LOCUS       NM_020840               7038 bp    mRNA    linear   PRI 17-MAR-2024
DEFINITION  Homo sapiens folliculin interacting protein 2 (FNIP2), transcript
            variant 1, mRNA.
ACCESSION   NM_020840
VERSION     NM_020840.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7038)
  AUTHORS   Xia,L., Nie,T., Lu,F., Huang,L., Shi,X., Ren,D., Lu,J., Li,X.,
            Xu,T., Cui,B., Wang,Q., Gao,G. and Yang,Q.
  TITLE     Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1
            activation and tumor progression in pancreatic cancer
  JOURNAL   Autophagy 20 (3), 505-524 (2024)
   PUBMED   37772772
  REMARK    GeneRIF: Direct regulation of FNIP1 and FNIP2 by MEF2 sustains
            MTORC1 activation and tumor progression in pancreatic cancer.
REFERENCE   2  (bases 1 to 7038)
  AUTHORS   Fernandez,L.P., Deleyto-Seldas,N., Colmenarejo,G., Sanz,A.,
            Wagner,S., Plata-Gomez,A.B., Gomez-Patino,M., Molina,S.,
            Espinosa-Salinas,I., Aguilar-Aguilar,E., Ortega,S.,
            Grana-Castro,O., Loria-Kohen,V., Fernandez-Marcos,P.J., Efeyan,A.
            and Ramirez de Molina,A.
  TITLE     Folliculin-interacting protein FNIP2 impacts on overweight and
            obesity through a polymorphism in a conserved 3' untranslated
            region
  JOURNAL   Genome Biol 23 (1), 230 (2022)
   PUBMED   36316722
  REMARK    GeneRIF: Folliculin-interacting protein FNIP2 impacts on overweight
            and obesity through a polymorphism in a conserved 3' untranslated
            region.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7038)
  AUTHORS   Jansen,R.M., Peruzzo,R., Fromm,S.A., Yokom,A.L., Zoncu,R. and
            Hurley,J.H.
  TITLE     Structural basis for FLCN RagC GAP activation in MiT-TFE
            substrate-selective mTORC1 regulation
  JOURNAL   Sci Adv 8 (37), eadd2926 (2022)
   PUBMED   36103527
REFERENCE   4  (bases 1 to 7038)
  AUTHORS   Glykofridis,I.E., Knol,J.C., Balk,J.A., Westland,D., Pham,T.V.,
            Piersma,S.R., Lougheed,S.M., Derakhshan,S., Veen,P., Rooimans,M.A.,
            van Mil,S.E., Bottger,F., Poddighe,P.J., van de Beek,I., Drost,J.,
            Zwartkruis,F.J., de Menezes,R.X., Meijers-Heijboer,H.E.,
            Houweling,A.C., Jimenez,C.R. and Wolthuis,R.M.
  TITLE     Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in
            human renal tubular epithelial cells
  JOURNAL   Elife 10, e61630 (2021)
   PUBMED   33459596
  REMARK    GeneRIF: Loss of FLCN-FNIP1/2 induces a non-canonical interferon
            response in human renal tubular epithelial cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7038)
  AUTHORS   Sano,S., Sakagami,R., Sekiguchi,M. and Hidaka,M.
  TITLE     Stabilization of MAPO1 by specific binding with folliculin and
            AMP-activated protein kinase in O-methylguanine-induced apoptosis
  JOURNAL   Biochem Biophys Res Commun 430 (2), 810-815 (2013)
   PUBMED   23201403
  REMARK    GeneRIF: this study obtained evidence to show that stabilization of
            MAPO1 is regulated through its specific interaction with folliculin
            and AMPK.
REFERENCE   6  (bases 1 to 7038)
  AUTHORS   Hong,S.B., Oh,H., Valera,V.A., Baba,M., Schmidt,L.S. and
            Linehan,W.M.
  TITLE     Inactivation of the FLCN tumor suppressor gene induces TFE3
            transcriptional activity by increasing its nuclear localization
  JOURNAL   PLoS One 5 (12), e15793 (2010)
   PUBMED   21209915
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 7038)
  AUTHORS   Wang,L., Kobayashi,T., Piao,X., Shiono,M., Takagi,Y., Mineki,R.,
            Taka,H., Zhang,D., Abe,M., Sun,G., Hagiwara,Y., Okimoto,K.,
            Matsumoto,I., Kouchi,M. and Hino,O.
  TITLE     Serine 62 is a phosphorylation site in folliculin, the
            Birt-Hogg-Dube gene product
  JOURNAL   FEBS Lett 584 (1), 39-43 (2010)
   PUBMED   19914239
REFERENCE   8  (bases 1 to 7038)
  AUTHORS   Komori,K., Takagi,Y., Sanada,M., Lim,T.H., Nakatsu,Y., Tsuzuki,T.,
            Sekiguchi,M. and Hidaka,M.
  TITLE     A novel protein, MAPO1, that functions in apoptosis triggered by
            O6-methylguanine mispair in DNA
  JOURNAL   Oncogene 28 (8), 1142-1150 (2009)
   PUBMED   19137017
REFERENCE   9  (bases 1 to 7038)
  AUTHORS   Takagi,Y., Kobayashi,T., Shiono,M., Wang,L., Piao,X., Sun,G.,
            Zhang,D., Abe,M., Hagiwara,Y., Takahashi,K. and Hino,O.
  TITLE     Interaction of folliculin (Birt-Hogg-Dube gene product) with a
            novel Fnip1-like (FnipL/Fnip2) protein
  JOURNAL   Oncogene 27 (40), 5339-5347 (2008)
   PUBMED   18663353
REFERENCE   10 (bases 1 to 7038)
  AUTHORS   Hasumi,H., Baba,M., Hong,S.B., Hasumi,Y., Huang,Y., Yao,M.,
            Valera,V.A., Linehan,W.M. and Schmidt,L.S.
  TITLE     Identification and characterization of a novel
            folliculin-interacting protein FNIP2
  JOURNAL   Gene 415 (1-2), 60-67 (2008)
   PUBMED   18403135
  REMARK    GeneRIF: The identification and characterization of a novel FNIP1
            homolog FNIP2 that also interacts with FLCN and AMPK, is reported.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY049314.1, AB040883.1 and
            AC093700.4.
            
            On Oct 23, 2018 this sequence version replaced NM_020840.2.
            
            Summary: This gene encodes a protein that binds to the tumor
            suppressor folliculin and to AMP-activated protein kinase (AMPK),
            and may play a role cellular metabolism and nutrient sensing by
            regulating the AMPK-mechanistic target of rapamycin signaling
            pathway. The encoded protein may also be involved in regulating the
            O6-methylguanine-induced apoptosis signaling pathway. This gene has
            a closely related paralog that encodes a protein with similar
            binding activities. Both related proteins also associate with the
            molecular chaperone heat shock protein-90 (Hsp90) and negatively
            regulate its ATPase activity and facilitate its association with
            folliculin. [provided by RefSeq, Jul 2017].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB040883.1, SRR1803613.268675.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264433.11/ ENSP00000264433.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-112               HY049314.1         33-144
            113-4608            AB040883.1         1-4496
            4609-7038           AC093700.4         6689-9118
FEATURES             Location/Qualifiers
     source          1..7038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.1"
     gene            1..7038
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /note="folliculin interacting protein 2"
                     /db_xref="GeneID:57600"
                     /db_xref="HGNC:HGNC:29280"
                     /db_xref="MIM:612768"
     exon            1..294
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..3532
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     FNIP1-like protein; O6-methylguanine-induced apoptosis 1
                     protein"
                     /codon_start=1
                     /product="folliculin-interacting protein 2 isoform 1"
                     /protein_id="NP_065891.1"
                     /db_xref="CCDS:CCDS47155.1"
                     /db_xref="GeneID:57600"
                     /db_xref="HGNC:HGNC:29280"
                     /db_xref="MIM:612768"
                     /translation="MAPTLLQKLFNKRGSSGSSAAASAQGRAPKEGPAFSWSCSEFDL
                     NEIRLIVYQDCDRRGRQVLFDSKAVQKIEEVTAQKTEDVPIKISAKCCQGSSSVSSSS
                     SSSISSHSSSGGSSHHAKEQLPKYQYTRPASDVNMLGEMMFGSVAMSYKGSTLKIHYI
                     RSPPQLMISKVFSARMGSFCGSTNNLQDSFEYINQDPNLGKLNTNQNSLGPCRTGSNL
                     AHSTPVDMPSRGQNEDRDSGIARSASLSSLLITPFPSPSSSTSSSSSYQRRWLRSQTT
                     SLENGIIPRRSTDETFSLAEETCSSNPAMVRRKKIAISIIFSLCEKEEAQRNFQDFFF
                     SHFPLFESHMNRLKSAIEKAMISCRKIAESSLRVQFYVSRLMEALGEFRGTIWNLYSV
                     PRIAEPVWLTMMSGTLEKNQLCQRFLKEFTLLIEQINKNQFFAALLTAVLTYHLAWVP
                     TVMPVDHPPIKAFSEKRTSQSVNMLAKTHPYNPLWAQLGDLYGAIGSPVRLTRTVVVG
                     KQKDLVQRILYVLTYFLRCSELQENQLTWSGNHGEGDQVLNGSKIITALEKGEVEESE
                     YVVITVRNEPALVPPILPPTAAERHNPWPTGFPECPEGTDSRDLGLKPDKEANRRPEQ
                     GSEACSAGCLGPASDASWKPQNAFCGDEKNKEAPQDGSSRLPSCEVLGAGMKMDQQAV
                     CELLKVEMPTRLPDRSVAWPCPDRHLREKPSLEKVTFQIGSFASPESDFESRMKKMEE
                     RVKACGPSLEASEAADVAQDPQVSRSPFKPGFQENVCCPQNRLSEGDEGESDKGFAED
                     RGSRNDMAADIAGQLSHAADLGTASHGAGGTGGRRLEATRGLYVKAAEGPVLEPVAPR
                     CVQRGPGLVAGANIPCGDDNKKANFRTEGDIPRNESSDSALGDSDDEACASAMLDLGH
                     GGDRTGGSLEVELPLPRSQSISTQNVRNFGRSLLAGYCPTYMPDLVLHGTGSDEKLKQ
                     CLVADLVHTVHHPVLDEPIAEAVCIIADTDKWSVQVATSQRKVTDNMKLGQDVLVSSQ
                     VSSLLQSILQLYKLHLPADFCIMHLEDRLQEMYLKSKMLSEYLRGHTRVHVKELGVVL
                     GIESNDLPLLTAIASTHSPYVAQILL"
     exon            295..421
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            422..568
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            569..669
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            670..741
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            742..842
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..914
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1044
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1045..1246
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1247..1335
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..1482
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1652
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1653..2979
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3136
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3337
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3338..3453
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     exon            3454..7038
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7013..7018
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /note="hexamer: AATAAA"
     polyA_site      7038
                     /gene="FNIP2"
                     /gene_synonym="FNIPL; MAPO1"
                     /note="major polyA site"
ORIGIN      
        1 agtcatatga ccggcagccg gcggctccgg cgccgagcag agttactcag tcgcagcggc
       61 cccgcgctcc cgcaaggctg ggcggccgcg ccgccgcgat ggccccgcca ccgcggccgc
      121 cgcccccggc tgcgcgctga gccgccggcc ccccgagcgc cacggccgga gctgcggcgg
      181 cggcatcatg gccccgaccc tgctccagaa gctcttcaac aaaaggggca gcagcggcag
      241 ctccgcggcg gcgtctgccc agggcagggc tcctaaggaa ggacccgcct ttagttggtc
      301 atgttcggag tttgacctga atgagattcg cctgatagtt taccaggact gtgacaggag
      361 aggcagacaa gtcttgtttg actctaaagc tgttcaaaag attgaggagg tgacagctca
      421 gaaaacagag gatgttccta ttaaaatatc agccaagtgc tgccagggaa gcagcagtgt
      481 cagcagcagt agcagcagca gcatctcttc ccacagttct tctgggggat cttcacatca
      541 tgctaaggaa cagcttccaa agtaccagta cacaagacca gcttccgatg tcaacatgtt
      601 aggggaaatg atgtttggct cagttgccat gagttacaaa ggctccacct taaagataca
      661 ctacatacgt tctcctccac aactgatgat tagtaaagtc ttctctgcta gaatgggcag
      721 cttctgtgga agtacaaata acttgcaaga cagctttgag tacatcaacc aagatcctaa
      781 tttgggaaaa ctgaacacaa atcaaaatag tttgggtcct tgtcgtactg gaagtaacct
      841 agcacacagc acaccagttg atatgccaag cagaggacag aatgaagaca gggacagtgg
      901 cattgctcga tcagcctcac taagcagtct tttgatcaca cctttcccat ctccaagctc
      961 ctctacatct tcttccagca gttaccagcg ccgctggctt cgaagtcaga caacaagttt
     1021 ggaaaatggc atcatcccaa gaaggtcaac tgatgagaca ttcagcttgg ctgaagaaac
     1081 ctgtagctct aatccagcta tggttaggag gaagaaaatt gccataagca tcatcttttc
     1141 cctatgtgag aaagaagaag cacaaaggaa tttccaggac ttcttctttt ctcattttcc
     1201 cctgtttgaa tctcacatga acaggctgaa gagtgcaatt gaaaaggcta tgatctcctg
     1261 taggaaaata gcagaatcaa gtctccgagt ccagttttat gtcagccgtt tgatggaagc
     1321 tctgggagaa ttcagaggaa ctatctggaa cttatattct gttccaagga tagctgaacc
     1381 tgtatggctt actatgatgt ccggcacttt ggaaaaaaac cagctctgcc agcgctttct
     1441 caaggagttt acacttctga tagaacagat aaataaaaac cagttttttg ctgccttact
     1501 gactgcggtg ttaacctacc acctggcctg ggtcccaact gtcatgcctg tggatcaccc
     1561 tcccatcaaa gccttctcag agaaacgtac ctcccagtca gtgaacatgc tggccaaaac
     1621 acatccgtat aatcctcttt gggcacagct gggtgatctt tacggagcca taggctctcc
     1681 agtgagactg actcgcaccg tagtggtagg gaagcagaag gacttagtcc agcgaatact
     1741 ttatgtcctg acctactttc tccgttgctc tgagctacaa gagaaccagc tgacctggag
     1801 tggcaatcat ggtgaaggtg accaagtttt aaatgggagc aagatcataa cagccttgga
     1861 gaaaggagag gtggaggagt ctgagtatgt ggtcattacg gtgaggaacg agcccgctct
     1921 tgtacccccc atcctaccac caacagcagc agagagacac aacccctggc cgacagggtt
     1981 tcctgagtgc ccagagggca ctgacagtag agacctgggt cttaaacctg acaaagaagc
     2041 taacaggagg ccagagcagg gttctgaggc ttgcagcgca gggtgcctgg ggccagcatc
     2101 agacgcttcc tggaaacctc agaatgcatt ttgtggggat gagaaaaata aagaggcacc
     2161 gcaagatggc tcttcaagac ttcccagctg tgaagttttg ggggcaggaa tgaagatgga
     2221 ccagcaagct gtctgtgagc tgttgaaagt ggagatgcct acaagactgc cagaccggtc
     2281 agtggcctgg ccttgccctg acagacatct ccgggagaaa ccttccttag aaaaggtcac
     2341 tttccagatt ggaagctttg catctccaga gtctgacttt gaaagccgca tgaaaaaaat
     2401 ggaggaacgg gtgaaggcct gtggcccctc cttggaggcc agtgaggctg ctgatgtggc
     2461 tcaggacccg caggtttcta ggagcccttt taaacctggc tttcaggaga atgtttgctg
     2521 tcctcagaat cggctttcag agggggatga aggcgagtct gacaagggtt ttgcagagga
     2581 cagaggcagc agaaacgaca tggcagcaga tattgctggg cagctcagcc acgctgctga
     2641 cttgggcaca gcctcccacg gtgcaggagg aacgggaggg aggaggctgg aggccactag
     2701 aggtttgtat gtgaaggctg cggaaggacc tgtgctggag cctgttgccc ccaggtgtgt
     2761 ccagcggggc cctggcctcg tggctggtgc gaatatcccc tgtggggatg acaacaagaa
     2821 ggccaacttc aggactgaag gagacattcc ccgaaatgaa agctcagata gcgccctggg
     2881 agacagtgac gacgaagcct gcgcttcagc catgctagat ctgggtcacg gtggtgacag
     2941 gactggaggg tccttggaag tggagctgcc tctgccaagg tctcagagca tcagcaccca
     3001 gaatgtaagg aactttggcc gctcacttct ggcgggctac tgccccacat acatgcctga
     3061 tcttgtgctt catgggaccg gcagtgatga gaagctgaag cagtgcctgg tggccgacct
     3121 tgtccacaca gtccatcatc cagtcctgga tgagccaata gctgaagctg tctgtattat
     3181 cgcagacacg gataaatgga gtgtgcaggt agctacaagt cagaggaaag tgacggacaa
     3241 catgaaacta ggccaggatg tcctggtctc tagtcaggtg tccagtttgc ttcagtccat
     3301 tttacagctc tataagcttc acctccctgc tgatttttgc atcatgcatc ttgaagatag
     3361 actacaggag atgtacctta aaagtaaaat gctatctgaa tatctccggg gacacacacg
     3421 agtccatgtg aaagaattag gtgtcgtact ggggattgaa tccaacgacc tgcctctgtt
     3481 gactgctatt gccagtactc attctcctta tgtggctcaa atactcttat aagctaaagc
     3541 tcaggacagt tcttccttgg aagaaaaaaa tcaaattctc aactgaagga gaaaggaata
     3601 agctctctgt gatgtcaaaa gcatgagaag agcaaacaga aacagtcatt ccaccttttt
     3661 gttttgtgtt tttgctgtca agctgatgct tcattgaaga cttaggttta cttgacataa
     3721 tagcatttgt gattgtcgtg aacactttag gccatttgtt acccatgaat caacaaagaa
     3781 actgaccttt ttggtaggag gaaacataag cactaaacac taagctgttg caacagattg
     3841 ccttgtgctg tttgggcaga ataaagacaa gtgacttgag cggggtggtc agcagtgtac
     3901 ataatattcc agtaggaaac tgcttccaag tttaagcatg agctccccaa actggagaaa
     3961 acatattttg ctattctgag acaacaatca gaatacagac tttggattcc aggtcacagt
     4021 ttgcttttta gacaaggtaa agcaaagaaa gccacattgt gccatcttca gctccagtgg
     4081 ctttagcagt gactgtttga cataaaacat gtaagaattg cttgttggga agagtgcttt
     4141 agggacccac tgttttcatt tcttcttgga gtttaccttg tttcagatgc agccatgggt
     4201 aggtcagaga tggattgttg gtgcaataaa cccaagaatc aatgtagcct cttaatccca
     4261 tcaagatgta gtttgtagca gcaaagtgta cagtctgaaa ccgtatgttt tatccttata
     4321 ttttagagct ttcagcagcc tttttaagag aggccactta ccaaagttat ttctataagc
     4381 tcaagagtgt ttcggttggt aagttcttcc agctgaagcc actttttcct tatagttaat
     4441 acaaatgact atttttactt taaaaggcac agctgtcctg gtgggaaatg aaacctgcag
     4501 cagttcagga tgactaatga aagcaattag cttgaacatt tagaaaaaat tcatatatga
     4561 tctaaatttt tatattatca tttctgtgcc ttctaattcc tgcatccttt tcaaaacatc
     4621 tttccagaca ttaacttaca cattgtataa aaccgaccaa aatgatttcc taaagttcat
     4681 gcaaaaaaaa aaaaaaaaca acctaatttt ctgttaatat aaaagaaact tcagtttact
     4741 gaccgtgaaa cagactatgt actgacatcc agggtaaagt aaaagacttt taaatattgg
     4801 tcattaaagg acaggagcta agctagcaaa gcaaaacatc tttagcactt tgcagatctc
     4861 aagcagttaa ccaggctctg attcccttcc actgttttat gaattaattc cagttctttt
     4921 catgtatctt tgaacctaag attatgaagt aatttcccta ttagggacta gaatgacttc
     4981 agttttttca tttgataaaa atcagaactg ctacctttcc cttttttaat gatgcaaaat
     5041 gtagatgagt gcattaagtt ttgtaagatc tttatcattt tatgtcattc attgaaaatt
     5101 gaaatgttca ttctttttaa tgttttccta tttccttttg cctagcattt gactttggtg
     5161 ttttaagttc tgtagttcca tgacatcatt gtttgctgtt gtgttacaga gagagaagga
     5221 acctcacctg tggctcagct caccccacat ccgtttctca ttacgtgtaa ataaactgtc
     5281 agagctgatg ttacagcttt tacagtttaa agcattcccc tcgtctctag ttcctttttt
     5341 cttgtttaca tgttttgggc actttccctc attcaccacc ttccagggtt tcatagaaaa
     5401 taacttgtta caaaatcagt tcaattctaa tgtggacata gtggcatgtt cataattaga
     5461 cccatatagg ggacactgag ctttaaatcg ttgattctaa actctataca ttaaaaaaat
     5521 tcagcccagg cccctcaaag cctgagaaaa tttaatttgc tcttaattta atgttccaaa
     5581 actcactctt ggaaaaatgc ctgttggaaa actacaggtg ggtcacatgt gggggctgtc
     5641 tccgtgacac tcaggattcc agtcagaacc taatcctcat atctattgcc tacaaaaata
     5701 gaccaagaat gttgctgctc ttttataatc ctttaaatat ttaacattca agttttcttt
     5761 gtcttaaatt cagcctcttc ctaaaagcaa aaaagaaaaa aaaaacctca cagaattgtg
     5821 ttgagatcca ccgctcacac gccgtacacc acccagtggc ttcattctgg cttagccgca
     5881 gaggcaagaa agggacccca cttgctccca tgcccacctc aagaaaaaac ataaaacaat
     5941 tttttttaaa aaagaaaaga aatctacctc agttgacagg attccacctt tagggtttct
     6001 tcaactttta agtcttacct gttgagtgta acttttgtag catcttgctt ttccaagcaa
     6061 gctagtgagg catgacagag cagaagtctg taaatgtccc tgtgatggac ctctttctag
     6121 catgttgcag ttttattttt aataaattgg taagtgaaat gaatgtaaag gtaattgtgt
     6181 acgttttaga catgacaatg aaaatttaaa atgtagcttc catacttgtg cataattcca
     6241 aagtatttta ttttttatca atcagtgtta aatagctttt tgtacaggct tcaatccatt
     6301 tttcgaagtg tgctgttttt taatgaaagt aactataatc ttttcacatc ccatggaact
     6361 gccgtttaca cattgcaact ttttaaactt aaccatattt ttcaaaatta acgtttttgg
     6421 agggagaaaa atccccgctt gctaaatgat actaaaccgt tgtttgggct cttataatta
     6481 ggtcctgaga ttttataaaa atttagtctg tagcttttta ggttcttcac tagagttggt
     6541 tgtacataaa aataataaag aatataaagt atcccaaaat tcttttaaag tctggatttt
     6601 tccgctaata tgtactttag agaatatttt gttcatgcat acttccacgt taaattgaaa
     6661 atgtcttcag cttctcttgg taaatgtgaa ccatttgttt tttattgtgc ttgggggaga
     6721 gggtatttta atataatttt tgcctaaatc aagaagtccc ctctgaatgt taatttttaa
     6781 atgtcaaaat atgatgaacg atatatcttg aaagtgagat tgcaatatgc ttaaacttaa
     6841 gtggtatttc aaaaacgaga aaattctgga atttgtcatt tgaagctcca taagagaaat
     6901 tgataggact tcgtttttga tcagtctgaa tagataccaa tgtcattgtg tgggaatttt
     6961 ttttaacttg tttatgtatt attttgatcc atttttctgt ggcatttggt gcaataaaac
     7021 ttttgaattt atcttgaa
//
