LOCUS       NM_005252               2104 bp    mRNA    linear   PRI 24-APR-2024
DEFINITION  Homo sapiens Fos proto-oncogene, AP-1 transcription factor subunit
            (FOS), mRNA.
ACCESSION   NM_005252
VERSION     NM_005252.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2104)
  AUTHORS   Yuan,H., Zhang,P., Xin,Y., Liu,Z. and Gao,B.
  TITLE     Single cell RNA-seq identifies a FOS/JUN-related monocyte signature
            associated with clinical response of heart failure patients with
            mesenchymal stem cell therapy
  JOURNAL   Aging (Albany NY) 16 (6), 5651-5675 (2024)
   PUBMED   38517374
  REMARK    GeneRIF: Single cell RNA-seq identifies a FOS/JUN-related monocyte
            signature associated with clinical response of heart failure
            patients with mesenchymal stem cell therapy.
REFERENCE   2  (bases 1 to 2104)
  AUTHORS   Yang,F., Cui,X., Wang,H., Zhang,D., Luo,S., Li,Y., Dai,Y., Yang,D.,
            Zhang,X., Wang,L., Zheng,G. and Zhang,X.
  TITLE     Iron overload promotes the progression of MLL-AF9 induced acute
            myeloid leukemia by upregulation of FOS
  JOURNAL   Cancer Lett 583, 216652 (2024)
   PUBMED   38242196
  REMARK    GeneRIF: Iron overload promotes the progression of MLL-AF9 induced
            acute myeloid leukemia by upregulation of FOS.
REFERENCE   3  (bases 1 to 2104)
  AUTHORS   Nanamiya,T., Takane,K., Yamaguchi,K., Okawara,Y., Arakawa,M.,
            Saku,A., Ikenoue,T., Fujiyuki,T., Yoneda,M., Kai,C. and Furukawa,Y.
  TITLE     Expression of PVRL4, a molecular target for cancer treatment, is
            transcriptionally regulated by FOS
  JOURNAL   Oncol Rep 51 (1) (2024)
   PUBMED   38063270
  REMARK    GeneRIF: Expression of PVRL4, a molecular target for cancer
            treatment, is transcriptionally regulated by FOS.
REFERENCE   4  (bases 1 to 2104)
  AUTHORS   Malsy,M., Graf,B., Bruendl,E., Maier-Stocker,C. and Bundscherer,A.
  TITLE     Over-expression of cFos by the Transcription Factors NFATc2 and Sp1
            in Pancreatic Cancer Cells
  JOURNAL   Anticancer Res 43 (11), 4897-4904 (2023)
   PUBMED   37909980
  REMARK    GeneRIF: Over-expression of cFos by the Transcription Factors
            NFATc2 and Sp1 in Pancreatic Cancer Cells.
REFERENCE   5  (bases 1 to 2104)
  AUTHORS   Angioni,M.M., Floris,A., Cangemi,I., Congia,M., Chessa,E.,
            Naitza,M.R., Piga,M. and Cauli,A.
  TITLE     Molecular profiling of clinical remission in psoriatic arthritis
            reveals dysregulation of FOS and CCDC50 genes: a gene expression
            study
  JOURNAL   Front Immunol 14, 1274539 (2023)
   PUBMED   37965313
  REMARK    GeneRIF: Molecular profiling of clinical remission in psoriatic
            arthritis reveals dysregulation of FOS and CCDC50 genes: a gene
            expression study.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2104)
  AUTHORS   Hsu,J.C., Bravo,R. and Taub,R.
  TITLE     Interactions among LRF-1, JunB, c-Jun, and c-Fos define a
            regulatory program in the G1 phase of liver regeneration
  JOURNAL   Mol Cell Biol 12 (10), 4654-4665 (1992)
   PUBMED   1406655
REFERENCE   7  (bases 1 to 2104)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
REFERENCE   8  (bases 1 to 2104)
  AUTHORS   Blanar,M.A. and Rutter,W.J.
  TITLE     Interaction cloning: identification of a helix-loop-helix zipper
            protein that interacts with c-Fos
  JOURNAL   Science 256 (5059), 1014-1018 (1992)
   PUBMED   1589769
REFERENCE   9  (bases 1 to 2104)
  AUTHORS   Tratner,I., Ofir,R. and Verma,I.M.
  TITLE     Alteration of a cyclic AMP-dependent protein kinase phosphorylation
            site in the c-Fos protein augments its transforming potential
  JOURNAL   Mol Cell Biol 12 (3), 998-1006 (1992)
   PUBMED   1545828
REFERENCE   10 (bases 1 to 2104)
  AUTHORS   Roux,P., Verrier,B., Klein,B., Niccolino,M., Marty,L., Alexandre,C.
            and Piechaczyk,M.
  TITLE     Retrovirus-mediated gene transfer of a human c-fos cDNA into mouse
            bone marrow stromal cells
  JOURNAL   Oncogene 6 (11), 2155-2160 (1991)
   PUBMED   1658710
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK291326.1 and AF111167.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_005252.3.
            
            Summary: The Fos gene family consists of 4 members: FOS, FOSB,
            FOSL1, and FOSL2.  These genes encode leucine zipper proteins that
            can dimerize with proteins of the JUN family, thereby forming the
            transcription factor complex AP-1.  As such, the FOS proteins have
            been implicated as regulators of cell proliferation,
            differentiation, and transformation.  In some cases, expression of
            the FOS gene has also been associated with apoptotic cell death.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BX647104.1, SRR3476690.806825.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000303562.9/ ENSP00000306245.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1387              AK291326.1         1-1387
            1388-2104           AF111167.2         26500-27216
FEATURES             Location/Qualifiers
     source          1..2104
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q24.3"
     gene            1..2104
                     /gene="FOS"
                     /gene_synonym="AP-1; C-FOS; p55"
                     /note="Fos proto-oncogene, AP-1 transcription factor
                     subunit"
                     /db_xref="GeneID:2353"
                     /db_xref="HGNC:HGNC:3796"
                     /db_xref="MIM:164810"
     exon            1..296
                     /gene="FOS"
                     /gene_synonym="AP-1; C-FOS; p55"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1298
                     /gene="FOS"
                     /gene_synonym="AP-1; C-FOS; p55"
                     /note="FBJ murine osteosarcoma viral (v-fos) oncogene
                     homolog (oncogene FOS); proto-oncogene c-Fos; activator
                     protein 1; cellular oncogene c-fos; G0/G1 switch
                     regulatory protein 7; FBJ murine osteosarcoma viral
                     oncogene homolog; Fos proto-oncogene, AP-1 trancription
                     factor subunit; transcription factor AP-1 subunit c-Fos"
                     /codon_start=1
                     /product="protein c-Fos"
                     /protein_id="NP_005243.1"
                     /db_xref="CCDS:CCDS9841.1"
                     /db_xref="GeneID:2353"
                     /db_xref="HGNC:HGNC:3796"
                     /db_xref="MIM:164810"
                     /translation="MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPV
                     NAQDFCTDLAVSSANFIPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPS
                     AGAYSRAGVVKTMTGGRAQSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRE
                     LTDTLQAETDQLEDEKSALQTEIANLLKEKEKLEFILAAHRPACKIPDDLGFPEEMSV
                     ASLDLTGGLPEVATPESEEAFTLPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPA
                     SSRPSGSETARSVPDMDLSGSFYAADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSC
                     TAYTSSFVFTYPEADSFPSCAAAHRKGSSSNEPSSDSLSSPTLLAL"
     exon            297..548
                     /gene="FOS"
                     /gene_synonym="AP-1; C-FOS; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            549..656
                     /gene="FOS"
                     /gene_synonym="AP-1; C-FOS; p55"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2104
                     /gene="FOS"
                     /gene_synonym="AP-1; C-FOS; p55"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2079..2084
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOS"
                     /gene_synonym="AP-1; C-FOS; p55"
                     /note="hexamer: AATAAA"
     polyA_site      2104
                     /gene="FOS"
                     /gene_synonym="AP-1; C-FOS; p55"
                     /note="major polyA site"
ORIGIN      
        1 aaccgcatct gcagcgagca tctgagaagc caagactgag ccggcggccg cggcgcagcg
       61 aacgagcagt gaccgtgctc ctacccagct ctgctccaca gcgcccacct gtctccgccc
      121 ctcggcccct cgcccggctt tgcctaaccg ccacgatgat gttctcgggc ttcaacgcag
      181 actacgaggc gtcatcctcc cgctgcagca gcgcgtcccc ggccggggat agcctctctt
      241 actaccactc acccgcagac tccttctcca gcatgggctc gcctgtcaac gcgcaggact
      301 tctgcacgga cctggccgtc tccagtgcca acttcattcc cacggtcact gccatctcga
      361 ccagtccgga cctgcagtgg ctggtgcagc ccgccctcgt ctcctccgtg gccccatcgc
      421 agaccagagc ccctcaccct ttcggagtcc ccgccccctc cgctggggct tactccaggg
      481 ctggcgttgt gaagaccatg acaggaggcc gagcgcagag cattggcagg aggggcaagg
      541 tggaacagtt atctccagaa gaagaagaga aaaggagaat ccgaagggaa aggaataaga
      601 tggctgcagc caaatgccgc aaccggagga gggagctgac tgatacactc caagcggaga
      661 cagaccaact agaagatgag aagtctgctt tgcagaccga gattgccaac ctgctgaagg
      721 agaaggaaaa actagagttc atcctggcag ctcaccgacc tgcctgcaag atccctgatg
      781 acctgggctt cccagaagag atgtctgtgg cttcccttga tctgactggg ggcctgccag
      841 aggttgccac cccggagtct gaggaggcct tcaccctgcc tctcctcaat gaccctgagc
      901 ccaagccctc agtggaacct gtcaagagca tcagcagcat ggagctgaag accgagccct
      961 ttgatgactt cctgttccca gcatcatcca ggcccagtgg ctctgagaca gcccgctccg
     1021 tgccagacat ggacctatct gggtccttct atgcagcaga ctgggagcct ctgcacagtg
     1081 gctccctggg gatggggccc atggccacag agctggagcc cctgtgcact ccggtggtca
     1141 cctgtactcc cagctgcact gcttacacgt cttccttcgt cttcacctac cccgaggctg
     1201 actccttccc cagctgtgca gctgcccacc gcaagggcag cagcagcaat gagccttcct
     1261 ctgactcgct cagctcaccc acgctgctgg ccctgtgagg gggcagggaa ggggaggcag
     1321 ccggcaccca caagtgccac tgcccgagct ggtgcattac agagaggaga aacacatctt
     1381 ccctagaggg ttcctgtaga cctagggagg accttatctg tgcgtgaaac acaccaggct
     1441 gtgggcctca aggacttgaa agcatccatg tgtggactca agtccttacc tcttccggag
     1501 atgtagcaaa acgcatggag tgtgtattgt tcccagtgac acttcagaga gctggtagtt
     1561 agtagcatgt tgagccaggc ctgggtctgt gtctcttttc tctttctcct tagtcttctc
     1621 atagcattaa ctaatctatt gggttcatta ttggaattaa cctggtgctg gatattttca
     1681 aattgtatct agtgcagctg attttaacaa taactactgt gttcctggca atagtgtgtt
     1741 ctgattagaa atgaccaata ttatactaag aaaagatacg actttatttt ctggtagata
     1801 gaaataaata gctatatcca tgtactgtag tttttcttca acatcaatgt tcattgtaat
     1861 gttactgatc atgcattgtt gaggtggtct gaatgttctg acattaacag ttttccatga
     1921 aaacgtttta ttgtgttttt aatttattta ttaagatgga ttctcagata tttatatttt
     1981 tattttattt ttttctacct tgaggtcttt tgacatgtgg aaagtgaatt tgaatgaaaa
     2041 atttaagcat tgtttgctta ttgttccaag acattgtcaa taaaagcatt taagttgaat
     2101 gcga
//
