LOCUS       NM_001453               3983 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens forkhead box C1 (FOXC1), mRNA.
ACCESSION   NM_001453
VERSION     NM_001453.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3983)
  AUTHORS   Wang,J., Gan,L., Liu,F., Yang,Q., Deng,Q., Jiang,D., Zhang,C.,
            Zhang,L. and Wang,X.
  TITLE     USP10 promotes pancreatic ductal adenocarcinoma progression by
            attenuating FOXC1 protein degradation to activate the WNT signaling
            pathway
  JOURNAL   Int J Biol Sci 20 (13), 5343-5362 (2024)
   PUBMED   39430239
  REMARK    GeneRIF: USP10 promotes pancreatic ductal adenocarcinoma
            progression by attenuating FOXC1 protein degradation to activate
            the WNT signaling pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3983)
  AUTHORS   Li,J., Chen,S., Xiao,J., Ji,J., Huang,C. and Shu,G.
  TITLE     FOXC1 transcriptionally suppresses ABHD5 to inhibit the progression
            of renal cell carcinoma through AMPK/mTOR pathway
  JOURNAL   Cell Biol Toxicol 40 (1), 62 (2024)
   PUBMED   39093497
  REMARK    GeneRIF: FOXC1 transcriptionally suppresses ABHD5 to inhibit the
            progression of renal cell carcinoma through AMPK/mTOR pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3983)
  AUTHORS   Li,B., Xiong,W., Zuo,W., Shi,Y., Wang,T., Chang,L., Wu,Y., Ma,H.,
            Bian,Q. and Chang,A.C.Y.
  TITLE     Proximal telomeric decompaction due to telomere shortening drives
            FOXC1-dependent myocardial senescence
  JOURNAL   Nucleic Acids Res 52 (11), 6269-6284 (2024)
   PUBMED   38634789
  REMARK    GeneRIF: Proximal telomeric decompaction due to telomere shortening
            drives FOXC1-dependent myocardial senescence.
REFERENCE   4  (bases 1 to 3983)
  AUTHORS   Wei,W., Li,B., Li,F., Sun,K., Jiang,X. and Xu,R.
  TITLE     Variants in FOXC1 and FOXC2 identified in patients with conotruncal
            heart defects
  JOURNAL   Genomics 116 (3), 110840 (2024)
   PUBMED   38580085
  REMARK    GeneRIF: Variants in FOXC1 and FOXC2 identified in patients with
            conotruncal heart defects.
REFERENCE   5  (bases 1 to 3983)
  AUTHORS   Zhang,F., Xu,Y., Lin,J., Pan,H., Giuliano,A.E., Cui,X. and Cui,Y.
  TITLE     Reciprocal regulation of forkhead box C1 and L1 cell adhesion
            molecule contributes to triple-negative breast cancer progression
  JOURNAL   Breast Cancer Res Treat 204 (3), 465-474 (2024)
   PUBMED   38183514
  REMARK    GeneRIF: Reciprocal regulation of forkhead box C1 and L1 cell
            adhesion molecule contributes to triple-negative breast cancer
            progression.
REFERENCE   6  (bases 1 to 3983)
  AUTHORS   Gould,D.B., Mears,A.J., Pearce,W.G. and Walter,M.A.
  TITLE     Autosomal dominant Axenfeld-Rieger anomaly maps to 6p25
  JOURNAL   Am J Hum Genet 61 (3), 765-768 (1997)
   PUBMED   9326342
REFERENCE   7  (bases 1 to 3983)
  AUTHORS   Mears,A.J., Mirzayans,F., Gould,D.B., Pearce,W.G. and Walter,M.A.
  TITLE     Autosomal dominant iridogoniodysgenesis anomaly maps to 6p25
  JOURNAL   Am J Hum Genet 59 (6), 1321-1327 (1996)
   PUBMED   8940278
REFERENCE   8  (bases 1 to 3983)
  AUTHORS   Larsson,C., Hellqvist,M., Pierrou,S., White,I., Enerback,S. and
            Carlsson,P.
  TITLE     Chromosomal localization of six human forkhead genes, freac-1
            (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8
            (FKHL12)
  JOURNAL   Genomics 30 (3), 464-469 (1995)
   PUBMED   8825632
REFERENCE   9  (bases 1 to 3983)
  AUTHORS   Pierrou,S., Hellqvist,M., Samuelsson,L., Enerback,S. and
            Carlsson,P.
  TITLE     Cloning and characterization of seven human forkhead proteins:
            binding site specificity and DNA bending
  JOURNAL   EMBO J 13 (20), 5002-5012 (1994)
   PUBMED   7957066
REFERENCE   10 (bases 1 to 3983)
  AUTHORS   Hromas,R., Moore,J., Johnston,T., Socha,C. and Klemsz,M.
  TITLE     Drosophila forkhead homologues are expressed in a
            lineage-restricted manner in human hematopoietic cells
  JOURNAL   Blood 81 (11), 2854-2859 (1993)
   PUBMED   8499623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL034344.24.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 11, 2018 this sequence version replaced NM_001453.2.
            
            Summary: This gene belongs to the forkhead family of transcription
            factors which is characterized by a distinct DNA-binding forkhead
            domain.  The specific function of this gene has not yet been
            determined; however, it has been shown to play a role in the
            regulation of embryonic and ocular development.  Mutations in this
            gene cause various glaucoma phenotypes including primary congenital
            glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and
            Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from genomic sequence
            data because mRNA transcripts were not available for the full
            length of the gene. The extent of this transcript is supported by
            tiled human transcripts and orthologous transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000645831.2/ ENSP00000493906.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3983              AL034344.24        64629-68611
FEATURES             Location/Qualifiers
     source          1..3983
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.3"
     gene            1..3983
                     /gene="FOXC1"
                     /gene_synonym="ARA; ASGD3; FKHL7; FREAC-3; FREAC3; IGDA;
                     IHG1; IRID1; RIEG3"
                     /note="forkhead box C1"
                     /db_xref="GeneID:2296"
                     /db_xref="HGNC:HGNC:3800"
                     /db_xref="MIM:601090"
     exon            1..3983
                     /gene="FOXC1"
                     /gene_synonym="ARA; ASGD3; FKHL7; FREAC-3; FREAC3; IGDA;
                     IHG1; IRID1; RIEG3"
                     /inference="alignment:Splign:2.1.0"
     CDS             532..2193
                     /gene="FOXC1"
                     /gene_synonym="ARA; ASGD3; FKHL7; FREAC-3; FREAC3; IGDA;
                     IHG1; IRID1; RIEG3"
                     /note="forkhead-related activator 3; forkhead/winged
                     helix-like transcription factor 7; forkhead, drosophila,
                     homolog-like 7; myeloid factor-delta; forkhead-related
                     protein FKHL7; forkhead-related transcription factor 3;
                     forkhead box C1 protein"
                     /codon_start=1
                     /product="forkhead box protein C1"
                     /protein_id="NP_001444.2"
                     /db_xref="CCDS:CCDS4473.1"
                     /db_xref="GeneID:2296"
                     /db_xref="HGNC:HGNC:3800"
                     /db_xref="MIM:601090"
                     /translation="MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPM
                     SVYSHPAHAEQYPGGMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLN
                     GIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYN
                     MFENGSFLRRRRRFKKKDAVKDKEEKDRLHLKEPPPPGRQPPPAPPEQADGNAPGPQP
                     PPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAAAVPKIESPDSSSSSLSSGSSPPGS
                     LPSARPLSLDGADSAPPPPAPSAPPPHHSQGFSVDNIMTSLRGSPQSAAAELSSGLLA
                     SAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQTSSAGSSGGGGGGAGAAGGAGGAGT
                     YHCNLQAMSLYAAGERGGHLQGAPGGAGGSAVDDPLPDYSLPPVTSSSSSSLSHGGGG
                     GGGGGGQEAGHHPAAHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSVR
                     EMFESQRIGLNNSPVNGNSSCQMAFPSSQSLYRTSGAFVYDCSKF"
     regulatory      3959..3964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXC1"
                     /gene_synonym="ARA; ASGD3; FKHL7; FREAC-3; FREAC3; IGDA;
                     IHG1; IRID1; RIEG3"
                     /note="hexamer: AATACA"
     polyA_site      3983
                     /gene="FOXC1"
                     /gene_synonym="ARA; ASGD3; FKHL7; FREAC-3; FREAC3; IGDA;
                     IHG1; IRID1; RIEG3"
                     /note="major polyA site"
ORIGIN      
        1 gctcaaaagt tcagaagttt tcccaatgct tccttaagcg gctggcgcgc gagagaccga
       61 gaaaaggtga cgcggggccc gggcaggcgg ccggcgcgcg gccccccccc cccccgccct
      121 ggttatttgg ccgccttcgc cggcagctca gggcagagtc tcctggaagg cgcaggcagt
      181 gtggcgagaa gggcgcctgc ttgttctttc tttttgtctg ctttcccccg tttgcgcctg
      241 gaagctgcgc cgcgagttcc tgcaaggcgg tctgccgcgg ccgggcccgg ccttctcccc
      301 tcgcagcgac cccgcctcgc ggccgcgcgg gccccgaggt agcccgaggc gccggaggag
      361 ccagccccag cgagcgccgg gagaggcggc agcgcagccg gacgcacagc gcagcgggcc
      421 ggcaccagct cggccgggcc cggactcgga ctcggcggcc ggcgcggcgc ggcccggccc
      481 gagcgagggt ggggggcggc gggcggcgcg gggcggcggc gagcgggggc catgcaggcg
      541 cgctactccg tgtccagccc caactccctg ggagtggtgc cctacctcgg cggcgagcag
      601 agctactacc gcgcggcggc cgcggcggcc gggggcggct acaccgccat gccggccccc
      661 atgagcgtgt actcgcaccc tgcgcacgcc gagcagtacc cgggcggcat ggcccgcgcc
      721 tacgggccct acacgccgca gccgcagccc aaggacatgg tgaagccgcc ctatagctac
      781 atcgcgctca tcaccatggc catccagaac gccccggaca agaagatcac cctgaacggc
      841 atctaccagt tcatcatgga ccgcttcccc ttctaccggg acaacaagca gggctggcag
      901 aacagcatcc gccacaacct ctcgctcaac gagtgcttcg tcaaggtgcc gcgcgacgac
      961 aagaagccgg gcaagggcag ctactggacg ctggacccgg actcctacaa catgttcgag
     1021 aacggcagct tcctgcggcg gcggcggcgc ttcaagaaga aggacgcggt gaaggacaag
     1081 gaggagaagg acaggctgca cctcaaggag ccgcccccgc ccggccgcca gcccccgccc
     1141 gcgccgccgg agcaggccga cggcaacgcg cccggtccgc agccgccgcc cgtgcgcatc
     1201 caggacatca agaccgagaa cggtacgtgc ccctcgccgc cccagcccct gtccccggcc
     1261 gccgccctgg gcagcggcag cgccgccgcg gtgcccaaga tcgagagccc cgacagcagc
     1321 agcagcagcc tgtccagcgg gagcagcccc ccgggcagcc tgccgtcggc gcggccgctc
     1381 agcctggacg gtgcggattc cgcgccgccg ccgcccgcgc cctccgcccc gccgccgcac
     1441 catagccagg gcttcagcgt ggacaacatc atgacgtcgc tgcgggggtc gccgcagagc
     1501 gcggccgcgg agctcagctc cggccttctg gcctcggcgg ccgcgtcctc gcgcgcgggg
     1561 atcgcacccc cgctggcgct cggcgcctac tcgcccggcc agagctccct ctacagctcc
     1621 ccctgcagcc agacctccag cgcgggcagc tcgggcggcg gcggcggcgg cgcgggggcc
     1681 gcggggggcg cgggcggcgc cgggacctac cactgcaacc tgcaagccat gagcctgtac
     1741 gcggccggcg agcgcggggg ccacttgcag ggcgcgcccg ggggcgcggg cggctcggcc
     1801 gtggacgacc ccctgcccga ctactctctg cctccggtca ccagcagcag ctcgtcgtcc
     1861 ctgagtcacg gcggcggcgg cggcggcggc gggggaggcc aggaggccgg ccaccaccct
     1921 gcggcccacc aaggccgcct cacctcgtgg tacctgaacc aggcgggcgg agacctgggc
     1981 cacttggcga gcgcggcggc ggcggcggcg gccgcaggct acccgggcca gcagcagaac
     2041 ttccactcgg tgcgggagat gttcgagtca cagaggatcg gcttgaacaa ctctccagtg
     2101 aacgggaata gtagctgtca aatggccttc ccttccagcc agtctctgta ccgcacgtcc
     2161 ggagctttcg tctacgactg tagcaagttt tgacacaccc tcaaagccga actaaatcga
     2221 accccaaagc aggaaaagct aaaggaaccc atcaaggcaa aatcgaaact aaaaaaaaaa
     2281 aatccaatta aaaaaaaccc ctgagaatat tcaccacacc agcgaacaga atatccctcc
     2341 aaaaattcag ctcaccagca ccagcacgaa gaaaactcta ttttcttaac cgattaattc
     2401 agagccacct ccactttgcc ttgtctaaat aaacaaaccc gtaaactgtt ttatacagag
     2461 acagcaaaat cttggtttat taaaggacag tgttactcca gataacacgt aagtttcttc
     2521 ttgcttttca gagacctgct ttcccctcct cccgtctccc ctctcttgcc ttcttccttg
     2581 cctctcacct gtaagatatt attttatcct atgttgaagg gagggggaaa gtccccgttt
     2641 atgaaagtcg ctttcttttt attcatggac ttgttttaaa atgtaaattg caacatagta
     2701 atttattttt aatttgtagt tggatgtcgt ggaccaaacg ccagaaagtg ttcccaaaac
     2761 ctgacgttaa attgcctgaa actttaaatt gtgctttttt tctcattata aaaagggaaa
     2821 ctgtattaat cttattctat cctcttttct ttctttttgt tgaacatatt cattgtttgt
     2881 ttattaataa attaccattc agtttgaatg agacctatat gtctggatac tttaatagag
     2941 ctttaattat tacgaaaaaa gatttcagag ataaaacact agaagttacc tattctccac
     3001 ctaaatctct gaaaaatgga gaaaccctct gactagtcca tgtcaaattt tactaaaagt
     3061 ctttttgttt agatttattt tcctgcagca tcttctgcaa aatgtactat atagtcagct
     3121 tgctttgagg ctagtaaaaa gatatttttc taaacagatt ggagttggca tataaacaaa
     3181 tacgttttct cactaatgac agtccatgat tcggaaattt taagcccatg aatcagccgc
     3241 ggtcttacca cggtgatgcc tgtgtgccga gagatgggac tgtgcggcca gatatgcaca
     3301 gataaatatt tggcttgtgt attccatata aaattgcagt gcatattata catccctgtg
     3361 agccagatgc tgaatagata ttttcctatt atttcagtcc tttataaaag gaaaaataaa
     3421 ccagttttta aatgtatgta tataattctc ccccatttac aatccttcat gtattacata
     3481 gaaggattgc ttttttaaaa atatactgcg ggttggaaag ggatatttaa tctttgagaa
     3541 actattttag aaaatatgtt tgtagaacaa ttatttttga aaaagattta aagcaataac
     3601 aagaaggaag gcgagaggag cagaacattt tggtctaggg tggtttcttt ttaaaccatt
     3661 ttttcttgtt aatttacagt taaacctagg ggacaatccg gattggccct cccccttttg
     3721 taaataaccc aggaaatgta ataaattcat tatcttaggg tgatctgccc tgccaatcag
     3781 actttgggga gatggcgatt tgattacaga cgttcggggg ggtggggggc ttgcagtttg
     3841 ttttggagat aatacagttt cctgctatct gccgctccta tctagaggca acacttaagc
     3901 agtaattgct gttgcttgtt gtcaaaattt gatcattgtt aaaggattgc tgcaaataaa
     3961 tacactttaa tttcagtcaa aaa
//
