LOCUS       NM_016729                930 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens folate receptor alpha (FOLR1), transcript variant 4,
            mRNA.
ACCESSION   NM_016729 NM_016731
VERSION     NM_016729.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 930)
  AUTHORS   Belmonte,B., Di Lorenzo,G., Mangogna,A., Bortot,B., Bertolazzi,G.,
            Sammataro,S., Merighi,S., Martorana,A., Zito,G., Romano,F.,
            Giorgiutti,A., Bottin,C., Zanconati,F., Romano,A., Ricci,G. and
            Biffi,S.
  TITLE     PARP-1, EpCAM, and FRalpha as potential targets for intraoperative
            detection and delineation of endometriosis: a quantitative tissue
            expression analysis
  JOURNAL   Reprod Biol Endocrinol 22 (1), 92 (2024)
   PUBMED   39085882
  REMARK    GeneRIF: PARP-1, EpCAM, and FRalpha as potential targets for
            intraoperative detection and delineation of endometriosis: a
            quantitative tissue expression analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 930)
  AUTHORS   Zhao,J., Lin,E., Bai,Z., Jia,Y., Wang,B., Dai,Y., Zhuo,W., Zeng,G.,
            Liu,X., Cai,C., Li,P., Zou,B. and Li,J.
  TITLE     Cancer-associated fibroblasts induce sorafenib resistance of
            hepatocellular carcinoma cells through CXCL12/FOLR1
  JOURNAL   BMC Cancer 23 (1), 1198 (2023)
   PUBMED   38057830
  REMARK    GeneRIF: Cancer-associated fibroblasts induce sorafenib resistance
            of hepatocellular carcinoma cells through CXCL12/FOLR1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 930)
  AUTHORS   Hussain,N., Malik,S., Faiz,T., Shafqat,F., Khan,A.A., Haq,T.U.,
            Ali,W., Aziz,T., Alharbi,M., Alshammari,A. and Alasmari,A.F.
  TITLE     Mutational analysis of FOLR1 and FOLR2 genes in children with
            Myelomeningocele
  JOURNAL   Acta Biochim Pol 70 (4), 885-889 (2023)
   PUBMED   37883728
  REMARK    GeneRIF: Mutational analysis of FOLR1 and FOLR2 genes in children
            with Myelomeningocele.
REFERENCE   4  (bases 1 to 930)
  AUTHORS   Saito,A., Nishikawa,T., Yoshida,H., Mizoguchi,C., Kitadai,R.,
            Yamamoto,K., Yazaki,S., Kojima,Y., Ishikawa,M., Kato,T. and
            Yonemori,K.
  TITLE     Folate receptor alpha is widely expressed and a potential
            therapeutic target in uterine and ovarian carcinosarcoma
  JOURNAL   Gynecol Oncol 176, 115-121 (2023)
   PUBMED   37506533
  REMARK    GeneRIF: Folate receptor alpha is widely expressed and a potential
            therapeutic target in uterine and ovarian carcinosarcoma.
REFERENCE   5  (bases 1 to 930)
  AUTHORS   Elwood,P.C., Nachmanoff,K., Saikawa,Y., Page,S.T., Pacheco,P.,
            Roberts,S. and Chung,K.N.
  TITLE     The divergent 5' termini of the alpha human folate receptor (hFR)
            mRNAs originate from two tissue-specific promoters and alternative
            splicing: characterization of the alpha hFR gene structure
  JOURNAL   Biochemistry 36 (6), 1467-1478 (1997)
   PUBMED   9063895
REFERENCE   6  (bases 1 to 930)
  AUTHORS   Goldman,I.D.
  TITLE     FOLR1-Related Cerebral Folate Transport Deficiency
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH,
            Gripp KW and Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38224559
REFERENCE   7  (bases 1 to 930)
  AUTHORS   Ragoussis,J., Senger,G., Trowsdale,J. and Campbell,I.G.
  TITLE     Genomic organization of the human folate receptor genes on
            chromosome 11q13
  JOURNAL   Genomics 14 (2), 423-430 (1992)
   PUBMED   1330883
REFERENCE   8  (bases 1 to 930)
  AUTHORS   Sadasivan,E., Cedeno,M. and Rothenberg,S.P.
  TITLE     Genomic organization of the gene and a related pseudogene for a
            human folate binding protein
  JOURNAL   Biochim Biophys Acta 1131 (1), 91-94 (1992)
   PUBMED   1581364
REFERENCE   9  (bases 1 to 930)
  AUTHORS   Campbell,I.G., Jones,T.A., Foulkes,W.D. and Trowsdale,J.
  TITLE     Folate-binding protein is a marker for ovarian cancer
  JOURNAL   Cancer Res 51 (19), 5329-5338 (1991)
   PUBMED   1717147
REFERENCE   10 (bases 1 to 930)
  AUTHORS   Luhrs,C.A., Pitiranggon,P., da Costa,M., Rothenberg,S.P.,
            Slomiany,B.L., Brink,L., Tous,G.I. and Stein,S.
  TITLE     Purified membrane and soluble folate binding proteins from cultured
            KB cells have similar amino acid compositions and molecular weights
            but differ in fatty acid acylation
  JOURNAL   Proc Natl Acad Sci U S A 84 (18), 6546-6549 (1987)
   PUBMED   3476960
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from U78793.1 and AP000812.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_016729.2.
            
            Summary: The protein encoded by this gene is a member of the folate
            receptor family. Members of this gene family bind folic acid and
            its reduced derivatives, and transport 5-methyltetrahydrofolate
            into cells. This gene product is a secreted protein that either
            anchors to membranes via a glycosyl-phosphatidylinositol linkage or
            exists in a soluble form. Mutations in this gene have been
            associated with neurodegeneration due to cerebral folate transport
            deficiency. Due to the presence of two promoters, multiple
            transcription start sites, and alternative splicing, multiple
            transcript variants encoding the same protein have been found for
            this gene. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (4) differs in the 5' UTR compared
            to variant 7. Variants 1, 2, 4 and 7 all encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.13148.1,
                                           SRR5189667.47872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968832, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000393676.5/ ENSP00000377281.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-202               U78793.1           12-213
            203-391             AP000812.4         102155-102343
            392-527             AP000812.4         102496-102631
            528-930             AP000812.4         102781-103183
FEATURES             Location/Qualifiers
     source          1..930
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.4"
     gene            1..930
                     /gene="FOLR1"
                     /gene_synonym="FBP; FOLR; FRalpha; NCFTD"
                     /note="folate receptor alpha"
                     /db_xref="GeneID:2348"
                     /db_xref="HGNC:HGNC:3791"
                     /db_xref="MIM:136430"
     exon            1..202
                     /gene="FOLR1"
                     /gene_synonym="FBP; FOLR; FRalpha; NCFTD"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..808
                     /gene="FOLR1"
                     /gene_synonym="FBP; FOLR; FRalpha; NCFTD"
                     /note="ovarian tumor-associated antigen MOv18; FR-alpha;
                     folate binding protein; KB cells FBP; folate receptor,
                     adult; adult folate-binding protein; folate receptor 1
                     (adult)"
                     /codon_start=1
                     /product="folate receptor alpha precursor"
                     /protein_id="NP_057941.1"
                     /db_xref="CCDS:CCDS8211.1"
                     /db_xref="GeneID:2348"
                     /db_xref="HGNC:HGNC:3791"
                     /db_xref="MIM:136430"
                     /translation="MAQRMTTQLLLLLVWVAVVGEAQTRIAWARTELLNVCMNAKHHK
                     EKPGPEDKLHEQCRPWRKNACCSTNTSQEAHKDVSYLYRFNWNHCGEMAPACKRHFIQ
                     DTCLYECSPNLGPWIQQVDQSWRKERVLNVPLCKEDCEQWWEDCRTSYTCKSNWHKGW
                     NWTSGFNKCAVGAACQPFHFYFPTPTVLCNEIWTHSYKVSNYSRGSGRCIQMWFDPAQ
                     GNPNEEVARFYAAAMSGAGPWAAWPFLLSLALMLLWLLS"
     exon            203..391
                     /gene="FOLR1"
                     /gene_synonym="FBP; FOLR; FRalpha; NCFTD"
                     /inference="alignment:Splign:2.1.0"
     exon            392..527
                     /gene="FOLR1"
                     /gene_synonym="FBP; FOLR; FRalpha; NCFTD"
                     /inference="alignment:Splign:2.1.0"
     exon            528..930
                     /gene="FOLR1"
                     /gene_synonym="FBP; FOLR; FRalpha; NCFTD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      913..918
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOLR1"
                     /gene_synonym="FBP; FOLR; FRalpha; NCFTD"
                     /note="hexamer: AATAAA"
     polyA_site      930
                     /gene="FOLR1"
                     /gene_synonym="FBP; FOLR; FRalpha; NCFTD"
                     /note="major polyA site"
ORIGIN      
        1 gccactgacc acagctcttt cttcagggac agacatggct cagcggatga caacacagct
       61 gctgctcctt ctagtgtggg tggctgtagt aggggaggct cagacaagga ttgcatgggc
      121 caggactgag cttctcaatg tctgcatgaa cgccaagcac cacaaggaaa agccaggccc
      181 cgaggacaag ttgcatgagc agtgtcgacc ctggaggaag aatgcctgct gttctaccaa
      241 caccagccag gaagcccata aggatgtttc ctacctatat agattcaact ggaaccactg
      301 tggagagatg gcacctgcct gcaaacggca tttcatccag gacacctgcc tctacgagtg
      361 ctcccccaac ttggggccct ggatccagca ggtggatcag agctggcgca aagagcgggt
      421 actgaacgtg cccctgtgca aagaggactg tgagcaatgg tgggaagatt gtcgcacctc
      481 ctacacctgc aagagcaact ggcacaaggg ctggaactgg acttcagggt ttaacaagtg
      541 cgcagtggga gctgcctgcc aacctttcca tttctacttc cccacaccca ctgttctgtg
      601 caatgaaatc tggactcact cctacaaggt cagcaactac agccgaggga gtggccgctg
      661 catccagatg tggttcgacc cagcccaggg caaccccaat gaggaggtgg cgaggttcta
      721 tgctgcagcc atgagtgggg ctgggccctg ggcagcctgg cctttcctgc ttagcctggc
      781 cctaatgctg ctgtggctgc tcagctgacc tccttttacc ttctgatacc tggaaatccc
      841 tgccctgttc agccccacag ctcccaacta tttggttcct gctccatggt cgggcctctg
      901 acagccactt tgaataaacc agacaccgca
//
