LOCUS       NM_012184               2486 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens forkhead box D4 like 1 (FOXD4L1), mRNA.
ACCESSION   NM_012184
VERSION     NM_012184.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2486)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2486)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   3  (bases 1 to 2486)
  AUTHORS   Wong,A., Vallender,E.J., Heretis,K., Ilkin,Y., Lahn,B.T.,
            Martin,C.L. and Ledbetter,D.H.
  TITLE     Diverse fates of paralogs following segmental duplication of
            telomeric genes
  JOURNAL   Genomics 84 (2), 239-247 (2004)
   PUBMED   15233989
REFERENCE   4  (bases 1 to 2486)
  AUTHORS   Fan,Y., Newman,T., Linardopoulou,E. and Trask,B.J.
  TITLE     Gene content and function of the ancestral chromosome fusion site
            in human chromosome 2q13-2q14.1 and paralogous regions
  JOURNAL   Genome Res 12 (11), 1663-1672 (2002)
   PUBMED   12421752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL078621.19.
            
            On Jun 22, 2021 this sequence version replaced NM_012184.4.
            
            Summary: This gene is a member of the forkhead/winged-helix (FOX)
            family of transcription factors with highly conserved FOX
            DNA-binding domains. Members of the FOX family of transcription
            factors are regulators of embryogenesis and may play a role in
            human cancer. This gene lies in a region of chromosome 2 that
            surrounds the site where two ancestral chromosomes fused to form
            human chromosome 2. This region is duplicated elsewhere in the
            human genome, primarily in subtelomeric and pericentromeric
            locations, thus mutiple copies of this gene have been found.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK125398.1, AK122950.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000306507.7/ ENSP00000302756.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2486              AL078621.19        4298-6783
FEATURES             Location/Qualifiers
     source          1..2486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q14.1"
     gene            1..2486
                     /gene="FOXD4L1"
                     /gene_synonym="bA395L14.1; FOXD5"
                     /note="forkhead box D4 like 1"
                     /db_xref="GeneID:200350"
                     /db_xref="HGNC:HGNC:18521"
                     /db_xref="MIM:611084"
     exon            1..2486
                     /gene="FOXD4L1"
                     /gene_synonym="bA395L14.1; FOXD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             593..1819
                     /gene="FOXD4L1"
                     /gene_synonym="bA395L14.1; FOXD5"
                     /note="FOXD4-like 1"
                     /codon_start=1
                     /product="forkhead box protein D4-like 1"
                     /protein_id="NP_036316.1"
                     /db_xref="CCDS:CCDS2117.1"
                     /db_xref="GeneID:200350"
                     /db_xref="HGNC:HGNC:18521"
                     /db_xref="MIM:611084"
                     /translation="MNLPRAERPRSTPQRSLRDSDGEDGKIDVLGEEEDEDEVEDEEE
                     EASQKFLEQSLQPGLQVARWGGVALPREHIEGGGPSDPSEFGTEFRAPPRSAAASEDA
                     RQPAKPPYSYIALITMAILQSPHKRLTLSGICAFISGRFPYYRRKFPAWQNSIRHNLS
                     LNDCFVKIPREPGHPGKGTYWSLDPASQDMFDNGSFLRRRKRFKRHQLTPGAHLPHPF
                     PLPAAHAALHNPRPGPLLGAPALPQPVPGAYPNTAPGRRPYALLHPHPPRYLLLSAPA
                     YAGAPKKAEGADLATPGTLPVLQPSLGPQPWEEGKGLASPPGGGCISFSIESIMQGVR
                     GAGTGAAQSLSPTAWSYCPLLQRPSSLSDNFAATAAASGGGLRQRLRSHQGRGAGRAP
                     VGRVGAAAVSGGGRGL"
ORIGIN      
        1 acatactttt acggttacac attcctttac aaacaaccgt gtacatttca gcctcctgcc
       61 ccaccatttc ttttctccag gagggaaggc tgcatgtcga gatggtcgta gaatgttgag
      121 tatcctactt tcctacctcg cttttatttg cgcgggttta aatgcgcctt aacagaaccc
      181 gtgcaaaggc ttgcctactt gtctggctgc accggatgag tagagcatct tccttggtgg
      241 caggtgggtg cgaggaggag ggggctgggc ttttctccgg acggtgtttg cccagaagac
      301 catcatccct ggactacgtt aggaggaagt ggcaccgctc cgaggtaggg gaagaagggt
      361 tataaagggg ggagtccacc acacatggtc ttgaagaagc ttttataaaa ggcaaaggca
      421 tctttgccgg acgttgttgc aaaggagtag aaacaagcag aggaaaacat cccaaagggt
      481 aaccactagc gttcctgctt cttgcaacat tcatcccagg cttccagctc agcccgcccc
      541 gggccaggtg atcggccgcc acatcccctg cgactgaagc acctgctccg ccatgaacct
      601 gccaagagct gagcgccctc gctccacacc gcagcgcagc ctccgggact ccgatgggga
      661 agacggtaaa atcgatgtcc tgggagagga ggaagatgaa gacgaggtgg aagacgagga
      721 ggaggaggcg agccagaagt tcctagagca gtcgctccag ccggggctgc aggtggcccg
      781 gtggggcggg gttgcgcttc cccgagagca catcgagggc ggcggcccga gcgacccctc
      841 agagtttggc accgagttca gggcaccgcc aaggtctgcg gcggcctctg aagatgcccg
      901 gcagccggca aagcccccct actcgtacat cgcgctcatc accatggcca tcctgcaaag
      961 cccgcacaag cgcctcacgc tcagcggcat ctgcgccttc attagtggcc gcttccccta
     1021 ctaccgccgc aagttccccg cctggcagaa cagcatccgc cacaacctct cgctgaacga
     1081 ctgcttcgtc aagatccccc gcgagccggg ccacccaggc aagggcacct actggagcct
     1141 ggaccccgcc tcccaggaca tgttcgacaa tggcagcttt ctccggcgta ggaagcgttt
     1201 caagcgccac caactgaccc cgggagccca cctgccccac cccttccctc tacctgctgc
     1261 acacgccgcc ctgcacaacc cccgcccagg ccctctgctt ggggcccctg ccctgccgca
     1321 gccagtcccg ggggcctacc ccaacaccgc ccccgggaga cgcccttacg ctctgctgca
     1381 cccgcatcct cctcgctacc tactgctctc ggcccccgcc tatgccgggg caccgaagaa
     1441 agcagaaggc gcggacctgg cgacccccgg cacccttccc gtgctgcagc cctcacttgg
     1501 tcctcagcct tgggaggagg gcaagggtct ggcgtcgcca ccgggaggcg gatgcatctc
     1561 tttcagcatt gagagtatca tgcaaggggt caggggagcg ggtacagggg ctgcgcagag
     1621 tttgtccccg accgcgtgga gctactgccc cctgctccag cgaccgtcaa gcctgtcgga
     1681 caattttgca gcaacagcag cagcatcagg aggaggactg cgccaacggc tgcgctccca
     1741 ccaagggcgc ggtgctgggc gggcacctgt cggccgcgtc ggcgctgctg cggtatcagg
     1801 cggtggcaga gggctctagg ctgacatcgc tggctgcccc tttgggcgga gaggggacct
     1861 caccagtttt tttagtatcg cccacgccca gttccctggc caagtccgca gggccctcct
     1921 agagccaggt gggagtgggg agcgatccgc agctgctcac tccaccttgc gcggcccata
     1981 ctgggcgtgt gcatctgaat cctgctggag agcaaacacg aacttctgtt ccctgcaaaa
     2041 tggttagaaa gaaacagctg gattacgttc ctctaaaaac cacctgaacg taaccttcgc
     2101 agggcgtcaa gtcatctttt cttgccttcg gctgtggctt ctgtggcttt ccggatttgc
     2161 acatttcctg gggtactatg aacgtgagtg gggtattttg ttctggcatt agaagaaaaa
     2221 caagcaagca aacaaaaaca cagcctccga tgccaaacat gttccccctt cttcacttcc
     2281 ttggaactgg aagtgttatt cctaagtcta gtgcaaaatg cttctactct ctgtgtcttc
     2341 ctgataggga tgtttaatgt aagtaggata ttaatttcag aacattgatt tcttatctgt
     2401 gtgtctgacg tgccatcttt aatgttaaaa ttaaggtgtt aaaattaagc ctagttatat
     2461 agacgaaata aaatgctaag tcacta
//
