LOCUS       NM_001375567            5794 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens focadhesin (FOCAD), transcript variant 2, mRNA.
ACCESSION   NM_001375567 XM_005251494
VERSION     NM_001375567.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5794)
  AUTHORS   Zheng,X., Xiao,H., Liu,X., Huang,T. and Deng,C.
  TITLE     Exosomal circKIAA1797 Regulates Cell Progression and Glycolysis by
            Targeting miR-4429/PBX3 Pathway in Gastric Cancer
  JOURNAL   Biochem Genet 62 (3), 1762-1778 (2024)
   PUBMED   37730964
  REMARK    GeneRIF: Exosomal circKIAA1797 Regulates Cell Progression and
            Glycolysis by Targeting miR-4429/PBX3 Pathway in Gastric Cancer.
REFERENCE   2  (bases 1 to 5794)
  AUTHORS   Moreno Traspas,R., Teoh,T.S., Wong,P.M., Maier,M., Chia,C.Y.,
            Lay,K., Ali,N.A., Larson,A., Al Mutairi,F., Al-Sannaa,N.A.,
            Faqeih,E.A., Alfadhel,M., Cheema,H.A., Dupont,J., Bezieau,S.,
            Isidor,B., Low,D.Y., Wang,Y., Tan,G., Lai,P.S., Piloquet,H.,
            Joubert,M., Kayserili,H., Kripps,K.A., Nahas,S.A., Wartchow,E.P.,
            Warren,M., Bhavani,G.S., Dasouki,M., Sandoval,R., Carvalho,E.,
            Ramos,L., Porta,G., Wu,B., Lashkari,H.P., AlSaleem,B.,
            BaAbbad,R.M., Abreu Ferrao,A.N., Karageorgou,V.,
            Ordonez-Herrera,N., Khan,S., Bauer,P., Cogne,B.,
            Bertoli-Avella,A.M., Vincent,M., Girisha,K.M. and Reversade,B.
  TITLE     Loss of FOCAD, operating via the SKI messenger RNA surveillance
            pathway, causes a pediatric syndrome with liver cirrhosis
  JOURNAL   Nat Genet 54 (8), 1214-1226 (2022)
   PUBMED   35864190
  REMARK    GeneRIF: Loss of FOCAD, operating via the SKI messenger RNA
            surveillance pathway, causes a pediatric syndrome with liver
            cirrhosis.
REFERENCE   3  (bases 1 to 5794)
  AUTHORS   MacFarland,S.P., Xie,H., Dent,M.H., Greed,B., Plon,S.E.,
            Scollon,S.R., Brodeur,G.M. and Howe,J.R.
  TITLE     FOCAD Indel in a Family With Juvenile Polyposis Syndrome
  JOURNAL   J Pediatr Gastroenterol Nutr 75 (1), 56-58 (2022)
   PUBMED   35622075
  REMARK    GeneRIF: FOCAD Indel in a Family With Juvenile Polyposis Syndrome.
REFERENCE   4  (bases 1 to 5794)
  AUTHORS   Brand,F., Forster,A., Christians,A., Bucher,M., Thome,C.M.,
            Raab,M.S., Westphal,M., Pietsch,T., von Deimling,A.,
            Reifenberger,G., Claus,P., Hentschel,B., Weller,M. and Weber,R.G.
  TITLE     FOCAD loss impacts microtubule assembly, G2/M progression and
            patient survival in astrocytic gliomas
  JOURNAL   Acta Neuropathol 139 (1), 175-192 (2020)
   PUBMED   31473790
  REMARK    GeneRIF: FOCAD loss impacts microtubule assembly, G2/M progression
            and patient survival in astrocytic gliomas.
REFERENCE   5  (bases 1 to 5794)
  AUTHORS   Long,Q., Argmann,C., Houten,S.M., Huang,T., Peng,S., Zhao,Y., Tu,Z.
            and Zhu,J.
  CONSRTM   GTEx Consortium
  TITLE     Inter-tissue coexpression network analysis reveals DPP4 as an
            important gene in heart to blood communication
  JOURNAL   Genome Med 8 (1), 15 (2016)
   PUBMED   26856537
  REMARK    GeneRIF: Results identified cardiac FOCAD expression to be
            correlated with protein biosynthetic processes in the lung.
            mediator of this process between the heart and lung.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5794)
  AUTHORS   Weren,R.D., Venkatachalam,R., Cazier,J.B., Farin,H.F., Kets,C.M.,
            de Voer,R.M., Vreede,L., Verwiel,E.T., van Asseldonk,M.,
            Kamping,E.J., Kiemeney,L.A., Neveling,K., Aben,K.K.,
            Carvajal-Carmona,L., Nagtegaal,I.D., Schackert,H.K., Clevers,H.,
            van de Wetering,M., Tomlinson,I.P., Ligtenberg,M.J.,
            Hoogerbrugge,N., Geurts van Kessel,A. and Kuiper,R.P.
  TITLE     Germline deletions in the tumour suppressor gene FOCAD are
            associated with polyposis and colorectal cancer development
  JOURNAL   J Pathol 236 (2), 155-164 (2015)
   PUBMED   25712196
  REMARK    GeneRIF: The data suggests that nonallelic germline deletions in
            the tumor suppressor gene FOCAD underlie moderate genetic
            predisposition to the development of polyposis and CRC
REFERENCE   7  (bases 1 to 5794)
  AUTHORS   Liao,J., Su,X., Chen,P., Wang,X., Xu,L., Li,X., Thean,L., Tan,C.,
            Tan,A.G., Tay,W.T., Jun,G., Zheng,Y., Chew,M., Wang,Y.X., Tan,Q.S.,
            Barathi,V.A., Klein,B.E., Saw,S.M., Vithana,E.N., Tai,E.S.,
            Iyengar,S.K., Mitchell,P., Khor,C.C., Aung,T., Wang,J.J.,
            Jonas,J.B., Teo,Y.Y., Wong,T.Y. and Cheng,C.Y.
  TITLE     Meta-analysis of genome-wide association studies in multiethnic
            Asians identifies two loci for age-related nuclear cataract
  JOURNAL   Hum Mol Genet 23 (22), 6119-6128 (2014)
   PUBMED   24951543
REFERENCE   8  (bases 1 to 5794)
  AUTHORS   Brockschmidt,A., Trost,D., Peterziel,H., Zimmermann,K., Ehrler,M.,
            Grassmann,H., Pfenning,P.N., Waha,A., Wohlleber,D.,
            Brockschmidt,F.F., Jugold,M., Hoischen,A., Kalla,C., Waha,A.,
            Seifert,G., Knolle,P.A., Latz,E., Hans,V.H., Wick,W., Pfeifer,A.,
            Angel,P. and Weber,R.G.
  TITLE     KIAA1797/FOCAD encodes a novel focal adhesion protein with tumour
            suppressor function in gliomas
  JOURNAL   Brain 135 (Pt 4), 1027-1041 (2012)
   PUBMED   22427331
  REMARK    GeneRIF: This stduy showed that frequently deleted KIAA1797 gene
            encodes a novel focal adhesion complex protein with tumour
            suppressor function in gliomas.
REFERENCE   9  (bases 1 to 5794)
  AUTHORS   Melton,P.E., Rutherford,S., Voruganti,V.S., Goring,H.H., Laston,S.,
            Haack,K., Comuzzie,A.G., Dyer,T.D., Johnson,M.P., Kent,J.W. Jr.,
            Curran,J.E., Moses,E.K., Blangero,J., Barac,A., Lee,E.T.,
            Best,L.G., Fabsitz,R.R., Devereux,R.B., Okin,P.M., Bella,J.N.,
            Broeckel,U., Howard,B.V., MacCluer,J.W., Cole,S.A. and Almasy,L.
  TITLE     Bivariate genetic association of KIAA1797 with heart rate in
            American Indians: the Strong Heart Family Study
  JOURNAL   Hum Mol Genet 19 (18), 3662-3671 (2010)
   PUBMED   20601674
  REMARK    GeneRIF: KIAA1797 genetic variation is associated with heart rate.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 5794)
  AUTHORS   Chapuis,J., Hot,D., Hansmannel,F., Kerdraon,O., Ferreira,S.,
            Hubans,C., Maurage,C.A., Huot,L., Bensemain,F., Laumet,G.,
            Ayral,A.M., Fievet,N., Hauw,J.J., DeKosky,S.T., Lemoine,Y.,
            Iwatsubo,T., Wavrant-Devrieze,F., Dartigues,J.F., Tzourio,C.,
            Buee,L., Pasquier,F., Berr,C., Mann,D., Lendon,C., Alperovitch,A.,
            Kamboh,M.I., Amouyel,P. and Lambert,J.C.
  TITLE     Transcriptomic and genetic studies identify IL-33 as a candidate
            gene for Alzheimer's disease
  JOURNAL   Mol Psychiatry 14 (11), 1004-1016 (2009)
   PUBMED   19204726
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL354879.12, AL445624.3,
            KF458909.1, AL392163.8 and AL662879.5.
            
            On Oct 29, 2019 this sequence version replaced XM_005251494.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.123669.1,
                                           SRR14038192.3005312.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338382.11/ ENSP00000344307.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                AL354879.12        76226-76260
            36-124              AL445624.3         152420-152508       c
            125-199             AL445624.3         149962-150036       c
            200-354             AL445624.3         147296-147450       c
            355-459             AL445624.3         127490-127594       c
            460-561             AL445624.3         109639-109740       c
            562-766             AL445624.3         102757-102961       c
            767-973             AL445624.3         97592-97798         c
            974-1061            AL445624.3         89062-89149         c
            1062-1264           AL445624.3         85901-86103         c
            1265-1522           AL445624.3         78222-78479         c
            1523-1627           AL445624.3         47930-48034         c
            1628-1729           AL445624.3         47405-47506         c
            1730-1860           AL445624.3         46759-46889         c
            1861-1987           AL445624.3         44715-44841         c
            1988-2122           AL445624.3         5118-5252           c
            2123-2173           AL445624.3         1854-1904           c
            2174-2257           KF458909.1         58-141              c
            2258-2384           AL392163.8         80200-80326
            2385-2570           AL392163.8         87390-87575
            2571-2692           AL392163.8         90628-90749
            2693-2785           AL392163.8         112669-112761
            2786-2874           AL392163.8         118385-118473
            2875-2919           AL392163.8         122412-122456
            2920-3028           AL662879.5         152631-152739       c
            3029-3145           AL662879.5         149982-150098       c
            3146-3384           AL662879.5         146803-147041       c
            3385-3474           AL662879.5         143296-143385       c
            3475-3622           AL662879.5         131625-131772       c
            3623-3742           AL662879.5         129579-129698       c
            3743-3865           AL662879.5         128006-128128       c
            3866-3943           AL662879.5         127471-127548       c
            3944-4015           AL662879.5         126724-126795       c
            4016-4118           AL662879.5         125301-125403       c
            4119-4199           AL662879.5         123334-123414       c
            4200-4328           AL662879.5         99851-99979         c
            4329-4444           AL662879.5         97945-98060         c
            4445-4705           AL662879.5         94713-94973         c
            4706-4795           AL662879.5         93953-94042         c
            4796-4973           AL662879.5         89934-90111         c
            4974-5071           AL662879.5         87970-88067         c
            5072-5323           AL662879.5         86025-86276         c
            5324-5399           AL662879.5         83071-83146         c
            5400-5794           AL662879.5         80449-80843         c
FEATURES             Location/Qualifiers
     source          1..5794
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9p21.3"
     gene            1..5794
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /note="focadhesin"
                     /db_xref="GeneID:54914"
                     /db_xref="HGNC:HGNC:23377"
                     /db_xref="MIM:614606"
     exon            1..35
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            36..124
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..5473
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /note="isoform 1 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="focadhesin isoform 1"
                     /protein_id="NP_001362496.1"
                     /db_xref="CCDS:CCDS34993.1"
                     /db_xref="GeneID:54914"
                     /db_xref="HGNC:HGNC:23377"
                     /db_xref="MIM:614606"
                     /translation="MSDDIRKRFEFPNSLIQSQAVGHLIAAVLKENGFSEKIHQSTNQ
                     TPALNLLWEKCCSDNVVVRTACCEGLVALVAQDHAEFSYVLNGILNLIPSTRNTHGLI
                     KAIMHLLQMQALKEGQGGEKNIQSIYTIRNHPHPLITVLEHRPDCWPVFLQQLTAFFQ
                     QCPERLEVSCIQIMAPFLWYLYCEPSQLQEYAKLRLALLKVLLQPQVLCDKDQPSILE
                     QQILQLCCDIVPCLQVKDLIQTTEAMMFIEEVCLSLLRHPVFWKIQLTQMSLQLLCVS
                     EVSLKITGECSSSIHLLEHSVELLKEDFPVELVIIGIALLLLQTPASQQKPILNLALK
                     LLSVTEDQKIPKSSLLLVMPILQILSSTALEDCISVDEEGPSRQQLALNLLEMIQQEC
                     YRDDHQKLSYKLVCPVTSMYGTIFTAWRILEVMTDSSAASDWLASVESLLPITAVIPA
                     PAFLLLAHLLVEDKGQNLHQILKVTTELAQADSSQVPNLIPVLMFKLGRPLEPILYND
                     ILYTLPKLGVHKVCIGQILRIIQLLGTTPRLRAVTLRLLTSLWEKQDRVYPELQRFMA
                     VSDVPSLSVGKEVQWEKLIAKAASIRDICKQRPYQHGADMLAAISQVLNECTKPDQAT
                     PAALVLQGLHALCQAEVVCIRSTWNALSPKLSCDTRPLILKTLSELFSLVPSLTVNTT
                     EYENFKVQVLSFLWTHTQNKDPIVANAAYRSLANFSAGEHTILHLPEKIRPEIPIPEE
                     LDDDEDVEDVDLSVPGSCYLKLLSLTPPLVLPALEEFFTSLVKQEMVNMPRGIYHSAL
                     KGGARSDQGKTVAGIPNFILKMYETNKQPGLKPGLAGGMLFCYDVSMYQSKDGKPLNR
                     LMASRGRSFKQTSLALVHEVHIQLSEWHRAIFLPQAWLAYMNRAYHAILQGRLGELEL
                     QLKHGKEEPEEVQYKKSTAWLWVRDMLTDEITKAAAKESPVVKGNALLALSSLAVVVS
                     RHEASLSSDSDGLLEVQPNFLSMKEWVSMVLDTLLVIVDSHYQPRGQLLSWFYYKSYS
                     GENTASAIARSAAATALSLLVPVFIISCKEKVEEILNMLTARLPGKPSADESQAVQIH
                     MGLALGMFLSRLCEEKLSDISGQEMNLLLMKSLDALENCCFDTSLEYNTGCILGVGLV
                     LSLMSHSSQMQSRVHVAALLRKLSAHVDDSGSQSRTFQEVLAYTLSCVCTSAFSAGII
                     EATEAEDVMNKLRLLVENSQQTSGFALALGNIVHGLSVCGHGKAEDLGSKLLPAWIRI
                     VLTEGTPTMLCLAALHGMVALVGSEGDVMQLKSEAIQTSHFQGRLNEVIRTLTQVISV
                     SGVIGLQSNAVWLLGHLHLSTLSSSQSRASVPTDYSYLPESSFIGAAIGFFITGGKKG
                     PESVPPSLLKVVMKPIATVGESYQYPPVNWAALLSPLMRLNFGEEIQQLCLEIMVTQA
                     QSSQNAAALLGLWVTPPLIHSLSLNTKRYLLISAPLWIKHISDEQILGFVENLMVAVF
                     KAASPLGSPELCPSALHGLSQAMKLPSPAHHLWSLLSEATGKIFDLLPNKIRRKDLEL
                     YISIAKCLLEMTDDDANRIAQVTKSNIEKAAFVKLYLVSQGRFPLVNLTDMLSVAVQH
                     REKEVLAWMILHSLYQARIVSHANTGVLKRMEWLLELMGYIRNVAYQSTSFHNTALDK
                     ALDFFLLIFATAVVAWADHTAPLLLGLSASWLPWHQENGPAGPVPSFLGRSPMHRVTL
                     QEVLTLLPNSMALLLQKEPWKEQTQKFIDWLFSIMESPKEALSAQSRDLLKATLLSLR
                     VLPEFKKKAVWTRAYGW"
     exon            125..199
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            200..354
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            355..459
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            460..561
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            562..766
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            767..973
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1061
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1264
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1522
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1523..1627
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1628..1729
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1860
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1987
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2122
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..2173
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2174..2257
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2384
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2385..2570
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2571..2692
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2693..2785
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2786..2874
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2875..2919
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            2920..3028
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            3029..3145
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            3146..3384
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            3385..3474
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            3475..3622
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            3623..3742
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            3743..3865
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            3866..3943
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            3944..4015
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            4016..4118
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            4119..4199
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            4200..4328
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            4329..4444
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            4445..4705
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            4706..4795
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            4796..4973
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            4974..5071
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            5072..5323
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            5324..5399
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     exon            5400..5794
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5776..5781
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /note="hexamer: AGTAAA"
     polyA_site      5794
                     /gene="FOCAD"
                     /gene_synonym="KIAA1797; SCOLIV"
                     /note="major polyA site"
ORIGIN      
        1 agccggcgct gggctgagct tgtggcagaa gggagaagct gcacacatac atgtaagaga
       61 agcaaaaatg tcagatgata tcaggaaaag gtttgaattt ccaaattctc ttatccaatc
      121 acaggctgtg ggtcatctta ttgctgcagt cctaaaggaa aatggttttt cagaaaagat
      181 tcaccaatct acaaatcaga ctcctgcttt gaacttgctg tgggagaagt gttgcagtga
      241 caatgtagtg gttcgaacag cctgctgtga aggtctggtg gcactcgttg ctcaggatca
      301 tgcagagttc agctatgttc tcaatgggat actcaacttg attccatcaa ccagaaatac
      361 acatggcttg ataaaagcca ttatgcactt actacaaatg caagctctta aggaaggaca
      421 aggtggggaa aagaatattc agagtatata taccattaga aatcatcctc atcctttgat
      481 aactgtgctt gaacacagac ctgattgctg gccagtgttt ttgcagcagc tgacagcgtt
      541 tttccagcag tgccctgaaa ggttagaagt ttcatgcatt caaataatgg caccatttct
      601 gtggtatctg tattgtgaac catctcagtt acaagaatat gctaaactcc gactagccct
      661 gctgaaagtc ttacttcaac cccaggttct ttgtgacaaa gatcaaccat caatactgga
      721 acagcagata cttcaactgt gttgtgacat agttccatgt ttgcaggtaa aagatttgat
      781 acagacaaca gaggcgatga tgtttattga ggaagtatgt ttaagccttt tgcgtcatcc
      841 tgttttctgg aaaattcagc ttacccagat gagtcttcag ctgctgtgtg tcagtgaagt
      901 cagcttaaag ataactggtg aatgttcatc ttcaattcac cttttagagc acagtgttga
      961 acttctgaag gaggattttc ctgttgaact ggtcataatt ggaatagctt tactacttct
     1021 acagactcca gcaagtcagc agaagccaat cttaaatcta gctttgaagc tcctctctgt
     1081 tactgaggat cagaaaatcc caaagtcctc tctgctgcta gtgatgccaa ttctgcagat
     1141 actatcttct actgccttgg aagactgtat atctgtggat gaagaaggtc cctctaggca
     1201 gcagttggct ctaaaccttt tggaaatgat acagcaggaa tgttacagag atgaccacca
     1261 aaagctctcc tacaagcttg tgtgccctgt aaccagtatg tatggtacaa tatttacagc
     1321 ctggaggatt cttgaagtaa tgacagactc gtctgctgca agtgactggt tggcttcagt
     1381 agagtcattg cttcctatta ctgctgtgat ccctgcgcct gcctttcttc tgctggctca
     1441 cctccttgtt gaagacaaag gacaaaatct tcaccaaata ctcaaggtca ctacagaatt
     1501 agcccaagca gattcctccc aggtgccaaa tctgattcca gttttgatgt tcaaattggg
     1561 aagaccactg gaacctatat tatataatga tatattgtat actttaccta agcttggtgt
     1621 tcacaaggtg tgtataggac aaattctacg aataatacaa ctacttggaa ccacaccacg
     1681 actaagagct gtcactttgc gcttgctgac atctttgtgg gaaaagcagg accgagtcta
     1741 tcctgaactg cagcgtttca tggctgtgtc tgatgtacct tctctttcgg tgggcaagga
     1801 agtccaatgg gagaaactga ttgcaaaagc agcatcaatc agagatatat gtaagcagag
     1861 gccatatcaa catggtgcag atatgttggc agctatttct caagtgttga atgaatgcac
     1921 caagcctgat caagctactc cagcagcctt ggtattacag ggtcttcatg cactctgtca
     1981 agctgaggtt gtttgcattc gctccacttg gaatgctctc tctccaaagc tgagttgtga
     2041 cacaagacct ctcattctga agacactgag tgaactattt tctctagttc cttccttaac
     2101 ggtcaataca actgaatatg agaattttaa agttcaagtc ctcagcttcc tctggactca
     2161 tactcaaaac aaggacccaa ttgtagcaaa tgctgcatat agatccctgg ccaactttag
     2221 tgcaggagaa cacaccattc ttcatctgcc tgaaaagata agaccagaaa ttcccattcc
     2281 tgaagagtta gatgacgatg aagatgttga ggatgtggat ctttcagttc ctggctcttg
     2341 ctatctcaaa ctgttgtcac tcactccccc tttggtttta ccagctttgg aggaattttt
     2401 tacatcactt gtgaagcaag aaatggtgaa tatgcctcgt gggatatatc actctgcatt
     2461 aaaaggaggt gcccgctcag accaaggaaa gactgtagca ggaatcccca attttatatt
     2521 gaaaatgtat gaaacaaaca agcaaccagg actgaaacct ggccttgcag gtggtatgtt
     2581 attttgctat gatgtttcca tgtatcagag taaagatgga aaaccattga acagactgat
     2641 ggccagcaga gggcgaagtt tcaagcagac ttcacttgct cttgtacatg aggttcatat
     2701 ccagctttca gagtggcacc gtgcaatttt tcttccacag gcctggcttg catacatgaa
     2761 tcgagcttat catgccattt tacagggaag actaggagag ctggagttgc agttaaaaca
     2821 tggaaaagaa gaacctgagg aggtgcagta caaaaaaagc acagcctggc tctgggttag
     2881 agacatgctg actgatgaga tcaccaaggc agctgcaaag gagagtccgg tagtgaaagg
     2941 caatgcgctg ttagctctaa gcagccttgc tgtcgtcgta tctagacatg aagccagcct
     3001 ctcctcagac tctgacgggc tcctggaggt tcaacctaat ttcctttcaa tgaaagagtg
     3061 ggtttccatg gtacttgata cactcttggt cattgtggat agccattacc aacccagagg
     3121 gcaacttctc tcctggtttt attataagtc ctattctggt gaaaacacag ctagtgccat
     3181 tgcccgttct gctgccgcca cggctttgtc tctccttgtg ccagttttca ttatctcttg
     3241 caaagagaag gttgaggaaa tcctgaacat gctgactgcc aggttacctg ggaaaccaag
     3301 tgctgatgag tctcaagccg tgcaaatcca catgggcctt gctttaggga tgtttctctc
     3361 tcgcttgtgt gaagagaaac tcagtgatat atctggccaa gagatgaacc ttcttctgat
     3421 gaagtcgttg gatgccctgg aaaattgctg ctttgacact agtcttgaat acaacacggg
     3481 ctgtatattg ggagttggac ttgttctgtc cctcatgagc cacagcagcc aaatgcagtc
     3541 ccgcgttcac gtagcagcat tgctccggaa gctgtctgcg cacgtagatg acagcgggag
     3601 ccagagcaga acgtttcagg aggtccttgc ctacacactt agctgtgtat gtacatcagc
     3661 gttcagtgct ggaattattg aggctacaga ggctgaggat gttatgaaca agcttcgact
     3721 gttagtggag aatagccagc agacttcagg ttttgccctg gctttaggaa acatagttca
     3781 tggattgtct gtgtgtggac atggaaaagc tgaagacttg ggcagcaaac tactccctgc
     3841 ctggatcaga attgttctaa cagagggcac tcccacaatg ctttgtctgg cagctcttca
     3901 tggcatggtg gccttggtag gctctgaagg ggatgtaatg cagctgaaat cagaagccat
     3961 ccagacctct cattttcaag gcagacttaa tgaagtcatt agaaccttaa ctcaggtcat
     4021 tagtgtctct ggggtgattg gtctccagtc aaatgcagtc tggcttcttg gacatcttca
     4081 tctatctact ctatcctcaa gtcaaagtag agcctctgtt cctactgact atagctactt
     4141 gcctgaaagc agttttattg gagcagctat tggcttcttc attacaggag gaaaaaaagg
     4201 tcctgaatct gtgcctcctt cccttcttaa agtagtgatg aaacccatag caactgttgg
     4261 agaaagctac caatatcctc ctgtgaactg ggctgcactt ctctctccac ttatgaggct
     4321 aaattttggt gaagagatcc agcaactgtg ccttgaaatt atggtgaccc aggcacagtc
     4381 atcccagaat gcagctgcac tattgggctt gtgggtgaca ccaccactga tccacagtct
     4441 gagtctgaat accaagagat atctcctgat atctgcacct ctgtggataa aacacatctc
     4501 tgatgaacag atcctgggtt ttgttgaaaa tttaatggtg gcagttttta aagcagcttc
     4561 cccacttgga agtcctgagc tatgcccaag tgctttacac ggtctgagcc aggccatgaa
     4621 actgcccagc cctgcccacc acctctggag tctgctctct gaagctactg ggaaaatttt
     4681 tgacctcctg ccaaataaga ttcggagaaa ggatctagag ctgtatatca gcatagcaaa
     4741 atgcctctta gaaatgacag atgatgatgc caatcggatc gcccaggtta ctaagagcaa
     4801 catagaaaaa gctgcctttg tcaaactgta cttagtctct caaggacgat tccccttggt
     4861 gaacctgacc gatatgctga gcgttgctgt gcagcaccgt gagaaagagg tgttggcctg
     4921 gatgattctg cacagcttat accaggcacg gattgtgagc catgccaata cgggcgtttt
     4981 gaagagaatg gagtggctct tggaactgat gggttatatt agaaatgttg cttaccagtc
     5041 aacatccttt cacaatacgg ctcttgacaa ggctttggac ttcttcttgc tgatatttgc
     5101 aaccgcagtg gttgcatggg ctgaccacac tgcccctctc ctcctcggcc tcagtgccag
     5161 ttggttgcca tggcatcagg agaatggccc ggctgggcca gtaccaagct tccttggcag
     5221 gagtccaatg cacagggtca ctctgcagga ggttctcact ctccttccca atagcatggc
     5281 tctgctgctg cagaaagagc catggaagga acagacccag aagttcattg actggctatt
     5341 cagcatcatg gaaagcccta aagaagccct ctcagcacag tccagggatc ttttgaaagc
     5401 caccctgctg tccttgagag ttctcccaga gtttaagaag aaagctgtat ggaccagagc
     5461 atatggttgg tgaacagttt tgcagtaacc agcagcattc tcagctggat gaggaaaacc
     5521 atataagtgg aagaagtttt tcagaattca tgcctggtat tgctgagaca tgatgcagag
     5581 agttaagggt catgaaaaga tggccacatc actgacagct tgacacatgc ctcctaagag
     5641 aggagtgcat tgctttagta cccgggccag ttgagactga aacaggaact tggattttct
     5701 ttatttggct tgagttcaat gtggagattt tctttgtgaa agcttgaaga tattatcttc
     5761 tccctgctaa attccagtaa aataatgttg tcaa
//
