LOCUS       NM_207305               2187 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens forkhead box D4 (FOXD4), mRNA.
ACCESSION   NM_207305
VERSION     NM_207305.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2187)
  AUTHORS   Chen,C.P., Lin,S.P., Su,Y.N., Su,J.W., Chern,S.R., Town,D.D. and
            Wang,W.
  TITLE     Pure distal 9p deletion in a female infant with cerebral palsy
  JOURNAL   Genet Couns 23 (2), 215-221 (2012)
   PUBMED   22876580
  REMARK    GeneRIF: FOXd4 encodes forkhead box D4 protein.
REFERENCE   3  (bases 1 to 2187)
  AUTHORS   Freitas,E.L., Gribble,S.M., Simioni,M., Vieira,T.P.,
            Silva-Grecco,R.L., Balarin,M.A., Prigmore,E.,
            Krepischi-Santos,A.C., Rosenberg,C., Szuhai,K., van Haeringen,A.,
            Carter,N.P. and Gil-da-Silva-Lopes,V.L.
  TITLE     Maternally inherited partial monosomy 9p (pter --> p24.1) and
            partial trisomy 20p (pter --> p12.1) characterized by microarray
            comparative genomic hybridization
  JOURNAL   Am J Med Genet A 155A (11), 2754-2761 (2011)
   PUBMED   21948691
REFERENCE   4  (bases 1 to 2187)
  AUTHORS   Chen,C.P., Su,Y.N., Chern,S.R., Hsu,C.Y., Tsai,F.J., Wu,P.C.,
            Lee,C.C., Chen,Y.T., Lee,M.S. and Wang,W.
  TITLE     Inv dup del(9p): prenatal diagnosis and molecular cytogenetic
            characterization by fluorescence in situ hybridization and array
            comparative genomic hybridization
  JOURNAL   Taiwan J Obstet Gynecol 50 (1), 67-73 (2011)
   PUBMED   21482378
REFERENCE   5  (bases 1 to 2187)
  AUTHORS   Minoretti,P., Arra,M., Emanuele,E., Olivieri,V., Aldeghi,A.,
            Politi,P., Martinelli,V., Pesenti,S. and Falcone,C.
  TITLE     A W148R mutation in the human FOXD4 gene segregating with dilated
            cardiomyopathy, obsessive-compulsive disorder, and suicidality
  JOURNAL   Int J Mol Med 19 (3), 369-372 (2007)
   PUBMED   17273782
  REMARK    GeneRIF: The W148R mutation disrupts an extremely highly conserved
            tryptophan residue in the forkhead domain of FOXD4, possibly
            resulting in reduced DNA binding capacity and altered
            transcriptional activity.
REFERENCE   6  (bases 1 to 2187)
  AUTHORS   Fan,Y., Newman,T., Linardopoulou,E. and Trask,B.J.
  TITLE     Gene content and function of the ancestral chromosome fusion site
            in human chromosome 2q13-2q14.1 and paralogous regions
  JOURNAL   Genome Res 12 (11), 1663-1672 (2002)
   PUBMED   12421752
REFERENCE   7  (bases 1 to 2187)
  AUTHORS   Freyaldenhoven,B.S., Fried,C. and Wielckens,K.
  TITLE     FOXD4a and FOXD4b, two new winged helix transcription factors, are
            expressed in human leukemia cell lines
  JOURNAL   Gene 294 (1-2), 131-140 (2002)
   PUBMED   12234674
REFERENCE   8  (bases 1 to 2187)
  AUTHORS   Cederberg,A., Betz,R., Lagercrantz,S., Larsson,C., Hulander,M.,
            Carlsson,P. and Enerback,S.
  TITLE     Chromosome localization, sequence analysis, and expression pattern
            identify FKHL 18 as a novel human forkhead gene
  JOURNAL   Genomics 44 (3), 344-346 (1997)
   PUBMED   9325056
REFERENCE   9  (bases 1 to 2187)
  AUTHORS   Larsson,C., Hellqvist,M., Pierrou,S., White,I., Enerback,S. and
            Carlsson,P.
  TITLE     Chromosomal localization of six human forkhead genes, freac-1
            (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8
            (FKHL12)
  JOURNAL   Genomics 30 (3), 464-469 (1995)
   PUBMED   8825632
REFERENCE   10 (bases 1 to 2187)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL449043.16.
            
            On Apr 14, 2020 this sequence version replaced NM_207305.4.
            
            Summary: This gene encodes a member of the forkhead/winged
            helix-box (FOX) family of transcription factors. FOX transcription
            factors play critical roles in the regulation of multiple processes
            including metabolism, cell proliferation and gene expression during
            ontogenesis. Mutations in this gene are associated with a complex
            phenotype consisting of dilated cardiomyopathy,
            obsessive-compulsive disorders, and suicidality. [provided by
            RefSeq, Mar 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC089432.1, AY344640.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382500.4/ ENSP00000371940.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2187              AL449043.16        84238-86424         c
FEATURES             Location/Qualifiers
     source          1..2187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p24.3"
     gene            1..2187
                     /gene="FOXD4"
                     /gene_synonym="FKHL9; FOXD4A; FREAC-5; FREAC5"
                     /note="forkhead box D4"
                     /db_xref="GeneID:2298"
                     /db_xref="HGNC:HGNC:3805"
                     /db_xref="MIM:601092"
     exon            1..2187
                     /gene="FOXD4"
                     /gene_synonym="FKHL9; FOXD4A; FREAC-5; FREAC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1618
                     /gene="FOXD4"
                     /gene_synonym="FKHL9; FOXD4A; FREAC-5; FREAC5"
                     /note="myeloid factor-alpha; forkhead-related
                     transcription factor 5; forkhead-related activator 5;
                     forkhead, Drosophila, homolog-like 9; forkhead-related
                     protein FKHL9"
                     /codon_start=1
                     /product="forkhead box protein D4"
                     /protein_id="NP_997188.2"
                     /db_xref="CCDS:CCDS34975.1"
                     /db_xref="GeneID:2298"
                     /db_xref="HGNC:HGNC:3805"
                     /db_xref="MIM:601092"
                     /translation="MNLPRAERLRSTPQRSLRDSDGEDGKIDVLGEEEDEDEEEAASQ
                     QFLEQSLQPGLQVARWGGVALPREHIEGGGGPSDPSEFGTEFRAPPRSAAASEDARQP
                     AKPPSSYIALITMAILQSPHKRLTLSGICAFISDRFPYYRRKFPAWQNSIRHNLSLND
                     CFVKIPREPGRPGKGNYWSLDPASQDMFDNGSFLRRRKRFQRHQPTPGAHLPHPFPLP
                     AAHAALHNPRPGPLLGAPAPPQPVPGAYPNTGPGRRPYALLHPHPPRYLLLSAPAYAG
                     APKKAEGADLATPAPFPCCSPHLVLSLGRRARVWRRHREADASLSALRVSCKGSGERV
                     QGLRRVCPRPRGATAPCSSDRQACRTILQQQQRHQEEDCANGCAPTKGAVLGGHLSAA
                     SALLRYQAVAEGSGLTSLAAPLGGEGTSPVFLVSPTPSSLAESAGPS"
ORIGIN      
        1 gaagaccatc atccctggac tacgttagga ggaagtggca ccgctccgag gtaggggaag
       61 aagggttata aagggaggcg tccaccacac atggtcttga agaagctttt ataaaaggcg
      121 aaggcatctt tgccggacgt tgttgcaaag gcgtagaaac aagcagagga aaacatccca
      181 aagggtaacc actagcgttc ctgcttcttg caacattcat cccgggcttc cagctcagcc
      241 cgccggggcc aggtgatccg gccgccacat cccctgcgac tgaagcacct gctccgccat
      301 gaacttgcca agagctgagc gccttcgctc cacaccgcag cgcagcctcc gggactccga
      361 tggggaagac ggtaaaatcg atgtcctggg agaggaggaa gatgaagacg aggaggaggc
      421 ggcgagccag cagttcctag agcagtcgct ccagccgggg ctgcaggtgg cccggtgggg
      481 cggggttgcg cttccccgag agcacatcga gggcggcggc ggcccgagcg acccctcaga
      541 gtttggcacc gagttcaggg caccgccaag gtctgcggcg gcctctgaag atgcccggca
      601 gccggcaaag cccccctcct cgtacatcgc gctcatcacc atggccatcc tgcaaagccc
      661 gcacaagcgc ctcacgctca gcggcatctg cgccttcatt agtgaccgct tcccctacta
      721 ccgccgcaag ttccccgcct ggcagaacag catccgccac aacctctcgc tgaacgactg
      781 cttcgtcaag atcccccgcg agccgggccg cccaggcaag ggcaactact ggagcctgga
      841 ccccgcctcc caggacatgt tcgacaatgg cagctttctc cggcgtagga agcgtttcca
      901 gcgccaccaa ccgaccccgg gagcccacct gccccacccc ttccctctac ctgctgcaca
      961 cgccgccctg cacaaccccc gcccaggccc tctgcttggg gcccctgccc cgccgcagcc
     1021 agtcccgggg gcctacccca acaccggccc cgggagacgc ccttacgctc tgctgcaccc
     1081 gcatcctcct cgctacctac tgctctcggc ccccgcctat gccggggcac cgaagaaagc
     1141 agaaggcgcg gacctggcga ccccggcacc cttcccgtgc tgcagccctc acttggtcct
     1201 cagccttggg aggagggcaa gggtctggcg tcgccaccgg gaggcggatg catctctttc
     1261 agcattgaga gtatcatgca aggggtcagg ggagcgggta caggggctgc gcagagtttg
     1321 tccccgaccg cgtggagcta ctgccccctg ctccagcgac cgtcaagcct gtcggacaat
     1381 tttgcagcaa cagcagcggc atcaggagga ggactgcgcc aacggctgcg ctcccaccaa
     1441 gggcgcggtg ctgggcgggc acctgtcggc cgcgtcggcg ctgctgcggt atcaggcggt
     1501 ggcagagggc tctgggctga catcgctggc cgcccctttg ggcggagagg ggacctcacc
     1561 agttttttta gtatcgccca cgcccagttc cctggccgag tccgcagggc cctcctagag
     1621 ccaggtggga gtggggagcg acccgcagct gctcactcca ccttgcgcgg cccatactgg
     1681 gcgtgtgcat ctgaatcccg ctggagagca aacacgaact tctgttccct gcaaaatggt
     1741 tagaaagaaa cagctggatt acgttcctct aaaaaccacc tgaacgtaac cttcgcaggg
     1801 cgtcaagtca tcttttcttg ccttcggttg tggcttctgt ggctttcccg atttgcacat
     1861 gtcctggggt actatgaacg tgagtggggt attttgttct ggcattaaaa gaaaaacaag
     1921 caagcaaaca aaaacacagc ctccgatgcc aaacatgttc ccccttcttc acttccttgg
     1981 aactggaagt attattccta agtctagtgc aaaatgcttc tactctctgt gtcttcctga
     2041 tagggatgtt taatgtaagt aggatattaa tttcagaaca ttgatttctt atctgtgtgt
     2101 ctgacgtgcc atctttaatg ttaaaattaa ggtgttaaaa ttaagcctag ttatatagac
     2161 gaaataaaat gctaagtcac tacacta
//
