgttcag atggactgtt ttaataaaaa tctttgagca agtgagttat ggcaagagaa
     3241 actcagcctc tttctgtata aacttaacag ggaagggctg gggtgtgaaa aagaagattg
     3301 tatgaaaacc attggtaatt tttatttttt atttttggga ctgcactatc ctgttcacga
     3361 agacatgtga acttggttca gtccaaatgg ggatttgtat aaaccagtgc tctccattag
     3421 aaatatggtg caagccacat atgtaatttt aaatattcta gtagccacat taataaagta
     3481 aaaagaaaca gg
//
