LOCUS       NM_005438               1702 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens FOS like 1, AP-1 transcription factor subunit (FOSL1),
            transcript variant 1, mRNA.
ACCESSION   NM_005438
VERSION     NM_005438.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1702)
  AUTHORS   Li,L., Li,D., Jin,J., Xu,F., He,N., Ren,Y., Wang,X., Tian,L.,
            Chen,B., Li,X., Chen,Z., Zhang,L., Qiao,L., Wang,L. and Wang,J.
  TITLE     FOSL1-mediated LINC01566 negatively regulates CD4+ T-cell
            activation in myasthenia gravis
  JOURNAL   J Neuroinflammation 21 (1), 197 (2024)
   PUBMED   39113081
  REMARK    GeneRIF: FOSL1-mediated LINC01566 negatively regulates CD4[+]
            T-cell activation in myasthenia gravis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1702)
  AUTHORS   Wang,H., Shi,Y., Zhou,X., Zhang,L., Yang,A., Zhou,D. and Ma,T.
  TITLE     HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined
            actions with FOSL1 to mediate vasculogenic mimicry in GBM cells
  JOURNAL   Cell Biol Toxicol 40 (1), 44 (2024)
   PUBMED   38862832
  REMARK    GeneRIF: HNRNPA2B1 stabilizes NFATC3 levels to potentiate its
            combined actions with FOSL1 to mediate vasculogenic mimicry in GBM
            cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1702)
  AUTHORS   Ramar,V., Guo,S., Hudson,B., Khedri,A., Guo,A.A., Li,J. and Liu,M.
  TITLE     Interaction of NF-kappaB and FOSL1 drives glioma stemness
  JOURNAL   Cell Mol Life Sci 81 (1), 255 (2024)
   PUBMED   38856747
  REMARK    GeneRIF: Interaction of NF-kappaB and FOSL1 drives glioma stemness.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1702)
  AUTHORS   Liang,Y., Han,D., Zhang,S. and Sun,L.
  TITLE     FOSL1 regulates hyperproliferation and NLRP3-mediated inflammation
            of psoriatic keratinocytes through the NF-kB signaling via
            transcriptionally activating TRAF3
  JOURNAL   Biochim Biophys Acta Mol Cell Res 1871 (4), 119689 (2024)
   PUBMED   38367916
  REMARK    GeneRIF: FOSL1 regulates hyperproliferation and NLRP3-mediated
            inflammation of psoriatic keratinocytes through the NF-kB signaling
            via transcriptionally activating TRAF3.
REFERENCE   5  (bases 1 to 1702)
  AUTHORS   Luo,X., Wang,J., Chen,Y., Zhou,X., Shao,Z., Liu,K. and Shang,Z.
  TITLE     Melatonin inhibits the stemness of head and neck squamous cell
            carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis
  JOURNAL   J Pineal Res 76 (2), e12940 (2024)
   PUBMED   38402581
  REMARK    GeneRIF: Melatonin inhibits the stemness of head and neck squamous
            cell carcinoma by modulating HA synthesis via the FOSL1/HAS3 axis.
REFERENCE   6  (bases 1 to 1702)
  AUTHORS   Arts,J., Herr,I., Lansink,M., Angel,P. and Kooistra,T.
  TITLE     Cell-type specific DNA-protein interactions at the tissue-type
            plasminogen activator promoter in human endothelial and HeLa cells
            in vivo and in vitro
  JOURNAL   Nucleic Acids Res 25 (2), 311-317 (1997)
   PUBMED   9016559
REFERENCE   7  (bases 1 to 1702)
  AUTHORS   Courseaux,A., Grosgeorge,J., Gaudray,P., Pannett,A.A., Forbes,S.A.,
            Williamson,C., Bassett,D., Thakker,R.V., Teh,B.T., Farnebo,F.,
            Shepherd,J., Skogseid,B., Larsson,C., Giraud,S., Zhang,C.X.,
            Salandre,J. and Calender,A.
  TITLE     Definition of the minimal MEN1 candidate area based on a 5-Mb
            integrated map of proximal 11q13. The European Consortium on Men1,
            (GENEM 1; Groupe d'Etude des Neoplasies Endocriniennes Multiples de
            type 1)
  JOURNAL   Genomics 37 (3), 354-365 (1996)
   PUBMED   8938448
REFERENCE   8  (bases 1 to 1702)
  AUTHORS   Tsuchiya,H., Fujii,M., Niki,T., Tokuhara,M., Matsui,M. and Seiki,M.
  TITLE     Human T-cell leukemia virus type 1 Tax activates transcription of
            the human fra-1 gene through multiple cis elements responsive to
            transmembrane signals
  JOURNAL   J Virol 67 (12), 7001-7007 (1993)
   PUBMED   8230424
REFERENCE   9  (bases 1 to 1702)
  AUTHORS   Sinke,R.J., Tanigami,A., Nakamura,Y. and Geurts van Kessel,A.
  TITLE     Reverse mapping of the gene encoding the human fos-related
            antigen-1 (fra-1) within chromosome band 11q13
  JOURNAL   Genomics 18 (1), 165 (1993)
   PUBMED   8276409
REFERENCE   10 (bases 1 to 1702)
  AUTHORS   Matsui,M., Tokuhara,M., Konuma,Y., Nomura,N. and Ishizaki,R.
  TITLE     Isolation of human fos-related genes and their expression during
            monocyte-macrophage differentiation
  JOURNAL   Oncogene 5 (3), 249-255 (1990)
   PUBMED   2107490
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ937004.1, BC016648.1,
            AA120824.1 and AP006287.2.
            
            On May 17, 2019 this sequence version replaced NM_005438.4.
            
            Summary: The Fos gene family consists of 4 members: FOS, FOSB,
            FOSL1, and FOSL2. These genes encode leucine zipper proteins that
            can dimerize with proteins of the JUN family, thereby forming the
            transcription factor complex AP-1. As such, the FOS proteins have
            been implicated as regulators of cell proliferation,
            differentiation, and transformation. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Jul 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016648.1, SRR1163658.220015.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000312562.7/ ENSP00000310170.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BQ937004.1         139-142
            5-1530              BC016648.1         1-1526
            1531-1615           AA120824.1         7-91                c
            1616-1702           AP006287.2         7300-7386           c
FEATURES             Location/Qualifiers
     source          1..1702
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..1702
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
                     /note="FOS like 1, AP-1 transcription factor subunit"
                     /db_xref="GeneID:8061"
                     /db_xref="HGNC:HGNC:13718"
                     /db_xref="MIM:136515"
     exon            1..148
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            149..346
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            347..454
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1702
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1510..1515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
                     /note="hexamer: AATAAA"
     polyA_site      1530
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
                     /note="major polyA site"
     polyA_site      1610
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
     polyA_site      1629
                     /gene="FOSL1"
                     /gene_synonym="FRA; fra-1; FRA1"
ORIGIN      
        1 gagtcagaac ccagcagccg tgtaccccgc agagccgcca gccccgggca tgttccgaga
       61 cttcggggaa cccggcccga gctccgggaa cggcggcggg tacggcggcc ccgcgcagcc
      121 cccggccgca gcgcaggcag cccagcagaa gttccacctg gtgccaagca tcaacaccat
      181 gagtggcagt caggagctgc agtggatggt acagcctcat ttcctggggc ccagcagtta
      241 ccccaggcct ctgacctacc ctcagtacag ccccccacaa ccccggccag gagtcatccg
      301 ggccctgggg ccgcctccag gggtacgtcg aaggccttgt gaacagatca gcccggagga
      361 agaggagcgc cgccgagtaa ggcgcgagcg gaacaagctg gctgcggcca agtgcaggaa
      421 ccggaggaag gaactgaccg acttcctgca ggcggagact gacaaactgg aagatgagaa
      481 atctgggctg cagcgagaga ttgaggagct gcagaagcag aaggagcgcc tagagctggt
      541 gctggaagcc caccgaccca tctgcaaaat cccggaagga gccaaggagg gggacacagg
      601 cagtaccagt ggcaccagca gcccaccagc cccctgccgc cctgtacctt gtatctccct
      661 ttccccaggg cctgtgcttg aacctgaggc actgcacacc cccacactca tgaccacacc
      721 ctccctaact cctttcaccc ccagcctggt cttcacctac cccagcactc ctgagccttg
      781 tgcctcagct catcgcaaga gtagcagcag cagcggagac ccatcctctg acccccttgg
      841 ctctccaacc ctcctcgctt tgtgaggcgc ctgagcccta ctccctgcag atgccaccct
      901 agccaatgtc tcctcccctt cccccaccgg tccagctggc ctggacagta tcccacatcc
      961 aactccagca acttcttctc catccctcta atgagactga ccatattgtg cttcacagta
     1021 gagccagctt ggggccacca aagctgccca ctgtttctct tgagctggcc tctctagcac
     1081 aatttgcact aaatcagaga caaaatattt cccatttgtg ccagaggaat cctggcagcc
     1141 cagagacttt gtagatcctt agaggtcctc tggagcccta accccttcca gatcactgcc
     1201 acactctcca tcaccctctt cctgtgatcc acccaaccct atctcctgac agaaggtgcc
     1261 actttaccca cctagaacac taactcacca gccccactgc cagcagcagc aggtgattgg
     1321 accaggccat tctgccgccc cctcctgaac cgcacagctc aggaggcgcc cttggcttct
     1381 gtgatgagct gatctgcgga tctcagcttt gagaagcctt cagctccagg gaatccaagc
     1441 ctccacagcg agggcagctg ctatttattt tcctaaagag agtattttta tacaaaccta
     1501 ccaaaatgga ataaaaggct tgaagctgtg gcctgagtgc ctcactggac ccagaggcca
     1561 atgggagagt atttggagcc ctaggtccca gccttagctc tacagactca ctgcatgacc
     1621 ttggacaaat tctttgatat ttttggactt tgtcttatct gacaagtggg gctacatccg
     1681 ctcggcctca tctccgggac tg
//
