LOCUS       NM_004497               1923 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens forkhead box A3 (FOXA3), mRNA.
ACCESSION   NM_004497
VERSION     NM_004497.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1923)
  AUTHORS   Wang,D., Cao,Y., Meng,M., Qiu,J., Ni,C., Guo,X., Li,Y., Liu,S.,
            Yu,J., Guo,M., Wang,J., Du,B., Qiu,W., Xie,C., Zhao,B., Ma,X.,
            Cheng,X. and Xu,L.
  TITLE     FOXA3 regulates cholesterol metabolism to compensate for low uptake
            during the progression of lung adenocarcinoma
  JOURNAL   PLoS Biol 22 (5), e3002621 (2024)
   PUBMED   38805565
  REMARK    GeneRIF: FOXA3 regulates cholesterol metabolism to compensate for
            low uptake during the progression of lung adenocarcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1923)
  AUTHORS   Zheng,B., Seltzsam,S., Wang,C., Schierbaum,L., Schneider,S.,
            Wu,C.W., Dai,R., Connaughton,D.M., Nakayama,M., Mann,N., Stajic,N.,
            Mane,S., Bauer,S.B., Tasic,V., Nam,H.J., Shril,S. and
            Hildebrandt,F.
  TITLE     Whole-exome sequencing identifies FOXL2, FOXA2 and FOXA3 as
            candidate genes for monogenic congenital anomalies of the kidneys
            and urinary tract
  JOURNAL   Nephrol Dial Transplant 37 (10), 1833-1843 (2022)
   PUBMED   34473308
  REMARK    GeneRIF: Whole-exome sequencing identifies FOXL2, FOXA2 and FOXA3
            as candidate genes for monogenic congenital anomalies of the
            kidneys and urinary tract.
REFERENCE   3  (bases 1 to 1923)
  AUTHORS   Vargas-Alarcon,G., Fragoso,J.M., Ramirez-Bello,J. and
            Posadas-Sanchez,R.
  TITLE     FOXA3 Polymorphisms Are Associated with Metabolic Parameters in
            Individuals with Subclinical Atherosclerosis and Healthy
            Controls-The GEA Mexican Study
  JOURNAL   Biomolecules 12 (5), 601 (2022)
   PUBMED   35625529
  REMARK    GeneRIF: FOXA3 Polymorphisms Are Associated with Metabolic
            Parameters in Individuals with Subclinical Atherosclerosis and
            Healthy Controls-The GEA Mexican Study.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1923)
  AUTHORS   Zhan,X. and Zhao,A.
  TITLE     Transcription factor FOXA3 promotes the development of
            Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression
  JOURNAL   J Clin Lab Anal 35 (3), e23686 (2021)
   PUBMED   33368532
  REMARK    GeneRIF: Transcription factor FOXA3 promotes the development of
            Hepatoblastoma via regulating HNF1A, AFP, and ZFHX3 expression.
REFERENCE   5  (bases 1 to 1923)
  AUTHORS   Zhou,T., Li,S., Xiang,D., Liu,J., Sun,W., Cui,X., Ning,B., Li,X.,
            Cheng,Z., Jiang,W., Zhang,C., Liang,X., Li,L., Cheng,X., Hui,L.,
            Wang,H. and Ding,J.
  TITLE     m6A RNA methylation-mediated HNF3gamma reduction renders
            hepatocellular carcinoma dedifferentiation and sorafenib resistance
  JOURNAL   Signal Transduct Target Ther 5 (1), 296 (2020)
   PUBMED   33361765
  REMARK    GeneRIF: m6A RNA methylation-mediated HNF3gamma reduction renders
            hepatocellular carcinoma dedifferentiation and sorafenib
            resistance.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1923)
  AUTHORS   Lin,B., Morris,D.W. and Chou,J.Y.
  TITLE     The role of HNF1alpha, HNF3gamma, and cyclic AMP in
            glucose-6-phosphatase gene activation
  JOURNAL   Biochemistry 36 (46), 14096-14106 (1997)
   PUBMED   9369482
REFERENCE   7  (bases 1 to 1923)
  AUTHORS   Mincheva,A., Lichter,P., Schutz,G. and Kaestner,K.H.
  TITLE     Assignment of the human genes for hepatocyte nuclear factor
            3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13,
            20p11, and 19q13.2-q13.4
  JOURNAL   Genomics 39 (3), 417-419 (1997)
   PUBMED   9119385
REFERENCE   8  (bases 1 to 1923)
  AUTHORS   Qian,X. and Costa,R.H.
  TITLE     Analysis of hepatocyte nuclear factor-3 beta protein domains
            required for transcriptional activation and nuclear targeting
  JOURNAL   Nucleic Acids Res 23 (7), 1184-1191 (1995)
   PUBMED   7739897
REFERENCE   9  (bases 1 to 1923)
  AUTHORS   Clark,K.L., Halay,E.D., Lai,E. and Burley,S.K.
  TITLE     Co-crystal structure of the HNF-3/fork head DNA-recognition motif
            resembles histone H5
  JOURNAL   Nature 364 (6436), 412-420 (1993)
   PUBMED   8332212
REFERENCE   10 (bases 1 to 1923)
  AUTHORS   Hromas,R., Moore,J., Johnston,T., Socha,C. and Klemsz,M.
  TITLE     Drosophila forkhead homologues are expressed in a
            lineage-restricted manner in human hematopoietic cells
  JOURNAL   Blood 81 (11), 2854-2859 (1993)
   PUBMED   8499623
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC016024.1.
            
            On Nov 23, 2018 this sequence version replaced NM_004497.2.
            
            Summary: This gene encodes a member of the forkhead class of
            DNA-binding proteins. These hepatocyte nuclear factors are
            transcriptional activators for liver-specific transcripts such as
            albumin and transthyretin, and they also interact with chromatin.
            Similar family members in mice have roles in the regulation of
            metabolism and in the differentiation of the pancreas and liver.
            The crystal structure of a similar protein in rat has been
            resolved. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016024.1, AK223473.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302177.3/ ENSP00000304004.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1923              BC016024.1         67-1989
FEATURES             Location/Qualifiers
     source          1..1923
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..1923
                     /gene="FOXA3"
                     /gene_synonym="FKHH3; HNF3G; TCF3G"
                     /note="forkhead box A3"
                     /db_xref="GeneID:3171"
                     /db_xref="HGNC:HGNC:5023"
                     /db_xref="MIM:602295"
     exon            1..200
                     /gene="FOXA3"
                     /gene_synonym="FKHH3; HNF3G; TCF3G"
                     /inference="alignment:Splign:2.1.0"
     CDS             132..1184
                     /gene="FOXA3"
                     /gene_synonym="FKHH3; HNF3G; TCF3G"
                     /note="HNF-3G; TCF-3G; HNF-3-gamma; forkhead box protein
                     A3; transcription factor 3G; fork head-related protein FKH
                     H3"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 3-gamma"
                     /protein_id="NP_004488.2"
                     /db_xref="CCDS:CCDS12677.1"
                     /db_xref="GeneID:3171"
                     /db_xref="HGNC:HGNC:5023"
                     /db_xref="MIM:602295"
                     /translation="MLGSVKMEAHDLAEWSYYPEAGEVYSPVTPVPTMAPLNSYMTLN
                     PLSSPYPPGGLPASPLPSGPLAPPAPAAPLGPTFPGLGVSGGSSSSGYGAPGPGLVHG
                     KEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQR
                     WQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEK
                     VKKGGSGAATTTRNGTGSAASTTTPAATVTSPPQPPPPAPEPEAQGGEDVGALDCGSP
                     ASSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTPAPPKLDVGFGGYGAEGGEP
                     GVYYQGLYSRSLLNAS"
     exon            201..1923
                     /gene="FOXA3"
                     /gene_synonym="FKHH3; HNF3G; TCF3G"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1898..1903
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXA3"
                     /gene_synonym="FKHH3; HNF3G; TCF3G"
                     /note="hexamer: ATTAAA"
     polyA_site      1923
                     /gene="FOXA3"
                     /gene_synonym="FKHH3; HNF3G; TCF3G"
                     /note="major polyA site"
ORIGIN      
        1 gggacagccg taccccgggc ggtcggacgg gcgggcgccg gtgggagctc gggccgtgcc
       61 cgctgagaga tccagagcgc tccgttcccc cggggccgga gcgggggcgg gtgggggcgt
      121 aagcccgggg gatgctgggc tcagtgaaga tggaggccca tgacctggcc gagtggagct
      181 actacccgga ggcgggcgag gtctactcgc cggtgacccc agtgcccacc atggcccccc
      241 tcaactccta catgaccctg aatcctctaa gctctcccta tccccctggg gggctccctg
      301 cctccccact gccctcagga cccctggcac ccccagcacc tgcagccccc ctggggccca
      361 ctttcccagg cctgggtgtc agcggtggca gcagcagctc cgggtacggg gccccgggtc
      421 ctgggctggt gcacgggaag gagatgccga aggggtatcg gcggcccctg gcacacgcca
      481 agccaccgta ttcctatatc tcactcatca ccatggccat ccagcaggcg ccgggcaaga
      541 tgctgacctt gagtgaaatc taccagtgga tcatggacct cttcccttac taccgggaga
      601 atcagcagcg ctggcagaac tccattcgcc actcgctgtc tttcaacgac tgcttcgtca
      661 aggtggcgcg ttccccagac aagcctggca agggctccta ctgggcccta caccccagct
      721 cagggaacat gtttgagaat ggctgctacc tgcgccgcca gaaacgcttc aagctggagg
      781 agaaggtgaa aaaagggggc agcggggctg ccaccaccac caggaacggg acagggtctg
      841 ctgcctcgac caccaccccc gcggccacag tcacctcccc gccccagccc ccgcctccag
      901 cccctgagcc tgaggcccag ggcggggaag atgtgggggc tctggactgt ggctcacccg
      961 cttcctccac accctatttc actggcctgg agctcccagg ggagctgaag ctggacgcgc
     1021 cctacaactt caaccaccct ttctccatca acaacctaat gtcagaacag acaccagcac
     1081 ctcccaaact ggacgtgggg tttgggggct acggggctga aggtggggag cctggagtct
     1141 actaccaggg cctctattcc cgctctttgc ttaatgcatc ctagcagggg ttgggaacat
     1201 ggtggtgggt atggctggag ctcacaccac gaagctcttg gggcctgatc cttctggtga
     1261 cacttcactt gtcccattgg ttaacatctg ggtgggtcta ttacttactg tgatgactgc
     1321 tgtctcagtg ggcatggtgt tgatccacgg ggtactgtga taaccaccat ggatacattt
     1381 tggtggccca ctgggtactg tgaggactgc tacattgatg gatgttattg gctaatccac
     1441 tgcatggttt gatggccacc atctcggttg gccctttggg tgtgatggtg atagcatttc
     1501 agtgacatct tctttggccc cccccattag gtgctgtgcc cacttctttt ttggtgtact
     1561 tggcacagta ggtgccaagt tggccaccat tctgtgtaac accttttttg gcccattggg
     1621 tgctttgatg gacatcatac tgggtaggtg acaacgtcag tgggccacca tgtgccatga
     1681 tggctgctgc agccccgtgt tggccatgtc gtcaccattc tctctggcat gggttgggta
     1741 ggggatggag gtgagaatac tccttggttt tctctgaagc ccaccctttc ccccaactct
     1801 ggtccaggag aaaccagaaa aggctggtta gggtgtgggg aatttctact gaagtctgat
     1861 tctttcccgg gaagcggggt actggctgtg tttaatcatt aaaggtaccg tgtccgcctc
     1921 tta
//
