LOCUS       NM_017559               1352 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens fibronectin type III domain containing 8 (FNDC8),
            mRNA.
ACCESSION   NM_017559
VERSION     NM_017559.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1352)
  AUTHORS   Jiang,H., Chu,B.L., He,J., Liu,Z. and Yang,L.
  TITLE     Expression and prognosis analyses of the fibronectin type-III
            domain-containing (FNDC) protein family in human cancers: A Review
  JOURNAL   Medicine (Baltimore) 101 (49), e31854 (2022)
   PUBMED   36626432
  REMARK    Review article
REFERENCE   2  (bases 1 to 1352)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1352)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1352)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK313775.1, AL133054.1 and BC024002.2.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_017559.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.254302.1,
                                           SRR5189667.59474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000158009.6/ ENSP00000158009.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                AK313775.1         37-82
            47-1345             AL133054.1         1-1299
            1346-1352           BC024002.2         1330-1336
FEATURES             Location/Qualifiers
     source          1..1352
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1352
                     /gene="FNDC8"
                     /note="fibronectin type III domain containing 8"
                     /db_xref="GeneID:54752"
                     /db_xref="HGNC:HGNC:25286"
     exon            1..288
                     /gene="FNDC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1054
                     /gene="FNDC8"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein
                     8"
                     /protein_id="NP_060029.1"
                     /db_xref="CCDS:CCDS11290.1"
                     /db_xref="GeneID:54752"
                     /db_xref="HGNC:HGNC:25286"
                     /translation="MASEALHQVGDGEEAVLKKENFNMMNALDQLPKPFSNPKSMNRT
                     VTTKGLPLASKGNLVNFLEDDTINLLKPLPVEDSDCSSDETSISAFSSTLLNPIKLAV
                     TQPNSSFFAGMLEGELNKLSFSPMAKNAENEDLALGPCPCPSKSQMATRGLLDLDNPE
                     LETETSSTHSESSVVVDLPDTPFIFEHTVNNSTAVISWTYALGKQPVSFYQLLLQEVA
                     KTQENELPEAKNRPWIFNKILGTTVKLMELKPNTCYCLSVRAANTAGVGKWCKPYKFA
                     TLATDFSSFPENYPIQITVRRKEPRQKIVSIGPEEMRRLEDLEYLFPC"
     exon            289..664
                     /gene="FNDC8"
                     /inference="alignment:Splign:2.1.0"
     exon            665..901
                     /gene="FNDC8"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1352
                     /gene="FNDC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1327..1332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNDC8"
                     /note="hexamer: ATTAAA"
     polyA_site      1352
                     /gene="FNDC8"
                     /note="major polyA site"
ORIGIN      
        1 actgccccca cagtttctct ctgcttctgg tcagctgggt tgtcctgcat ggtgacgggt
       61 gtcatcccga acaaatcaga tggcatcaga ggcactccat caagtgggag atggggagga
      121 ggctgtactg aagaaagaaa acttcaacat gatgaatgcc cttgaccaac tgccaaaacc
      181 cttttcaaac cccaagtcta tgaaccggac cgtcactacc aaaggactcc cactagcctc
      241 aaagggcaat ttggtcaact tcttggagga tgataccatc aacctactga agccgctgcc
      301 agtagaggat tcagactgca gctctgatga gaccagcatc tctgccttct catccacctt
      361 gctgaacccc atcaaattag ctgtgaccca gcccaacagc agcttctttg cagggatgct
      421 ggagggggag ctgaacaaac tcagcttctc cccaatggcc aagaatgcag aaaatgagga
      481 cctggcgctc ggcccctgcc catgcccatc gaagtcccag atggccacaa ggggcctgct
      541 ggaccttgac aaccctgagc tggagacaga aacctcctca acgcactcag aatcttctgt
      601 ggttgtggac ctgccggaca cccccttcat ctttgagcac accgtcaaca attccacagc
      661 tgtgatttcc tggacctacg ccttgggcaa gcagccggtc agtttctacc agctcctgtt
      721 acaggaggtg gccaagacac aggagaatga gttgcccgag gcaaagaatc gtccatggat
      781 cttcaacaag attttgggca ctactgtcaa gctgatggag ctaaagccta acacgtgtta
      841 ctgcctcagt gtccgtgcag ccaacacagc tggggtgggg aagtggtgca agccctacaa
      901 atttgcaacc ctggccactg acttcagcag ctttcctgag aactacccca tccagatcac
      961 cgtgcggcgc aaggaacccc ggcaaaagat cgtgtccatc gggccggagg agatgcggag
     1021 gctggaggat ctggaatacc tatttccctg ttaaggggga gggccccagg acacccctca
     1081 cctactttca gcttcaaccc caggccctca gaaaccagag ccatgagacc taccatacca
     1141 ccagcaccct gcgggcccgg ggtctggcag agtggtatgg gcaccccacc cctgggctgg
     1201 ggccaaggct acataggggc cccattcacc tggaggcatc tcaggccagg ccatgccagg
     1261 ctcagccact gcccacagct gctagactcc ctcctcctcc aaatctgggc tgggtctagg
     1321 tccctcatta aagaactgca ggtcatccag ca
//
