LOCUS       NP_004467                750 aa            linear   PRI 28-APR-2025
DEFINITION  glutamate carboxypeptidase 2 isoform 1 [Homo sapiens].
ACCESSION   NP_004467
VERSION     NP_004467.1
DBSOURCE    REFSEQ: accession NM_004476.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 750)
  AUTHORS   Li,R.X., Hao,Y. and Ettel,M.
  TITLE     Expression of PSMA in Tumor-Associated Vasculature Predicts Poorer
            Survival in Patients With Hepatocellular Carcinoma and Is Likely
            Associated With PD-L1
  JOURNAL   Int J Surg Pathol 32 (7), 1248-1255 (2024)
   PUBMED   38321782
  REMARK    GeneRIF: Expression of PSMA in Tumor-Associated Vasculature
            Predicts Poorer Survival in Patients With Hepatocellular Carcinoma
            and Is Likely Associated With PD-L1.
REFERENCE   2  (residues 1 to 750)
  AUTHORS   Zhou,W., Halder,S., Herwald,S., Ghijsen,M., Shafi,G., Uttarwar,M.,
            Rosen,E., Franc,B. and Kishore,S.
  TITLE     Frequent Amplification and Overexpression of PSMA in Basallike
            Breast Cancer from Analysis of The Cancer Genome Atlas
  JOURNAL   J Nucl Med 65 (7), 1004-1006 (2024)
   PUBMED   38664014
  REMARK    GeneRIF: Frequent Amplification and Overexpression of PSMA in
            Basallike Breast Cancer from Analysis of The Cancer Genome Atlas.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 750)
  AUTHORS   Mlcochova,P., Barinka,C., Tykvart,J., Sacha,P. and Konvalinka,J.
  TITLE     Prostate-specific membrane antigen and its truncated form PSM'
  JOURNAL   Prostate 69 (5), 471-479 (2009)
   PUBMED   19107881
  REMARK    GeneRIF: PSM' protein is likely not generated by alternative
            splicing of the PSMA gene but by different mechanism, probably via
            an endoproteolytic cleavage of the full-length PSMA.
REFERENCE   4  (residues 1 to 750)
  AUTHORS   Lambert,L.A. and Mitchell,S.L.
  TITLE     Molecular evolution of the transferrin receptor/glutamate
            carboxypeptidase II family
  JOURNAL   J Mol Evol 64 (1), 113-128 (2007)
   PUBMED   17160644
REFERENCE   5  (residues 1 to 750)
  AUTHORS   Davis,M.I., Bennett,M.J., Thomas,L.M. and Bjorkman,P.J.
  TITLE     Crystal structure of prostate-specific membrane antigen, a tumor
            marker and peptidase
  JOURNAL   Proc Natl Acad Sci U S A 102 (17), 5981-5986 (2005)
   PUBMED   15837926
  REMARK    GeneRIF: Structure and relevance to the development of
            chemotherapeutics and cancer-imaging agents.
REFERENCE   6  (residues 1 to 750)
  AUTHORS   Pangalos,M.N., Neefs,J.M., Somers,M., Verhasselt,P., Bekkers,M.,
            van der Helm,L., Fraiponts,E., Ashton,D. and Gordon,R.D.
  TITLE     Isolation and expression of novel human glutamate carboxypeptidases
            with N-acetylated alpha-linked acidic dipeptidase and dipeptidyl
            peptidase IV activity
  JOURNAL   J Biol Chem 274 (13), 8470-8483 (1999)
   PUBMED   10085079
REFERENCE   7  (residues 1 to 750)
  AUTHORS   Troyer,J.K., Beckett,M.L. and Wright,G.L. Jr.
  TITLE     Detection and characterization of the prostate-specific membrane
            antigen (PSMA) in tissue extracts and body fluids
  JOURNAL   Int J Cancer 62 (5), 552-558 (1995)
   PUBMED   7665226
REFERENCE   8  (residues 1 to 750)
  AUTHORS   Su,S.L., Huang,I.P., Fair,W.R., Powell,C.T. and Heston,W.D.
  TITLE     Alternatively spliced variants of prostate-specific membrane
            antigen RNA: ratio of expression as a potential measurement of
            progression
  JOURNAL   Cancer Res 55 (7), 1441-1443 (1995)
   PUBMED   7882349
REFERENCE   9  (residues 1 to 750)
  AUTHORS   Israeli,R.S., Powell,C.T., Corr,J.G., Fair,W.R. and Heston,W.D.
  TITLE     Expression of the prostate-specific membrane antigen
  JOURNAL   Cancer Res 54 (7), 1807-1811 (1994)
   PUBMED   7511053
REFERENCE   10 (residues 1 to 750)
  AUTHORS   Israeli,R.S., Powell,C.T., Fair,W.R. and Heston,W.D.
  TITLE     Molecular cloning of a complementary DNA encoding a
            prostate-specific membrane antigen
  JOURNAL   Cancer Res 53 (2), 227-230 (1993)
   PUBMED   8417812
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from M99487.1, AC118273.4 and
            CA432757.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            Summary: This gene encodes a type II transmembrane glycoprotein
            belonging to the M28 peptidase family. The protein acts as a
            glutamate carboxypeptidase on different alternative substrates,
            including the nutrient folate and the neuropeptide
            N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of
            tissues such as prostate, central and peripheral nervous system and
            kidney. A mutation in this gene may be associated with impaired
            intestinal absorption of dietary folates, resulting in low blood
            folate levels and consequent hyperhomocysteinemia. Expression of
            this protein in the brain may be involved in a number of
            pathological conditions associated with glutamate excitotoxicity.
            In the prostate the protein is up-regulated in cancerous cells and
            is used as an effective diagnostic and prognostic indicator of
            prostate cancer. This gene likely arose from a duplication event of
            a nearby chromosomal region. Alternative splicing gives rise to
            multiple transcript variants encoding several different isoforms.
            [provided by RefSeq, Jul 2010].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M99487.1, AF176574.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000256999.7/ ENSP00000256999.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..750
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.12"
     Protein         1..750
                     /product="glutamate carboxypeptidase 2 isoform 1"
                     /EC_number="3.4.17.21"
                     /note="glutamate carboxylase II; N-acetylated alpha-linked
                     acidic dipeptidase 1; pteroylpoly-gamma-glutamate
                     carboxypeptidase; folylpoly-gamma-glutamate
                     carboxypeptidase; membrane glutamate carboxypeptidase;
                     glutamate carboxypeptidase 2; glutamate carboxypeptidase
                     II; NAALADase I; cell growth-inhibiting gene 27 protein;
                     N-acetylated-alpha-linked acidic dipeptidase I"
                     /calculated_mol_wt=84200
     Site            10
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P70627; propagated from
                     UniProtKB/Swiss-Prot (Q04609.1)"
     Site            20..43
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04609.1)"
     Site            51
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:15152093; propagated from
                     UniProtKB/Swiss-Prot (Q04609.1)"
     Region          58..>114
                     /region_name="Zinc_peptidase_like"
                     /note="Zinc peptidases M18, M20, M28, and M42; cl14876"
                     /db_xref="CDD:472712"
     Site            76
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:15152093, ECO:0000269|PubMed:16467855,
                     ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
                     ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
                     ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
                     ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
                     ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
                     ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
                     ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
                     ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
                     ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
                     ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
                     ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
                     ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
                     ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
                     ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
                     ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
                     ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
                     ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
                     ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
                     ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
                     ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
                     ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
                     ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
                     ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
                     ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
                     ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
                     ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
                     ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
                     ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
                     ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
                     ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
                     ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
                     ECO:0007744|PDB:4P4J; propagated from UniProtKB/Swiss-Prot
                     (Q04609.1)"
     Region          120..346
                     /region_name="PA_GCPII_like"
                     /note="Protease-associated domain containing protein,
                     glutamate carboxypeptidase II (GCPII)-like. This group
                     contains various PA domain-containing proteins similar to
                     GCPII including, GCPIII (NAALADase2) and NAALADase L.
                     These proteins belong to the peptidase...; cd02121"
                     /db_xref="CDD:239036"
     Site            121
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:15152093,
                     ECO:0000269|PubMed:16467855, ECO:0000269|PubMed:17372356,
                     ECO:0000269|PubMed:17567119, ECO:0000269|PubMed:18234225,
                     ECO:0000269|PubMed:19053759, ECO:0000269|PubMed:19301871,
                     ECO:0007744|PDB:1Z8L, ECO:0007744|PDB:2C6C,
                     ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2CIJ,
                     ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
                     ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
                     ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
                     ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
                     ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
                     ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
                     ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
                     ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
                     ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
                     ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
                     ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
                     ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
                     ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
                     ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
                     ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
                     ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
                     ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
                     ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
                     ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
                     ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
                     ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
                     ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
                     ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
                     ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
                     ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
                     ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
                     ECO:0007744|PDB:4P4J; propagated from UniProtKB/Swiss-Prot
                     (Q04609.1)"
     Site            140
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:15152093,
                     ECO:0000269|PubMed:16467855, ECO:0000269|PubMed:17372356,
                     ECO:0000269|PubMed:17567119, ECO:0000269|PubMed:18234225,
                     ECO:0000269|PubMed:19053759, ECO:0000269|PubMed:19301871,
                     ECO:0007744|PDB:1Z8L, ECO:0007744|PDB:2C6C,
                     ECO:0007744|PDB:2C6G, ECO:0007744|PDB:2C6P,
                     ECO:0007744|PDB:2CIJ, ECO:0007744|PDB:2JBJ,
                     ECO:0007744|PDB:2JBK, ECO:0007744|PDB:2OOT,
                     ECO:0007744|PDB:2OR4, ECO:0007744|PDB:2PVV,
                     ECO:0007744|PDB:2PVW, ECO:0007744|PDB:2XEF,
                     ECO:0007744|PDB:2XEG, ECO:0007744|PDB:2XEI,
                     ECO:0007744|PDB:2XEJ, ECO:0007744|PDB:3BHX,
                     ECO:0007744|PDB:3BI0, ECO:0007744|PDB:3BI1,
                     ECO:0007744|PDB:3BXM, ECO:0007744|PDB:3D7D,
                     ECO:0007744|PDB:3D7F, ECO:0007744|PDB:3D7G,
                     ECO:0007744|PDB:3D7H, ECO:0007744|PDB:3IWW,
                     ECO:0007744|PDB:3RBU, ECO:0007744|PDB:3SJE,
                     ECO:0007744|PDB:3SJF, ECO:0007744|PDB:3SJG,
                     ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
                     ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
                     ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
                     ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
                     ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
                     ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
                     ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
                     ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
                     ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
                     ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
                     ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
                     ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
                     ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
                     ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
                     ECO:0007744|PDB:4P4J; propagated from UniProtKB/Swiss-Prot
                     (Q04609.1)"
     Site            153
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:15152093,
                     ECO:0007744|PDB:1Z8L; propagated from UniProtKB/Swiss-Prot
                     (Q04609.1)"
     Site            order(164,253..255,257,263..266,269)
                     /site_type="other"
                     /note="apical/protease domain interface [polypeptide
                     binding]"
                     /db_xref="CDD:239036"
     Site            195
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:15152093,
                     ECO:0000269|PubMed:16467855, ECO:0000269|PubMed:17372356,
                     ECO:0000269|PubMed:17567119, ECO:0000269|PubMed:18234225,
                     ECO:0000269|PubMed:19053759, ECO:0000269|PubMed:19301871,
                     ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2CIJ,
                     ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
                     ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
                     ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
                     ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
                     ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
                     ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
                     ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
                     ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
                     ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
                     ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
                     ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
                     ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
                     ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
                     ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
                     ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
                     ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
                     ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
                     ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
                     ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4OC0,
                     ECO:0007744|PDB:4OC1, ECO:0007744|PDB:4OC2,
                     ECO:0007744|PDB:4OC3, ECO:0007744|PDB:4OC4,
                     ECO:0007744|PDB:4OC5, ECO:0007744|PDB:4OME,
                     ECO:0007744|PDB:4P44, ECO:0007744|PDB:4P45,
                     ECO:0007744|PDB:4P4B, ECO:0007744|PDB:4P4D,
                     ECO:0007744|PDB:4P4E, ECO:0007744|PDB:4P4F,
                     ECO:0007744|PDB:4P4I, ECO:0007744|PDB:4P4J; propagated
                     from UniProtKB/Swiss-Prot (Q04609.1)"
     Site            order(210,257)
                     /site_type="other"
                     /note="substrate binding [chemical binding]"
                     /db_xref="CDD:239036"
     Site            order(272..273,275,277)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:239036"
     Region          274..587
                     /region_name="NAALADase"
                     /note="propagated from UniProtKB/Swiss-Prot (Q04609.1)"
     Site            336
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:15152093; propagated from
                     UniProtKB/Swiss-Prot (Q04609.1)"
     Region          <354..595
                     /region_name="M28_PSMA_like"
                     /note="M28 Zn-peptidase prostate-specific membrane
                     antigen; cd08022"
                     /db_xref="CDD:349942"
     Site            order(368..369,371,415,436..437,444)
                     /site_type="other"
                     /note="dimer interface [polypeptide binding]"
                     /db_xref="CDD:349942"
     Site            order(377,387,424..425,427..428,453..454,456..457,
                     518..519,536,549,552..553)
                     /site_type="active"
                     /db_xref="CDD:349942"
     Site            459
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:15152093, ECO:0000269|PubMed:16467855,
                     ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
                     ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
                     ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
                     ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
                     ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
                     ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
                     ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
                     ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
                     ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
                     ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
                     ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
                     ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
                     ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
                     ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
                     ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
                     ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
                     ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
                     ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
                     ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
                     ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
                     ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
                     ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
                     ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
                     ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
                     ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
                     ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
                     ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
                     ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
                     ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
                     ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
                     ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
                     ECO:0007744|PDB:4P4J; propagated from UniProtKB/Swiss-Prot
                     (Q04609.1)"
     Site            476
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:15152093, ECO:0000269|PubMed:16467855,
                     ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
                     ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
                     ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
                     ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
                     ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
                     ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
                     ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
                     ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
                     ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
                     ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
                     ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
                     ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
                     ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
                     ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
                     ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
                     ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
                     ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
                     ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
                     ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
                     ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
                     ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
                     ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
                     ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
                     ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
                     ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
                     ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
                     ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
                     ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
                     ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
                     ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
                     ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
                     ECO:0007744|PDB:4P4J; propagated from UniProtKB/Swiss-Prot
                     (Q04609.1)"
     Region          627..747
                     /region_name="TFR_dimer"
                     /note="Transferrin receptor-like dimerization domain;
                     pfam04253"
                     /db_xref="CDD:461238"
     Site            638
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:12754519,
                     ECO:0000269|PubMed:15152093, ECO:0000269|PubMed:16467855,
                     ECO:0000269|PubMed:17372356, ECO:0000269|PubMed:17567119,
                     ECO:0000269|PubMed:18234225, ECO:0000269|PubMed:19053759,
                     ECO:0000269|PubMed:19301871, ECO:0007744|PDB:1Z8L,
                     ECO:0007744|PDB:2C6C, ECO:0007744|PDB:2C6G,
                     ECO:0007744|PDB:2C6P, ECO:0007744|PDB:2CIJ,
                     ECO:0007744|PDB:2JBJ, ECO:0007744|PDB:2JBK,
                     ECO:0007744|PDB:2OOT, ECO:0007744|PDB:2OR4,
                     ECO:0007744|PDB:2PVV, ECO:0007744|PDB:2PVW,
                     ECO:0007744|PDB:2XEF, ECO:0007744|PDB:2XEG,
                     ECO:0007744|PDB:2XEI, ECO:0007744|PDB:2XEJ,
                     ECO:0007744|PDB:3BHX, ECO:0007744|PDB:3BI0,
                     ECO:0007744|PDB:3BI1, ECO:0007744|PDB:3BXM,
                     ECO:0007744|PDB:3D7D, ECO:0007744|PDB:3D7F,
                     ECO:0007744|PDB:3D7G, ECO:0007744|PDB:3D7H,
                     ECO:0007744|PDB:3IWW, ECO:0007744|PDB:3RBU,
                     ECO:0007744|PDB:3SJE, ECO:0007744|PDB:3SJF,
                     ECO:0007744|PDB:3SJG, ECO:0007744|PDB:3SJX,
                     ECO:0007744|PDB:4JYW, ECO:0007744|PDB:4JZ0,
                     ECO:0007744|PDB:4LQG, ECO:0007744|PDB:4MCP,
                     ECO:0007744|PDB:4MCQ, ECO:0007744|PDB:4MCR,
                     ECO:0007744|PDB:4MCS, ECO:0007744|PDB:4NGM,
                     ECO:0007744|PDB:4NGN, ECO:0007744|PDB:4NGP,
                     ECO:0007744|PDB:4NGQ, ECO:0007744|PDB:4NGR,
                     ECO:0007744|PDB:4NGS, ECO:0007744|PDB:4NGT,
                     ECO:0007744|PDB:4OC0, ECO:0007744|PDB:4OC1,
                     ECO:0007744|PDB:4OC2, ECO:0007744|PDB:4OC3,
                     ECO:0007744|PDB:4OC4, ECO:0007744|PDB:4OC5,
                     ECO:0007744|PDB:4OME, ECO:0007744|PDB:4P44,
                     ECO:0007744|PDB:4P45, ECO:0007744|PDB:4P4B,
                     ECO:0007744|PDB:4P4D, ECO:0007744|PDB:4P4E,
                     ECO:0007744|PDB:4P4F, ECO:0007744|PDB:4P4I,
                     ECO:0007744|PDB:4P4J; propagated from UniProtKB/Swiss-Prot
                     (Q04609.1)"
     CDS             1..750
                     /gene="FOLH1"
                     /gene_synonym="FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1;
                     PSM; PSMA"
                     /coded_by="NM_004476.3:194..2446"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS7946.1"
                     /db_xref="GeneID:2346"
                     /db_xref="HGNC:HGNC:3788"
                     /db_xref="MIM:600934"
ORIGIN      
        1 mwnllhetds avatarrprw lcagalvlag gffllgflfg wfikssneat nitpkhnmka
       61 fldelkaeni kkflynftqi phlagteqnf qlakqiqsqw kefgldsvel ahydvllsyp
      121 nkthpnyisi inedgneifn tslfeppppg yenvsdivpp fsafspqgmp egdlvyvnya
      181 rtedffkler dmkincsgki viarygkvfr gnkvknaqla gakgvilysd padyfapgvk
      241 sypdgwnlpg ggvqrgniln lngagdpltp gypaneyayr rgiaeavglp sipvhpigyy
      301 daqkllekmg gsappdsswr gslkvpynvg pgftgnfstq kvkmhihstn evtriynvig
      361 tlrgavepdr yvilgghrds wvfggidpqs gaavvheivr sfgtlkkegw rprrtilfas
      421 wdaeefgllg stewaeensr llqergvayi nadssiegny tlrvdctplm yslvhnltke
      481 lkspdegfeg kslyeswtkk spspefsgmp risklgsgnd fevffqrlgi asgrarytkn
      541 wetnkfsgyp lyhsvyetye lvekfydpmf kyhltvaqvr ggmvfelans ivlpfdcrdy
      601 avvlrkyadk iysismkhpq emktysvsfd slfsavknft eiaskfserl qdfdksnpiv
      661 lrmmndqlmf lerafidplg lpdrpfyrhv iyapsshnky agesfpgiyd alfdieskvd
      721 pskawgevkr qiyvaaftvq aaaetlseva
//
