LOCUS       NM_000803               1112 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens folate receptor beta (FOLR2), transcript variant 1,
            mRNA.
ACCESSION   NM_000803
VERSION     NM_000803.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1112)
  AUTHORS   Chen,Y., Liu,F., Chen,X., Li,W., Li,K., Cai,H., Wang,S., Wang,H.,
            Xu,K., Zhang,C., Ye,S., Shen,Y., Mou,T., Cai,S., Zhou,J. and Yu,J.
  TITLE     microRNA-622 upregulates cell cycle process by targeting FOLR2 to
            promote CRC proliferation
  JOURNAL   BMC Cancer 24 (1), 26 (2024)
   PUBMED   38166756
  REMARK    GeneRIF: microRNA-622 upregulates cell cycle process by targeting
            FOLR2 to promote CRC proliferation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1112)
  AUTHORS   Hussain,N., Malik,S., Faiz,T., Shafqat,F., Khan,A.A., Haq,T.U.,
            Ali,W., Aziz,T., Alharbi,M., Alshammari,A. and Alasmari,A.F.
  TITLE     Mutational analysis of FOLR1 and FOLR2 genes in children with
            Myelomeningocele
  JOURNAL   Acta Biochim Pol 70 (4), 885-889 (2023)
   PUBMED   37883728
  REMARK    GeneRIF: Mutational analysis of FOLR1 and FOLR2 genes in children
            with Myelomeningocele.
REFERENCE   3  (bases 1 to 1112)
  AUTHORS   .
  TITLE     FOLR2+ Macrophages Are Associated with T-cell Infiltration and
            Improved Prognosis
  JOURNAL   Cancer Discov 12 (6), 1407 (2022)
   PUBMED   35394484
  REMARK    GeneRIF: FOLR2+ Macrophages Are Associated with T-cell Infiltration
            and Improved Prognosis.
REFERENCE   4  (bases 1 to 1112)
  AUTHORS   Song,X., Huang,P., Wang,T., Zhang,S., Chen,L. and Qin,J.
  TITLE     Association of periconceptional folate supplements and FOLR1 and
            FOLR2 gene polymorphisms with risk of congenital heart disease in
            offspring: A hospital-based case-control study
  JOURNAL   Zhong Nan Da Xue Xue Bao Yi Xue Ban 47 (1), 52-62 (2022)
   PUBMED   35545363
  REMARK    GeneRIF: Association of periconceptional folate supplements and
            FOLR1 and FOLR2 gene polymorphisms with risk of congenital heart
            disease in offspring: A hospital-based case-control study.', trans
            'FOLR1FOLR2.
REFERENCE   5  (bases 1 to 1112)
  AUTHORS   Warmink,K., Siebelt,M., Low,P.S., Riemers,F.M., Wang,B.,
            Plomp,S.G.M., Tryfonidou,M.A., van Weeren,P.R., Weinans,H. and
            Korthagen,N.M.
  TITLE     Folate Receptor Expression by Human Monocyte-Derived Macrophage
            Subtypes and Effects of Corticosteroids
  JOURNAL   Cartilage 13 (1), 19476035221081469 (2022)
   PUBMED   35255727
  REMARK    GeneRIF: Folate Receptor Expression by Human Monocyte-Derived
            Macrophage Subtypes and Effects of Corticosteroids.
REFERENCE   6  (bases 1 to 1112)
  AUTHORS   Ragoussis,J., Senger,G., Trowsdale,J. and Campbell,I.G.
  TITLE     Genomic organization of the human folate receptor genes on
            chromosome 11q13
  JOURNAL   Genomics 14 (2), 423-430 (1992)
   PUBMED   1330883
REFERENCE   7  (bases 1 to 1112)
  AUTHORS   Henderson,G.B.
  TITLE     Folate-binding proteins
  JOURNAL   Annu Rev Nutr 10, 319-335 (1990)
   PUBMED   2166548
  REMARK    Review article
REFERENCE   8  (bases 1 to 1112)
  AUTHORS   Ratnam,M., Marquardt,H., Duhring,J.L. and Freisheim,J.H.
  TITLE     Homologous membrane folate binding proteins in human placenta:
            cloning and sequence of a cDNA
  JOURNAL   Biochemistry 28 (20), 8249-8254 (1989)
   PUBMED   2605182
REFERENCE   9  (bases 1 to 1112)
  AUTHORS   Freisheim,J.H., Price,E.M. and Ratnam,M.
  TITLE     Folate coenzyme and antifolate transport proteins in normal and
            neoplastic cells
  JOURNAL   Adv Enzyme Regul 29, 13-26 (1989)
   PUBMED   2561247
REFERENCE   10 (bases 1 to 1112)
  AUTHORS   Antony,A.C., Kane,M.A., Portillo,R.M., Elwood,P.C. and
            Kolhouse,J.F.
  TITLE     Studies of the role of a particulate folate-binding protein in the
            uptake of 5-methyltetrahydrofolate by cultured human KB cells
  JOURNAL   J Biol Chem 260 (28), 14911-14917 (1985)
   PUBMED   4066659
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK222643.1 and CD014063.1.
            
            On Nov 22, 2018 this sequence version replaced NM_000803.4.
            
            Summary: The protein encoded by this gene is a member of the folate
            receptor (FOLR) family, and these genes exist in a cluster on
            chromosome 11. Members of this gene family have a high affinity for
            folic acid and for several reduced folic acid derivatives, and they
            mediate delivery of 5-methyltetrahydrofolate to the interior of
            cells. This protein has a 68% and 79% sequence homology with the
            FOLR1 and FOLR3 proteins, respectively. Although this protein was
            originally thought to be specific to placenta, it can also exist in
            other tissues, and it may play a role in the transport of
            methotrexate in synovial macrophages in rheumatoid arthritis
            patients. Multiple transcript variants that encode the same protein
            have been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All variants (1-4) encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.74568.1,
                                           SRR5189655.16057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000298223.11/
                                                ENSP00000298223.6
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1080              AK222643.1         2-1081
            1081-1112           CD014063.1         951-982
FEATURES             Location/Qualifiers
     source          1..1112
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..1112
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /note="folate receptor beta"
                     /db_xref="GeneID:2350"
                     /db_xref="HGNC:HGNC:3793"
                     /db_xref="MIM:136425"
     exon            1..132
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            133..306
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..924
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /note="folate-binding protein, fetal/placental; folate
                     receptor 2 (fetal); folate receptor, fetal/placental;
                     placental folate-binding protein; folate receptor alpha"
                     /codon_start=1
                     /product="folate receptor beta precursor"
                     /protein_id="NP_000794.3"
                     /db_xref="CCDS:CCDS8212.1"
                     /db_xref="GeneID:2350"
                     /db_xref="HGNC:HGNC:3793"
                     /db_xref="MIM:136425"
                     /translation="MVWKWMPLLLLLVCVATMCSAQDRTDLLNVCMDAKHHKTKPGPE
                     DKLHDQCSPWKKNACCTASTSQELHKDTSRLYNFNWDHCGKMEPACKRHFIQDTCLYE
                     CSPNLGPWIQQVNQSWRKERFLDVPLCKEDCQRWWEDCHTSHTCKSNWHRGWDWTSGV
                     NKCPAGALCRTFESYFPTPAALCEGLWSHSYKVSNYSRGSGRCIQMWFDSAQGNPNEE
                     VARFYAAAMHVNAGEMLHGTGGLLLSLALMLQLWLLG"
     exon            307..495
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            496..631
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /inference="alignment:Splign:2.1.0"
     exon            632..1112
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1084..1089
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /note="hexamer: AATAAA"
     polyA_site      1112
                     /gene="FOLR2"
                     /gene_synonym="BETA-HFR; FBP; FBP/PL-1; FOLR1; FR-BETA;
                     FR-P3; FRbeta"
                     /note="major polyA site"
ORIGIN      
        1 agagcgcgtt gtctaccctg taccgaagac agaggctgtg gggacagcct aggggcctgg
       61 atctattgcc tacttagaga gaggccaact cagacacagc cgtgtatgct cccagcagca
      121 acggaggttc agctccgcct gcagggacag aaagacatgg tctggaaatg gatgccactt
      181 ctgctgcttc tggtctgtgt agccaccatg tgcagtgccc aggacaggac tgatctcctc
      241 aatgtctgta tggatgccaa gcaccacaag acaaagccag gtcctgagga caagctgcat
      301 gaccaatgca gtccctggaa gaagaatgcc tgctgcacag ccagcaccag ccaggagctg
      361 cacaaggaca cctcccgcct gtacaacttt aactgggacc actgcggcaa gatggagccc
      421 gcctgcaagc gccacttcat ccaggacacc tgtctctatg agtgctcacc caacctgggg
      481 ccctggatcc agcaggtgaa tcagagctgg cgcaaagaac gcttcctgga tgtgccctta
      541 tgcaaagagg actgtcagcg ctggtgggag gattgtcaca cctcccacac gtgcaagagc
      601 aactggcaca gaggatggga ctggacctca ggagttaaca agtgcccagc tggggctctc
      661 tgccgcacct ttgagtccta cttccccact ccagctgccc tttgtgaagg cctctggagt
      721 cactcataca aggtcagcaa ctacagccga gggagcggcc gctgcatcca gatgtggttt
      781 gattcagccc agggcaaccc caacgaggaa gtggcgaggt tctatgctgc agccatgcat
      841 gtgaatgctg gtgagatgct tcatgggact gggggtctcc tgctcagtct ggccctgatg
      901 ctgcaactct ggctccttgg ctgagttcag tcctcccaga ctacctgccc tcagcttgga
      961 taaccaggct gggctcagct cagctcccac aaatgacagc cccttaagca tgcttctatt
     1021 agtcacctaa ccctctgtca cccagtctgt tgctgctcca tggtggggcc aagagtcact
     1081 tctaataaac agactgtttt ctaataattc ca
//
