LOCUS       NM_012183               2562 bp    mRNA    linear   PRI 02-MAY-2024
DEFINITION  Homo sapiens forkhead box D3 (FOXD3), mRNA.
ACCESSION   NM_012183
VERSION     NM_012183.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2562)
  AUTHORS   Wang,K., Chu,Y., Zhang,H., Qu,X., Wang,B. and Han,Y.
  TITLE     FOXD3 Suppresses the Proliferation of CRC Bone Metastatic Cells via
            the Ras/Raf/MEK/ERK Signaling Pathway
  JOURNAL   Comb Chem High Throughput Screen 27 (3), 436-445 (2024)
   PUBMED   37151068
  REMARK    GeneRIF: FOXD3 Suppresses the Proliferation of CRC Bone Metastatic
            Cells via the Ras/Raf/MEK/ERK Signaling Pathway.
REFERENCE   2  (bases 1 to 2562)
  AUTHORS   Wang,S., Ma,Y., Hu,Y., Zhao,X., Li,Y., Ouyang,S. and Luo,G.
  TITLE     FOXD3 confers chemo-sensitivity in ovarian cancer through a
            miR-335/DAAM1/myosin II axis-dependent mechanism
  JOURNAL   J Ovarian Res 16 (1), 8 (2023)
   PUBMED   36627652
  REMARK    GeneRIF: FOXD3 confers chemo-sensitivity in ovarian cancer through
            a miR-335/DAAM1/myosin II axis-dependent mechanism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2562)
  AUTHORS   Liu,R., Sun,Y., Chen,S., Hong,Y. and Lu,Z.
  TITLE     FOXD3 and GAB2 as a pair of rivals antagonistically control
            hepatocellular carcinogenesis
  JOURNAL   FEBS J 289 (15), 4536-4548 (2022)
   PUBMED   35178865
  REMARK    GeneRIF: FOXD3 and GAB2 as a pair of rivals antagonistically
            control hepatocellular carcinogenesis.
REFERENCE   4  (bases 1 to 2562)
  AUTHORS   Wu,Z., Li,Y., Niu,Y., Lu,J., Yan,Z., Xu,T., Guo,Y., Dong,Z. and
            Guo,W.
  TITLE     FOXD3 suppresses epithelial-mesenchymal transition through direct
            transcriptional promotion of SMAD7 in esophageal squamous cell
            carcinoma
  JOURNAL   Mol Carcinog 60 (12), 859-873 (2021)
   PUBMED   34551139
  REMARK    GeneRIF: FOXD3 suppresses epithelial-mesenchymal transition through
            direct transcriptional promotion of SMAD7 in esophageal squamous
            cell carcinoma.
REFERENCE   5  (bases 1 to 2562)
  AUTHORS   Hu,J., Pan,J., Luo,Z., Duan,Q. and Wang,D.
  TITLE     Long non-coding RNA FOXD3-AS1 silencing exerts tumor suppressive
            effects in nasopharyngeal carcinoma by downregulating FOXD3
            expression via microRNA-185-3p upregulation
  JOURNAL   Cancer Gene Ther 28 (6), 602-618 (2021)
   PUBMED   33204001
  REMARK    GeneRIF: Long non-coding RNA FOXD3-AS1 silencing exerts tumor
            suppressive effects in nasopharyngeal carcinoma by downregulating
            FOXD3 expression via microRNA-185-3p upregulation.
REFERENCE   6  (bases 1 to 2562)
  AUTHORS   Fain,P.R., Gowan,K., LaBerge,G.S., Alkhateeb,A., Stetler,G.L.,
            Talbert,J., Bennett,D.C. and Spritz,R.A.
  TITLE     A genomewide screen for generalized vitiligo: confirmation of AIS1
            on chromosome 1p31 and evidence for additional susceptibility loci
  JOURNAL   Am J Hum Genet 72 (6), 1560-1564 (2003)
   PUBMED   12707860
REFERENCE   7  (bases 1 to 2562)
  AUTHORS   Guo,Y., Costa,R., Ramsey,H., Starnes,T., Vance,G., Robertson,K.,
            Kelley,M., Reinbold,R., Scholer,H. and Hromas,R.
  TITLE     The embryonic stem cell transcription factors Oct-4 and FoxD3
            interact to regulate endodermal-specific promoter expression
  JOURNAL   Proc Natl Acad Sci U S A 99 (6), 3663-3667 (2002)
   PUBMED   11891324
REFERENCE   8  (bases 1 to 2562)
  AUTHORS   Alkhateeb,A., Stetler,G.L., Old,W., Talbert,J., Uhlhorn,C.,
            Taylor,M., Fox,A., Miller,C., Dills,D.G., Ridgway,E.C.,
            Bennett,D.C., Fain,P.R. and Spritz,R.A.
  TITLE     Mapping of an autoimmunity susceptibility locus (AIS1) to
            chromosome 1p31.3-p32.2
  JOURNAL   Hum Mol Genet 11 (6), 661-667 (2002)
   PUBMED   11912181
REFERENCE   9  (bases 1 to 2562)
  AUTHORS   Saleem,R.A., Banerjee-Basu,S., Berry,F.B., Baxevanis,A.D. and
            Walter,M.A.
  TITLE     Analyses of the effects that disease-causing missense mutations
            have on the structure and function of the winged-helix protein
            FOXC1
  JOURNAL   Am J Hum Genet 68 (3), 627-641 (2001)
   PUBMED   11179011
REFERENCE   10 (bases 1 to 2562)
  AUTHORS   Hromas,R., Moore,J., Johnston,T., Socha,C. and Klemsz,M.
  TITLE     Drosophila forkhead homologues are expressed in a
            lineage-restricted manner in human hematopoietic cells
  JOURNAL   Blood 81 (11), 2854-2859 (1993)
   PUBMED   8499623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL049636.22 and AF086235.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_012183.2.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which is characterized by a distinct forkhead domain.
            Mutations in this gene cause autoimmune susceptibility 1. [provided
            by RefSeq, Nov 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371116.4/ ENSP00000360157.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               AL049636.22        51861-52352
            493-2132            AL049636.22        52353-53992
            2133-2560           AF086235.1         1-428
            2561-2562           AL049636.22        54421-54422
FEATURES             Location/Qualifiers
     source          1..2562
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..2562
                     /gene="FOXD3"
                     /gene_synonym="AIS1; Genesis; HFH2; VAMAS2"
                     /note="forkhead box D3"
                     /db_xref="GeneID:27022"
                     /db_xref="HGNC:HGNC:3804"
                     /db_xref="MIM:611539"
     exon            1..2562
                     /gene="FOXD3"
                     /gene_synonym="AIS1; Genesis; HFH2; VAMAS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..1929
                     /gene="FOXD3"
                     /gene_synonym="AIS1; Genesis; HFH2; VAMAS2"
                     /note="HNF3/FH transcription factor genesis; autoimmune
                     susceptibility 1"
                     /codon_start=1
                     /product="forkhead box protein D3"
                     /protein_id="NP_036315.1"
                     /db_xref="CCDS:CCDS624.1"
                     /db_xref="GeneID:27022"
                     /db_xref="HGNC:HGNC:3804"
                     /db_xref="MIM:611539"
                     /translation="MTLSGGGSASDMSGQTVLTAEDVDIDVVGEGDDGLEEKDSDAGC
                     DSPAGPPELRLDEADEVPPAAPHHGQPQPPHQQPLTLPKEAAGAGAGPGGDVGAPEAD
                     GCKGGVGGEEGGASGGGPGAGSGSAGGLAPSKPKNSLVKPPYSYIALITMAILQSPQK
                     KLTLSGICEFISNRFPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLD
                     PQSEDMFDNGSFLRRRKRFKRHQQEHLREQTALMMQSFGAYSLAAAAGAAGPYGRPYG
                     LHPAAAAGAYSHPAAAAAAAAAAALQYPYALPPVAPVLPPAVPLLPSGELGRKAAAFG
                     SQLGPGLQLQLNSLGAAAAAAGTAGAAGTTASLIKSEPSARPSFSIENIIGGGPAAPG
                     GSAVGAGVAGGTGGSGGGSTAQSFLRPPGTVQSAALMATHQPLSLSRTTATIAPILSV
                     PLSGQFLQPAASAAAAAAAAAQAKWPAQ"
     regulatory      2542..2547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXD3"
                     /gene_synonym="AIS1; Genesis; HFH2; VAMAS2"
                     /note="hexamer: AATAAA"
     polyA_site      2562
                     /gene="FOXD3"
                     /gene_synonym="AIS1; Genesis; HFH2; VAMAS2"
                     /note="major polyA site"
ORIGIN      
        1 ccttaaaacg ggactttcga ctaccggggc ttcggcgtcc ctgacaccca gccccctgcc
       61 cccccgctac tgtccctgcc cgcgccctcc cgagctgctc ggcgcccggc gtcccgcgcc
      121 cgcctggacc gctcctgcgc cccacgccag ggccagaggc cgaggaaggc gggctaagtg
      181 agggggcgcg gcgtggagaa ccgccggggc cgggagcggt agcgagcgcc tagtaccgag
      241 cgccagggac ggcaggagtt cgcggagcgc ggccgctggg ggcggacggc agagcccgcg
      301 ccacgcgatg cggggccgcc gagtgtgagc tgagcccagc gggccccaag ccacctgcgg
      361 ccccctcccc tctccctgcc ccccatcttt cgggggcact caaaccctct tcccctgagc
      421 tccgtggcag cccccgaaca ccctcatcgc ccgctgcccc ctccccgccg ccgctaccaa
      481 ccccgaggag ggatgaccct ctccggcggc ggcagcgcca gcgacatgtc cggccagacg
      541 gtgctgacgg ccgaggacgt ggacatcgat gtggtgggcg agggcgacga cgggctggaa
      601 gagaaggaca gcgacgcagg ttgcgatagc cccgcggggc cgccggagct gcgcctggac
      661 gaggcggacg aggtgccccc ggcggcaccc catcacggac agcctcagcc gccccaccag
      721 cagcccctga cattgcccaa ggaggcggcc ggagccgggg ccggaccggg gggcgacgtg
      781 ggcgcgccgg aggcggacgg ctgcaagggc ggtgttggcg gcgaggaggg cggcgcgagc
      841 ggcggcgggc ctggcgcggg cagcggttcg gcgggaggcc tggccccgag caagcccaag
      901 aacagcctag tgaagccgcc ttactcgtac atcgcgctca tcaccatggc catcctgcag
      961 agcccgcaga agaagctgac cctgagcggc atctgcgagt tcatcagcaa ccgcttcccc
     1021 tactacaggg agaagttccc cgcctggcag aacagcatcc gccacaacct ctcactcaac
     1081 gactgcttcg tcaagatccc ccgcgagccg ggcaacccgg gcaagggcaa ctactggacc
     1141 ctggacccgc agtccgagga catgttcgac aacggcagct tcctgcggcg ccggaaacgc
     1201 ttcaagcgcc accagcagga gcacctgcgc gagcagacgg cgctcatgat gcagagcttc
     1261 ggcgcttaca gcctggcggc ggcggccggc gccgcgggac cctacggccg cccctacggc
     1321 ctgcaccctg cggcggcggc cggtgcctat tcgcacccgg cagcggcggc ggccgcggct
     1381 gctgcggcgg cgctccagta cccgtacgcg ctgccgccgg tggcaccggt gctgcctccc
     1441 gctgtgccgc tgctgccctc gggcgagctg ggccgcaaag cggccgcctt cggctcacag
     1501 ctcggcccgg gcctgcagct gcagctcaat agcctgggcg ccgccgcggc cgctgcgggc
     1561 acagcgggcg ccgcgggcac caccgcgtcg ctcatcaagt ccgagccaag cgcgcggccg
     1621 tcgttcagca tcgagaacat cataggtggg ggccccgcgg ctcctggggg ctcggcggtg
     1681 ggcgctgggg tcgccggcgg cactgggggt tcagggggcg gcagcacggc gcagtcgttt
     1741 ctgcggccac ccgggaccgt gcagtcggca gcgctcatgg ccacccacca accgctgtcg
     1801 ctgagccgga cgactgccac catcgcgccc attcttagcg tgccactctc cggacagttt
     1861 ctgcagcccg cagcctcggc cgccgccgct gctgcggccg ccgctcaagc caaatggccg
     1921 gcgcaatagg gacgcgccaa tggccgggac ccagggtccg gcggcggcct cgagcaacaa
     1981 atgcacctcc aggctgcgcg ccctgtccca agcccggtcc cggtcccgct gcccaatcct
     2041 ggactctgcc tctccccaat ttcctttccc ctgagccccc aacgcctacc ttccgcggcc
     2101 tccatcccct cgcgcacacc taagctggtc gagcaaactc accgcgcgcc cgccggggat
     2161 agctttccat acaggtaaaa ccgaaaaccg aattttccaa aaatgcaccc cgacggcgcc
     2221 tgctcttagt accgtgggga tgggagggaa attctttgta tatatttgta aaaaaattat
     2281 tgactttcct tttggggttt ttattttttt aagaaaaaac aaattccgta gatttagagc
     2341 tctgaacttt catttttttt gaaggttcac tctccgaagt tttatctgag aaaagaatgt
     2401 atagagacgt tgggagattt taaatataaa aaattttcaa aaaggcaaaa agtgtcattc
     2461 tattataaaa gtctgtttat atatgaatga atatatatgg tattctaaat gttattccat
     2521 cgtgttgtac acaactttgt aaataaattt ttaaaatgcc ca
//
