LOCUS       NM_006732               3775 bp    mRNA    linear   PRI 21-MAR-2025
DEFINITION  Homo sapiens FosB proto-oncogene, AP-1 transcription factor subunit
            (FOSB), transcript variant 1, mRNA.
ACCESSION   NM_006732
VERSION     NM_006732.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3775)
  AUTHORS   Deng,Y., Hahn,Q., Yu,L., Zhu,Z., Boyer,J.A., Wang,J., Kong,D.,
            Carey,L.M., Hepperla,A.J., Simon,J.M., Temple,B., Zhang,Z.,
            Zhang,Y., Santos,C., Frank,J.E., Herring,L.E., Wang,X.,
            Dokholyan,N.V., Campbell,S.L., Baldwin,A.S., Damania,B., Zhang,Q.
            and Liu,P.
  TITLE     2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB signaling
            in cell migration control independent of innate immunity
  JOURNAL   Sci Adv 10 (42), eado7024 (2024)
   PUBMED   39413198
  REMARK    GeneRIF: 2'3'-cGAMP interactome identifies 2'3'-cGAMP/Rab18/FosB
            signaling in cell migration control independent of innate immunity.
            Erratum:[Sci Adv. 2025 Jan 17;11(3):eadv6581. doi:
            10.1126/sciadv.adv6581. PMID: 39823348]
REFERENCE   2  (bases 1 to 3775)
  AUTHORS   Zilla,M.L., Naous,R. and John,I.
  TITLE     Lack of FOS/FOSB Gene Rearrangements in Ischemic Fasciitis
            Indicates Distinct Pathogenesis from Proliferative Fasciitis and
            Proliferative Myositis
  JOURNAL   Int J Surg Pathol 32 (4), 726-730 (2024)
   PUBMED   37461273
  REMARK    GeneRIF: Lack of FOS/FOSB Gene Rearrangements in Ischemic Fasciitis
            Indicates Distinct Pathogenesis from Proliferative Fasciitis and
            Proliferative Myositis.
REFERENCE   3  (bases 1 to 3775)
  AUTHORS   Cordier,F. and Creytens,D.
  TITLE     New kids on the block: FOS and FOSB gene
  JOURNAL   J Clin Pathol 76 (11), 721-726 (2023)
   PUBMED   37553246
  REMARK    GeneRIF: New kids on the block: FOS and FOSB gene.
            Review article
REFERENCE   4  (bases 1 to 3775)
  AUTHORS   Lopez-Lopez,S., Romero de Avila,M.J., Gonzalez-Gomez,M.J.,
            Nueda,M.L., Baladron,V., Monsalve,E.M., Garcia-Ramirez,J.J. and
            Diaz-Guerra,M.J.M.
  TITLE     NOTCH4 potentiates the IL-13 induced genetic program in M2
            alternative macrophages through the AP1 and IRF4-JMJD3 axis
  JOURNAL   Int Immunol 35 (10), 497-509 (2023)
   PUBMED   37478314
  REMARK    GeneRIF: NOTCH4 potentiates the IL-13 induced genetic program in M2
            alternative macrophages through the AP1 and IRF4-JMJD3 axis.
REFERENCE   5  (bases 1 to 3775)
  AUTHORS   Kim,H.Y., Kang,H.G., Kim,H.M. and Jeong,H.J.
  TITLE     Expression of SARS-CoV-2 receptor angiotensin-converting enzyme 2
            by activating protein-1 in human mast cells
  JOURNAL   Cell Immunol 386, 104705 (2023)
   PUBMED   36898276
  REMARK    GeneRIF: Expression of SARS-CoV-2 receptor angiotensin-converting
            enzyme 2 by activating protein-1 in human mast cells.
REFERENCE   6  (bases 1 to 3775)
  AUTHORS   Itoh,K., Matsubara,K. and Okubo,K.
  TITLE     Identification of an active gene by using large-scale cDNA
            sequencing
  JOURNAL   Gene 140 (2), 295-296 (1994)
   PUBMED   8144043
REFERENCE   7  (bases 1 to 3775)
  AUTHORS   Martin-Gallardo,A., McCombie,W.R., Gocayne,J.D., FitzGerald,M.G.,
            Wallace,S., Lee,B.M., Lamerdin,J., Trapp,S., Kelley,J.M., Liu,L.I.
            et al.
  TITLE     Automated DNA sequencing and analysis of 106 kilobases from human
            chromosome 19q13.3
  JOURNAL   Nat Genet 1 (1), 34-39 (1992)
   PUBMED   1301997
REFERENCE   8  (bases 1 to 3775)
  AUTHORS   Schuermann,M., Jooss,K. and Muller,R.
  TITLE     fosB is a transforming gene encoding a transcriptional activator
  JOURNAL   Oncogene 6 (4), 567-576 (1991)
   PUBMED   1903195
REFERENCE   9  (bases 1 to 3775)
  AUTHORS   Nakabeppu,Y. and Nathans,D.
  TITLE     A naturally occurring truncated form of FosB that inhibits Fos/Jun
            transcriptional activity
  JOURNAL   Cell 64 (4), 751-759 (1991)
   PUBMED   1900040
REFERENCE   10 (bases 1 to 3775)
  AUTHORS   Siderovski,D.P., Blum,S., Forsdyke,R.E. and Forsdyke,D.R.
  TITLE     A set of human putative lymphocyte G0/G1 switch genes includes
            genes homologous to rodent cytokine and zinc finger
            protein-encoding genes
  JOURNAL   DNA Cell Biol 9 (8), 579-587 (1990)
   PUBMED   1702972
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA589470.1, DB275824.1,
            BC036724.1 and AC138128.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006732.2.
            
            Summary: The Fos gene family consists of 4 members: FOS, FOSB,
            FOSL1, and FOSL2. These genes encode leucine zipper proteins that
            can dimerize with proteins of the JUN family, thereby forming the
            transcription factor complex AP-1. As such, the FOS proteins have
            been implicated as regulators of cell proliferation,
            differentiation, and transformation. Alternatively spliced
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036724.1, L49169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000353609.8/ ENSP00000245919.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-547               DA589470.1         2-548
            548-708             DB275824.1         372-532
            709-1973            BC036724.1         689-1953
            1974-3775           AC138128.1         1995-3796           c
FEATURES             Location/Qualifiers
     source          1..3775
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.32"
     gene            1..3775
                     /gene="FOSB"
                     /gene_synonym="AP-1; G0S3; GOS3; GOSB"
                     /note="FosB proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:2354"
                     /db_xref="HGNC:HGNC:3797"
                     /db_xref="MIM:164772"
     exon            1..717
                     /gene="FOSB"
                     /gene_synonym="AP-1; G0S3; GOS3; GOSB"
                     /inference="alignment:Splign:2.1.0"
     CDS             592..1608
                     /gene="FOSB"
                     /gene_synonym="AP-1; G0S3; GOS3; GOSB"
                     /note="isoform 1 is encoded by transcript variant 1;
                     activator protein 1; G0/G1 switch regulatory protein 3;
                     FBJ murine osteosarcoma viral oncogene homolog B; FosB
                     proto-oncogene, AP-1 trancription factor subunit;
                     transcription factor AP-1 subunit FosB"
                     /codon_start=1
                     /product="protein FosB isoform 1"
                     /protein_id="NP_006723.2"
                     /db_xref="CCDS:CCDS12664.1"
                     /db_xref="GeneID:2354"
                     /db_xref="HGNC:HGNC:3797"
                     /db_xref="MIM:164772"
                     /translation="MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQEC
                     AGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPVVDPYDMPGT
                     SYSTPGMSGYSSGGASGSGGPSTSGTTSGPGPARPARARPRRPREETLTPEEEEKRRV
                     RRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAH
                     KPGCKIPYEEGPGPGPLAEVRDLPGSAPAKEDGFSWLLPPPPPPPLPFQTSQDAPPNL
                     TASLFTHSEVQVLGDPFPVVNPSYTSSFVLTCPEVSAFAGAQRTSGSDQPSDPLNSPS
                     LLAL"
     exon            718..1038
                     /gene="FOSB"
                     /gene_synonym="AP-1; G0S3; GOS3; GOSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1146
                     /gene="FOSB"
                     /gene_synonym="AP-1; G0S3; GOS3; GOSB"
                     /inference="alignment:Splign:2.1.0"
     exon            1147..3775
                     /gene="FOSB"
                     /gene_synonym="AP-1; G0S3; GOS3; GOSB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3753..3758
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOSB"
                     /gene_synonym="AP-1; G0S3; GOS3; GOSB"
                     /note="hexamer: AATAAA"
     polyA_site      3775
                     /gene="FOSB"
                     /gene_synonym="AP-1; G0S3; GOS3; GOSB"
                     /note="major polyA site"
ORIGIN      
        1 attcataaga ctcagagcta cggccacggc agggacacgc ggaaccaaga cttggaaact
       61 tgattgttgt ggttcttctt gggggttatg aaatttcatt aatctttttt tttccgggga
      121 gaaagttttt ggaaagattc ttccagatat ttcttcattt tcttttggag gaccgactta
      181 ctttttttgg tcttctttat tactcccctc cccccgtggg acccgccgga cgcgtggagg
      241 agaccgtagc tgaagctgat tctgtacagc gggacagcgc tttctgcccc tgggggagca
      301 acccctccct cgcccctggg tcctacggag cctgcacttt caagaggtac agcggcatcc
      361 tgtgggggcc tgggcaccgc aggaagactg cacagaaact ttgccattgt tggaacggga
      421 cgttgctcct tccccgagct tccccggaca gcgtactttg aggactcgct cagctcaccg
      481 gggactccca cggctcaccc cggacttgca ccttacttcc ccaacccggc catagccttg
      541 gcttcccggc gacctcagcg tggtcacagg ggcccccctg tgcccaggga aatgtttcag
      601 gctttccccg gagactacga ctccggctcc cggtgcagct cctcaccctc tgccgagtct
      661 caatatctgt cttcggtgga ctccttcggc agtccaccca ccgccgccgc ctcccaggag
      721 tgcgccggtc tcggggaaat gcccggttcc ttcgtgccca cggtcaccgc gatcacaacc
      781 agccaggacc tccagtggct tgtgcaaccc accctcatct cttccatggc ccagtcccag
      841 gggcagccac tggcctccca gcccccggtc gtcgacccct acgacatgcc gggaaccagc
      901 tactccacac caggcatgag tggctacagc agtggcggag cgagtggcag tggtgggcct
      961 tccaccagcg gaactaccag tgggcctggg cctgcccgcc cagcccgagc ccggcctagg
     1021 agaccccgag aggagacgct caccccagag gaagaggaga agcgaagggt gcgccgggaa
     1081 cgaaataaac tagcagcagc taaatgcagg aaccggcgga gggagctgac cgaccgactc
     1141 caggcggaga cagatcagtt ggaggaagaa aaagcagagc tggagtcgga gatcgccgag
     1201 ctccaaaagg agaaggaacg tctggagttt gtgctggtgg cccacaaacc gggctgcaag
     1261 atcccctacg aagaggggcc cgggccgggc ccgctggcgg aggtgagaga tttgccgggc
     1321 tcagcaccgg ctaaggaaga tggcttcagc tggctgctgc cgcccccgcc accaccgccc
     1381 ctgcccttcc agaccagcca agacgcaccc cccaacctga cggcttctct ctttacacac
     1441 agtgaagttc aagtcctcgg cgaccccttc cccgttgtta acccttcgta cacttcttcg
     1501 tttgtcctca cctgcccgga ggtctccgcg ttcgccggcg cccaacgcac cagcggcagt
     1561 gaccagcctt ccgatcccct gaactcgccc tccctcctcg ctctgtgaac tctttagaca
     1621 cacaaaacaa acaaacacat gggggagaga gacttggaag aggaggagga ggaggagaag
     1681 gaggagagag aggggaagag acaaagtggg tgtgtggcct ccctggctcc tccgtctgac
     1741 cctctgcggc cactgcgcca ctgccatcgg acaggaggat tccttgtgtt ttgtcctgcc
     1801 tcttgtttct gtgccccggc gaggccggag agctggtgac tttggggaca gggggtggga
     1861 aggggatgga cacccccagc tgactgttgg ctctctgacg tcaacccaag ctctggggat
     1921 gggtggggag gggggcgggt gacgcccacc ttcgggcagt cctgtgtgag gattaaggga
     1981 cgggggtggg aggtaggctg tggggtgggc tggagtcctc tccagagagg ctcaacaagg
     2041 aaaaatgcca ctccctaccc aatgtctccc acacccaccc tttttttggg gtgcctaggt
     2101 tggtttcccc tgcactcccg accttagctt attgatccca catttccatg gtgtgagatc
     2161 ctctttactc tgggcagaag tgagcccccc ccttaaaggg aattcgatgc ccccctagaa
     2221 taatctcatc cccccacccg acttcttttg aaatgtgaac gtccttcctt gactgtctag
     2281 ccactccctc ccagaaaaac tggctctgat tggaatttct ggcctcctaa ggctccccac
     2341 cccgaaatca gcccccagcc ttgtttctga tgacagtgtt atcccaagac cctgccccct
     2401 gccagccgac cctcctggcc ttcctcgttg ggccgctctg atttcaggca gcaggggctg
     2461 ctgtgatgcc gtcctgctgg agtgatttat actgtgaaat gagttggcca gattgtgggg
     2521 tgcagctggg tggggcagca cacctctggg gggataatgt ccccactccc gaaagccttt
     2581 cctcggtctc ccttccgtcc atcccccttc ttcctcccct caacagtgag ttagactcaa
     2641 gggggtgaca gaaccgagaa gggggtgaca gtcctccatc cacgtggcct ctctctctct
     2701 cctcaggacc ctcagccctg gcctttttct ttaaggtccc ccgaccaatc cccagcctag
     2761 gacgccaact tctcccaccc cttggcccct cacatcctct ccaggaaggg agtgaggggc
     2821 tgtgacattt ttccggagaa gatttcagag ctgaggcttt ggtaccccca aacccccaat
     2881 atttttggac tggcagactc aaggggctgg aatctcatga ttccatgccc gagtccgccc
     2941 atccctgacc atggttttgg ctctcccacc ccgccgttcc ctgcgcttca tctcatgagg
     3001 atttctttat gaggcaaatt tatatttttt aatatcgggg ggtggaccac gccgccctcc
     3061 atccgtgctg catgaaaaac attccacgtg ccccttgtcg cgcgtctccc atcctgatcc
     3121 cagacccatt ccttagctat ttatcccttt cctggtttcc gaaaggcaat tatatctatt
     3181 atgtataagt aaatatatta tatatggatg tgtgtgtgtg cgtgcgcgtg agtgtgtgag
     3241 cgcttctgca gcctcggcct aggtcacgtt ggccctcaaa gcgagccgtt gaattggaaa
     3301 ctgcttctag aaactctggc tcagcctgtc tcgggctgac ccttttctga tcgtctcggc
     3361 ccctctgatt gttcccgatg gtctctctcc ctctgtcttt tctcctccgc ctgtgtccat
     3421 ctgaccgttt tcacttgtct cctttctgac tgtccctgcc aatgctccag ctgtcgtctg
     3481 actctgggtt cgttggggac atgagatttt attttttgtg agtgagactg agggatcgta
     3541 gatttttaca atctgtatct ttgacaattc tgggtgcgag tgtgagagtg tgagcagggc
     3601 ttgctcctgc caaccacaat tcaatgaatc cccgaccccc ctaccccatg ctgtacttgt
     3661 ggttctcttt ttgtattttg catctgaccc cggggggctg ggacagattg gcaatgggcc
     3721 gtcccctctc cccttggttc tgcactgttg ccaataaaaa gctcttaaaa acgca
//
