LOCUS       NM_022823               1612 bp    mRNA    linear   PRI 11-SEP-2024
DEFINITION  Homo sapiens fibronectin type III domain containing 4 (FNDC4),
            mRNA.
ACCESSION   NM_022823
VERSION     NM_022823.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1612)
  AUTHORS   Neira,G., Becerril,S., Valenti,V., Moncada,R., Catalan,V.,
            Gomez-Ambrosi,J., Colina,I., Silva,C., Escalada,J., Fruhbeck,G. and
            Rodriguez,A.
  TITLE     FNDC4 reduces hepatocyte inflammatory cell death via AMPKalpha in
            metabolic dysfunction-associated steatotic liver disease
  JOURNAL   Clin Nutr 43 (9), 2221-2233 (2024)
   PUBMED   39173437
  REMARK    GeneRIF: FNDC4 reduces hepatocyte inflammatory cell death via
            AMPKalpha in metabolic dysfunction-associated steatotic liver
            disease.
REFERENCE   2  (bases 1 to 1612)
  AUTHORS   Xiao,C., Xie,S. and Ouyang,S.
  TITLE     FNDC4 reduces inflammation, proliferation, invasion and migration
            of rheumatoid synovial cells by inhibiting CCL2/ERK signaling
  JOURNAL   Tissue Cell 86, 102294 (2024)
   PUBMED   38181585
  REMARK    GeneRIF: FNDC4 reduces inflammation, proliferation, invasion and
            migration of rheumatoid synovial cells by inhibiting CCL2/ERK
            signaling.
REFERENCE   3  (bases 1 to 1612)
  AUTHORS   Daudon,M., Bigot,Y., Dupont,J. and Price,C.A.
  TITLE     Irisin and the fibronectin type III domain-containing family:
            structure, signaling and role in female reproduction
  JOURNAL   Reproduction 164 (1), R1-R9 (2022)
   PUBMED   35521900
  REMARK    GeneRIF: Irisin and the fibronectin type III domain-containing
            family: structure, signaling and role in female reproduction.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1612)
  AUTHORS   Fruhbeck,G., Catalan,V., Valenti,V., Moncada,R., Gomez-Ambrosi,J.,
            Becerril,S., Silva,C., Portincasa,P., Escalada,J. and Rodriguez,A.
  TITLE     FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike
            glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in
            human adipocytes
  JOURNAL   Cell Mol Immunol 18 (10), 2457-2459 (2021)
   PUBMED   34465884
  REMARK    GeneRIF: FNDC4 and FNDC5 reduce SARS-CoV-2 entry points and spike
            glycoprotein S1-induced pyroptosis, apoptosis, and necroptosis in
            human adipocytes.
REFERENCE   5  (bases 1 to 1612)
  AUTHORS   Georgiadi,A., Lopez-Salazar,V., Merahbi,R.E., Karikari,R.A., Ma,X.,
            Mourao,A., Klepac,K., Buhler,L., Alfaro,A.J., Kaczmarek,I.,
            Linford,A., Bosma,M., Shilkova,O., Ritvos,O., Nakamura,N.,
            Hirose,S., Lassi,M., Teperino,R., Machado,J., Scheideler,M.,
            Dietrich,A., Geerlof,A., Feuchtinger,A., Blutke,A., Fischer,K.,
            Muller,T.D., Kessler,K., Schoneberg,T., Thor,D., Hornemann,S.,
            Kruse,M., Nawroth,P., Pivovarova-Ramich,O., Pfeiffer,A.F.H.,
            Sattler,M., Bluher,M. and Herzig,S.
  TITLE     Orphan GPR116 mediates the insulin sensitizing effects of the
            hepatokine FNDC4 in adipose tissue
  JOURNAL   Nat Commun 12 (1), 2999 (2021)
   PUBMED   34016966
  REMARK    GeneRIF: Orphan GPR116 mediates the insulin sensitizing effects of
            the hepatokine FNDC4 in adipose tissue.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1612)
  AUTHORS   O'Seaghdha,C.M., Yang,Q., Glazer,N.L., Leak,T.S., Dehghan,A.,
            Smith,A.V., Kao,W.H., Lohman,K., Hwang,S.J., Johnson,A.D.,
            Hofman,A., Uitterlinden,A.G., Chen,Y.D., Brown,E.M.,
            Siscovick,D.S., Harris,T.B., Psaty,B.M., Coresh,J., Gudnason,V.,
            Witteman,J.C., Liu,Y.M., Kestenbaum,B.R., Fox,C.S. and Kottgen,A.
  CONSRTM   GEFOS Consortium
  TITLE     Common variants in the calcium-sensing receptor gene are associated
            with total serum calcium levels
  JOURNAL   Hum Mol Genet 19 (21), 4296-4303 (2010)
   PUBMED   20705733
REFERENCE   7  (bases 1 to 1612)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   8  (bases 1 to 1612)
  AUTHORS   Kottgen,A., Pattaro,C., Boger,C.A., Fuchsberger,C., Olden,M.,
            Glazer,N.L., Parsa,A., Gao,X., Yang,Q., Smith,A.V., O'Connell,J.R.,
            Li,M., Schmidt,H., Tanaka,T., Isaacs,A., Ketkar,S., Hwang,S.J.,
            Johnson,A.D., Dehghan,A., Teumer,A., Pare,G., Atkinson,E.J.,
            Zeller,T., Lohman,K., Cornelis,M.C., Probst-Hensch,N.M.,
            Kronenberg,F., Tonjes,A., Hayward,C., Aspelund,T., Eiriksdottir,G.,
            Launer,L.J., Harris,T.B., Rampersaud,E., Mitchell,B.D.,
            Arking,D.E., Boerwinkle,E., Struchalin,M., Cavalieri,M.,
            Singleton,A., Giallauria,F., Metter,J., de Boer,I.H.,
            Haritunians,T., Lumley,T., Siscovick,D., Psaty,B.M.,
            Zillikens,M.C., Oostra,B.A., Feitosa,M., Province,M., de
            Andrade,M., Turner,S.T., Schillert,A., Ziegler,A., Wild,P.S.,
            Schnabel,R.B., Wilde,S., Munzel,T.F., Leak,T.S., Illig,T.,
            Klopp,N., Meisinger,C., Wichmann,H.E., Koenig,W., Zgaga,L.,
            Zemunik,T., Kolcic,I., Minelli,C., Hu,F.B., Johansson,A., Igl,W.,
            Zaboli,G., Wild,S.H., Wright,A.F., Campbell,H., Ellinghaus,D.,
            Schreiber,S., Aulchenko,Y.S., Felix,J.F., Rivadeneira,F.,
            Uitterlinden,A.G., Hofman,A., Imboden,M., Nitsch,D.,
            Brandstatter,A., Kollerits,B., Kedenko,L., Magi,R., Stumvoll,M.,
            Kovacs,P., Boban,M., Campbell,S., Endlich,K., Volzke,H.,
            Kroemer,H.K., Nauck,M., Volker,U., Polasek,O., Vitart,V.,
            Badola,S., Parker,A.N., Ridker,P.M., Kardia,S.L., Blankenberg,S.,
            Liu,Y., Curhan,G.C., Franke,A., Rochat,T., Paulweber,B.,
            Prokopenko,I., Wang,W., Gudnason,V., Shuldiner,A.R., Coresh,J.,
            Schmidt,R., Ferrucci,L., Shlipak,M.G., van Duijn,C.M., Borecki,I.,
            Kramer,B.K., Rudan,I., Gyllensten,U., Wilson,J.F., Witteman,J.C.,
            Pramstaller,P.P., Rettig,R., Hastie,N., Chasman,D.I., Kao,W.H.,
            Heid,I.M. and Fox,C.S.
  TITLE     New loci associated with kidney function and chronic kidney disease
  JOURNAL   Nat Genet 42 (5), 376-384 (2010)
   PUBMED   20383146
REFERENCE   9  (bases 1 to 1612)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   10 (bases 1 to 1612)
  AUTHORS   Teufel,A., Malik,N., Mukhopadhyay,M. and Westphal,H.
  TITLE     Frcp1 and Frcp2, two novel fibronectin type III repeat containing
            genes
  JOURNAL   Gene 297 (1-2), 79-83 (2002)
   PUBMED   12384288
  REMARK    GeneRIF: Reports the cloning, expression and subcellular
            localization of the related mouse protein.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB452792.1 and BC032725.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022823.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK026015.1, BC024175.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264703.4/ ENSP00000264703.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-421               DB452792.1         60-480
            422-1612            BC032725.1         112-1302
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p23.3"
     gene            1..1612
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /note="fibronectin type III domain containing 4"
                     /db_xref="GeneID:64838"
                     /db_xref="HGNC:HGNC:20239"
                     /db_xref="MIM:611905"
     exon            1..323
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            324..480
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             348..1052
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /note="fibronectin type III domain-containing protein 4;
                     fibronectin type III repeat-containing protein 1"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein 4
                     precursor"
                     /protein_id="NP_073734.1"
                     /db_xref="CCDS:CCDS1756.1"
                     /db_xref="GeneID:64838"
                     /db_xref="HGNC:HGNC:20239"
                     /db_xref="MIM:611905"
                     /translation="MPSGCHSSPPSGLRGDMASLVPLSPYLSPTVLLLVSCDLGFVRA
                     DRPPSPVNVTVTHLRANSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTTTRA
                     CALWGLAEDSDYTVQVRSIGLRGESPPGPRVHFRTLKGSDRLPSNSSSPGDITVEGLD
                     GERPLQTGEVVIIVVVLLMWAAVIGLFCRQYDIIKDNDSNNNPKEKGKGPEQSPQGRP
                     VGTRQKKSPSINTIDV"
     exon            481..596
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            597..801
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..891
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1016
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1612
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /note="hexamer: AATAAA"
     polyA_site      1612
                     /gene="FNDC4"
                     /gene_synonym="FRCP1"
                     /note="major polyA site"
ORIGIN      
        1 gcagaaggcg gcggctggct ctccgggacg gtcacatccc gctgcagggg cgggcggagg
       61 ccgccgcact gcctcccgca ccggggaccc aggccagcgt ccgggcaacg ccccctgctc
      121 ccggacagac tccgtggccc gctcgagccc tgggggctcc gcagacccgc gcccgctccg
      181 cccgcagctc ggccccgcgc tgcccgcgtc gccgggcccg cgccgggatg gggtaggggc
      241 agcgccaccg agtcgggcga tgggccgccc tctgggcacc gagcagcccc ccgaggcctg
      301 accaaccgcg aggaccggcg gaggagcccc gcctggatgt caagcggatg ccaagcggat
      361 gccacagttc cccccccagc ggactccgtg gggacatggc ttcgctggtg cccctttccc
      421 catatctaag ccccacggtc ctcctgctgg tcagctgtga cctgggcttc gtgcgagcag
      481 accggcctcc ctctcctgtg aatgtgacgg tcactcacct cagagccaac tcggccactg
      541 tgtcctggga cgtcccagaa ggcaacatcg tcattggcta ctccatttcc cagcaacggc
      601 agaatggccc cgggcagcgt gtgattcggg aggtgaacac caccacccgg gcctgtgccc
      661 tctggggcct ggctgaagac agtgactaca cagtgcaggt caggagcatc ggccttcggg
      721 gagagagtcc cccagggccc cgggtgcact tccgaactct caagggttct gaccggctac
      781 cttcaaacag ttcaagccca ggtgacatca cagtggaagg tctggatgga gagcggccac
      841 tgcagactgg ggaagtggtc atcattgtgg tggtgttgct catgtgggct gctgtaattg
      901 ggctgttctg ccgtcagtat gacatcatca aggacaatga ctccaacaac aatcccaagg
      961 agaagggaaa ggggccggaa cagagtcctc agggaaggcc agtggggaca agacagaaaa
     1021 agtcaccatc tatcaacacc atcgacgttt gagtgaagaa acacacccag aagagagatg
     1081 cactaacaac tggggatagg gatggggtca gggggagccc aagatggtga tctgcccgag
     1141 actcccagag ggtaatgcca ctcccacaat ctcaggcctg gtacccatcc tctttccact
     1201 gtgagcagag ccagaaggta ggtctgttca gagtctgtgc ccctggacct ggggagtgga
     1261 tatcagatgg gatatctcct tccattcccc ggtccagggg agagtcacta gttgtaccct
     1321 actccattag gtcccaaatg ggggccccat ttcacctgta tcaggactct gagcatcccc
     1381 agctgcccca catcttgcct ctggccctca gagaggggtg tttctgtggg tactcctctt
     1441 accccagcaa ataaaaggaa ttgtctgacc ctagaggcag atgctgcact gcactactcc
     1501 aatgtcttcc atggagcctc aggtgctccc cctctcacct ggcagcccct tcagctgcta
     1561 gtgatatcac ttgttggaca tttttccaat aaaggttctt ggacaaactg ga
//
