LOCUS       NM_004474               2648 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens forkhead box D2 (FOXD2), mRNA.
ACCESSION   NM_004474
VERSION     NM_004474.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2648)
  AUTHORS   Kim,H.M., Kang,B., Park,S., Park,H., Kim,C.J., Lee,H., Yoo,M.,
            Kweon,M.N., Im,S.H., Kim,T.I. and Roh,T.Y.
  TITLE     Forkhead box protein D2 suppresses colorectal cancer by
            reprogramming enhancer interactions
  JOURNAL   Nucleic Acids Res 51 (12), 6143-6155 (2023)
   PUBMED   37158258
  REMARK    GeneRIF: Forkhead box protein D2 suppresses colorectal cancer by
            reprogramming enhancer interactions.
REFERENCE   2  (bases 1 to 2648)
  AUTHORS   Arabpour,M., Layeghi,S.M., Bazzaz,J.T., Naghizadeh,M.M.,
            Majidzadeh-A,K. and Shakoori,A.
  TITLE     The potential roles of lncRNAs DUXAP8, LINC00963, and FOXD2-AS1 in
            luminal breast cancer based on expression analysis and
            bioinformatic approaches
  JOURNAL   Hum Cell 34 (4), 1227-1243 (2021)
   PUBMED   34043149
  REMARK    GeneRIF: The potential roles of lncRNAs DUXAP8, LINC00963, and
            FOXD2-AS1 in luminal breast cancer based on expression analysis and
            bioinformatic approaches.
REFERENCE   3  (bases 1 to 2648)
  AUTHORS   Huang,P. and Xue,J.
  TITLE     Long non-coding RNA FOXD2-AS1 regulates the tumorigenesis and
            progression of breast cancer via the S100 calcium binding protein
            A1/Hippo signaling pathway
  JOURNAL   Int J Mol Med 46 (4), 1477-1489 (2020)
   PUBMED   32945354
  REMARK    GeneRIF: Long noncoding RNA FOXD2AS1 regulates the tumorigenesis
            and progression of breast cancer via the S100 calcium binding
            protein A1/Hippo signaling pathway.
REFERENCE   4  (bases 1 to 2648)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2648)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   6  (bases 1 to 2648)
  AUTHORS   Clark,S.L., Adkins,D.E., Aberg,K., Hettema,J.M., McClay,J.L.,
            Souza,R.P. and van den Oord,E.J.
  TITLE     Pharmacogenomic study of side-effects for antidepressant treatment
            options in STAR*D
  JOURNAL   Psychol Med 42 (6), 1151-1162 (2012)
   PUBMED   22041458
REFERENCE   7  (bases 1 to 2648)
  AUTHORS   Iida,R., Ueki,M. and Yasuda,T.
  TITLE     Identification of Rhit as a novel transcriptional repressor of
            human Mpv17-like protein with a mitigating effect on mitochondrial
            dysfunction, and its transcriptional regulation by FOXD3 and GABP
  JOURNAL   Free Radic Biol Med 52 (8), 1413-1422 (2012)
   PUBMED   22306510
  REMARK    GeneRIF: identified transcription factors FOXD2 and GABP that bind
            to specific elements in the promoter of the RhitH gene
REFERENCE   8  (bases 1 to 2648)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   9  (bases 1 to 2648)
  AUTHORS   Johansson,C.C., Dahle,M.K., Blomqvist,S.R., Gronning,L.M.,
            Aandahl,E.M., Enerback,S. and Tasken,K.
  TITLE     A winged helix forkhead (FOXD2) tunes sensitivity to cAMP in T
            lymphocytes through regulation of cAMP-dependent protein kinase
            RIalpha
  JOURNAL   J Biol Chem 278 (19), 17573-17579 (2003)
   PUBMED   12621056
  REMARK    GeneRIF: FOXD2 is a physiological regulator which increases cAMP
            sensitivity and sets the threshold for cAMP-mediated negative
            modulation of T cell activation
REFERENCE   10 (bases 1 to 2648)
  AUTHORS   Ernstsson,S., Betz,R., Lagercrantz,S., Larsson,C., Ericksson,S.,
            Cederberg,A., Carlsson,P. and Enerback,S.
  TITLE     Cloning and characterization of freac-9 (FKHL17), a novel
            kidney-expressed human forkhead gene that maps to chromosome
            1p32-p34
  JOURNAL   Genomics 46 (1), 78-85 (1997)
   PUBMED   9403061
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL607122.20.
            
            On Jul 26, 2019 this sequence version replaced NM_004474.3.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which is characterized by a distinct forkhead domain.  The
            specific function of this gene has not yet been determined.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: DRR138528.127167.1, AF042832.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334793.6/ ENSP00000335493.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2648              AL607122.20        96044-98691
FEATURES             Location/Qualifiers
     source          1..2648
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p33"
     gene            1..2648
                     /gene="FOXD2"
                     /gene_synonym="FKHL17; FREAC-9; FREAC9"
                     /note="forkhead box D2"
                     /db_xref="GeneID:2306"
                     /db_xref="HGNC:HGNC:3803"
                     /db_xref="MIM:602211"
     exon            1..2648
                     /gene="FOXD2"
                     /gene_synonym="FKHL17; FREAC-9; FREAC9"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1580
                     /gene="FOXD2"
                     /gene_synonym="FKHL17; FREAC-9; FREAC9"
                     /note="forkhead-related activator 9; forkhead-like 17;
                     forkhead, drosophila, homolog-like 17; forkhead-related
                     protein FKHL17; forkhead-related transcription factor 9"
                     /codon_start=1
                     /product="forkhead box protein D2"
                     /protein_id="NP_004465.3"
                     /db_xref="CCDS:CCDS30708.1"
                     /db_xref="GeneID:2306"
                     /db_xref="HGNC:HGNC:3803"
                     /db_xref="MIM:602211"
                     /translation="MTLGSCCCEIMSSESSPAALSEADADIDVVGGGSGGGELPARSG
                     PRAPRDVLPHGHEPPAEEAEADLAEDEEESGGCSDGEPRALASRGAAAAAGSPGPGAA
                     AARGAAGPGPGPPSGGAATRSPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGR
                     FPYYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLR
                     RRKRFKRQPLPPPHPHPHPHPELLLRGGAAAAGDPGAFLPGFAAYGAYGYGYGLALPA
                     YGAPPPGPAPHPHPHPHAFAFAAAAAAAPCQLSVPPGRAAAPPPGPPTASVFAGAGSA
                     PAPAPASGSGPGPGPAGLPAFLGAELGCAKAFYAASLSPPAAGTAAGLPTALLRQGLK
                     TDAGGGAGGGGAGAGQRPSFSIDHIMGHGGGGAAPPGAGEGSPGPPFAAAAGPGGQAQ
                     VLAMLTAPALAPVAGHIRLSHPGDALLSSGSRFASKVAGLSGCHF"
     regulatory      2628..2633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXD2"
                     /gene_synonym="FKHL17; FREAC-9; FREAC9"
                     /note="hexamer: AATAAA"
     polyA_site      2648
                     /gene="FOXD2"
                     /gene_synonym="FKHL17; FREAC-9; FREAC9"
                     /note="major polyA site"
ORIGIN      
        1 gcaaaacgca ctcgccccag aggcagcgcg gccgagcccg agccgctgcc ggagcggagc
       61 cggagagtgg cggcggcggc ggcagcggca ccatgaccct gggcagctgc tgctgcgaga
      121 tcatgtcctc cgagagctcc ccggccgcgc tgtccgaggc cgacgcagac atagacgtgg
      181 tgggcggcgg cagcggcggg ggggagctcc cagctcgctc cgggccccgc gccccccggg
      241 acgtgctccc ccacggccac gagcctcccg cggaggaagc cgaggcagac ttagccgagg
      301 acgaggagga gtctggtggc tgctcggacg gcgagccccg cgctctggcg tcccgggggg
      361 cggcggccgc agcggggagc ccggggccag gcgccgcggc ggcccgcggc gcagcggggc
      421 ccgggccggg accgccgtcg gggggcgcgg cgacgcggag cccgctggtg aagccgccct
      481 actcgtacat cgcgctcatc accatggcca tcctgcagag ccccaagaag cggctgacgt
      541 tgagcgagat ctgcgagttc atcagcggcc gcttccccta ctaccgggag aagttccccg
      601 cctggcagaa cagcatccgc cacaacctct ctctcaacga ctgcttcgtc aagatccccc
      661 gcgagccggg caacccgggc aagggcaact actggacgct ggacccggag tcggccgaca
      721 tgttcgacaa cggcagcttc ctgcggcgtc gcaagcgctt caagcggcag cccctgccgc
      781 cgccgcaccc acacccgcac cctcacccgg agctgctgct gcgtggcggg gccgcggcgg
      841 cgggggatcc cggcgctttc ctgcccggct tcgctgccta cggcgcctac ggctacggct
      901 acgggctggc tctcccggcc tacggcgcac ccccgccggg gccggccccg catccgcacc
      961 cgcacccgca cgccttcgct ttcgccgcgg cagccgccgc cgctccttgc cagctgtcgg
     1021 tacccccagg ccgcgccgcc gcgcctccac ccggacctcc gacggcctcg gtgttcgcag
     1081 gcgcgggatc ggccccagct cctgcgcctg cctcaggctc gggcccgggc ccgggccccg
     1141 caggcctgcc cgccttcctg ggcgcggagc tgggctgcgc caaagccttc tacgcggcgt
     1201 ccctgagtcc tcccgcagcc ggcaccgcgg cgggtctgcc caccgcactt ctgcgccagg
     1261 gcctcaagac ggacgcgggc ggtggtgcag gcggcggggg cgccggggca gggcagaggc
     1321 cttccttctc tatagaccac atcatgggcc acggtggcgg cggggcagca cccccgggcg
     1381 ccggcgaggg ctctccggga ccgccattcg cggcagccgc gggtcctggg ggccaagccc
     1441 aggtcttggc catgctgact gctccggccc tggctcccgt tgctggccac attcgcctct
     1501 cgcatcccgg ggacgcgctg ctgtcctcag ggtcccggtt tgccagcaaa gtcgccggcc
     1561 ttagtggctg ccacttctga ccgcagcagg cccagggccg gttaggtccg cactcctcag
     1621 cctctcccgg gagttcctgc ggtcccagcg gaactcaggg agtctattta tgaagtctcc
     1681 agaccttggg ccggcacgcg tgacacggca cttcaggctc cacgcacaga atctcgcaga
     1741 tagttgggac taagcgggct ctatcgctca gggcgacagg cccggggcta cgcgaagaag
     1801 tcgcaggcca agattcttta cagtttgaga aataaaagca ggggggtggg ggcttcgttt
     1861 ttttccctgc ctctgcgcct ctcggggaac acattccggg agagatgcct ggccaggctc
     1921 cacggatccc gccagaaaca ccaacagagg gtctcccttt ctgcctttcc cctctcactt
     1981 cttccccaac gttgagaccc tgcttgtcca atattataat ttaaagacat ctattatctg
     2041 ctttgtgctt aaaagaaaaa ttcaaccttt tttttttttt tttttttttt gctgttctcc
     2101 aaggaagttc gtttcctctg aagcctaaac cagtgtctac gcaggcggag ctgaacggag
     2161 aggtgaagca gggggtcttt atattccctg cagaaaccct ggatcccact ccactgagga
     2221 aaatcctttc tcttttgtgt ttgggtgctt ttaaaggaat ttctttcctt tcccttggct
     2281 ggctgggtcc agccatctcc ggccagcaac cctgtcagtg ttccaccctg tcccaggccc
     2341 tgtgatattt attgtggcta aaggcaatga gattgggtgg aagagaaggg tctgggccag
     2401 ggactggaga ggtgggggtg gagtgggcaa gggcacaccc tgtggcaggg ggtcctataa
     2461 ttttgtgtaa atatctgtac agcgcgctgc tctcggcgtt ctctgtccac tgggtgtgca
     2521 ttgatttaaa cttctccact gtggggaagc tctgtgaaat cgtctgatgg tctgtgtgga
     2581 agaaaagaaa aatctgtctg ccgcctattt cccattggtg tcgattgaat aaatgtatgt
     2641 gaacttca
//
