LOCUS       NM_001013735            1299 bp    mRNA    linear   PRI 29-JUL-2024
DEFINITION  Homo sapiens forkhead box B2 (FOXB2), mRNA.
ACCESSION   NM_001013735 XM_498331
VERSION     NM_001013735.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1299)
  AUTHORS   Moparthi,L., Pizzolato,G. and Koch,S.
  TITLE     Wnt activator FOXB2 drives the neuroendocrine differentiation of
            prostate cancer
  JOURNAL   Proc Natl Acad Sci U S A 116 (44), 22189-22195 (2019)
   PUBMED   31611391
  REMARK    GeneRIF: FOXB2 strongly activates Wnt signaling via the neurogenic
            ligand WNT7B and imposes a neuronal differentiation program on
            prostate cancer cells.
REFERENCE   2  (bases 1 to 1299)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353637.21.
            
            On Mar 30, 2005 this sequence version replaced XM_498331.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376708.1/ ENSP00000365898.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1299              AL353637.21        107130-108428
FEATURES             Location/Qualifiers
     source          1..1299
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.2"
     gene            1..1299
                     /gene="FOXB2"
                     /gene_synonym="bA159H20.4; FKH4"
                     /note="forkhead box B2"
                     /db_xref="GeneID:442425"
                     /db_xref="HGNC:HGNC:23315"
                     /db_xref="MIM:619962"
     CDS             1..1299
                     /gene="FOXB2"
                     /gene_synonym="bA159H20.4; FKH4"
                     /codon_start=1
                     /product="forkhead box protein B2"
                     /protein_id="NP_001013757.1"
                     /db_xref="CCDS:CCDS35045.1"
                     /db_xref="GeneID:442425"
                     /db_xref="HGNC:HGNC:23315"
                     /db_xref="MIM:619962"
                     /translation="MPRPGKSSYSDQKPPYSYISLTAMAIQHSAEKMLPLSDIYKFIM
                     ERFPYYREHTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPDCGDMFENGSF
                     LRRRKRFKVLRADHTHLHAGSTKSAPGAGPGGHLHPHHHHHPHHHHHHHAAAHHHHHH
                     HPPQPPPPPPPPPPHMVHYFHQQPPTAPQPPPHLPSQPPQQPPQQSQPQQPSHPGKMQ
                     EAAAVAAAAAAAAAAAVGSVGRLSQFPPYGLGSAAAAAAAAAASTSGFKHPFAIENII
                     GRDYKGVLQAGGLPLASVMHHLGYPVPGQLGNVVSSVWPHVGVMDSVAAAAAAAAAAG
                     VPVGPEYGAFGVPVKSLCHSASQSLPAMPVPIKPTPALPPVSALQPGLTVPAASQQPP
                     APSTVCSAAAASPVASLLEPTAPTSAESKGGSLHSVLVHS"
     exon            1..1299
                     /gene="FOXB2"
                     /gene_synonym="bA159H20.4; FKH4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccgcggc cggggaagag ctcgtacagc gaccaaaaac cgccctactc ttacatctcg
       61 ctgaccgcca tggcaatcca gcactcggcc gagaagatgc tgccgctgag cgacatctac
      121 aagttcatca tggagcgctt cccctactac cgcgagcaca cacagcgctg gcagaacagc
      181 ctgcgccaca acctctcctt caacgactgc ttcatcaaga ttccgcggag gcccgaccag
      241 cctggcaagg gtagcttctg ggcgctgcac cccgactgcg gggacatgtt cgagaacggc
      301 agcttcctgc ggcgtcgcaa gcgcttcaag gtgctgcgcg ccgaccatac tcacttgcac
      361 gcgggaagca ccaagagcgc gccgggcgcc ggtccgggag ggcaccttca cccccatcac
      421 caccaccacc cccaccacca ccatcatcac cacgctgccg cacaccacca ccatcaccac
      481 cacccacccc agccgccgcc gccgccgccc ccgccgccgc cgcacatggt acactatttc
      541 catcagcaac cgcctactgc tccgcagccg cctccgcacc tcccgtcaca gcccccgcag
      601 caaccgcccc agcagtcgca gcctcagcag ccgtctcacc ccggcaagat gcaggaggcg
      661 gcggccgtgg cggcggcggc ggcggcggcc gcggcagccg cggtgggcag cgtgggacgc
      721 ctgtctcagt tcccacccta cgggctgggc tcggccgccg ccgctgccgc cgcggccgcg
      781 gcgtccacgt caggcttcaa gcaccccttt gccattgaga acattattgg ccgggactac
      841 aagggcgtgc tgcaggctgg agggctgccc ttggcgtccg tcatgcacca cctgggctac
      901 cccgtgcccg gccagcttgg caacgtcgtc agctccgtgt ggccgcacgt tggcgtcatg
      961 gattcggtgg ccgccgccgc ggccgccgca gccgcagccg gagtccctgt aggcccggag
     1021 tatggggcct tcggggtccc ggtcaagtcc ctgtgccact cggcaagcca gagcctgcct
     1081 gccatgccgg tgcccatcaa gcccacgcct gcgctgccgc ccgtgtccgc gctgcagccg
     1141 gggctcactg tccccgcggc ttcgcagcag cctccggcgc catccaccgt gtgctccgcg
     1201 gccgcggcct cgcccgttgc ctctctgctg gagcccacag cccctacctc ggccgaaagc
     1261 aagggcggct ccttgcactc ggtgctagtg cactcctag
//
