LOCUS       NM_002028               2711 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens farnesyltransferase, CAAX box, subunit beta (FNTB),
            mRNA.
ACCESSION   NM_002028
VERSION     NM_002028.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2711)
  AUTHORS   Verhasselt,H., Stelmach,P., Domin,M., Jung,D., Hagemann,A.,
            Manthey,I. and Bachmann,H.S.
  TITLE     Characterization of the promoter of the human farnesyltransferase
            beta subunit and the impact of the transcription factor OCT-1 on
            its expression
  JOURNAL   Genomics 114 (2), 110314 (2022)
   PUBMED   35167937
  REMARK    GeneRIF: Characterization of the promoter of the human
            farnesyltransferase beta subunit and the impact of the
            transcription factor OCT-1 on its expression.
REFERENCE   2  (bases 1 to 2711)
  AUTHORS   Jeong,A., Cheng,S., Zhong,R., Bennett,D.A., Bergo,M.O. and Li,L.
  TITLE     Protein farnesylation is upregulated in Alzheimer's human brains
            and neuron-specific suppression of farnesyltransferase mitigates
            pathogenic processes in Alzheimer's model mice
  JOURNAL   Acta Neuropathol Commun 9 (1), 129 (2021)
   PUBMED   34315531
  REMARK    GeneRIF: Protein farnesylation is upregulated in Alzheimer's human
            brains and neuron-specific suppression of farnesyltransferase
            mitigates pathogenic processes in Alzheimer's model mice.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2711)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 2711)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 2711)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2711)
  AUTHORS   Wang,T., Danielson,P.D., Li,B.Y., Shah,P.C., Kim,S.D. and
            Donahoe,P.K.
  TITLE     The p21(RAS) farnesyltransferase alpha subunit in TGF-beta and
            activin signaling
  JOURNAL   Science 271 (5252), 1120-1122 (1996)
   PUBMED   8599089
REFERENCE   7  (bases 1 to 2711)
  AUTHORS   Sinensky,M., Fantle,K., Trujillo,M., McLain,T., Kupfer,A. and
            Dalton,M.
  TITLE     The processing pathway of prelamin A
  JOURNAL   J Cell Sci 107 (Pt 1), 61-67 (1994)
   PUBMED   8175923
REFERENCE   8  (bases 1 to 2711)
  AUTHORS   Andres,D.A., Milatovich,A., Ozcelik,T., Wenzlau,J.M., Brown,M.S.,
            Goldstein,J.L. and Francke,U.
  TITLE     cDNA cloning of the two subunits of human CAAX farnesyltransferase
            and chromosomal mapping of FNTA and FNTB loci and related sequences
  JOURNAL   Genomics 18 (1), 105-112 (1993)
   PUBMED   8276393
REFERENCE   9  (bases 1 to 2711)
  AUTHORS   Omer,C.A., Kral,A.M., Diehl,R.E., Prendergast,G.C., Powers,S.,
            Allen,C.M., Gibbs,J.B. and Kohl,N.E.
  TITLE     Characterization of recombinant human farnesyl-protein transferase:
            cloning, expression, farnesyl diphosphate binding, and functional
            homology with yeast prenyl-protein transferases
  JOURNAL   Biochemistry 32 (19), 5167-5176 (1993)
   PUBMED   8494894
REFERENCE   10 (bases 1 to 2711)
  AUTHORS   Manne,V., Roberts,D., Tobin,A., O'Rourke,E., De Virgilio,M.,
            Meyers,C., Ahmed,N., Kurz,B., Resh,M., Kung,H.F. et al.
  TITLE     Identification and preliminary characterization of protein-cysteine
            farnesyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7541-7545 (1990)
   PUBMED   2217184
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU122768.1, BC013574.1 and BC020232.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002028.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.258946.1,
                                           SRR1660803.31334.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000246166.3/ ENSP00000246166.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AU122768.1         107-126
            21-44               BC013574.1         1-24
            45-2711             BC020232.1         1-2667
FEATURES             Location/Qualifiers
     source          1..2711
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q23.3"
     gene            1..2711
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /note="farnesyltransferase, CAAX box, subunit beta"
                     /db_xref="GeneID:2342"
                     /db_xref="HGNC:HGNC:3785"
                     /db_xref="MIM:134636"
     exon            1..203
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1373
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /EC_number="2.5.1.58"
                     /note="FTase-beta; CAAX farnesyltransferase subunit beta;
                     farnesyltransferase, CAAX box, beta; ras proteins
                     prenyltransferase subunit beta; epididymis secretory sperm
                     binding protein"
                     /codon_start=1
                     /product="protein farnesyltransferase subunit beta"
                     /protein_id="NP_002019.1"
                     /db_xref="CCDS:CCDS9769.1"
                     /db_xref="GeneID:2342"
                     /db_xref="HGNC:HGNC:3785"
                     /db_xref="MIM:134636"
                     /translation="MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVT
                     SIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPW
                     LCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNAL
                     CIIGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIIT
                     PDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQW
                     VTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQA
                     LQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPEN
                     ALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDETSAEPATD"
     exon            204..268
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            269..341
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            342..433
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            434..580
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            581..664
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            665..751
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            752..881
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1014
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1126
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            1127..1241
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..2711
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2692..2697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /note="hexamer: AATAAA"
     polyA_site      2711
                     /gene="FNTB"
                     /gene_synonym="FPTB"
                     /note="major polyA site"
ORIGIN      
        1 aatgcgcgtt gttgcttaac gaagcagagt cctacacact gtctgctgct ctcctgatca
       61 tggcttctcc gagttctttc acctactatt gccctccatc ttcctccccc gtctggtcag
      121 agccgctgta cagtctgagg cccgagcacg cgcgagagcg gttgcaggac gactcggtgg
      181 aaacagtcac gtccatagaa caggcaaaag tagaagaaaa gatccaagag gtcttcagtt
      241 cttacaagtt caaccacctt gtaccaaggc ttgttttgca gagggagaag cacttccatt
      301 atctgaaaag aggccttcga caactgacag atgcctatga gtgtctggat gccagccgcc
      361 catggctctg ctattggatc ctgcacagct tggaactgct agatgaaccc atcccccaga
      421 tagtggctac agatgtgtgt cagttcctgg agctgtgtca gagcccagaa ggtggctttg
      481 gaggaggacc cggtcagtat ccacaccttg cacccacata tgcagcagtc aatgcattgt
      541 gcatcattgg caccgaggag gcctatgaca tcattaacag agagaagctt cttcagtatt
      601 tgtactccct gaagcaacct gacggctcct ttctcatgca tgtcggaggt gaggtggatg
      661 tgagaagcgc atactgtgct gcctccgtag cctcgctgac caacatcatc actccagacc
      721 tctttgaggg cactgctgaa tggatagcaa ggtgtcagaa ctgggaaggt ggcattggcg
      781 gggtaccagg gatggaagcc catggtggct ataccttctg tggcctggcc gcgctggtaa
      841 tcctcaagag ggaacgttcc ttgaacttga agagcttatt acaatgggtg acaagccggc
      901 agatgcgatt tgaaggagga tttcagggcc gctgcaacaa gctggtggat ggctgctact
      961 ccttctggca ggcggggctc ctgcccctgc tccaccgcgc actgcacgcc caaggtgacc
     1021 ctgcccttag catgagccac tggatgttcc atcagcaggc cctgcaggag tacatcctga
     1081 tgtgctgcca gtgccctgcg ggggggcttc tggataaacc tggcaagtcg cgtgatttct
     1141 accacacctg ctactgcctg agcggcctgt ccatagccca gcacttcggc agcggagcca
     1201 tgttgcatga tgtggtcctg ggtgtgcccg aaaacgctct gcagcccact cacccagtgt
     1261 acaacattgg accagacaag gtgatccagg ccactacata ctttctacag aagccagtcc
     1321 caggttttga ggagcttaag gatgagacat cggcagagcc tgcaaccgac tagaggacct
     1381 gggtcccggc agctctttgc tcacccatct ccccagtcag acaaggttta tacgtttcaa
     1441 tacatactgc attctgtgct acacaagcct tagcctcagt ggagctgtgg ttctcttggt
     1501 actttcttgt caaacaaaac caatggctct gggtttggag aacacagtgg ctggttttaa
     1561 aaattctttc cacacctgtc aaaccaaaaa tctatcagcc cacgtggtgt ggttggtgaa
     1621 cagtgcatgc caggaggaag cagtccctcc tcaccagctc tccagccagg acgatcacac
     1681 agagatgaat ggcatctgag tattacggca tccagagcca ctgctgactc ccacttgcac
     1741 gccaccattc agtcaccaga ctgggtgccc tccgatgggt ggaataagtc tgcttcatgc
     1801 caaggctggg ctttgggtcc caccaagatg agttctctgt aagactgtgg tggagttgca
     1861 ccaggaggtg cctctgcctc tcgacttgca ccctggtcat ttgtaaggga aaagagctgg
     1921 aggtggggag agaaagatct ccttcagttg ggagtccttc cacttcaaca ctggagaact
     1981 gagccttgca tctctccagg gtccaaggcc acgcttggtg cacaggcaag acttgcttca
     2041 gccccaggtg tggtgactta gacctaggaa accaattatg agtggaaagt gaccctctag
     2101 ttcaactgtg ccagaggaaa cagccctcca gtgcccacct gcctcactcc tccctatcat
     2161 gtaccgtgaa aaccccctct gatggcctca aggcagtgcc tgcaggccga ggcccttctg
     2221 ggggtttcta tctttcttcc accagactcc aagcccactc tcctccaaga ctgtgttgtc
     2281 ttttctcacc aagagtatta acactactaa gtctttcacc ttaacttatg actcaggatt
     2341 tattcacgtc ctgcccactc taggctcaca ggaataaaat caagtgctag acacactggc
     2401 tgctactaag gcactagcct ctgtagctgg tggtggcagc gtggggtgcc gcccagcgtg
     2461 ctgggtcctg gcagtgcctc tgctgtgctg cacattgagc cctttctcag tcagtggagt
     2521 atcaagttgg gccatctgtc tactgacctg gccttcatgt aagcagctgt gggctgcggg
     2581 cagacaggag ctcagagatg cagcatgagg cgcttagaaa aacctggcca tttgctgcct
     2641 ctaattccct tttgctttgc catattgggc tatgtattac ctccttgaaa taataaaaga
     2701 ataacatttt c
//
