LOCUS       NM_012182               2871 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens forkhead box B1 (FOXB1), mRNA.
ACCESSION   NM_012182
VERSION     NM_012182.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2871)
  AUTHORS   Yin,Y., Morgunova,E., Jolma,A., Kaasinen,E., Sahu,B.,
            Khund-Sayeed,S., Das,P.K., Kivioja,T., Dave,K., Zhong,F.,
            Nitta,K.R., Taipale,M., Popov,A., Ginno,P.A., Domcke,S., Yan,J.,
            Schubeler,D., Vinson,C. and Taipale,J.
  TITLE     Impact of cytosine methylation on DNA binding specificities of
            human transcription factors
  JOURNAL   Science 356 (6337) (2017)
   PUBMED   28473536
REFERENCE   2  (bases 1 to 2871)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA685771.1, AF071554.1 and AC009654.8.
            
            On Nov 23, 2018 this sequence version replaced NM_012182.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290944.1, AK314075.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396057.6/ ENSP00000379369.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-371               DA685771.1         90-460
            372-689             AF071554.1         9-326
            690-1370            AC009654.8         94091-94771
            1371-2871           AC009654.8         94772-96272
FEATURES             Location/Qualifiers
     source          1..2871
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.2"
     gene            1..2871
                     /gene="FOXB1"
                     /gene_synonym="FKH5; HFKH-5"
                     /note="forkhead box B1"
                     /db_xref="GeneID:27023"
                     /db_xref="HGNC:HGNC:3799"
                     /db_xref="MIM:619961"
     exon            1..333
                     /gene="FOXB1"
                     /gene_synonym="FKH5; HFKH-5"
                     /inference="alignment:Splign:2.1.0"
     exon            334..2871
                     /gene="FOXB1"
                     /gene_synonym="FKH5; HFKH-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             391..1368
                     /gene="FOXB1"
                     /gene_synonym="FKH5; HFKH-5"
                     /note="transcription factor FKH-5"
                     /codon_start=1
                     /product="forkhead box protein B1"
                     /protein_id="NP_036314.2"
                     /db_xref="CCDS:CCDS32255.1"
                     /db_xref="GeneID:27023"
                     /db_xref="HGNC:HGNC:3799"
                     /db_xref="MIM:619961"
                     /translation="MPRPGRNTYSDQKPPYSYISLTAMAIQSSPEKMLPLSEIYKFIM
                     DRFPYYRENTQRWQNSLRHNLSFNDCFIKIPRRPDQPGKGSFWALHPSCGDMFENGSF
                     LRRRKRFKVLKSDHLAPSKPADAAQYLQQQAKLRLSALAASGTHLPQMPAAAYNLGGV
                     AQPSGFKHPFAIENIIAREYKMPGGLAFSAMQPVPAAYPLPNQLTTMGSSLGTGWPHV
                     YGSAGMIDSATPISMASGDYSAYGVPLKPLCHAAGQTLPAIPVPIKPTPAAVPALPAL
                     PAPIPTLLSNSPPSLSPTSSQTATSQSSPATPSETLTSPASALHSVAVH"
     regulatory      2851..2856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXB1"
                     /gene_synonym="FKH5; HFKH-5"
                     /note="hexamer: ATTAAA"
     polyA_site      2871
                     /gene="FOXB1"
                     /gene_synonym="FKH5; HFKH-5"
                     /note="major polyA site"
ORIGIN      
        1 atcagatggt tcgagggagg acatggaggc agccacctag ctcagcggag acgcggagcc
       61 cacagcagcg ccctccggag ccctaacacg tcgctgccac catccgcgcc gggactccgc
      121 agccgagctc ggccgcccgc aggacgctcc aggagcgtcg cggaccgggc ggcacgggac
      181 gctgcggggc tgagctcaag agcccaggtt cgcgccgagt ccaaccggac ccggacgctg
      241 cgcgcggagt gcgcgtcgag tgcgcgccga gagagaagcg gcgcgcagcg gcgtcctccc
      301 ggatgcggac gcgcaacttg aagcaacttt aagatccgag cagtccgccg gcccgcgcgg
      361 acccagagca agaagagggc gaggaagaag atgcctcggc ccggccgcaa cacgtacagc
      421 gaccagaagc cgccctactc gtacatctcg ctgaccgcta tggccatcca gagctctccc
      481 gagaagatgc tgccgctgag cgagatctac aagttcatca tggaccgctt cccctactac
      541 agggagaaca cgcagcgctg gcagaacagt ctgcgccaca acctctcctt caacgactgc
      601 ttcatcaaga tcccgcggcg gccggaccag ccaggcaagg gcagcttctg ggcgctgcac
      661 ccaagctgcg gggacatgtt cgagaacggc agcttcctgc ggcgccgcaa gcgcttcaag
      721 gtgcttaagt ccgaccacct ggcgcccagc aagccagccg acgcggcgca gtacctgcag
      781 cagcaggcca agctgcggct cagcgcgctg gcggcctcgg gcacgcacct gccacagatg
      841 cccgccgccg cctacaactt gggcggcgtg gcgcagccct cgggcttcaa gcaccccttc
      901 gccatcgaga acatcatcgc gcgggaatac aagatgcctg gggggctggc cttctccgcc
      961 atgcagccgg tgcccgctgc ctacccgctc cccaaccagt tgactaccat gggcagctcg
     1021 ctgggcaccg gctggccaca cgtgtatggc tccgccggca tgatcgactc ggccaccccc
     1081 atctccatgg cgagtggcga ctacagcgcc tacggcgtgc cgttgaagcc gctgtgccac
     1141 gcggcgggcc aaacgctgcc cgccatcccc gtgcccatta agcccacgcc ggccgccgtg
     1201 cccgcgctgc ctgcgctgcc agcgcccatc cccaccttgc tctcgaactc gccgccctcg
     1261 ctcagcccca cgtcctcgca aacagccacc agccaaagca gccccgccac ccccagcgaa
     1321 acgctcacca gcccggcctc cgccttgcac tcggtggcgg tgcactgacc cgcaggagcc
     1381 cacgccccct ctcgttctcc tccccaccac ctcactcgcc ttccctggct cccagtcctg
     1441 ccggccccca cctgggaccg ccaccctaac ttgttcattt caccttcggc caacccgcct
     1501 tgccccaaga gaactttgtt ttggacccag gagaccaaac acaaacttgc agatgggccg
     1561 agaggcgcgt gggagttgtc ctcgccccca catcaaggaa ggccggggcc acctgagccg
     1621 aaccatcccc tccctgaggc cccgaaaccc cctcctattt gaccggcggg ggaaaccctg
     1681 tcaccccctc ttcgccgaga aaagcgcgtc ttccctccgc ccagatcggc ggagccccga
     1741 actctgcgca gtttcaagac tagagaaact gcctcagatg tttccaggaa cagatccccc
     1801 ccacaccccc tccccgcgag ggctgcaaca gcgcagggga gggccggatc tctttacgtc
     1861 ttggaaatct gcagcaaaaa ggagccacta atcttcctac cccactcgcc tccgcccatc
     1921 cggcaggggc tgggccgacc acagcttccc ggggttgcgg ccctgcctcc taggcttctg
     1981 cggagatttt gttgttgttt ggggttttgt ttccttccag aggctccagg cgctgggagt
     2041 taggaaagag gctgccaagc tgagaaagcg acgctcgtcc tcacacagca aaacaaaact
     2101 aaaagtaacc ttgtattgtt tacaaagcgc ccagtaatat gtaaacagtg aacttgaatc
     2161 tgtcttgcta ggcggacgaa cgggcaaagc ccacattata agtacctgtt gtaatgtgaa
     2221 tgtttactct tcatttctgg ccaggtttag aaagggaggg aagtggggat gggaaagtta
     2281 attgggatgt taactttccg atgacttaga gaccttttta gctatttatt ttattgttgg
     2341 gaaaaaaaaa aaaaaaaaag aaggaaagaa aatgaaataa gcccaaacca agaaagcatc
     2401 aagggcaacc cgggaagaac ttagataagc tgactggtaa catgaaggga tgtcaccgga
     2461 tagctctccc acggacaagt ctttctgttt gctaccagaa cttttccaag aagctaaagg
     2521 gctgcaaaga gatgtaaata cttgtgaata ggaatgatta tacactgtgt aaaatgcact
     2581 tttgtttgct gtattccttt agaatcttag ataattggct ggaaaacgaa ctgttgttct
     2641 ggtgtgacct gcttaagtta aaaaaaaaaa aagttgtagt gtcatcagag ctgtaaaatt
     2701 tttacctttc attttccctc cctgtacaga attagcgtgg cattttaaat attgatgttc
     2761 ttgttcccag catgcctgtt ttaaaacaaa ggatttaaaa aaaaagggtg tctacattaa
     2821 attatgacct agtccaaata atattttctc attaaaatat gtaaattcaa a
//
