LOCUS       NM_002027               1667 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens farnesyltransferase, CAAX box, subunit alpha (FNTA),
            transcript variant 1, mRNA.
ACCESSION   NM_002027
VERSION     NM_002027.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1667)
  AUTHORS   Jeong,A., Cheng,S., Zhong,R., Bennett,D.A., Bergo,M.O. and Li,L.
  TITLE     Protein farnesylation is upregulated in Alzheimer's human brains
            and neuron-specific suppression of farnesyltransferase mitigates
            pathogenic processes in Alzheimer's model mice
  JOURNAL   Acta Neuropathol Commun 9 (1), 129 (2021)
   PUBMED   34315531
  REMARK    GeneRIF: Protein farnesylation is upregulated in Alzheimer's human
            brains and neuron-specific suppression of farnesyltransferase
            mitigates pathogenic processes in Alzheimer's model mice.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1667)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1667)
  AUTHORS   Klimpel,A., Stillger,K., Wiederstein,J.L., Kruger,M. and
            Neundorf,I.
  TITLE     Cell-permeable CaaX-peptides affect K-Ras downstream signaling and
            promote cell death in cancer cells
  JOURNAL   FEBS J 288 (9), 2911-2929 (2021)
   PUBMED   33112492
  REMARK    GeneRIF: Cell-permeable CaaX-peptides affect K-Ras downstream
            signaling and promote cell death in cancer cells.
REFERENCE   4  (bases 1 to 1667)
  AUTHORS   Zhou,M., Kuruvilla,L., Shi,X., Viviano,S., Ahearn,I.M.,
            Amendola,C.R., Su,W., Badri,S., Mahaffey,J., Fehrenbacher,N.,
            Skok,J., Schlessinger,J., Turk,B.E., Calderwood,D.A. and
            Philips,M.R.
  TITLE     Scaffold association factor B (SAFB) is required for expression of
            prenyltransferases and RAS membrane association
  JOURNAL   Proc Natl Acad Sci U S A 117 (50), 31914-31922 (2020)
   PUBMED   33257571
  REMARK    GeneRIF: Scaffold association factor B (SAFB) is required for
            expression of prenyltransferases and RAS membrane association.
            Erratum:[Proc Natl Acad Sci U S A. 2021 Jul 20;118(29):e2111162118.
            doi: 10.1073/pnas.2111162118.. PMID: 34261796]
REFERENCE   5  (bases 1 to 1667)
  AUTHORS   Armstrong,S.A., Hannah,V.C., Goldstein,J.L. and Brown,M.S.
  TITLE     CAAX geranylgeranyl transferase transfers farnesyl as efficiently
            as geranylgeranyl to RhoB
  JOURNAL   J Biol Chem 270 (14), 7864-7868 (1995)
   PUBMED   7713879
REFERENCE   6  (bases 1 to 1667)
  AUTHORS   Zhang,F.L., Diehl,R.E., Kohl,N.E., Gibbs,J.B., Giros,B., Casey,P.J.
            and Omer,C.A.
  TITLE     cDNA cloning and expression of rat and human protein
            geranylgeranyltransferase type-I
  JOURNAL   J Biol Chem 269 (5), 3175-3180 (1994)
   PUBMED   8106351
REFERENCE   7  (bases 1 to 1667)
  AUTHORS   Andres,D.A., Milatovich,A., Ozcelik,T., Wenzlau,J.M., Brown,M.S.,
            Goldstein,J.L. and Francke,U.
  TITLE     cDNA cloning of the two subunits of human CAAX farnesyltransferase
            and chromosomal mapping of FNTA and FNTB loci and related sequences
  JOURNAL   Genomics 18 (1), 105-112 (1993)
   PUBMED   8276393
REFERENCE   8  (bases 1 to 1667)
  AUTHORS   Omer,C.A., Kral,A.M., Diehl,R.E., Prendergast,G.C., Powers,S.,
            Allen,C.M., Gibbs,J.B. and Kohl,N.E.
  TITLE     Characterization of recombinant human farnesyl-protein transferase:
            cloning, expression, farnesyl diphosphate binding, and functional
            homology with yeast prenyl-protein transferases
  JOURNAL   Biochemistry 32 (19), 5167-5176 (1993)
   PUBMED   8494894
REFERENCE   9  (bases 1 to 1667)
  AUTHORS   Adamson,P., Marshall,C.J., Hall,A. and Tilbrook,P.A.
  TITLE     Post-translational modifications of p21rho proteins
  JOURNAL   J Biol Chem 267 (28), 20033-20038 (1992)
   PUBMED   1400319
REFERENCE   10 (bases 1 to 1667)
  AUTHORS   Manne,V., Roberts,D., Tobin,A., O'Rourke,E., De Virgilio,M.,
            Meyers,C., Ahmed,N., Kurz,B., Resh,M., Kung,H.F. et al.
  TITLE     Identification and preliminary characterization of protein-cysteine
            farnesyltransferase
  JOURNAL   Proc Natl Acad Sci U S A 87 (19), 7541-7545 (1990)
   PUBMED   2217184
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI913631.1 and BC084566.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002027.2.
            
            Summary: Prenyltransferases can attach either a farnesyl group or a
            geranylgeranyl group in thioether linkage to the cysteine residue
            of proteins with a C-terminal CAAX box. CAAX
            geranylgeranyltransferase and CAAX farnesyltransferase are
            heterodimers that share the same alpha subunit but have different
            beta subunits. This gene encodes the alpha subunit of these
            transferases. Alternative splicing results in multiple transcript
            variants. Related pseudogenes have been identified on chromosomes
            11 and 13. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the functional protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.117697.1,
                                           SRR3476690.545875.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302279.8/ ENSP00000303423.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BI913631.1         171-186
            17-1667             BC084566.1         1-1651
FEATURES             Location/Qualifiers
     source          1..1667
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..1667
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /note="farnesyltransferase, CAAX box, subunit alpha"
                     /db_xref="GeneID:2339"
                     /db_xref="HGNC:HGNC:3782"
                     /db_xref="MIM:134635"
     exon            1..224
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1164
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /EC_number="2.5.1.59"
                     /EC_number="2.5.1.58"
                     /note="protein prenyltransferase alpha subunit repeat
                     containing 2; FTase-alpha; type I protein
                     geranyl-geranyltransferase alpha subunit; GGTase-I-alpha;
                     farnesyl-protein transferase alpha-subunit; ras proteins
                     prenyltransferase subunit alpha; farnesyltransferase, CAAX
                     box, alpha"
                     /codon_start=1
                     /product="protein
                     farnesyltransferase/geranylgeranyltransferase type-1
                     subunit alpha"
                     /protein_id="NP_002018.1"
                     /db_xref="CCDS:CCDS6140.1"
                     /db_xref="GeneID:2339"
                     /db_xref="HGNC:HGNC:3782"
                     /db_xref="MIM:134635"
                     /translation="MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAG
                     EAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDY
                     FRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIE
                     EQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDN
                     ELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESA
                     WNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDIL
                     NKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ"
     exon            225..310
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..425
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..530
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            531..657
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            658..806
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            807..869
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            870..1041
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1667
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1648..1653
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /note="hexamer: ATTATA"
     polyA_site      1667
                     /gene="FNTA"
                     /gene_synonym="FPTA; PGGT1A; PTAR2"
                     /note="major polyA site"
ORIGIN      
        1 acctcagctg cggaccgagg cgagatggcg gccaccgagg gggtcgggga ggctgcgcaa
       61 gggggcgagc ccgggcagcc ggcgcaaccc ccgccccagc cgcacccacc gccgccccag
      121 cagcagcaca aggaagagat ggcggccgag gctggggaag ccgtggcgtc ccccatggac
      181 gacgggtttg tgagcctgga ctcgccctcc tatgtcctgt acagggacag agcagaatgg
      241 gctgatatag atccggtgcc gcagaatgat ggccccaatc ccgtggtcca gatcatttat
      301 agtgacaaat ttagagatgt ttatgattac ttccgagctg tcctgcagcg tgatgaaaga
      361 agtgaacgag cttttaagct aacccgggat gctattgagt taaatgcagc caattataca
      421 gtgtggcatt tccggagagt tcttttgaag tcacttcaga aggatctaca tgaggaaatg
      481 aactacatca ctgcaataat tgaggagcag cccaaaaact atcaagtttg gcatcatagg
      541 cgagtattag tggaatggct aagagatcca tctcaggagc ttgaatttat tgctgatatt
      601 cttaatcagg atgcaaagaa ttatcatgcc tggcagcatc gacaatgggt tattcaggaa
      661 tttaaacttt gggataatga gctgcagtat gtggaccaac ttctgaaaga ggatgtgaga
      721 aataactctg tctggaacca aagatacttc gttatttcta acaccactgg ctacaatgat
      781 cgtgctgtat tggagagaga agtccaatac actctggaaa tgattaaact agtaccacat
      841 aatgaaagtg catggaacta tttgaaaggg attttgcagg atcgtggtct ttccaaatat
      901 cctaatctgt taaatcaatt acttgattta caaccaagtc atagttcccc ctacctaatt
      961 gcctttcttg tggatatcta tgaagacatg ctagaaaatc agtgtgacaa taaggaagac
     1021 attcttaata aagcattaga gttatgtgaa atcctagcta aagaaaagga cactataaga
     1081 aaggaatatt ggagatacat tggaagatcc cttcaaagca aacacagcac agaaaatgac
     1141 tcaccaacaa atgtacagca ataacaccat ccagaagaac ttgatggaat gcttttattt
     1201 tttattaagg gaccctgcag gagtttcaca cgagagtggt ccttcccttt gcctgtggtg
     1261 taaaagtgca tcacacaggt attgcttttt aacaagaact gatgctcctt gggtgctgct
     1321 gctactcaga ctagctctaa gtaatgtgat tcttctaaag caaagtcatt ggatgggagg
     1381 aggaagaaaa agtcccataa aggaactttt gtagtcttat caacatataa tctaatccct
     1441 tagcatcagc tcctccctca gtggtacatg cgtcaagatt tgtagcagta ataactgcag
     1501 gtcacttgta tgtaatggat gtgaggtagc cgaagtttgg ttcagtaagc agggaataca
     1561 gtcgttccat cagagctggt ctgcacactc acattatctt gctatcactg taaccaacta
     1621 atgccaaaag aacggttttg taataaaatt atagctgtat ctaaaaa
//
