LOCUS       NM_001079673            6286 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens fibronectin type III domain containing 3A (FNDC3A),
            transcript variant 1, mRNA.
ACCESSION   NM_001079673
VERSION     NM_001079673.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6286)
  AUTHORS   Manfrini,N., Mancino,M., Miluzio,A., Oliveto,S., Balestra,M.,
            Calamita,P., Alfieri,R., Rossi,R.L., Sassoe-Pognetto,M., Salio,C.,
            Cuomo,A., Bonaldi,T., Manfredi,M., Marengo,E., Ranzato,E.,
            Martinotti,S., Cittaro,D., Tonon,G. and Biffo,S.
  TITLE     FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors That Act
            in Concert to Impair Clearing of Protein Aggregates and Autophagy
  JOURNAL   Cancer Res 80 (21), 4693-4706 (2020)
   PUBMED   32963011
  REMARK    GeneRIF: FAM46C and FNDC3A Are Multiple Myeloma Tumor Suppressors
            That Act in Concert to Impair Clearing of Protein Aggregates and
            Autophagy.
REFERENCE   2  (bases 1 to 6286)
  AUTHORS   Fucci,C., Resnati,M., Riva,E., Perini,T., Ruggieri,E.,
            Orfanelli,U., Paradiso,F., Cremasco,F., Raimondi,A.,
            Pasqualetto,E., Nuvolone,M., Rampoldi,L., Cenci,S. and Milan,E.
  TITLE     The Interaction of the Tumor Suppressor FAM46C with p62 and FNDC3
            Proteins Integrates Protein and Secretory Homeostasis
  JOURNAL   Cell Rep 32 (12), 108162 (2020)
   PUBMED   32966780
  REMARK    GeneRIF: The Interaction of the Tumor Suppressor FAM46C with p62
            and FNDC3 Proteins Integrates Protein and Secretory Homeostasis.
REFERENCE   3  (bases 1 to 6286)
  AUTHORS   Ro,M., Park,J., Nam,M., Bang,H.J., Yang,J.W., Choi,K.S., Kim,S.K.,
            Chung,J.H. and Kwack,K.
  TITLE     Associations between single-nucleotide polymorphism in the FNDC3A
            and autism spectrum disorder in a Korean population
  JOURNAL   Psychiatry Res 209 (2), 246-248 (2013)
   PUBMED   23639254
  REMARK    GeneRIF: The results of this study concluded that FNDC3A influences
            the prevalence of autism spectrum disorder.
REFERENCE   4  (bases 1 to 6286)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   5  (bases 1 to 6286)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 6286)
  AUTHORS   Carrouel,F., Couble,M.L., Vanbelle,C., Staquet,M.J., Magloire,H.
            and Bleicher,F.
  TITLE     HUGO (FNDC3A): a new gene overexpressed in human odontoblasts
  JOURNAL   J Dent Res 87 (2), 131-136 (2008)
   PUBMED   18218838
  REMARK    GeneRIF: We report the 1st characterization of new gene we named
            HUGO, and its associated deduced protein sequence. HUGO proteins
            are mainly composed of a proline-rich region at N-terminus, 8 type
            III-fibronectin modules, and transmembranous helix at C-terminus.
REFERENCE   7  (bases 1 to 6286)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ749706.1, AL137000.6 and BM973827.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001079673.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1). Variants 1 and 3 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.81414.1, BX648141.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000492622.6/ ENSP00000417257.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4779              AJ749706.1         3-4781
            4780-5974           AL137000.6         132283-133477
            5975-6286           BM973827.1         18-329              c
FEATURES             Location/Qualifiers
     source          1..6286
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..6286
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /note="fibronectin type III domain containing 3A"
                     /db_xref="GeneID:22862"
                     /db_xref="HGNC:HGNC:20296"
                     /db_xref="MIM:615794"
     exon            1..266
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            267..404
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     CDS             306..3902
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /note="isoform 1 is encoded by transcript variant 1; human
                     gene expressed in odontoblasts; fibronectin type-III
                     domain-containing protein 3A"
                     /codon_start=1
                     /product="fibronectin type-III domain-containing protein
                     3A isoform 1"
                     /protein_id="NP_001073141.1"
                     /db_xref="CCDS:CCDS41886.1"
                     /db_xref="GeneID:22862"
                     /db_xref="HGNC:HGNC:20296"
                     /db_xref="MIM:615794"
                     /translation="MAEHPPLLDTTQILSSDISLLSAPIVSADGTQQVILVQVNPGEA
                     FTIRREDGQFQCITGPAQVPMMSPNGSVPPIYVPPGYAPQVIEDNGVRRVVVVPQAPE
                     FHPGSHTVLHRSPHPPLPGFIPVPTMMPPPPRHMYSPVTGAGDMTTQYMPQYQSSQVY
                     GDVDAHSTHGRSNFRDERSSKTYERLQKKLKDRQGTQKDKMSSPPSSPQKCPSPINEH
                     NGLIKGQIAGGINTGSAKIKSGKGKGGTQVDTEIEEKDEETKAFEALLSNIVKPVASD
                     IQARTVVLTWSPPSSLINGETDESSVPELYGYEVLISSTGKDGKYKSVYVGEETNITL
                     NDLKPAMDYHAKVQAEYNSIKGTPSEAEIFTTLSCEPDIPNPPRIANRTKNSLTLQWK
                     APSDNGSKIQNFVLEWDEGKGNGEFCQCYMGSQKQFKITKLSPAMGCKFRLSARNDYG
                     TSGFSEEVLYYTSGCAPSMPASPVLTKAGITWLSLQWSKPSGTPSDEGISYILEMEEE
                     TSGYGFKPKYDGEDLAYTVKNLRRSTKYKFKVIAYNSEGKSNPSEVVEFTTCPDKPGI
                     PVKPSVKGKIHSHSFKITWDPPKDNGGATINKYVVEMAEGSNGNKWEMIYSGATREHL
                     CDRLNPGCFYRLRVYCISDGGQSAVSESLLVQTPAVPPGPCLPPRLQGRPKAKEIQLR
                     WGPPLVDGGSPISCYSVEMSPIEKDEPREVYQGSEVECTVSSLLPGKTYSFRLRAANK
                     MGFGPFSEKCDITTAPGPPDQCKPPQVTCRSATCAQVNWEVPLSNGTDVTEYRLEWGG
                     VEGSMQICYCGPGLSYEIKGLSPATTYYCRVQALSVVGAGPFSEVVACVTPPSVPGIV
                     TCLQEISDDEIENPHYSPSTCLAISWEKPCDHGSEILAYSIDFGDKQSLTVGKVTSYI
                     INNLQPDTTYRIRIQALNSLGAGPFSHMIKLKTKPLPPDPPRLECVAFSHQNLKLKWG
                     EGTPKTLSTDSIQYHLQMEDKNGRFVSLYRGPCHTYKVQRLNESTSYKFCIQACNEAG
                     EGPLSQEYIFTTPKSVPAALKAPKIEKVNDHICEITWECLQPMKGDPVIYSLQVMLGK
                     DSEFKQIYKGPDSSFRYSSLQLNCEYRFRVCAIRQCQDSLGHQDLVGPYSTTVLFISQ
                     RTEPPASTNRDTVESTRTRRALSDEQCAAVILVLFAFFSILIAFIIQYFVIK"
     exon            405..480
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            481..557
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            558..795
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            796..1065
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1124
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1282
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1342
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1481
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1535
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1660
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1835
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1922
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            1923..2061
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2062..2130
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2131..2249
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2355
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2356..2531
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2645
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2646..2795
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            2796..3079
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            3080..3292
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..3459
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            3460..3587
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     exon            3588..6286
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6075..6080
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /note="hexamer: AATAAA"
     polyA_site      6100
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /note="major polyA site"
     regulatory      6263..6268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
                     /note="hexamer: AATAAA"
     polyA_site      6286
                     /gene="FNDC3A"
                     /gene_synonym="bA203I16.1; bA203I16.5; FNDC3; HUGO"
ORIGIN      
        1 ctcccggctc cgtagtaagc atggcggcgg cggcgttcgt ggtccctcgg gtgaaacaga
       61 aagcgggagc tacgcggaga gggagcgaag agcggggctg aggcggcggc gtcactgcca
      121 ggaaacaacc ccaacagtca gcgcgccggc ggccgcggcg gccctgagag ctgactctgc
      181 agctgaggta gagagacaac gatcaggaac cctaagaaga ggcgccagag gagccgcctt
      241 ctgcctcaga acggcgtgac tcggagaatt ggagcgttat tcagtatatt aatgtcttat
      301 tgataatggc agaacatcca ccactactgg atacaactca gatcttaagt agtgatattt
      361 ctcttttgtc tgcccctatt gtaagtgcag atggaacaca acaggttatt ctggtacaag
      421 ttaacccagg agaagcattt acaataagaa gagaagatgg acagtttcag tgcattacag
      481 gtcctgctca ggttccaatg atgtccccaa atggttctgt gcctcctatc tatgtgcctc
      541 ctggatatgc cccacaggtt attgaagaca atggtgttcg aagagttgtc gtggtccctc
      601 aggcaccaga gtttcaccct ggtagtcaca cagttctcca ccgttctcca catcctcctc
      661 tacctggttt cattcctgtc ccaactatga tgccgcctcc accacgtcat atgtactcac
      721 ccgtgactgg agctggagac atgacaacac agtatatgcc acagtatcag tcttcacaag
      781 tctatggaga tgtagatgct cactctacac atggaaggtc caactttaga gatgaacgat
      841 ctagtaaaac atatgaacgt ttgcagaaaa aattgaagga tcgccaagga acacagaaag
      901 ataaaatgag cagtccacca tcatcacccc agaaatgccc ttctcccatt aatgaacata
      961 atggacttat aaaaggacaa attgctggtg gtataaacac aggatcagca aaaatcaagt
     1021 ctgggaaggg gaaaggtggt acacaagttg atacagaaat tgaagaaaaa gatgaagaaa
     1081 ctaaagcatt tgaagcactt ctttccaaca ttgtcaaacc agtggcctcc gacatccagg
     1141 caaggacagt agtacttacc tggtcaccac cttccagcct cattaatggt gaaacagatg
     1201 aaagtagtgt accagagctc tatggttatg aagttctgat ctcaagtact ggaaaagatg
     1261 ggaaatacaa aagtgtatat gtaggagaag aaacaaatat cactttaaat gatctcaagc
     1321 cagccatgga ttaccatgca aaagtccagg cagaatataa ttctataaag ggaactcctt
     1381 cagaggctga aatctttacc accttgagct gtgaacctga tatacctaat ccaccaagga
     1441 tagccaatcg gaccaaaaat tcactcactt tgcaatggaa ggcacctagt gacaatggtt
     1501 ctaaaatcca aaactttgta ttagaatggg atgaaggaaa aggaaatgga gaattttgtc
     1561 agtgttacat gggctcacag aaacaattta aaattactaa actttcacca gcaatgggct
     1621 gtaaattcag actatcggcc agaaatgact atggtacaag tggttttagt gaagaagtct
     1681 tatattacac ctcaggctgt gctccttcta tgccagcaag tcctgtatta accaaggctg
     1741 gaattacttg gttatcctta caatggagta agccctcagg aacaccatca gatgaaggaa
     1801 tttcttacat tttagagatg gaggaagaaa cttcaggata tggttttaag cctaaatatg
     1861 atggagaaga tcttgcttac acagtgaaaa atctcagacg tagtactaag tataaattta
     1921 aggttattgc ttacaactca gaaggtaaaa gtaatccaag tgaagtagta gaatttacta
     1981 cttgccctga taaaccaggc atacctgtaa agccttcagt gaaaggaaag atacattcac
     2041 acagttttaa aataacctgg gatccaccaa aagacaatgg cggagcaacc atcaataaat
     2101 atgtagtgga gatggcagaa ggttctaacg gaaacaaatg ggaaatgata tacagtggtg
     2161 ctaccaggga acatctttgt gatcgactga atccaggctg tttctatcgt ttacgagttt
     2221 actgcatcag tgatggagga cagagtgcgg tctctgaatc tttacttgtg cagactccag
     2281 ctgtgcctcc tggcccatgc ctccctccca gattacaggg tagacccaaa gcaaaagaaa
     2341 tacagttacg atggggaccc cctctggttg atggtggatc acccatttcc tgttacagtg
     2401 tggaaatgtc tcctatagaa aaagatgaac ctagagaagt ttaccaaggt tctgaagtag
     2461 aatgtacagt gagcagcctt cttcctggaa agacatacag cttcagacta cgtgcagcta
     2521 acaaaatggg gtttggacca ttttcagaaa aatgtgatat tactacagcc cctgggccac
     2581 cagatcagtg caagccccct caagtgacat gtagatctgc aacttgtgca caagtgaatt
     2641 gggaggttcc tttgagtaat ggaacagatg tcactgaata tcgactggag tggggaggag
     2701 ttgaaggaag tatgcagata tgttactgtg ggcctggtct cagttatgaa ataaaaggac
     2761 tttcaccagc aactacctat tattgcaggg tccaggctct gagtgttgtg ggtgcaggcc
     2821 ctttcagtga agtagtagcc tgtgtgactc caccatcagt tcctggcatt gtgacctgtc
     2881 ttcaagaaat aagcgatgat gagatagaaa atccccatta ttcaccttct acatgccttg
     2941 caataagctg ggaaaagcct tgtgatcatg gttcggaaat ccttgcctac agcatagact
     3001 ttggagataa acaatcccta acagtgggaa aggttacaag ctatattatc aacaatttgc
     3061 aaccagatac aacatacaga atacgaattc aagccttgaa tagccttgga gctggtcctt
     3121 tcagccatat gataaaatta aaaactaagc ctctccctcc tgatccacct cgtctggaat
     3181 gtgttgcctt tagccaccag aaccttaagc tgaaatgggg agaaggaact ccaaagacat
     3241 tgtcaaccga ttctattcag taccaccttc agatggagga taagaatgga cggtttgtat
     3301 ccctatacag aggaccatgt catacataca aagtacaaag acttaatgag tcaacatcct
     3361 ataaattctg tattcaagct tgtaatgaag ctggggaagg tcccctctcc caagaatata
     3421 ttttcactac tccaaaatct gtcccagctg ccttgaaagc ccccaaaata gagaaagtaa
     3481 atgatcacat ttgtgaaatt acatgggagt gtttacagcc aatgaaaggt gatccagtta
     3541 tttacagtct tcaagttatg ttgggaaaag attcagaatt caaacagatt tacaagggtc
     3601 ccgactcttc cttccggtat tccagccttc agctgaactg tgaatatcgc ttccgtgtat
     3661 gtgccattcg ccagtgccaa gactctctgg gacaccagga cctcgtaggt ccctacagca
     3721 ccacagtgct cttcatctct cagaggactg aaccaccagc cagcaccaac agagacactg
     3781 tggaaagcac aaggacccga cgggcactga gtgacgagca gtgtgctgcc gtcatccttg
     3841 tgctgtttgc tttcttttcc attttgattg cctttatcat tcagtacttt gtaatcaagt
     3901 gaaaatataa ctttattttt taactctatt acattttatt ttgtcatgta ctaaaattat
     3961 ttctgtattg cttttataaa aaacagtggc atttagcact ggcattgaga ctatagcaca
     4021 tcatttttgc cattttcagt gcttatattg ttaggtagag gctggcactt tattagaatg
     4081 caagccacaa aaatatcaat tttgtttttt ttgttagggt gggtcttctt tttttctttc
     4141 cctctctctt tttttaacaa atgccttctt atagaaaaac tttctaagag gcaacaattt
     4201 agaatggata ttttgacgaa tcggcatgag tgtaacagtg ataacctgat ctgtttgttt
     4261 taaagattat taccaagtga aaaattcaga atgaatagaa tttacactaa catgctatat
     4321 aaaatgttaa agtctgatgc tgtgaaagca atctagtgct atatttctac ctcctcattt
     4381 gtcttaatta tttggtaagt gggattatga tgagtaactg gaggggctta gaaacaaaaa
     4441 ctggatgaaa gagtatgcat gaagaaaagc ttctttgata aatgtggagt tcttcattat
     4501 aaatatatat tcatgaattc acagataagt acttaaagaa cagacagttt acttggccta
     4561 aaaatatttt gatgtttact caaaaagtac ctcttcaggt cttgagaaca tggaaaagaa
     4621 ttgagtgctt ttaaatactt tttagaaagt aatcataaaa gtaaattgaa tttcaaacct
     4681 atttggcttc tgttttgtga acctttgaac tatatgtatg tgtataaggg tatacacata
     4741 catatatggc atataacaag tgtacacata tacacataac aagtgtagaa gtatatatta
     4801 catacataca ctcactctgt ctggtatagg ctaattttga agaactccca taagtttctg
     4861 ctgcttctcc cataactgct gccaccacca tcagaattca taatcaaacc taaccttttt
     4921 gtttggggca ccaaatctga agacaaaatt aatttgcacc agtaaacttc aagctgcttt
     4981 ctttcttgaa aactaaacgt ttaacgtata atgtctgttt ggatactgtt ccaaattgtt
     5041 gattgcatgt ggttaatgtt gcattagagc actttgcaat tgcataattc attaatgttt
     5101 tgtgagcttg catttgtgag ttattggatg atcagactga attttgtcaa gtatcacatt
     5161 gtacatcttg cctagatgtc gatgactgca agtaataata cagtttataa tgaaactatc
     5221 tacaattctt gttttagcac atctgttatc cgtaaaacac ctgtaactag cttttttaat
     5281 ttattatttg aattttagga tagcgaatca ctaattttta gttgctgagg ttggcatttt
     5341 agtgattatt aagcacttct gtcagtcttt gaaaaaagaa cgtatttttt gtgctttgaa
     5401 gatctctgaa gaatttcttt tataatagaa tgggcatgta ttgtaacagt tttatgtcaa
     5461 atgatctgtg ctgtagaaaa acattaaccc ttgttcaaaa aagaaatgga taaacttggc
     5521 ctttctaagt ggtaagaatg acctgtcact ataatatact gtatgtttac attttattta
     5581 aatttaatct cttatgtata gggtgataac cttccccaga aacaacagtg attgcgattg
     5641 ttttctagaa acttctttaa agtgccacat ttggcagtac aaatgagtct gagtgtaata
     5701 gcccagagat ttatatatag ttgaatgtct aaaatggtaa aatgtgccac tgtgtcaagt
     5761 tacagtggct tatgtttttc atagtaattc aaatgaactt cctatttttg atagtaaatg
     5821 tcatttaata gtatacttgc catttgagcc tcactgcaaa attagtgcag aggagaaaac
     5881 aatttttaat gtaatcttga ttttacctca tatactgtac attccaaaaa ctctaaactt
     5941 tttaaagatt atagatacac taccaaacat atcaccttaa aattgtataa ggctgaatga
     6001 acttcataca aatgaaaaaa atctcataaa aatacataaa ctatgtagca aaagtatctg
     6061 taaaatccat ggaaaataaa agttgtatca ttctttttga gatacgttta ttgtattcat
     6121 atatattcat tatttgctac ctgtttaaga aagtgaaatg ttatggtctc ccctcttcca
     6181 atgagcttaa aacatttttc ccaacagtat ataaatcttc aacatgagag gatgtatatt
     6241 tattatataa agcccagtaa agaataaaat tagaagtttt atccta
//
