LOCUS       NM_022763               8031 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens fibronectin type III domain containing 3B (FNDC3B),
            transcript variant 1, mRNA.
ACCESSION   NM_022763
VERSION     NM_022763.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8031)
  AUTHORS   Wang,Y., Kong,Y., Yang,Q., Zhong,C. and Zhou,D.
  TITLE     Identification of fibronectin type III domain containing 3B as a
            potential prognostic and therapeutic target for pancreatic cancer:
            a preliminary analysis
  JOURNAL   Eur J Med Res 29 (1), 221 (2024)
   PUBMED   38581008
  REMARK    GeneRIF: Identification of fibronectin type III domain containing
            3B as a potential prognostic and therapeutic target for pancreatic
            cancer: a preliminary analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8031)
  AUTHORS   Song,D., Ye,Z., Chen,F., Zhan,L. and Sun,X.
  TITLE     circFNDC3B promotes esophageal squamous cell carcinoma progression
            by targeting MYO5A via miR-370-3p/miR-136-5p
  JOURNAL   BMC Cancer 23 (1), 821 (2023)
   PUBMED   37667251
  REMARK    GeneRIF: circFNDC3B promotes esophageal squamous cell carcinoma
            progression by targeting MYO5A via miR-370-3p/miR-136-5p.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8031)
  AUTHORS   Kondkar,A.A., Sultan,T., Azad,T.A., Osman,E.A., Almobarak,F.A.,
            Lobo,G.P. and Al-Obeidan,S.A.
  TITLE     Lack of Association of Polymorphism Located Upstream of ABCA1
            (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1 Genes
            (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi
            Origin
  JOURNAL   Genes (Basel) 14 (3), 704 (2023)
   PUBMED   36980976
  REMARK    GeneRIF: Lack of Association of Polymorphism Located Upstream of
            ABCA1 (rs2472493), in FNDC3B (rs7636836), and Near ANKRD55-MAP3K1
            Genes (rs61275591) in Primary Open-Angle Glaucoma Patients of Saudi
            Origin.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8031)
  AUTHORS   Zeng,Q., Ji,X., Li,X. and Tian,Y.
  TITLE     Circ_0000285 regulates nasopharyngeal carcinoma progression through
            miR-1278/FNDC3B axis
  JOURNAL   Hum Exp Toxicol 42, 9603271221141689 (2023)
   PUBMED   36738165
  REMARK    GeneRIF: Circ_0000285 regulates nasopharyngeal carcinoma
            progression through miR-1278/FNDC3B axis.
REFERENCE   5  (bases 1 to 8031)
  AUTHORS   Zeng,W., Zhu,J.F., Guo,J., Huang,G.J., Ai,L.S., Zeng,Y. and
            Liao,W.J.
  TITLE     m6A-modified circFNDC3B inhibits colorectal cancer stemness and
            metastasis via RNF41-dependent ASB6 degradation
  JOURNAL   Cell Death Dis 13 (11), 1008 (2022)
   PUBMED   36446779
  REMARK    GeneRIF: m[6]A-modified circFNDC3B inhibits colorectal cancer
            stemness and metastasis via RNF41-dependent ASB6 degradation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8031)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   7  (bases 1 to 8031)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 8031)
  AUTHORS   Zhang,X., Liu,S., Hu,T., Liu,S., He,Y. and Sun,S.
  TITLE     Up-regulated microRNA-143 transcribed by nuclear factor kappa B
            enhances hepatocarcinoma metastasis by repressing fibronectin
            expression
  JOURNAL   Hepatology 50 (2), 490-499 (2009)
   PUBMED   19472311
  REMARK    GeneRIF: Up-regulation of miR-143 expression transcribed by
            NF-kappaB in hepatitis B virus-related hepatocellular carcinoma
            promotes cancer cell invasion/migration and tumor metastasis by
            repression of FNDC3B expression.
REFERENCE   9  (bases 1 to 8031)
  AUTHORS   Tominaga,K., Kondo,C., Johmura,Y., Nishizuka,M. and Imagawa,M.
  TITLE     The novel gene fad104, containing a fibronectin type III domain,
            has a significant role in adipogenesis
  JOURNAL   FEBS Lett 577 (1-2), 49-54 (2004)
   PUBMED   15527760
REFERENCE   10 (bases 1 to 8031)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069259.14, AK223599.1, AK314478.1, AB098597.1, AI417065.1 and
            AC069523.15.
            
            On Nov 23, 2018 this sequence version replaced NM_022763.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.158366.1,
                                           SRR1660803.183645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000415807.7/ ENSP00000411242.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-50                AC069259.14        107916-107965       c
            51-1595             AK223599.1         32-1576
            1596-3469           AK314478.1         1473-3346
            3470-7059           AB098597.1         3305-6894
            7060-7065           AI417065.1         13-18               c
            7066-8031           AC069523.15        65467-66432
FEATURES             Location/Qualifiers
     source          1..8031
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.31"
     gene            1..8031
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /note="fibronectin type III domain containing 3B"
                     /db_xref="GeneID:64778"
                     /db_xref="HGNC:HGNC:24670"
                     /db_xref="MIM:611909"
     exon            1..194
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            195..333
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..3837
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /note="factor for adipocyte differentiation 104; HCV
                     NS5A-binding protein 37"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein
                     3B"
                     /protein_id="NP_073600.3"
                     /db_xref="CCDS:CCDS3217.1"
                     /db_xref="GeneID:64778"
                     /db_xref="HGNC:HGNC:24670"
                     /db_xref="MIM:611909"
                     /translation="MYVTMMMTDQIPLELPPLLNGEVAMMPHLVNGDAAQQVILVQVN
                     PGETFTIRAEDGTLQCIQGPAEVPMMSPNGSIPPIHVPPGYISQVIEDSTGVRRVVVT
                     PQSPECYPPSYPSAMSPTHHLPPYLTHHPHFIHNSHTAYYPPVTGPGDMPPQFFPQHH
                     LPHTIYGEQEIIPFYGMSTYITREDQYSKPPHKKLKDRQIDRQNRLNSPPSSIYKSSC
                     TTVYNGYGKGHSGGSGGGGSGSGPGIKKTERRARSSPKSNDSDLQEYELEVKRVQDIL
                     SGIEKPQVSNIQARAVVLSWAPPVGLSCGPHSGLSFPYSYEVALSDKGRDGKYKIIYS
                     GEELECNLKDLRPATDYHVRVYAMYNSVKGSCSEPVSFTTHSCAPECPFPPKLAHRSK
                     SSLTLQWKAPIDNGSKITNYLLEWDEGKRNSGFRQCFFGSQKHCKLTKLCPAMGYTFR
                     LAARNDIGTSGYSQEVVCYTLGNIPQMPSAPRLVRAGITWVTLQWSKPEGCSPEEVIT
                     YTLEIQEDENDNLFHPKYTGEDLTCTVKNLKRSTQYKFRLTASNTEGKSCPSEVLVCT
                     TSPDRPGPPTRPLVKGPVTSHGFSVKWDPPKDNGGSEILKYLLEITDGNSEANQWEVA
                     YSGSATEYTFTHLKPGTLYKLRACCISTGGHSQCSESLPVRTLSIAPGQCRPPRVLGR
                     PKHKEVHLEWDVPASESGCEVSEYSVEMTEPEDVASEVYHGPELECTVGNLLPGTVYR
                     FRVRALNDGGYGPYSDVSEITTAAGPPGQCKAPCISCTPDGCVLVGWESPDSSGADIS
                     EYRLEWGEDEESLELIYHGTDTRFEIRDLLPAAQYCCRLQAFNQAGAGPYSELVLCQT
                     PASAPDPVSTLCVLEEEPLDAYPDSPSACLVLNWEEPCNNGSEILAYTIDLGDTSITV
                     GNTTMHVMKDLLPETTYRIRIQAINEIGAGPFSQFIKAKTRPLPPLPPRLECAAAGPQ
                     SLKLKWGDSNSKTHAAEDIVYTLQLEDRNKRFISIYRGPSHTYKVQRLTEFTCYSFRI
                     QAASEAGEGPFSETYTFSTTKSVPPTIKAPRVTQLEGNSCEILWETVPSMKGDPVNYI
                     LQVLVGRESEYKQVYKGEEATFQISGLQTNTDYRFRVCACRRCLDTSQELSGAFSPSA
                     AFVLQRSEVMLTGDMGSLDDPKMKSMMPTDEQFAAIIVLGFATLSILFAFILQYFLMK
                     "
     exon            334..409
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            410..486
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            487..730
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            731..1012
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1013..1071
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1223
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1283
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1422
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1476
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1601
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1776
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1863
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..2002
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            2003..2074
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            2075..2193
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2299
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2472
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            2473..2586
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            2587..2736
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            2737..3017
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3230
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            3231..3397
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            3398..3525
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..8031
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7036..7041
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /note="hexamer: AATAAA"
     polyA_site      7065
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /note="major polyA site"
     polyA_site      7084
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
     regulatory      8005..8010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
                     /note="hexamer: AATAAA"
     polyA_site      8031
                     /gene="FNDC3B"
                     /gene_synonym="FAD104; PRO4979; YVTM2421"
ORIGIN      
        1 attgacatgg cggaatcccc catcaaaccc tcctggtagt tatttgagcg gcggcggcgg
       61 cggctggagg aggagagcgg cggcggcggg agcagcgaag ggggcggcag ggatcctcca
      121 ggctgccggc tgggaaggcg tgggcgaccc ggtgtgtggc gcgcccagag ccccgcgttt
      181 cagccctagg gaaggaagcc agttgaggga agttctccat gaatgtacgt cacaatgatg
      241 atgaccgacc aaatccctct ggaactgcca ccattgctga acggagaggt agccatgatg
      301 ccccacttgg tgaatggaga tgcagctcag caggttattc tcgttcaagt taatccaggt
      361 gagactttca caataagagc agaggatgga acacttcagt gcattcaagg acctgctgaa
      421 gttcccatga tgtcacccaa tggatccatt cctcccattc atgtgcctcc aggttatatc
      481 tcacaggtga ttgaagatag tactggagtc cgccgggtgg tggtcacacc ccagtctcct
      541 gagtgttatc ccccaagcta cccctcagcc atgtctccaa cccatcatct ccctccctat
      601 ctgactcacc atccacattt tattcataac tcacacacgg cttactaccc acctgttacc
      661 ggacctggag atatgccgcc tcagtttttt ccccagcatc atcttcccca cacaatatat
      721 ggtgagcaag aaattatacc attttatgga atgtcaacct acatcacccg agaagaccag
      781 tacagcaagc ctccgcacaa aaaactgaaa gaccgccaga tcgatcgcca gaaccgcctc
      841 aacagccctc cttcttctat ctacaaaagc agctgcacaa cagtatacaa tggctatggg
      901 aagggccata gtggtggaag tggcggaggc ggcagcggta gtggtcccgg aattaagaaa
      961 acagagcgac gagcaagaag cagcccaaag tcgaatgatt cagacttgca agaatatgag
     1021 ttggaagtaa agagggtgca agacattctt tcgggaatag agaaaccaca ggtttctaat
     1081 attcaggcaa gagcagttgt gttgtcctgg gctccccctg ttggactttc ctgtggaccc
     1141 cacagtggtc tttccttccc ctacagttac gaggtggcct tatcagacaa aggacgagat
     1201 ggaaaataca agataattta cagtggagaa gaattagaat gtaacctgaa agatcttaga
     1261 ccagcaacag attatcatgt gagggtgtat gccatgtaca attccgtaaa gggatcctgc
     1321 tccgagcctg ttagcttcac cacccacagc tgtgcacccg agtgtccttt cccccctaag
     1381 ctggcacata ggagcaaaag ttcactaacc ctgcagtgga aggcaccaat tgacaacggt
     1441 tcaaaaatca ccaactacct tttagagtgg gatgagggaa aaagaaatag tggtttcaga
     1501 cagtgcttct tcgggagcca gaagcactgc aagttgacaa agctttgtcc ggcaatgggg
     1561 tacacattca ggctggccgc tcgaaacgac attggtacca gtggttatag ccaagaggtg
     1621 gtgtgctaca cattaggaaa tatccctcag atgccttctg caccaaggct ggttcgagct
     1681 ggcatcacat gggtcacgtt gcagtggagt aagccagaag gctgttcacc cgaggaagtg
     1741 atcacctaca ccttggaaat tcaggaggat gaaaatgata accttttcca cccaaaatac
     1801 actggagagg atttaacctg tactgtgaaa aatctcaaaa gaagcacaca gtataaattc
     1861 aggctgactg cttctaatac ggaaggaaaa agctgtccaa gcgaagttct tgtttgtacg
     1921 acgagtcctg acaggcctgg acctcctacc agaccgcttg tcaaaggccc agttacatct
     1981 catggcttta gtgtcaaatg ggatccccct aaggacaatg gtggttcaga aatcctcaag
     2041 tacttgctag agattactga tggaaattct gaagcgaatc agtgggaagt ggcctacagt
     2101 gggtcggcta ccgaatacac cttcacccac ttgaaaccag gcactttgta caaactccga
     2161 gcatgctgca tcagtaccgg cggacacagc cagtgttctg aaagtctccc tgttcgcaca
     2221 ctaagcattg caccaggtca atgtcgacca ccgagggttt tgggtagacc aaagcacaaa
     2281 gaagtccact tagagtggga tgttcctgca tcggaaagtg gctgtgaggt ctcagagtac
     2341 agcgtggaga tgacggagcc cgaagacgta gcctcggaag tgtaccatgg cccagagctg
     2401 gagtgcaccg tcggcaacct gcttcctgga accgtgtatc gcttccgggt gagggctctg
     2461 aatgatggag ggtatggtcc ctattctgat gtctcagaaa ttaccactgc tgcagggcct
     2521 cctggacaat gcaaagcacc ttgtatttct tgtacacctg atggatgtgt cttagtgggt
     2581 tgggagagtc ctgatagttc tggtgctgac atctcagagt acaggttgga atggggagaa
     2641 gatgaagaat ccttagaact catttatcat gggacagaca cccgttttga aataagagac
     2701 ctgttgcctg ctgcacagta ttgctgtaga ctacaggcct tcaatcaagc aggggcaggg
     2761 ccgtacagtg aacttgtcct ttgccagacg ccagcgtctg cccctgaccc cgtctccact
     2821 ctctgtgtcc tggaggagga gccccttgat gcctaccctg attcaccttc tgcgtgcctt
     2881 gtactgaact gggaagagcc gtgcaataac ggatctgaaa tccttgctta caccattgat
     2941 ctaggagaca ctagcattac cgtgggcaac accaccatgc atgttatgaa agatctcctt
     3001 ccagaaacca cctaccggat cagaattcag gctataaatg aaattggagc tggaccattt
     3061 agtcagttca ttaaagcaaa aactcggcca ttaccaccct tgcctcctag gctagaatgt
     3121 gctgctgctg gtcctcagag cctgaagcta aaatggggag acagtaactc caagacacat
     3181 gctgctgagg acattgtgta cacactacag ctggaggaca gaaacaagag gtttatttca
     3241 atctacagag gacccagcca cacctacaag gtccagagac tgacggaatt cacatgctac
     3301 tccttcagaa tccaggcagc aagcgaggct ggagaagggc ccttctcaga aacctatacc
     3361 ttcagcacaa ccaaaagtgt cccccccacc atcaaagcac ctcgagtaac acagttagaa
     3421 ggaaattcat gtgaaatttt atgggagacg gtaccatcaa tgaaaggtga ccctgttaac
     3481 tacattctgc aggtattggt tggaagagaa tctgagtaca aacaggtgta caagggagaa
     3541 gaagccacat tccaaatctc aggcctccag accaacacag actacaggtt ccgcgtatgt
     3601 gcgtgtcgtc gctgtttaga cacctctcag gagctaagcg gagccttcag cccctctgcg
     3661 gcttttgtat tacaacgaag tgaggtcatg cttacagggg acatggggag cttagatgat
     3721 cccaaaatga agagcatgat gcctactgat gaacagtttg cagccatcat tgtgcttggc
     3781 tttgcaactt tgtccatttt atttgccttt atattacagt acttcttaat gaagtaaacc
     3841 caacaaaact agaggtatga attaatgcta cacattttaa tacacacatt tattcagata
     3901 ctcccctttt taaagccctt ttgttttttg atttatatac tctgttttac agatttagct
     3961 agaaaaaaaa tgtcagtgtt ttggtgcacc tttttgaaat gcaaaactag gaaaaggtta
     4021 aactggattt ttttttttaa aaaaaagaaa aaaaaagaag aaaagtatac cagataccaa
     4081 aagctagctt tcttatgttt tcctttaaat tttcagattt accttcattc tgttttcact
     4141 gatgtctttt gcaagccttt gatttttttt tttttgttac agtttagtaa tttatattca
     4201 ccagtcactt catatgtctt gaacatctgt atctgtaaac atgaatcacc gtgtgtgtac
     4261 ttacagggct aggatttcag tgttgtcaga gtattaccac acagcaacag caacatacag
     4321 aagatatgtt cactcagata agactgccct aaacaaccat tttgtcactc agttatttaa
     4381 ctgtgtttag ctcatttaaa tcaaaatgtg tactttaatc taaaatgttt taataatctg
     4441 tatttcttat aattttaaca ctatgagctg cctgtataag aaatcaagta accagaatgc
     4501 acctataaat tatggagcat tgtagatttt accacatcaa ttcatagcag taactttaag
     4561 agggcattgt gcaatagtta gttgttttct tgttcagcta ttttaaaggc tgctttaact
     4621 tgtttgtttg tctttgtata taactacttc taatctaatc actagagtta ttatattctg
     4681 ttatgtttga ccagaattat atgacaagaa ctggtgacag tttagtgcct ctgcccattg
     4741 tccatgattt acactaattg tgagcagtct tcttatgtgt cagctcatta tttttgaaac
     4801 atttgccttt aggctgttct ttgaggtatc aatgaagtga ttgaatttca ataccttaat
     4861 tcagtgcaca taatactaat gtaacagcag atgaaaattg ataaaaccca aaagagagtc
     4921 atctaaattt gtagttccta tttctgtggg tttgcctggc catggttgga gagggaatgg
     4981 tgtttgatgg taaacacagg gtgtttgggg atcaaggagc ctagattctc tccctggatc
     5041 tgtcactaac ttgctgcgtg acctgaacac gtcactttac ctctctgtgc ctcagttttc
     5101 ccatgcatga aaaataaaat aaaataaaac ggggattcta atgtttgtaa gtgctttgag
     5161 atctttgacc aacaggtgct attggagtgc aaagtgttac tcttacgtgt ttattttgag
     5221 tcatgagata atcaatttta acccaaagtc attggattat ttatatgaag tccataatgt
     5281 tcgagtacct cagggacatt taagagttgg aggtgcaaat atattccaaa agggtgcaac
     5341 agacacagtg tatccccctg cttctgtttt tgtatatttt tgctacttgg tttttcttga
     5401 tcatagctat tttgtgcttg atctttattg tctaagatgc agtatcctgt actagcttat
     5461 aatattccca taccaaagtc atggggaaac aaacattatt ttgtttttgg tttatttata
     5521 ctatattctg catacagtac tttaaatgcc aattacagtg caatctttat ttattgtaaa
     5581 attttttaag tgtacttatg tactaatttt cccttgtagc atgttatatt tttgtgtttt
     5641 atacttttgt aattttaggt cagtcttgtt ccttggcaac atctgtagta ttattaatct
     5701 tctgacattt tcttatgttt ttaaaaagat aagagcatct agtgcattaa atgccaaaaa
     5761 aaaaatacat tatcagtgat tgaaacgttt acatgtaccc aaaaaccata atcatctctt
     5821 ggaagaaaat gctgagatca atgaattatt ctgtgtgcct atattgacgt agtgagtact
     5881 agagagttct gtattttatt attgactata ataattagtt taattagctt tgcaaactga
     5941 tggcatcaag gtaaatatat ttttgccaaa gttctggcct tccaaaactc acccccttat
     6001 ttaaatgtgt gctatgaccc actatgacca cagcatctgc attttctaaa aaattccatg
     6061 caggtgtttt ggggagaggt attttttaag caatgaaaat tcaactgagt acaaagcccc
     6121 ctcttggggg gttggggaag tctctttttt gaaacacttc agaactgctg ctataaagaa
     6181 attctctaat tggttgaatt ttttttttaa gtaaatagta ctttaggcca aaatttatat
     6241 gaatatttga tcttcttgag attttcatac tatcatttaa ccaccaggaa gctgaagtgt
     6301 gtgaagtaca aagctgacag cactttattt tattgctctc cattatttgg tattcattat
     6361 attccttcag tcagaaaatt attactctct atggcactgt tttttatcac aaatatgtat
     6421 atgtgatatt gatatataac tatatatatt gccatcacac acgaacaata aaataaagtg
     6481 ttctattaac ctgatctctt tgcccttttg ctatgtgagg agtgaatgag tggccttctg
     6541 atgctctgac tcttctctgt atgtcaaact catccctggc acaagaaatt ccagtcatgt
     6601 gaagcaaact gccctttgtc ctcaaagaaa ttgttgaaaa agaaaacttt ttaaagagat
     6661 tttttgcata ttctctgcct tgttcttatc aacttgaaat gttggcattt tctaaccttg
     6721 ttttgttggc tacaataatt cagtattcat gtcaaaattg agaagtgccc taattgaatg
     6781 tgtttgaatg ttatccttgc acaattcttt aaattgaaag ataaaatgtt ttacctcact
     6841 gttggacata cattccaagc ttttcaactc taggagaaaa agaaaatcat gttttcctgt
     6901 attgtaaatt ttagactatt tcatatacat tgtattaaaa ctgccatatc aattttaatg
     6961 tatagatttt gcaaatatta tgctatatgt aatacctaac tgtatctgta gtgtatatgt
     7021 aatatattta tgcccaataa atgttttaat tctttctgac ttaaataggg tttttctgcc
     7081 atgactagga ttgcttttgt tgttgttgtt gttgtttctt tctttttttt tttttttgag
     7141 acggagtctt gctctgtcgc caggctggag tgcagtggcg cgatctcagc tcactgcaac
     7201 ctccagctcc caggttcaag tgattcccct gcctcagcct cccaagtagc tggggattac
     7261 aggcactcgc caccatgccc ggataatttt tttttttttt ttgagttgga gtcttgctct
     7321 gtcgcccagg ctggagtgca gtgacccaat ctcggctcac tgcaagctcc acctcccggg
     7381 ttcatgccat tctcctgcct cagcctccca agtagctggg actacaggtg cccgccacca
     7441 cgcccggcta atttttttaa ttttagtaga gtcggggttt caccatgttg gccaagatgg
     7501 tctcgatctg acctcgtgat ctgcccgcct cggcctccca aagtgctggg attacaggtg
     7561 tgagcccccg cacccagcct tattcttccc ttttaaatac ttaaagcaca ttcagattag
     7621 ttgaaaattc acgtgttttt ggaggccagg caggtggcct tctgcagaga cagcagcagc
     7681 tcagctcttg ctgaccaagg ccttggagga ctgtgagcca caatcacata tgtccatgtt
     7741 tcaaaagaag ctaaatatcc agatttcctc catgggccaa ctaaaaggtg attgtggact
     7801 atacaggctg ccagtttaat cctttatcag agtctctgtg gataatgtac cttgttgcct
     7861 aatactttat ctgtctacca aaactcagtc cagatctccc tctgttcacc tggcacactg
     7921 ggtgcttcct ctcccctgac gaactctata gagtgttcat gtcctttcct gcaggtctca
     7981 ttcaacaaca acaacaacaa cagcaataaa acacagtgtt cctgctatgg c
//
