LOCUS       NP_004487                472 aa            linear   PRI 29-APR-2025
DEFINITION  hepatocyte nuclear factor 3-alpha [Homo sapiens].
ACCESSION   NP_004487
VERSION     NP_004487.2
DBSOURCE    REFSEQ: accession NM_004496.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 472)
  AUTHORS   Jin,R., Li,H., Nan,S. and Wang,H.
  TITLE     FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical
            cancer cell growth
  JOURNAL   Syst Biol Reprod Med 70 (1), 113-123 (2024)
   PUBMED   38743820
  REMARK    GeneRIF: FOXA1 co-activates circODC1 and ODC1 in HPV-positive
            cervical cancer cell growth.
REFERENCE   2  (residues 1 to 472)
  AUTHORS   Zhang,T., Liu,S., Durojaye,O., Xiong,F., Fang,Z., Ullah,T., Fu,C.,
            Sun,B., Jiang,H., Xia,P., Wang,Z., Yao,X. and Liu,X.
  TITLE     Dynamic phosphorylation of FOXA1 by Aurora B guides post-mitotic
            gene reactivation
  JOURNAL   Cell Rep 43 (9), 114739 (2024)
   PUBMED   39276350
  REMARK    GeneRIF: Dynamic phosphorylation of FOXA1 by Aurora B guides
            post-mitotic gene reactivation.
REFERENCE   3  (residues 1 to 472)
  AUTHORS   Zhu,J., Wei,Y., Deng,F., Zhou,Y., Yang,Z. and Ma,Y.
  TITLE     The Role of FOXA1 in Human Normal Development and Its Functions in
            Sex Hormone-Related Cancers
  JOURNAL   Front Biosci (Landmark Ed) 29 (6), 225 (2024)
   PUBMED   38940052
  REMARK    GeneRIF: The Role of FOXA1 in Human Normal Development and Its
            Functions in Sex Hormone-Related Cancers.
            Review article
REFERENCE   4  (residues 1 to 472)
  AUTHORS   Xin,X., Liu,Y., Li,Y., Ji,X., Yun,Y., Yang,G., Liu,H., Liang,X. and
            Yang,S.
  TITLE     LINC01133 contributes to the malignant phenotypes of non-small cell
            lung cancer by targeting miR-30b-5p/FOXA1 pathway
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (6), 42-47 (2024)
   PUBMED   38836682
  REMARK    GeneRIF: LINC01133 contributes to the malignant phenotypes of
            non-small cell lung cancer by targeting miR-30b-5p/FOXA1 pathway.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 472)
  AUTHORS   Pu,J., Zhang,D., Wang,B., Zhu,P., Yang,W., Wang,K., Yang,Z. and
            Song,Q.
  TITLE     FOXA1/UBE2T Inhibits CD8+T Cell Activity by Inducing Mediates
            Glycolysis in Lung Adenocarcinoma
  JOURNAL   Front Biosci (Landmark Ed) 29 (4), 134 (2024)
   PUBMED   38682180
  REMARK    GeneRIF: FOXA1/UBE2T Inhibits CD8[+]T Cell Activity by Inducing
            Mediates Glycolysis in Lung Adenocarcinoma.
REFERENCE   6  (residues 1 to 472)
  AUTHORS   Mincheva,A., Lichter,P., Schutz,G. and Kaestner,K.H.
  TITLE     Assignment of the human genes for hepatocyte nuclear factor
            3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13,
            20p11, and 19q13.2-q13.4
  JOURNAL   Genomics 39 (3), 417-419 (1997)
   PUBMED   9119385
REFERENCE   7  (residues 1 to 472)
  AUTHORS   Bingle,C.D. and Gowan,S.
  TITLE     Molecular cloning of the forkhead transcription factor HNF-3 alpha
            from a human pulmonary adenocarcinoma cell line
  JOURNAL   Biochim Biophys Acta 1307 (1), 17-20 (1996)
   PUBMED   8652662
REFERENCE   8  (residues 1 to 472)
  AUTHORS   Kaestner,K.H., Hiemisch,H., Luckow,B. and Schutz,G.
  TITLE     The HNF-3 gene family of transcription factors in mice: gene
            structure, cDNA sequence, and mRNA distribution
  JOURNAL   Genomics 20 (3), 377-385 (1994)
   PUBMED   8034310
REFERENCE   9  (residues 1 to 472)
  AUTHORS   Avraham,K.B., Prezioso,V.R., Chen,W.S., Lai,E., Sladek,F.M.,
            Zhong,W., Darnell,J.E. Jr., Jenkins,N.A. and Copeland,N.G.
  TITLE     Murine chromosomal location of four hepatocyte-enriched
            transcription factors: HNF-3 alpha, HNF-3 beta, HNF-3 gamma, and
            HNF-4
  JOURNAL   Genomics 13 (2), 264-268 (1992)
   PUBMED   1612587
REFERENCE   10 (residues 1 to 472)
  AUTHORS   Lai,E., Prezioso,V.R., Tao,W.F., Chen,W.S. and Darnell,J.E. Jr.
  TITLE     Hepatocyte nuclear factor 3 alpha belongs to a gene family in
            mammals that is homologous to the Drosophila homeotic gene fork
            head
  JOURNAL   Genes Dev 5 (3), 416-427 (1991)
   PUBMED   1672118
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL121790.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 3, 2002 this sequence version replaced NP_004487.1.
            
            Summary: This gene encodes a member of the forkhead class of
            DNA-binding proteins. These hepatocyte nuclear factors are
            transcriptional activators for liver-specific transcripts such as
            albumin and transthyretin, and they also interact with chromatin.
            Similar family members in mice have roles in the regulation of
            metabolism and in the differentiation of the pancreas and liver.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC033890.1, SRR7346977.1217667.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000250448.5/ ENSP00000250448.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..472
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q21.1"
     Protein         1..472
                     /product="hepatocyte nuclear factor 3-alpha"
                     /note="HNF-3A; TCF-3A; HNF-3-alpha; forkhead box protein
                     A1; transcription factor 3A"
                     /calculated_mol_wt=49017
     Region          17..169
                     /region_name="Forkhead_N"
                     /note="Forkhead N-terminal region; pfam08430"
                     /db_xref="CDD:369872"
     Region          157..268
                     /region_name="FH_FOXA1"
                     /note="Forkhead (FH) domain found in Forkhead box protein
                     A1 (FOXA1) and similar proteins; cd20038"
                     /db_xref="CDD:410812"
     Site            order(174..175,193,213,216..217,219..220,223,230,241..242,
                     244,260..262,264..265)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410812"
     Region          269..392
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P55317.2)"
     Site            307
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:23186163,
                     ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P55317.2)"
     Site            331
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:24275569; propagated from
                     UniProtKB/Swiss-Prot (P55317.2)"
     Region          397..461
                     /region_name="HNF_C"
                     /note="HNF3 C-terminal domain; pfam09354"
                     /db_xref="CDD:430552"
     CDS             1..472
                     /gene="FOXA1"
                     /gene_synonym="HNF3A; TCF3A"
                     /coded_by="NM_004496.5:278..1696"
                     /db_xref="CCDS:CCDS9665.1"
                     /db_xref="GeneID:3169"
                     /db_xref="HGNC:HGNC:5021"
                     /db_xref="MIM:602294"
ORIGIN      
        1 mlgtvkmegh etsdwnsyya dtqeayssvp vsnmnsglgs mnsmntymtm ntmttsgnmt
       61 pasfnmsyan pglgaglspg avagmpggsa gamnsmtaag vtamgtalsp sgmgamgaqq
      121 aasmnglgpy aaamnpcmsp mayapsnlgr sraggggdak tfkrsyphak ppysyislit
      181 maiqqapskm ltlseiyqwi mdlfpyyrqn qqrwqnsirh slsfndcfvk varspdkpgk
      241 gsywtlhpds gnmfengcyl rrqkrfkcek qpgagggggs gsggsgakgg pesrkdpsga
      301 snpsadsplh rgvhgktgql egapapgpaa spqtldhsga tatggaselk tpasstappi
      361 ssgpgalasv pashpahgla phesqlhlkg dphysfnhpf sinnlmssse qqhkldfkay
      421 eqalqyspyg stlpaslplg sasvttrspi epsalepayy qgvysrpvln ts
//
