LOCUS       NM_004472               2512 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens forkhead box D1 (FOXD1), mRNA.
ACCESSION   NM_004472
VERSION     NM_004472.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2512)
  AUTHORS   Feng,W.Q., Zhang,Y.C., Gao,H., Li,W.C., Miao,Y.M., Xu,Z.F.,
            Xu,Z.Q., Zhao,J.K., Zheng,M.H., Zong,Y.P. and Lu,A.G.
  TITLE     FOXD1 promotes chemotherapy resistance by enhancing cell stemness
            in colorectal cancer through beta-catenin nuclear localization
  JOURNAL   Oncol Rep 50 (1) (2023)
   PUBMED   37203394
  REMARK    GeneRIF: FOXD1 promotes chemotherapy resistance by enhancing cell
            stemness in colorectal cancer through beta-catenin nuclear
            localization.
REFERENCE   2  (bases 1 to 2512)
  AUTHORS   Cai,K., Chen,S., Zhu,C., Li,L., Yu,C., He,Z. and Sun,C.
  TITLE     FOXD1 facilitates pancreatic cancer cell proliferation, invasion,
            and metastasis by regulating GLUT1-mediated aerobic glycolysis
  JOURNAL   Cell Death Dis 13 (9), 765 (2022)
   PUBMED   36057597
  REMARK    GeneRIF: FOXD1 facilitates pancreatic cancer cell proliferation,
            invasion, and metastasis by regulating GLUT1-mediated aerobic
            glycolysis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2512)
  AUTHORS   Zhang,Q., Chen,Z., Tang,Q., Wang,Z., Lu,J., You,Y. and Wang,H.
  TITLE     USP21 promotes self-renewal and tumorigenicity of mesenchymal
            glioblastoma stem cells by deubiquitinating and stabilizing FOXD1
  JOURNAL   Cell Death Dis 13 (8), 712 (2022)
   PUBMED   35974001
  REMARK    GeneRIF: USP21 promotes self-renewal and tumorigenicity of
            mesenchymal glioblastoma stem cells by deubiquitinating and
            stabilizing FOXD1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2512)
  AUTHORS   Zong,Y., Miao,Y., Li,W., Zheng,M., Xu,Z., Gao,H., Feng,W., Xu,Z.,
            Zhao,J., Shen,L. and Lu,A.
  TITLE     Combination of FOXD1 and Plk2: A novel biomarker for predicting
            unfavourable prognosis of colorectal cancer
  JOURNAL   J Cell Mol Med 26 (12), 3471-3482 (2022)
   PUBMED   35579380
  REMARK    GeneRIF: Combination of FOXD1 and Plk2: A novel biomarker for
            predicting unfavourable prognosis of colorectal cancer.
REFERENCE   5  (bases 1 to 2512)
  AUTHORS   Xie,F., Li,Y. and Liang,B.
  TITLE     The Expression and Survival Significance of FOXD1 in Lung Squamous
            Cell Carcinoma: A Meta-Analysis, Immunohistochemistry Validation,
            and Bioinformatics Analysis
  JOURNAL   Biomed Res Int 2022, 7798654 (2022)
   PUBMED   35607308
  REMARK    GeneRIF: The Expression and Survival Significance of FOXD1 in Lung
            Squamous Cell Carcinoma: A Meta-Analysis, Immunohistochemistry
            Validation, and Bioinformatics Analysis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2512)
  AUTHORS   Berg,D.T., Myers,L.J., Richardson,M.A., Sandusky,G. and
            Grinnell,B.W.
  TITLE     Smad6s regulates plasminogen activator inhibitor-1 through a
            protein kinase C-beta-dependent up-regulation of transforming
            growth factor-beta
  JOURNAL   J Biol Chem 280 (15), 14943-14947 (2005)
   PUBMED   15716278
  REMARK    GeneRIF: the level of Smad6s can alter the level of TGF-beta and
            the subsequent induction of PAI-1 via a FoxD1 transcription site
REFERENCE   7  (bases 1 to 2512)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Human FOX gene family (Review)
  JOURNAL   Int J Oncol 25 (5), 1495-1500 (2004)
   PUBMED   15492844
  REMARK    Review article
REFERENCE   8  (bases 1 to 2512)
  AUTHORS   Ernstsson,S., Pierrou,S., Hulander,M., Cederberg,A., Hellqvist,M.,
            Carlsson,P. and Enerback,S.
  TITLE     Characterization of the human forkhead gene FREAC-4. Evidence for
            regulation by Wilms' tumor suppressor gene (WT-1) and p53
  JOURNAL   J Biol Chem 271 (35), 21094-21099 (1996)
   PUBMED   8702877
REFERENCE   9  (bases 1 to 2512)
  AUTHORS   Larsson,C., Hellqvist,M., Pierrou,S., White,I., Enerback,S. and
            Carlsson,P.
  TITLE     Chromosomal localization of six human forkhead genes, freac-1
            (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8
            (FKHL12)
  JOURNAL   Genomics 30 (3), 464-469 (1995)
   PUBMED   8825632
REFERENCE   10 (bases 1 to 2512)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC099522.3 and U59832.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004472.2.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which are characterized by a distinct forkhead domain.
            Studies of the orthologous mouse protein indicate that it functions
            in kidney development by promoting nephron progenitor
            differentiation, and it also functions in the development of the
            retina and optic chiasm. It may also regulate inflammatory
            reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: U59832.1, DRR138513.88996.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615637.3/ ENSP00000481581.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-250               AC099522.3         71402-71651
            251-2512            U59832.1           1-2262
FEATURES             Location/Qualifiers
     source          1..2512
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q13.2"
     gene            1..2512
                     /gene="FOXD1"
                     /gene_synonym="FKHL8; FREAC-4; FREAC4"
                     /note="forkhead box D1"
                     /db_xref="GeneID:2297"
                     /db_xref="HGNC:HGNC:3802"
                     /db_xref="MIM:601091"
     exon            1..2512
                     /gene="FOXD1"
                     /gene_synonym="FKHL8; FREAC-4; FREAC4"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1813
                     /gene="FOXD1"
                     /gene_synonym="FKHL8; FREAC-4; FREAC4"
                     /note="forkhead-related activator 4; Forkhead, drosophila,
                     homolog-like 8; forkhead-like 8; forkhead-related protein
                     FKHL8; forkhead-related transcription factor 4"
                     /codon_start=1
                     /product="forkhead box protein D1"
                     /protein_id="NP_004463.1"
                     /db_xref="CCDS:CCDS75259.1"
                     /db_xref="GeneID:2297"
                     /db_xref="HGNC:HGNC:3802"
                     /db_xref="MIM:601091"
                     /translation="MTLSTEMSDASGLAEETDIDVVGEGEDEEDEEEEDDDEGGGGGP
                     RLAVPAQRRRRRRSYAGEDELEDLEEEEDDDDILLAPPAGGSPAPPGPAPAAGAGAGG
                     GGGGGGAGGGGSAGSGAKNPLVKPPYSYIALITMAILQSPKKRLTLSEICEFISGRFP
                     YYREKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDPESADMFDNGSFLRRR
                     KRFKRQPLLPPNAAAAESLLLRGAGAAGGAGDPAAAAALFPPAPPPPPHAYGYGPYGC
                     GYGLQLPPYAPPSALFAAAAAAAAAAAFHPHSPPPPPPPHGAAAELARTAFGYRPHPL
                     GAALPGPLPASAAKAGGPGASALARSPFSIESIIGGSLGPAAAAAAAAQAAAAAQASP
                     SPSPVAAPPAPGSSGGGCAAQAAVGPAAALTRSLVAAAAAAASSVSSSAALGTLHQGT
                     ALSSVENFTARISNC"
     regulatory      2485..2490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXD1"
                     /gene_synonym="FKHL8; FREAC-4; FREAC4"
                     /note="hexamer: AATAAA"
     polyA_site      2512
                     /gene="FOXD1"
                     /gene_synonym="FKHL8; FREAC-4; FREAC4"
                     /note="major polyA site"
ORIGIN      
        1 ggactcagcc ctggcctcgc cgagctctgt tcttagactc tcacccgtcc cgcacgttcc
       61 tgggcgcctg gcgttctgat tcgcccgccc gggccccgcc accccctcct cagctgacgg
      121 ggcaaaagct gctccgagag gagaaggtca agtcctccgc ccgggccggg cgcgagcgga
      181 gcccagggag cgcagcatcc gcgcggctac cgcggcggcg caggagttat aaagtcggcg
      241 cgcgagactc cgccgccacc cggcagcccc ggcgcagctc cggcagccgc agtcgcagcg
      301 cccccagcgt ggcgcccccc ggccgggcct gccgcccggg acccgggctg gggcgcagag
      361 ggagcccgga gcccggcgcc cccatgcgcc gccccgccgc cgccgcgcca cagctatgac
      421 cctgagcact gagatgtccg atgcctctgg cctcgccgag gaaacagaca tcgacgtggt
      481 gggggagggc gaggacgaag aagacgagga agaggaggac gacgacgagg gcggcggtgg
      541 cgggccccgg ctggctgtcc ccgcgcagcg gcggcggcgg cggcgctcgt acgccgggga
      601 ggacgagctg gaggatctgg aggaggagga ggacgacgat gacatcctgc tggccccgcc
      661 tgctgggggc tccccggcgc ccccgggccc ggccccggcg gcgggggcag gagccggtgg
      721 gggcggcggc ggcggcggcg cgggcggcgg cgggagcgcg ggtagcggcg ccaagaaccc
      781 gctggtgaag ccgccctact cgtatatcgc gctcatcact atggccatcc tgcagagccc
      841 caagaagcgg ctgacgctga gcgagatctg tgagttcatc agcggccgct tcccctacta
      901 ccgggagaag ttccccgcct ggcagaacag catccgccac aacctctcgc tcaacgactg
      961 cttcgtcaag atcccccgcg agcccggcaa cccgggcaag ggcaactact ggacgctgga
     1021 cccggagtcc gccgacatgt tcgacaacgg cagcttcctg cgccggagga agcgcttcaa
     1081 gcggcagccg ctgctcccac ccaacgccgc ggccgccgag tctctgctgc tgcgcggcgc
     1141 gggagccgca gggggcgcgg gcgacccggc agccgccgcc gcgctcttcc cgcccgcgcc
     1201 cccgccgccc ccgcatgcct acggctacgg cccctacggc tgcggctacg gcctgcagct
     1261 gccgccttac gcgccgccct cggccctctt cgccgccgca gcggccgccg ccgccgccgc
     1321 cgccttccac ccgcactcgc ccccgccgcc cccgccaccg cacggcgcgg ccgccgagct
     1381 ggcccggacc gccttcggct accggccgca cccgctcggc gccgccctac ccggccccct
     1441 gccggcctcc gcggccaagg cgggcggccc gggcgcctca gcgctggcgc gctcgccctt
     1501 ctccatcgag agcatcatcg ggggcagctt gggcccggcc gccgctgccg ccgccgccgc
     1561 gcaggccgcc gccgccgctc aggcctcgcc ctcgccctcg ccggtggcgg cgccgccagc
     1621 tcccggatcc agcggaggag gctgcgcggc gcaggcggcc gtgggcccgg cggccgcgct
     1681 cacccgatcc ctcgtggccg ccgcggccgc cgccgcctcc tcagtctcct cgtccgccgc
     1741 cttggggact ctgcaccaag ggactgccct gtccagtgtc gagaacttta ctgctaggat
     1801 ttccaattgt taataacgct atgttagcgc gctcgaggaa gaaggtagga atcccggctc
     1861 cttttctcgt cttggtggtt cggtgttttg ttcgctcctc caggcgcggc ccctctcgac
     1921 ctcgcgcgcc cattttcgcc gctgcgaatt ctcggacaaa actgtcaaca gcccgggcgc
     1981 gccttttggc tctgcgggtc cctctattta tgcaaagccg acctatgcta cagcccccca
     2041 acccccgacc tggggtaggg aggaagaggg tgccggggaa gggagtccgc cctgtccagg
     2101 cactagaggc tcccttgacg tttggcagat gaaaaacaac taagcctttt tgaggtgtag
     2161 agattctcag gtccaggcgt taaaaaataa tggtcaaaag aataatacaa aaatagtaaa
     2221 ggtcttgaag aatgccagcg aagcaattct tttttatttg aggacacttg tctggtgtac
     2281 tttttcatga aaaggaaaaa tggttaacat gtttacacaa gaaaaaaagt caaaattatc
     2341 atttatttca acctgtgttt tgtatcataa cagacgtgtg gatttttttg tacttactgc
     2401 gtattcttta caaggagtat tgtaaatttt actggcaatt attattgtac tattctaaat
     2461 gtaagatttt tacacttttt cagaaataaa aatgcttaat tttcaaagaa aa
//
