LOCUS       NM_133372               6568 bp    mRNA    linear   PRI 17-JUN-2024
DEFINITION  Homo sapiens folliculin interacting protein 1 (FNIP1), transcript
            variant 1, mRNA.
ACCESSION   NM_133372
VERSION     NM_133372.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6568)
  AUTHORS   Mao,Y., Jin,Z., Yang,J., Xu,D., Zhao,L., Kiram,A., Yin,Y., Zhou,D.,
            Sun,Z., Xiao,L., Zhou,Z., Yang,L., Fu,T., Xu,Z., Jia,Y., Chen,X.,
            Niu,F.N., Li,X., Zhu,Z. and Gan,Z.
  TITLE     Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is
            associated with bone metabolism in human and mouse
  JOURNAL   Sci Transl Med 16 (750), eadk9811 (2024)
   PUBMED   38838134
  REMARK    GeneRIF: Muscle-bone cross-talk through the FNIP1-TFEB-IGF2 axis is
            associated with bone metabolism in human and mouse.
REFERENCE   2  (bases 1 to 6568)
  AUTHORS   Xia,L., Nie,T., Lu,F., Huang,L., Shi,X., Ren,D., Lu,J., Li,X.,
            Xu,T., Cui,B., Wang,Q., Gao,G. and Yang,Q.
  TITLE     Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1
            activation and tumor progression in pancreatic cancer
  JOURNAL   Autophagy 20 (3), 505-524 (2024)
   PUBMED   37772772
  REMARK    GeneRIF: Direct regulation of FNIP1 and FNIP2 by MEF2 sustains
            MTORC1 activation and tumor progression in pancreatic cancer.
REFERENCE   3  (bases 1 to 6568)
  AUTHORS   Malik,N., Ferreira,B.I., Hollstein,P.E., Curtis,S.D., Trefts,E.,
            Weiser Novak,S., Yu,J., Gilson,R., Hellberg,K., Fang,L.,
            Sheridan,A., Hah,N., Shadel,G.S., Manor,U. and Shaw,R.J.
  TITLE     Induction of lysosomal and mitochondrial biogenesis by AMPK
            phosphorylation of FNIP1
  JOURNAL   Science 380 (6642), eabj5559 (2023)
   PUBMED   37079666
  REMARK    GeneRIF: Induction of lysosomal and mitochondrial biogenesis by
            AMPK phosphorylation of FNIP1.
REFERENCE   4  (bases 1 to 6568)
  AUTHORS   van de Beek,I., Glykofridis,I.E., Tanck,M.W.T., Luijten,M.N.H.,
            Starink,T.M., Balk,J.A., Johannesma,P.C., Hennekam,E., van den
            Hoff,M.J.B., Gunst,Q.D., Gille,J.J.P., Polstra,A.M., Postmus,P.E.,
            van Steensel,M.A.M., Postma,A.V., Wolthuis,R.M.F., Menko,F.H.,
            Houweling,A.C. and Waisfisz,Q.
  TITLE     Familial multiple discoid fibromas is linked to a locus on
            chromosome 5 including the FNIP1 gene
  JOURNAL   J Hum Genet 68 (4), 273-279 (2023)
   PUBMED   36599954
  REMARK    GeneRIF: Familial multiple discoid fibromas is linked to a locus on
            chromosome 5 including the FNIP1 gene.
REFERENCE   5  (bases 1 to 6568)
  AUTHORS   Woodford,M.R., Dunn,D.M., Blanden,A.R., Capriotti,D., Loiselle,D.,
            Prodromou,C., Panaretou,B., Hughes,P.F., Smith,A., Ackerman,W.,
            Haystead,T.A., Loh,S.N., Bourboulia,D., Schmidt,L.S., Marston
            Linehan,W., Bratslavsky,G. and Mollapour,M.
  TITLE     The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and
            enhance drug binding
  JOURNAL   Nat Commun 7, 12037 (2016)
   PUBMED   27353360
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6568)
  AUTHORS   Wang,L., Kobayashi,T., Piao,X., Shiono,M., Takagi,Y., Mineki,R.,
            Taka,H., Zhang,D., Abe,M., Sun,G., Hagiwara,Y., Okimoto,K.,
            Matsumoto,I., Kouchi,M. and Hino,O.
  TITLE     Serine 62 is a phosphorylation site in folliculin, the
            Birt-Hogg-Dube gene product
  JOURNAL   FEBS Lett 584 (1), 39-43 (2010)
   PUBMED   19914239
REFERENCE   7  (bases 1 to 6568)
  AUTHORS   Edwards,T.L., Wang,X., Chen,Q., Wormly,B., Riley,B., O'Neill,F.A.,
            Walsh,D., Ritchie,M.D., Kendler,K.S. and Chen,X.
  TITLE     Interaction between interleukin 3 and dystrobrevin-binding protein
            1 in schizophrenia
  JOURNAL   Schizophr Res 106 (2-3), 208-217 (2008)
   PUBMED   18804346
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   8  (bases 1 to 6568)
  AUTHORS   Takagi,Y., Kobayashi,T., Shiono,M., Wang,L., Piao,X., Sun,G.,
            Zhang,D., Abe,M., Hagiwara,Y., Takahashi,K. and Hino,O.
  TITLE     Interaction of folliculin (Birt-Hogg-Dube gene product) with a
            novel Fnip1-like (FnipL/Fnip2) protein
  JOURNAL   Oncogene 27 (40), 5339-5347 (2008)
   PUBMED   18663353
REFERENCE   9  (bases 1 to 6568)
  AUTHORS   Hasumi,H., Baba,M., Hong,S.B., Hasumi,Y., Huang,Y., Yao,M.,
            Valera,V.A., Linehan,W.M. and Schmidt,L.S.
  TITLE     Identification and characterization of a novel
            folliculin-interacting protein FNIP2
  JOURNAL   Gene 415 (1-2), 60-67 (2008)
   PUBMED   18403135
REFERENCE   10 (bases 1 to 6568)
  AUTHORS   Baba,M., Hong,S.B., Sharma,N., Warren,M.B., Nickerson,M.L.,
            Iwamatsu,A., Esposito,D., Gillette,W.K., Hopkins,R.F. 3rd,
            Hartley,J.L., Furihata,M., Oishi,S., Zhen,W., Burke,T.R. Jr.,
            Linehan,W.M., Schmidt,L.S. and Zbar,B.
  TITLE     Folliculin encoded by the BHD gene interacts with a binding
            protein, FNIP1, and AMPK, and is involved in AMPK and mTOR
            signaling
  JOURNAL   Proc Natl Acad Sci U S A 103 (42), 15552-15557 (2006)
   PUBMED   17028174
  REMARK    GeneRIF: Results suggest that FLCN, mutated in Birt-Hogg-Dube
            syndrome, and its interacting partner FNIP1 may be involved in
            energy and/or nutrient sensing through the AMPK and mTOR signaling
            pathways.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005593.1 and AC008695.9.
            
            On Nov 23, 2018 this sequence version replaced NM_133372.2.
            
            Summary: This gene encodes a protein that binds to the tumor
            suppressor protein folliculin and to AMP-activated protein kinase
            (AMPK). The encoded protein participates in the regulation of
            cellular metabolism and nutrient sensing by modulating the AMPK and
            target of rapamycin signaling pathways. This gene has a closely
            related paralog that encodes a protein with similar binding
            activities. Both related proteins also associate with the molecular
            chaperone heat shock protein-90 (Hsp90) and negatively regulate its
            ATPase activity and facilitate its association with folliculin.
            [provided by RefSeq, Jul 2017].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292473.1, SRR1660805.102209.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000510461.6/ ENSP00000421985.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-188               AC005593.1         77589-77776         c
            189-315             AC005593.1         25323-25449         c
            316-450             AC005593.1         11663-11797         c
            451-551             AC008695.9         143022-143122       c
            552-626             AC008695.9         142691-142765       c
            627-718             AC008695.9         140270-140361       c
            719-802             AC008695.9         134283-134366       c
            803-874             AC008695.9         132906-132977       c
            875-1010            AC008695.9         130116-130251       c
            1011-1212           AC008695.9         127770-127971       c
            1213-1298           AC008695.9         122622-122707       c
            1299-1445           AC008695.9         102734-102880       c
            1446-1615           AC008695.9         101408-101577       c
            1616-3035           AC008695.9         95210-96629         c
            3036-3204           AC008695.9         94168-94336         c
            3205-3402           AC008695.9         75507-75704         c
            3403-3518           AC008695.9         70795-70910         c
            3519-6568           AC008695.9         65419-68468         c
FEATURES             Location/Qualifiers
     source          1..6568
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q31.1"
     gene            1..6568
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /note="folliculin interacting protein 1"
                     /db_xref="GeneID:96459"
                     /db_xref="HGNC:HGNC:29418"
                     /db_xref="MIM:610594"
     exon            1..188
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..3597
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="folliculin-interacting protein 1 isoform 1"
                     /protein_id="NP_588613.3"
                     /db_xref="CCDS:CCDS34227.1"
                     /db_xref="GeneID:96459"
                     /db_xref="HGNC:HGNC:29418"
                     /db_xref="MIM:610594"
                     /translation="MAPTLFQKLFSKRTGLGAPGRDARDPDCGFSWPLPEFDPSQIRL
                     IVYQDCERRGRNVLFDSSVKRRNEDISVSKLGSDAQVKVFGKCCQLKPGGDSSSSLDS
                     SVTSSSDIKDQCLKYQGSRCSSDANMLGEMMFGSVAMSYKGSTLKIHQIRSPPQLMLS
                     KVFTARTGSSICGSLNTLQDSLEFINQDNNTLKADNNTVINGLLGNIGLSQFCSPRRA
                     FSEQGPLRLIRSASFFAVHSNPMDMPGRELNEDRDSGIARSASLSSLLITPFPSPNSS
                     LTRSCASSYQRRWRRSQTTSLENGVFPRWSIEESFNLSDESCGPNPGIVRKKKIAIGV
                     IFSLSKDEDENNKFNEFFFSHFPLFESHMNKLKSAIEQAMKMSRRSADASQRSLAYNR
                     IVDALNEFRTTICNLYTMPRIGEPVWLTMMSGTPEKNHLCYRFMKEFTFLMENASKNQ
                     FLPALITAVLTNHLAWVPTVMPNGQPPIKIFLEKHSSQSVDMLAKTHPYNPLWAQLGD
                     LYGAIGSPVRLARTVVVGKRQDMVQRLLYFLTYFIRCSELQETHLLENGEDEAIVMPG
                     TVITTTLEKGEIEESEYVLVTMHRNKSSLLFKESEEIRTPNCNCKYCSHPLLGQNVEN
                     ISQQEREDIQNSSKELLGISDECQMISPSDCQEENAVDVKQYRDKLRTCFDAKLETVV
                     CTGSVPVDKCALSESGLESTEETWQSEKLLDSDSHTGKAMRSTGMVVEKKPPDKIVPA
                     SFSCEAAQTKVTFLIGDSMSPDSDTELRSQAVVDQITRHHTKPLKEERGAIDQHQETK
                     QTTKDQSGESDTQNMVSEEPCELPCWNHSDPESMSLFDEYFNDDSIETRTIDDVPFKT
                     STDSKDHCCMLEFSKILCTKNNKQNNEFCKCIETVPQDSCKTCFPQQDQRDTLSILVP
                     HGDKESSDKKIAVGTEWDIPRNESSDSALGDSESEDTGHDMTRQVSSYYGGEQEDWAE
                     EDEIPFPGSKLIEVSAVQPNIANFGRSLLGGYCSSYVPDFVLQGIGSDERFRQCLMSD
                     LSHAVQHPVLDEPIAEAVCIIADMDKWTVQVASSQRRVTDNKLGKEVLVSSLVSNLLH
                     STLQLYKHNLSPNFCVMHLEDRLQELYFKSKMLSEYLRGQMRVHVKELGVVLGIESSD
                     LPLLAAVASTHSPYVAQILL"
     exon            189..315
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            316..450
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            451..551
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            552..626
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            627..718
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            719..802
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            803..874
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1010
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1011..1212
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1298
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1445
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1615
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..3035
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3204
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            3205..3402
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            3403..3518
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     exon            3519..6568
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6546..6551
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /note="hexamer: AATAAA"
     polyA_site      6568
                     /gene="FNIP1"
                     /gene_synonym="IMD93"
                     /note="major polyA site"
ORIGIN      
        1 atatgactga ggcgcccatg ggggtggcgg ggcggctgta ggagcagggg cctagcaagc
       61 gcccagcgga gcgacccctg cctggccgtg gctagcatgg cccctacgct gttccagaag
      121 ctcttcagca agaggaccgg gctgggcgcg cccggccgcg acgcccggga cccagattgc
      181 gggttcagtt ggcctttacc agagtttgat ccaagccaga ttcgactgat tgtatatcaa
      241 gactgtgaaa gacgagggag aaatgttttg tttgactcca gtgttaagag aagaaatgag
      301 gacatatcag tatcgaaact cggcagtgat gctcaagtta aagtctttgg gaaatgctgc
      361 caactgaaac ctggaggaga cagttcttcc tctttagata gttctgtgac ttcatcttct
      421 gatataaaag accagtgtct taagtaccag ggttctcggt gctcttctga tgccaatatg
      481 cttggagaga tgatgtttgg ctcagtagca atgagctaca aaggatccac cttaaaaatt
      541 catcagattc gttcccctcc acagctcatg ctcagcaaag tgtttactgc tcggactggc
      601 agcagtattt gtgggagtct caatacgcta caagatagtc ttgaattcat caatcaggac
      661 aacaatacat taaaggctga taataacaca gttattaatg gactgcttgg aaatataggt
      721 ctttcacagt tctgcagccc caggcgggca ttctctgagc agggtccgct ccgcctgatc
      781 aggagcgcct ctttctttgc agttcacagc aacccaatgg acatgcctgg aagagagctc
      841 aatgaggaca gagacagtgg catagcacgg tctgcatctc tcagcagctt gctgatcact
      901 ccatttcctt ccccaaactc ctcacttacc cgaagttgtg ccagcagcta ccagcgacgt
      961 tggcgacgca gccaaacaac aagtttggaa aatggggtat ttcctagatg gtctatagaa
     1021 gaaagcttta atctctcaga tgaaagctgt ggccctaacc caggaattgt gcggaaaaag
     1081 aagattgcaa ttggggtaat cttttcattg tccaaagatg aagatgaaaa taacaaattt
     1141 aatgaattct ttttttcaca ttttcctctc tttgaaagcc acatgaacaa attaaagagt
     1201 gcaatagaac aggctatgaa aatgagccgg agatcagctg atgccagtca gagaagtttg
     1261 gcatataatc gaatagttga tgccctaaat gaattcagaa caacaatttg taatctttac
     1321 acgatgccac gaattggaga acctgtctgg cttacaatga tgtcggggac tccagaaaag
     1381 aaccaccttt gctatcgttt catgaaggag ttcacctttc taatggaaaa tgcttccaaa
     1441 aatcaattct tgccagctct cattactgca gttctgacca atcatcttgc ctgggttcca
     1501 acagtcatgc caaatggaca accacctata aaaatatttt tagaaaagca ttcctctcag
     1561 agtgtggaca tgttggcaaa gactcatcca tataacccac tttgggcaca actgggagac
     1621 ttgtatggcg ctattggctc tcccgtacgg ttagcaagga ctgtggtagt tggcaaacga
     1681 caagacatgg tccagaggct actttatttt cttacttatt ttataagatg ctctgaactt
     1741 caagaaacgc atcttttaga aaatggagaa gatgaagcca tcgttatgcc aggcacagta
     1801 attactacca ctttagagaa aggtgaaata gaagaatcag agtatgtcct tgtcacaatg
     1861 catagaaaca aaagcagttt gctctttaaa gagtcagaag aaattagaac tcccaattgt
     1921 aactgtaaat attgcagtca tccactcctt gggcaaaatg tagagaacat ttcacaacaa
     1981 gagagagaag atattcaaaa cagctctaag gagctgctag gaatttcaga tgagtgccag
     2041 atgatttctc cttctgactg ccaagaagaa aatgctgttg atgttaaaca gtacagagat
     2101 aaattaagaa cttgctttga cgccaagtta gagacagttg tttgcacagg atctgttcca
     2161 gtagacaaat gtgcattgtc agagtcaggc ttagagtcaa cagaggaaac atggcagagt
     2221 gagaagttgc tggattcaga cagtcacaca ggcaaagcaa tgagatccac aggaatggtt
     2281 gtggaaaaaa aacctccaga taagattgtg cctgcttcat tttcttgtga ggctgcccag
     2341 acaaaggtta ctttcctgat tggggattct atgtcacctg attcagatac tgagcttcga
     2401 agtcaggcag tggtggatca gattaccaga catcacacca aaccattgaa ggaagaaaga
     2461 ggggctattg atcagcatca agaaactaaa caaacaacca aggaccaatc tggagagtct
     2521 gatacacaga acatggtttc tgaagagccc tgtgaacttc cctgttggaa tcattcagac
     2581 ccagaaagca tgagcttatt cgacgaatat tttaatgatg attcaatcga aaccaggact
     2641 attgatgatg ttccatttaa aacaagtaca gatagtaaag accattgctg tatgttagag
     2701 ttttcaaaaa tattgtgtac aaaaaataac aagcagaaca atgaattttg taaatgtata
     2761 gaaacagttc cccaagattc atgtaaaacc tgctttcctc agcaggacca aagagataca
     2821 ctctccattc ttgtccccca tggggataaa gagagttcag ataaaaaaat tgctgtagga
     2881 actgaatggg acattccaag aaatgaaagt tcagacagtg cccttgggga tagtgaaagt
     2941 gaagatacag gtcatgatat gactagacaa gttagcagtt attatggagg agagcaagaa
     3001 gattgggcag aagaggatga gatacctttt cctgggtcaa agttaatcga agtgagtgct
     3061 gttcagccca acattgccaa cttcgggagg tccttgctgg gtggctactg ctcatcttat
     3121 gtgcctgact ttgttcttca aggaattggg agtgatgaga ggttccgtca gtgtctgatg
     3181 tcagatttat ctcatgctgt gcagcatcca gttttggatg aaccaatagc agaagctgtc
     3241 tgtattatag ctgacatgga taaatggact gttcaagtgg ccagtagcca gagacgagtg
     3301 acagataata aattgggaaa ggaagtattg gtttccagtc ttgtttccaa tctgcttcat
     3361 tccacacttc agctttataa gcataacttg tctccaaatt tttgtgtaat gcatcttgaa
     3421 gaccggttgc aggagctata cttcaaaagt aaaatgctgt ctgaatacct gagggggcag
     3481 atgcgtgttc atgtcaagga gctgggagtg gttctgggga ttgaatccag tgatcttcca
     3541 cttctggctg ctgtagcaag cactcactct ccatatgttg cacaaatact cctttaatat
     3601 acctaaaaat tgttagaaat tggtgggaaa ataggtagaa accaaggaag cagacacaac
     3661 atgcatttat ggagattctt tttccctttt agacttccat ctgaatgagt cagtcaccag
     3721 ggtattctgc atagcattgt atattctgtg tatgtcagat ggctttttct ttttgactgg
     3781 acttttgggt ggtggtagat ttttaaacaa atgaaattaa agcaacaata attttgaagc
     3841 atttgaaaaa gccaaagtgt acggtagaaa tttctacaaa atgaatatta tcaagagttt
     3901 catgtgatca ctgcagtgtt gtcacagctc ataaatagca acagtgtctc atgatttaat
     3961 ggctcagaaa tagttattca ttagttttta atttttaatt tctaaggtac agagatctat
     4021 aaaaccttga ttatttgtta gttttgcaat tcaaaacagc taatgtctgg ttatttctca
     4081 aagtaagtat tttaaacagc ctgttaatta taagaaactc agaataatga gtgtaaatgt
     4141 gttatgttat ccacccaagt gtacatatgt acctattttt ttttaaaaag cagaaataga
     4201 aatacaagac tggtaaacat gcctttaaaa atatatatat tttcaactag tattgtctat
     4261 aatgctgaaa tattacttat tggtgatttt tctgtttcac acactctaaa atataagtaa
     4321 agccaacctt ttttttaagg ctgagattcc caaaatgaga atactacttt ataccatttg
     4381 tttataagta tgaactgttc ttataaatat taatatttac atattcacta atttaacata
     4441 aatgaaaatt aggattaaaa attgcaccaa agcatcggca aaaacaatac tatattcttt
     4501 aaaagtgctc aggtagccaa ggcccttgct tttggtatca accctcatga acccatagga
     4561 gctgaatatt tgtttcactg cttaataatc ctcaatttac actattcata actcttaaaa
     4621 ttattctctt tttttctaag agtccctccc ttccaaaagt gtattttttt caaagatttt
     4681 cacttctcaa ttgttgcctt tgtacatact atagagtgtt gcttgtaaga aaggctaata
     4741 tggaaccaaa ctcttgtaag taatgtaaat agaaaggtgg gtggataaag ttttcaatac
     4801 tttctactac ctcagtttac ttgagtacta cattatagtt tattctttgc ttatctggtc
     4861 taagagactt ttaatgctag tagtaaagtt ggtttctgct ttcattgact attttcatca
     4921 taatttcatc attgattaaa aaaagaaaac cacttgttta ttcagttatt aaatatattt
     4981 actatataac acatccattc ttgctgttta aattttcaat agttaatgga aagttgtctt
     5041 tgaccttgaa tttacagcat tgggtcacat tttgccttgc tgtgtatgta ttcaagagac
     5101 ttccaactag acaaagaaaa aattgttgtt ttaatggaat gtaaacctga aattggtgtg
     5161 tctgcaatct gtttggccca tgacctttta cctagtccca gttattacct gagtctccca
     5221 tggatgactt gctgccaagg agtgtttgtg gatatatttt ctttggctta attttcttat
     5281 tctgtgcatt aacaaaatta tccagttgtc tgattttgga attctatgag tcaatctttt
     5341 tggcagaatt cagaatatta aaaagttcat acatttgcgg gccattgtac cttttttttt
     5401 tttttttttt ttttgacgga gtttcactct tgttacccag gctggagtgc aatggtgcga
     5461 tctcagctca ctgcaacctc cgcctcccag ttcaagtgat tctcctgcct cagcccccaa
     5521 gtagctggga ttacaagtgt gcgccaccac acccagctaa ttttttattt ttagtagaga
     5581 tgagatttca ccatgtgttg gtcaggctgg tcttgaactc ctgaactcaa gtgatccacc
     5641 tgcctcgacc tcccaaagta ctgggattac aggcgtgagc cactgtgccc agccttgtac
     5701 tttttttttt ttttattgta gctctgtata gcacttggat aatgtctggg tgtctcctta
     5761 accatcaaac tgttctttat ttaaaatgtt taattaccgt ttagaaattc tagtcctcaa
     5821 taagtgggtg gctcatgcta ttgttgttcc taaagctaag ctttgctggg aaggaaatga
     5881 cctatagttt cttaaagaat cattaatcct tataggattc ctgagttact gttttgttcc
     5941 tccccactgc ttcccattcc tgagttttgt aattcctaat ccttctataa tttctattac
     6001 cttcaccata gtcattcttt ccttacgcaa agcccaagga atgagctgct gctactttaa
     6061 agtgtggtca ttatgatgaa tgtgaaaaga gttttggctt gttctaaata atttttacaa
     6121 gttatggtac agacagttgt tacatatcaa aaaaaacctg tttattgaaa caggaaataa
     6181 aaaagggatc ttttacatta tagaattaaa actaattttt tcttgtatat aaactaattg
     6241 gtttgatttt aaatatttct ggcttttatt aatatgtctt aattttgagt ttgaaaatgt
     6301 taagtgcaat aaaaacatac tagtacagat tttgttttgt tccaattggc atactctggg
     6361 gatgatcact taaaaaaaca gattttacat aatgcctact tctggtagat gtcttatgag
     6421 attgttctgc tttttctaag ttacttagat gttggatatg tacatagctg tttcttgttc
     6481 tgtatacatt tctcaaatgt acacttgtat tataataacc tcccagttct aggggatatt
     6541 tgtgcaataa atacacatgt caacttga
//
