LOCUS       NM_004496               3509 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens forkhead box A1 (FOXA1), mRNA.
ACCESSION   NM_004496
VERSION     NM_004496.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3509)
  AUTHORS   Jin,R., Li,H., Nan,S. and Wang,H.
  TITLE     FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical
            cancer cell growth
  JOURNAL   Syst Biol Reprod Med 70 (1), 113-123 (2024)
   PUBMED   38743820
  REMARK    GeneRIF: FOXA1 co-activates circODC1 and ODC1 in HPV-positive
            cervical cancer cell growth.
REFERENCE   2  (bases 1 to 3509)
  AUTHORS   Zhang,T., Liu,S., Durojaye,O., Xiong,F., Fang,Z., Ullah,T., Fu,C.,
            Sun,B., Jiang,H., Xia,P., Wang,Z., Yao,X. and Liu,X.
  TITLE     Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic
            gene reactivation
  JOURNAL   Cell Rep 43 (9), 114739 (2024)
   PUBMED   39276350
  REMARK    GeneRIF: Dynamic phosphorylation of FOXA1 by Aurora B guides
            post-mitotic gene reactivation.
REFERENCE   3  (bases 1 to 3509)
  AUTHORS   Zhu,J., Wei,Y., Deng,F., Zhou,Y., Yang,Z. and Ma,Y.
  TITLE     The Role of FOXA1 in Human Normal Development and Its Functions in
            Sex Hormone-Related Cancers
  JOURNAL   Front Biosci (Landmark Ed) 29 (6), 225 (2024)
   PUBMED   38940052
  REMARK    GeneRIF: The Role of FOXA1 in Human Normal Development and Its
            Functions in Sex Hormone-Related Cancers.
            Review article
REFERENCE   4  (bases 1 to 3509)
  AUTHORS   Xin,X., Liu,Y., Li,Y., Ji,X., Yun,Y., Yang,G., Liu,H., Liang,X. and
            Yang,S.
  TITLE     LINC01133 contributes to the malignant phenotypes of non-small cell
            lung cancer by targeting miR-30b-5p/FOXA1 pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (6), 42-47 (2024)
   PUBMED   38836682
  REMARK    GeneRIF: LINC01133 contributes to the malignant phenotypes of
            non-small cell lung cancer by targeting miR-30b-5p/FOXA1 pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3509)
  AUTHORS   Pu,J., Zhang,D., Wang,B., Zhu,P., Yang,W., Wang,K., Yang,Z. and
            Song,Q.
  TITLE     FOXA1/UBE2T Inhibits CD8+T Cell Activity by Inducing Mediates
            Glycolysis in Lung Adenocarcinoma
  JOURNAL   Front Biosci (Landmark Ed) 29 (4), 134 (2024)
   PUBMED   38682180
  REMARK    GeneRIF: FOXA1/UBE2T Inhibits CD8[+]T Cell Activity by Inducing
            Mediates Glycolysis in Lung Adenocarcinoma.
REFERENCE   6  (bases 1 to 3509)
  AUTHORS   Mincheva,A., Lichter,P., Schutz,G. and Kaestner,K.H.
  TITLE     Assignment of the human genes for hepatocyte nuclear factor
            3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13,
            20p11, and 19q13.2-q13.4
  JOURNAL   Genomics 39 (3), 417-419 (1997)
   PUBMED   9119385
REFERENCE   7  (bases 1 to 3509)
  AUTHORS   Bingle,C.D. and Gowan,S.
  TITLE     Molecular cloning of the forkhead transcription factor HNF-3 alpha
            from a human pulmonary adenocarcinoma cell line
  JOURNAL   Biochim Biophys Acta 1307 (1), 17-20 (1996)
   PUBMED   8652662
REFERENCE   8  (bases 1 to 3509)
  AUTHORS   Kaestner,K.H., Hiemisch,H., Luckow,B. and Schutz,G.
  TITLE     The HNF-3 gene family of transcription factors in mice: gene
            structure, cDNA sequence, and mRNA distribution
  JOURNAL   Genomics 20 (3), 377-385 (1994)
   PUBMED   8034310
REFERENCE   9  (bases 1 to 3509)
  AUTHORS   Avraham,K.B., Prezioso,V.R., Chen,W.S., Lai,E., Sladek,F.M.,
            Zhong,W., Darnell,J.E. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of four hepatocyte-enriched
            transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and
            HNF-4
  JOURNAL   Genomics 13 (2), 264-268 (1992)
   PUBMED   1612587
REFERENCE   10 (bases 1 to 3509)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121790.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 3, 2019 this sequence version replaced NM_004496.4.
            
            Summary: This gene encodes a member of the forkhead class of
            DNA-binding proteins. These hepatocyte nuclear factors are
            transcriptional activators for liver-specific transcripts such as
            albumin and transthyretin, and they also interact with chromatin.
            Similar family members in mice have roles in the regulation of
            metabolism and in the differentiation of the pancreas and liver.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033890.1, SRR7346977.1217667.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250448.5/ ENSP00000250448.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-349               AL121790.4         123470-123818       c
            350-3509            AL121790.4         118121-121280       c
FEATURES             Location/Qualifiers
     source          1..3509
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     gene            1..3509
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
                     /note="forkhead box A1"
                     /db_xref="GeneID:3169"
                     /db_xref="HGNC:HGNC:5021"
                     /db_xref="MIM:602294"
     exon            1..349
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..1696
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
                     /note="HNF-3A; TCF-3A; HNF-3-alpha; forkhead box protein
                     A1; transcription factor 3A"
                     /codon_start=1
                     /product="hepatocyte nuclear factor 3-alpha"
                     /protein_id="NP_004487.2"
                     /db_xref="CCDS:CCDS9665.1"
                     /db_xref="GeneID:3169"
                     /db_xref="HGNC:HGNC:5021"
                     /db_xref="MIM:602294"
                     /translation="MLGTVKMEGHETSDWNSYYADTQEAYSSVPVSNMNSGLGSMNSM
                     NTYMTMNTMTTSGNMTPASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVT
                     AMGTALSPSGMGAMGAQQAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAK
                     TFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSI
                     RHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGG
                     GGGSGSGGSGAKGGPESRKDPSGASNPSADSPLHRGVHGKTGQLEGAPAPGPAASPQT
                     LDHSGATATGGASELKTPASSTAPPISSGPGALASVPASHPAHGLAPHESQLHLKGDP
                     HYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGSTLPASLPLGSASVTTRSPI
                     EPSALEPAYYQGVYSRPVLNTS"
     exon            350..3509
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3056..3061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
                     /note="hexamer: AATAAA"
     polyA_site      3077
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
                     /note="major polyA site"
     regulatory      3467..3472
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
                     /note="hexamer: AATAAA"
     polyA_site      3509
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
ORIGIN      
        1 agaggcagcc cgctcacttc ccgcggaggc gctccccggc gccgcgctcc gcggcagccg
       61 cctgcccccg gcgctgcccc cgcccgccgc gccgccgccg ccgccgcgca cgccgcgccc
      121 cgcagctctg ggcttcctct tcgcccgggt ggcgttgggc ccgcgcgggc gctcgggtga
      181 ctgcagctgc tcagctcccc tcccccgccc cgcgccgcgc ggccgcccgt cgcttcgcac
      241 agggctggat ggttgtattg ggcagggtgg ctccaggatg ttaggaactg tgaagatgga
      301 agggcatgaa accagcgact ggaacagcta ctacgcagac acgcaggagg cctactcctc
      361 cgtcccggtc agcaacatga actcaggcct gggctccatg aactccatga acacctacat
      421 gaccatgaac accatgacta cgagcggcaa catgaccccg gcgtccttca acatgtccta
      481 tgccaacccg ggcctagggg ccggcctgag tcccggcgca gtagccggca tgccgggggg
      541 ctcggcgggc gccatgaaca gcatgactgc ggccggcgtg acggccatgg gtacggcgct
      601 gagcccgagc ggcatgggcg ccatgggtgc gcagcaggcg gcctccatga atggcctggg
      661 cccctacgcg gccgccatga acccgtgcat gagccccatg gcgtacgcgc cgtccaacct
      721 gggccgcagc cgcgcgggcg gcggcggcga cgccaagacg ttcaagcgca gctacccgca
      781 cgccaagccg ccctactcgt acatctcgct catcaccatg gccatccagc aggcgcccag
      841 caagatgctc acgctgagcg agatctacca gtggatcatg gacctcttcc cctattaccg
      901 gcagaaccag cagcgctggc agaactccat ccgccactcg ctgtccttca atgactgctt
      961 cgtcaaggtg gcacgctccc cggacaagcc gggcaagggc tcctactgga cgctgcaccc
     1021 ggactccggc aacatgttcg agaacggctg ctacttgcgc cgccagaagc gcttcaagtg
     1081 cgagaagcag ccgggggccg gcggcggggg cgggagcgga agcgggggca gcggcgccaa
     1141 gggcggccct gagagccgca aggacccctc tggcgcctct aaccccagcg ccgactcgcc
     1201 cctccatcgg ggtgtgcacg ggaagaccgg ccagctagag ggcgcgccgg cccccgggcc
     1261 cgccgccagc ccccagactc tggaccacag tggggcgacg gcgacagggg gcgcctcgga
     1321 gttgaagact ccagcctcct caactgcgcc ccccataagc tccgggcccg gggcgctggc
     1381 ctctgtgccc gcctctcacc cggcacacgg cttggcaccc cacgagtccc agctgcacct
     1441 gaaaggggac ccccactact ccttcaacca cccgttctcc atcaacaacc tcatgtcctc
     1501 ctcggagcag cagcataagc tggacttcaa ggcatacgaa caggcactgc aatactcgcc
     1561 ttacggctct acgttgcccg ccagcctgcc tctaggcagc gcctcggtga ccaccaggag
     1621 ccccatcgag ccctcagccc tggagccggc gtactaccaa ggtgtgtatt ccagacccgt
     1681 cctaaacact tcctagctcc cgggactggg gggtttgtct ggcatagcca tgctggtagc
     1741 aagagagaaa aaatcaacag caaacaaaac cacacaaacc aaaccgtcaa cagcataata
     1801 aaatcccaac aactattttt atttcatttt tcatgcacaa cctttccccc agtgcaaaag
     1861 actgttactt tattattgta ttcaaaattc attgtgtata ttactacaaa gacaacccca
     1921 aaccaatttt tttcctgcga agtttaatga tccacaagtg tatatatgaa attctcctcc
     1981 ttccttgccc ccctctcttt cttccctctt tcccctccag acattctagt ttgtggaggg
     2041 ttatttaaaa aaacaaaaaa ggaagatggt caagtttgta aaatatttgt ttgtgctttt
     2101 tccccctcct tacctgaccc cctacgagtt tacaggtctg tggcaatact cttaaccata
     2161 agaattgaaa tggtgaagaa acaagtatac actagaggct cttaaaagta ttgaaagaca
     2221 atactgctgt tatatagcaa gacataaaca gattataaac atcagagcca tttgcttctc
     2281 agtttacatt tctgatacat gcagatagca gatgtcttta aatgaaatac atgtatattg
     2341 tgtatggact taattatgca catgctcaga tgtgtagaca tcctccgtat atttacataa
     2401 catatagagg taatagatag gtgatataca tgatacattc tcaagagttg cttgaccgaa
     2461 agttacaagg accccaaccc ctttgtcctc tctacccaca gatggccctg ggaatcaatt
     2521 cctcaggaat tgccctcaag aactctgctt cttgctttgc agagtgccat ggtcatgtca
     2581 ttctgaggtc acataacaca taaaattagt ttctatgagt gtataccatt taaagaattt
     2641 ttttttcagt aaaagggaat attacaatgt tggaggagag ataagttata gggagctgga
     2701 tttcaaaacg tggtccaaga ttcaaaaatc ctattgatag tggccatttt aatcattgcc
     2761 atcgtgtgct tgtttcatcc agtgttatgc actttccaca gttggacatg gtgttagtat
     2821 agccagacgg gtttcattat tatttctctt tgctttctca atgttaattt attgcatggt
     2881 ttattctttt tctttacagc tgaaattgct ttaaatgatg gttaaaatta caaattaaat
     2941 tgttaatttt tatcaatgtg attgtaatta aaaatatttt gatttaaata acaaaaataa
     3001 taccagattt taagccgtgg aaaatgttct tgatcatttg cagttaagga ctttaaataa
     3061 atcaaatgtt aacaaaagag catttctgtt attttttttc acttaactaa atccgaagtg
     3121 aatatttctg aatacgatat ttttcaaatt ctagaactga atataaatga caaaaatgaa
     3181 aataaaattg ttttgtctgt tgttataatg aatgtgtagc tagtaaaaag gagtgaaaga
     3241 aattcaagta aagtgtataa gttgatttaa tattccaaga gttgagattt ttaagattct
     3301 ttattcccag tgatgtttac ttcatttttt tttttttttt tgacaccggc ttaagccttc
     3361 tgtgtttcct ttgagccttt tcactacaaa atcaaatatt aatttaacta cctttcctcc
     3421 ttccccaatg tatcactttt ctttatctga gaattcttcc aatgaaaata aaatatcagc
     3481 tgtggctgat agaattaagt tgtgtccaa
//
