LOCUS       NM_000804                849 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens folate receptor gamma (FOLR3), transcript variant 1,
            coding, mRNA.
ACCESSION   NM_000804
VERSION     NM_000804.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 849)
  AUTHORS   Qu,Y., Zhang,X., Qiao,R., Di,F., Song,Y., Wang,J., Ji,L., Zhang,J.,
            Gu,W., Fang,Y., Han,B., Yang,R., Dai,L. and Ouyang,S.
  TITLE     Blood FOLR3 methylation dysregulations and heterogeneity in
            non-small lung cancer highlight its strong associations with lung
            squamous carcinoma
  JOURNAL   Respir Res 25 (1), 59 (2024)
   PUBMED   38273401
  REMARK    GeneRIF: Blood FOLR3 methylation dysregulations and heterogeneity
            in non-small lung cancer highlight its strong associations with
            lung squamous carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 849)
  AUTHORS   Quinn,C., Rico,M.C., Merali,C., Barrero,C.A., Perez-Leal,O.,
            Mischley,V., Karanicolas,J., Friedman,S.L. and Merali,S.
  TITLE     Secreted folate receptor gamma drives fibrogenesis in metabolic
            dysfunction-associated steatohepatitis by amplifying TGFbeta
            signaling in hepatic stellate cells
  JOURNAL   Sci Transl Med 15 (715), eade2966 (2023)
   PUBMED   37756380
  REMARK    GeneRIF: Secreted folate receptor gamma drives fibrogenesis in
            metabolic dysfunction-associated steatohepatitis by amplifying
            TGFbeta signaling in hepatic stellate cells.
REFERENCE   3  (bases 1 to 849)
  AUTHORS   Lu,R.J., Shirvani,P. and Holick,M.F.
  TITLE     A Novel Immunomodulatory Mechanism by Which Vitamin D Influences
            Folate Receptor 3 Expression to Reduce COVID-19 Severity
  JOURNAL   Anticancer Res 42 (10), 5043-5048 (2022)
   PUBMED   36192006
  REMARK    GeneRIF: A Novel Immunomodulatory Mechanism by Which Vitamin D
            Influences Folate Receptor 3 Expression to Reduce COVID-19
            Severity.
            Review article
REFERENCE   4  (bases 1 to 849)
  AUTHORS   Shen,N., Liu,T., Liu,W., Zhong,Z., Li,Q., Zhu,X., Zou,P., You,Y.,
            Guo,A.Y. and Zhu,X.
  TITLE     A folate receptor 3 SNP promotes mitochondria-induced clonogenicity
            of CML leukemia cells: Implications for treatment free remission
  JOURNAL   Clin Transl Med 11 (2), e317 (2021)
   PUBMED   33634983
  REMARK    GeneRIF: A folate receptor 3 SNP promotes mitochondria-induced
            clonogenicity of CML leukemia cells: Implications for treatment
            free remission.
REFERENCE   5  (bases 1 to 849)
  AUTHORS   Yoshitomi,R., Nakayama,K., Yamashita,S., Kumazoe,M., Lin,T.A.,
            Mei,C.Y., Marugame,Y., Fujimura,Y., Maeda-Yamamoto,M., Kuriyama,S.
            and Tachibana,H.
  TITLE     Plasma Homocysteine Concentration is Associated with the Expression
            Level of Folate Receptor 3
  JOURNAL   Sci Rep 10 (1), 10283 (2020)
   PUBMED   32581311
  REMARK    GeneRIF: Plasma Homocysteine Concentration is Associated with the
            Expression Level of Folate Receptor 3.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 849)
  AUTHORS   Boyles,A.L., Wilcox,A.J., Taylor,J.A., Shi,M., Weinberg,C.R.,
            Meyer,K., Fredriksen,A., Ueland,P.M., Johansen,A.M., Drevon,C.A.,
            Jugessur,A., Trung,T.N., Gjessing,H.K., Vollset,S.E., Murray,J.C.,
            Christensen,K. and Lie,R.T.
  TITLE     Oral facial clefts and gene polymorphisms in metabolism of
            folate/one-carbon and vitamin A: a pathway-wide association study
  JOURNAL   Genet Epidemiol 33 (3), 247-255 (2009)
   PUBMED   19048631
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 849)
  AUTHORS   Hillman,R.T., Green,R.E. and Brenner,S.E.
  TITLE     An unappreciated role for RNA surveillance
  JOURNAL   Genome Biol 5 (2), R8 (2004)
   PUBMED   14759258
REFERENCE   8  (bases 1 to 849)
  AUTHORS   Wang,H., Ross,J.F. and Ratnam,M.
  TITLE     Structure and regulation of a polymorphic gene encoding folate
            receptor type gamma/gamma'
  JOURNAL   Nucleic Acids Res 26 (9), 2132-2142 (1998)
   PUBMED   9547271
REFERENCE   9  (bases 1 to 849)
  AUTHORS   Shen,F., Wu,M., Ross,J.F., Miller,D. and Ratnam,M.
  TITLE     Folate receptor type gamma is primarily a secretory protein due to
            lack of an efficient signal for glycosylphosphatidylinositol
            modification: protein characterization and cell type specificity
  JOURNAL   Biochemistry 34 (16), 5660-5665 (1995)
   PUBMED   7727426
REFERENCE   10 (bases 1 to 849)
  AUTHORS   Shen,F., Ross,J.F., Wang,X. and Ratnam,M.
  TITLE     Identification of a novel folate receptor, a truncated receptor,
            and receptor type beta in hematopoietic cells: cDNA cloning,
            expression, immunoreactivity, and tissue specificity
  JOURNAL   Biochemistry 33 (5), 1209-1215 (1994)
   PUBMED   8110752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC030285.1, U08471.1 and
            CD368314.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_000804.3.
            
            Summary: This gene encodes a member of the folate receptor (FOLR)
            family of proteins, which have a high affinity for folic acid and
            for several reduced folic acid derivatives, and mediate delivery of
            5-methyltetrahydrofolate to the interior of cells. Expression of
            this gene may be elevated in ovarian and primary peritoneal
            carcinoma. This gene is present in a gene cluster on chromosome 11.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1, coding) represents the allele
            encoded by the GRCh38 reference genome and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC126398.1, DN998894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000611028.3/ ENSP00000481114.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               BC030285.1         16-198
            184-847             U08471.1           145-808
            848-849             CD368314.1         19-20               c
FEATURES             Location/Qualifiers
     source          1..849
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..849
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /note="folate receptor gamma"
                     /db_xref="GeneID:2352"
                     /db_xref="HGNC:HGNC:3795"
                     /db_xref="MIM:602469"
     exon            1..44
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /inference="alignment:Splign:2.1.0"
     exon            45..218
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..788
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /EC_number="3.1.3.11"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1, coding; folate receptor 3 (gamma)"
                     /codon_start=1
                     /product="folate receptor gamma isoform 1 precursor"
                     /protein_id="NP_000795.2"
                     /db_xref="CCDS:CCDS73344.1"
                     /db_xref="GeneID:2352"
                     /db_xref="HGNC:HGNC:3795"
                     /db_xref="MIM:602469"
                     /translation="MDMAWQMMQLLLLALVTAAGSAQPRSARARTDLLNVCMNAKHHK
                     TQPSPEDELYGQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPTCKRHFIQ
                     DSCLYECSPNLGPWIRQVNQSWRKERILNVPLCKEDCERWWEDCRTSYTCKSNWHKGW
                     NWTSGINECPAGALCSTFESYFPTPAALCEGLWSHSFKVSNYSRGSGRCIQMWFDSAQ
                     GNPNEEVAKFYAAAMNAGAPSRGIIDS"
     exon            219..407
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /inference="alignment:Splign:2.1.0"
     exon            408..543
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /inference="alignment:Splign:2.1.0"
     exon            544..849
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      830..835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /note="hexamer: AATAGA"
     polyA_site      849
                     /gene="FOLR3"
                     /gene_synonym="FR-G; FR-gamma; FRgamma; gamma-hFR"
                     /note="major polyA site"
ORIGIN      
        1 agagcctgga cctacagcgc tgttggtgga ggtcctgcct ccaggaatag atggacatgg
       61 cctggcagat gatgcagctg ctgcttctgg ctttggtgac tgctgcgggg agtgcccagc
      121 ccaggagtgc gcgggccagg acggacctgc tcaatgtctg catgaacgcc aagcaccaca
      181 agacacagcc cagccccgag gacgagctgt atggccagtg cagtccctgg aagaagaatg
      241 cctgctgcac ggccagcacc agccaggagc tgcacaagga cacctcccgc ctgtacaact
      301 ttaactggga tcactgtggt aagatggaac ccacctgcaa gcgccacttt atccaggaca
      361 gctgtctcta tgagtgctca cccaacctgg ggccctggat ccggcaggtc aaccagagct
      421 ggcgcaaaga gcgcattctg aacgtgcccc tgtgcaaaga ggactgtgag cgctggtggg
      481 aggactgtcg cacctcctac acctgcaaaa gcaactggca caaaggctgg aattggacct
      541 cagggattaa tgagtgtccg gccggggccc tctgcagcac ctttgagtcc tacttcccca
      601 ctccagccgc cctttgtgaa ggcctctgga gccactcctt caaggtcagc aactatagtc
      661 gagggagcgg ccgctgcatc cagatgtggt ttgactcagc ccagggcaac cccaatgagg
      721 aggtggccaa gttctatgct gcggccatga atgctggggc cccgtctcgt gggattattg
      781 attcctgatc caagaagggt cctctggggt tcttccaaca acctattcta atagacaaat
      841 ccacatgtg
//
