LOCUS       NM_005253               6713 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens FOS like 2, AP-1 transcription factor subunit (FOSL2),
            mRNA.
ACCESSION   NM_005253 NM_024530
VERSION     NM_005253.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6713)
  AUTHORS   Du,H., Sun,J., Wang,X., Zhao,L., Liu,X., Zhang,C., Wang,F. and
            Wu,J.
  TITLE     FOSL2-mediated transcription of ISG20 induces M2 polarization of
            macrophages and enhances tumorigenic ability of glioblastoma cells
  JOURNAL   J Neurooncol 169 (3), 659-670 (2024)
   PUBMED   39073688
  REMARK    GeneRIF: FOSL2-mediated transcription of ISG20 induces M2
            polarization of macrophages and enhances tumorigenic ability of
            glioblastoma cells.
REFERENCE   2  (bases 1 to 6713)
  AUTHORS   Rampioni Vinciguerra,G.L., Capece,M., Scafetta,G., Rentsch,S.,
            Vecchione,A., Lovat,F. and Croce,C.M.
  TITLE     Role of Fra-2 in cancer
  JOURNAL   Cell Death Differ 31 (2), 136-149 (2024)
   PUBMED   38104183
  REMARK    GeneRIF: Role of Fra-2 in cancer.
            Review article
REFERENCE   3  (bases 1 to 6713)
  AUTHORS   Chen,H., Wang,L., Liu,J., Wan,Z., Zhou,L., Liao,H. and Wan,R.
  TITLE     LncRNA ITGB2-AS1 promotes cisplatin resistance of non-small cell
            lung cancer by inhibiting ferroptosis via activating the
            FOSL2/NAMPT axis
  JOURNAL   Cancer Biol Ther 24 (1), 2223377 (2023)
   PUBMED   37370246
  REMARK    GeneRIF: LncRNA ITGB2-AS1 promotes cisplatin resistance of
            non-small cell lung cancer by inhibiting ferroptosis via activating
            the FOSL2/NAMPT axis.
REFERENCE   4  (bases 1 to 6713)
  AUTHORS   Zhang,S., Li,P., Li,J., Gao,J., Qi,Q., Dong,G., Liu,X., Jiao,Q.,
            Wang,Y., Du,L., Zhan,H., Xu,S. and Wang,C.
  TITLE     Chromatin accessibility uncovers KRAS-driven FOSL2 promoting
            pancreatic ductal adenocarcinoma progression through up-regulation
            of CCL28
  JOURNAL   Br J Cancer 129 (3), 426-443 (2023)
   PUBMED   37380804
  REMARK    GeneRIF: Chromatin accessibility uncovers KRAS-driven FOSL2
            promoting pancreatic ductal adenocarcinoma progression through
            up-regulation of CCL28.
REFERENCE   5  (bases 1 to 6713)
  AUTHORS   Ding,M., Huang,W., Liu,G., Zhai,B., Yan,H. and Zhang,Y.
  TITLE     Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives human
            liver progenitor-like cell aging by regulating inflammatory factors
  JOURNAL   BMC Genomics 24 (1), 260 (2023)
   PUBMED   37173651
  REMARK    GeneRIF: Integration of ATAC-Seq and RNA-Seq reveals FOSL2 drives
            human liver progenitor-like cell aging by regulating inflammatory
            factors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6713)
  AUTHORS   Ng,D.C., Shafaee,S., Lee,D. and Bikle,D.D.
  TITLE     Requirement of an AP-1 site in the calcium response region of the
            involucrin promoter
  JOURNAL   J Biol Chem 275 (31), 24080-24088 (2000)
   PUBMED   10816578
REFERENCE   7  (bases 1 to 6713)
  AUTHORS   Miyamoto,N.G., Medberry,P.S., Hesselgesser,J., Boehlk,S.,
            Nelson,P.J., Krensky,A.M. and Perez,H.D.
  TITLE     Interleukin-1beta induction of the chemokine RANTES promoter in the
            human astrocytoma line CH235 requires both constitutive and
            inducible transcription factors
  JOURNAL   J Neuroimmunol 105 (1), 78-90 (2000)
   PUBMED   10713367
REFERENCE   8  (bases 1 to 6713)
  AUTHORS   Outinen,P.A., Sood,S.K., Pfeifer,S.I., Pamidi,S., Podor,T.J.,
            Li,J., Weitz,J.I. and Austin,R.C.
  TITLE     Homocysteine-induced endoplasmic reticulum stress and growth arrest
            leads to specific changes in gene expression in human vascular
            endothelial cells
  JOURNAL   Blood 94 (3), 959-967 (1999)
   PUBMED   10419887
REFERENCE   9  (bases 1 to 6713)
  AUTHORS   Molven,A., Houge,G. and Berger,R.
  TITLE     Chromosomal assignment of the human gene encoding the Fos-related
            antigen-2 (FRA2) to chromosome 2p22-p23
  JOURNAL   Genomics 38 (1), 72-75 (1996)
   PUBMED   8954781
REFERENCE   10 (bases 1 to 6713)
  AUTHORS   Matsui,M., Tokuhara,M., Konuma,Y., Nomura,N. and Ishizaki,R.
  TITLE     Isolation of human fos-related genes and their expression during
            monocyte-macrophage differentiation
  JOURNAL   Oncogene 5 (3), 249-255 (1990)
   PUBMED   2107490
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104695.2, BM023443.1,
            AK055579.1, BC022791.1, BX647822.1 and AK026959.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005253.3.
            
            Summary: The Fos gene family consists of 4 members: FOS, FOSB,
            FOSL1, and FOSL2. These genes encode leucine zipper proteins that
            can dimerize with proteins of the JUN family, thereby forming the
            transcription factor complex AP-1. As such, the FOS proteins have
            been implicated as regulators of cell proliferation,
            differentiation, and transformation. [provided by RefSeq, Jul
            2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK055579.1, SRR1660807.74443.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264716.9/ ENSP00000264716.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-54                AC104695.2         54773-54826
            55-102              BM023443.1         1-48
            103-649             AK055579.1         103-649
            650-2366            BC022791.1         20-1736
            2367-4032           BX647822.1         1489-3154
            4033-4045           AK026959.1         1714-1726
            4046-6713           AC104695.2         76565-79232
FEATURES             Location/Qualifiers
     source          1..6713
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.2"
     gene            1..6713
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /note="FOS like 2, AP-1 transcription factor subunit"
                     /db_xref="GeneID:2355"
                     /db_xref="HGNC:HGNC:3798"
                     /db_xref="MIM:601575"
     exon            1..965
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             864..1844
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /note="FRA-2; FOS like antigen 2; FOS like 2, AP-1
                     trancription factor subunit"
                     /codon_start=1
                     /product="fos-related antigen 2"
                     /protein_id="NP_005244.1"
                     /db_xref="CCDS:CCDS1766.1"
                     /db_xref="GeneID:2355"
                     /db_xref="HGNC:HGNC:3798"
                     /db_xref="MIM:601575"
                     /translation="MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSG
                     SAFIPTINAITTSQDLQWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGV
                     IKTIGTTVGRRRRDEQLSPEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELE
                     EEKSGLQKEIAELQKEKEKLEFMLVAHGPVCKISPEERRSPPAPGLQPMRSGGGSVGA
                     VVVKQEPLEEDSPSSSSAGLDKAQRSVIKPISIAGGFYGEEPLHTPIVVTSTPAVTPG
                     TSNLVFTYPSVLEQESPASPSESCSKAHRRSSSSGDQSSDSLNSPTLLAL"
     exon            966..1217
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1325
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..6713
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2346..2351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /note="hexamer: ATTAAA"
     polyA_site      2367
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /note="major polyA site"
     regulatory      6067..6072
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /note="hexamer: ATTAAA"
     polyA_site      6087
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /note="major polyA site"
     regulatory      6258..6263
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /note="hexamer: AGTAAA"
     polyA_site      6289
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
     regulatory      6692..6697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
                     /note="hexamer: AATGAA"
     polyA_site      6713
                     /gene="FOSL2"
                     /gene_synonym="ACED; FRA2"
ORIGIN      
        1 gtagtgactc atctcgggca gagcgctagg gctccgagcg aaccagcgag cgagcgaacg
       61 agcggcgctc ggcggggaca gaaagaggga gagagagaga gagagagagg gagaggcgcg
      121 gccgggcgag gcgggcccgt ccgggagcgg gctccgggga aggggtgcgg gtctgggcgc
      181 cggagcgggg agcggggccg cgtccctctc agcgccagct ctacttgagc cccacgagcc
      241 gctgtccccc tggcgcgctc ggggccgcgg gacgggcgca cgccgccttc tcctagtcaa
      301 gtatccgagc cgccccgaaa ctcgggcggc gagtcggcca cgggaagttt attctccggc
      361 tccttttcta aaaggaagaa acagaagttt ctcccagcgg acagcttttc tttccgcctt
      421 tttggccctg tctgaaatcg ggggtcccca gggctggcag gccaggctcg ctgggctcct
      481 aatctttttt ttaatttcca atttttgatt gggccgtggg tccccgctga gctccggctg
      541 cgcgcggggg cgggagggcg cgcgcagggg agggaccgag agacgcgccg actttttaga
      601 gggagggatc gggtggacaa ctggtcccgc ggcgctcgca gagccggaaa gaagtgctgt
      661 aagggacgct cgggggacgc tgttcctgag gtgtcgccgc ctccctgtcc tcgccctccg
      721 cggtggggga gaaacccagg agcgaagccc agagcccgcg gcgcggccgg cggacgaacg
      781 agcgcgcagc agccggtgcg cggccgcggc gagggcgggg gaagaaaaac accctgtttc
      841 ctctccggcc cccaccgcgg atcatgtacc aggattatcc cgggaacttt gacacctcgt
      901 cccggggcag cagcggctct cctgcgcacg ccgagtccta ctccagcggc ggcggcggcc
      961 agcagaaatt ccgggtagat atgcctggct caggcagtgc attcatcccc accatcaacg
     1021 ccatcacgac cagccaggac ctgcagtgga tggtgcagcc cacagtgatc acctccatgt
     1081 ccaacccata ccctcgctcg cacccctaca gccccctgcc gggcctggcc tctgtccctg
     1141 gacacatggc cctcccaaga cctggcgtga tcaagaccat tggcaccacc gtgggccgca
     1201 ggaggagaga tgagcagctg tctcctgaag aggaggagaa gcgtcgcatc cggcgggaga
     1261 ggaacaagct ggctgcagcc aagtgccgga accgacgccg ggagctgaca gagaagctgc
     1321 aggcggagac agaggagctg gaggaggaga agtcaggcct gcagaaggag attgctgagc
     1381 tgcagaagga gaaggagaag ctggagttca tgttggtggc tcacggccca gtgtgcaaga
     1441 ttagccccga ggagcgccga tcgcccccag cccctgggct gcagcccatg cgcagtgggg
     1501 gtggctcggt gggcgctgta gtggtgaaac aggagcccct ggaagaggac agcccctcgt
     1561 cctcgtcggc ggggctggac aaggcccagc gctctgtcat caagcccatc agcattgctg
     1621 ggggcttcta cggtgaggag cccctgcaca cccccatcgt ggtgacctcc acacctgctg
     1681 tcactccggg cacctcgaac ctcgtcttca cctatcctag cgtcctggag caggagtcac
     1741 ccgcatctcc ctccgaatcc tgctccaagg ctcaccgcag aagcagtagc agcggggacc
     1801 aatcatcaga ctccttgaac tcccccactc tgctggctct gtaacccagt gcacctccct
     1861 ccccagctcc ggagggggtc ctcctcgctc ctccttccca gggaccagca ccttcaagcg
     1921 ctccagggcc gtgagggcaa gagggggacc tgccaccagg gagcttcctg gctctggggg
     1981 acccaggtgg gacttagcag tgagtattgg aagacttggg ttgatctctt agaagccatg
     2041 ggacctcctc cctcattcat cttgcaagca aatcccattt cttgaaaagc cttggagaac
     2101 tcggtttggt agacttggac atctctctgg cttctgaaga gcctgaagct ggcctggacc
     2161 attcctgtcc ctttgttacc atactgtctc tggagtgatg gtgtccttcc ctgccccacc
     2221 acgcatgctc agtgcctttt ggtttcacct tccctcgact tgaccctttc ctcccccagc
     2281 gtcagtttca ctccctcttg gtttttatca aatttgccat gacatttcat ctgggtggtc
     2341 tgaatattaa agctcttcat ttctggagat ggggcagcag gtggctcttc tgctggggct
     2401 gacttgtcca gaaggggaca aagtgcaata cagagccttc cctaccctga cgcctcccag
     2461 tcatcatctc cagaactccc agcggggctc cctgagctct caaggagatg ctgccatcac
     2521 tgggaggctc agaggaccct tcctgcccac cttcggagac ggcttctgga ggaacggctt
     2581 ggccagaaga cagggtgtga gtgagacagt ggggcacagg ttgggtttgc caaacgccta
     2641 attaccaggc caggaagcat gccaacaaag ccacacgggt gtcctagcca gcttcccttc
     2701 acctggtgtc ttgagtaggg cgtctcctgt aattactgcc ttgccattct gcccctggac
     2761 ccttctctcc ggaccaggga ggcgtccctc cctaggagcc acacattata ctccaagtcc
     2821 ctgccgggct ccgcctttcc cccaccctgg ctctcagggt gacgccaccc acagagattt
     2881 aatgagcgtg ggcctggacc ttccccagat gctgccaggc agcccctccc caagcctcaa
     2941 agaagcattt gctgaggatg gagaggcagg ggagggaggc gggaggccgt cactggagtg
     3001 gcgtctgcag cagctgctgc cccagcaccc gctcagcctg tcctggctgc tcacctcccc
     3061 gcagggcacc gggcctttcc tgccctctgt ggtcatctgc cacctgctgg atcaagtgct
     3121 ttctctttta cactcccctg tccccacccc agtgcactct tctggcccag gcagcaagca
     3181 agctgtgaac agctggcctg agctgtcgct gtggcttgtg gctcatgcgc cattcctggt
     3241 tgtctgttga atctttctgg ctgctggaat tggagatagg atgttttgct tcccactgca
     3301 ggagagctgc cccctttcac ggggttgggg aagggtcccc ctggcctcca gcaggagcac
     3361 agctcagcag ggtccctgct gcccacccct ctgagccttt tctccccagg gtatggctcc
     3421 tgctgagttt cttgtccagc agggccttga caggaatcca gggagtagct cctggccaga
     3481 accagcctct gcggggcttg tgctctgcaa agactctgct gctggggatt cagctctaga
     3541 ggtcacagta tcctcgtttg aaagataatt aagatccccc gtggagaaag cagtgacaca
     3601 ttcacacagc tgttccctcg catgttattt catgaacatg acctgttttc gtgcactaga
     3661 cacacagagt ggaacagccg tatgcttaaa gtacatgggc cagtgggact ggaagtgacc
     3721 tgtacaagtg atgcagaaag gagggtttca aagaaaaagg attttgttta aaatacttta
     3781 aaaatgttat ttcctgcatc ccttggctgt gatgcccctc tcccgatttc ccaggggctc
     3841 tgggagggac ccttctaaga agattgggca gttgggtttc tggcttgaga tgaatccaag
     3901 cagcagaatg agccaggagt agcaggagat gggcaaagaa aactggggtg cactcagctc
     3961 tcacaggggt aatcatctca agtggtattt gtagccaagt gggagctatt ttcttttttg
     4021 tgcatataga tatttcttaa atgaagctgc tttcttgtct tttatttcta aaagccccct
     4081 tataccccac tttgtgcagc aaagatcccc gtgcaggtca cagcctgatt tgtggccagg
     4141 ctggacaaat tcctgaggca caacttggct tcagttcaga tttcaagctg tgttggtgtt
     4201 gggaccagca gaaggcaaac gtccagccaa cacacaggac tgtaagagga ctctgagcta
     4261 cgtgccctgt gaagaccccc aggctttgtc ataggaggtc gttcagcttc cccaaagtca
     4321 gaggtgattt gatttgggga agactgaata ttcacaccta agtcgtgagc atatcctgag
     4381 ttttacttcc ttatggcttg ccctccaagt tctctctctc atacacacac acacccttgc
     4441 tccagaatca ccagacacct ccatggctcc agctatggga acagctgcat tggggctgcc
     4501 tttctgtttg gcttaggaac ttctgtgctt cttgtggctc cactcgcgag gcagctcgga
     4561 ggtgtggact ccgattgggc tgcaggcagc tctgggacgg cacagggcgg gcgctctgat
     4621 cagctcgtgt aaaacacacc gtcttcttgg cctcctggcc agtctttctg cgaatagtcc
     4681 tctccctggc cagttgaatg ggggaagctg ctggcacagg aaggagaggc gatcccggct
     4741 gaggcttagg aaattgctgg agccggctcc aagcagataa ttcactgggg aggttttcag
     4801 agtcaaacat cattctgcct gtgttggggg ccaggtgtgt cacacaagca tctcaaagtc
     4861 aaaagccatc tggggctgct gcttctgttt ctcaggctct ggggaaagga atctccctct
     4921 cctctcactt gattccaagt gtggttgaat tgtctggagc actgggactt tttttctctt
     4981 ttccttgatg gaccaacagt gcaaatgcaa tctcgccatt taactttcag gtcgatttcc
     5041 tttcctgatc agacatcttt gtgccccctt taggaaggaa aagaatacac ctacgatgtg
     5101 ccaggcactg tgttaggcgc ttttatatag atcctcgtta ggatgagact aagggatgag
     5161 gacatctctt tataaaaggc ccctaagtaa tggataaaca gaaacactta gaggtgagaa
     5221 ggtctgtctt caagatccaa ggtaagattg ccttcagtct gatgtttgtt ctcaaggact
     5281 tatcccctac aatattctcc cactccatac ttctccttct accccaccat gtgctcccgt
     5341 gcactcctca gatggtcaga ggggtaaccc aagtccttag agaatttggg gaccaataga
     5401 atatgtgatg tgtgaatttt ctttaaaaaa cttaaggagt ctttgctacc ttctgcttgt
     5461 tgagttgttt tggcattcat attaaaagcc agcatctcac tatttattga caggttgggc
     5521 tgtgtgtgtg cgcatgtgtg tatacatttc caggcgtgcc tgtgtcctgt agctttttaa
     5581 aaggaaaccc agtcatccca ctatgaatct ggcatcttct tatgcttcta gtgttttggc
     5641 catacatcaa ccaaggggtt taatttatcc aatgcttgac gacatgttca ggaggggctg
     5701 gatcaaattt tgagagggtt atgggaaagg gagggggaga agaaattgac atttatttta
     5761 ttatttattt taaatgttta catcttcttt atgttgtatc aagcctgaat agaaactgat
     5821 agcattaaaa tactccgttc ctctctctct tctcgcttcc tttttttttt tttttttaaa
     5881 tttaggataa cacatttttg tttctaaagt gatttgtgat ttgtgctgta taaactgtat
     5941 aaaaggttct gtttttaaag gtggattttc attcctctgg ggacagtggt cgccaagaca
     6001 tctacattgt aagagaacac agtggaagat cctgtcctga ttctcaaaaa ttattttctc
     6061 tgtatgatta aaagtttatt ccatttattt tagtttgtgt ttacttgatt ttgaggaaga
     6121 aaatatttga ctttgtgtaa agagtagggt atcagggtgt cttttctgcc gtgggagatg
     6181 tgtatatata tagtattttg gtgtatagta gaaaataagc tttgtgcatc tgtatttgag
     6241 atatgttaat gacgtggagt aaagtcagct gtaagactct ggaggcaaac aagttgtata
     6301 tggttcatat ggctctatgg ggaatttaat tacctttctg ggcacttttt tttttttttt
     6361 ttttttaagt aatggtgaaa tggtcccatt ggagagtctc ctaaatagac cttccaggca
     6421 gaaccgcaag ctcaaaatct ttgtatagtt ttgaaaattg aggagtagct ttgtttggaa
     6481 gcctttctgg tggtggtttt tgttgttgtt gttgttttgt tgttttacta tatgtaatac
     6541 aagcctacag tatttgcact aaagaaagct tgttagaaaa agcttgctgc tatggaagaa
     6601 agaacatatt aaaacttctt tcccttgcga tttttttggg ggaggggggt tagcatttcc
     6661 actttcagtt gagtagcatt ttgtagaata aaatgaatta agattgaaga gcc
//
