LOCUS       NM_032532               6548 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens fibronectin type III domain containing 1 (FNDC1),
            mRNA.
ACCESSION   NM_032532 XM_027658
VERSION     NM_032532.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6548)
  AUTHORS   Ma,Z., Gao,Q., Xin,W., Wang,L., Chen,Y., Su,C., Gao,S. and Sun,R.
  TITLE     The role of miR-143-3p/FNDC1 axis on the progression of non-small
            cell lung cancer
  JOURNAL   Eur J Histochem 67 (2), 3577 (2023)
   PUBMED   37132497
  REMARK    GeneRIF: The role of miR-143-3p/FNDC1 axis on the progression of
            non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6548)
  AUTHORS   Hong,H., Zhu,H., Li,C., Zang,C., Sang,H., Chen,L. and Wang,A.
  TITLE     [FNDC1 is highly expressed in lung adenocarcinoma and closely
            related with poor prognosis]
  JOURNAL   Nan Fang Yi Ke Da Xue Xue Bao 42 (8), 1182-1190 (2022)
   PUBMED   36073217
  REMARK    GeneRIF: [FNDC1 is highly expressed in lung adenocarcinoma and
            closely related with poor prognosis].
REFERENCE   3  (bases 1 to 6548)
  AUTHORS   Chen,L., Liu,J., Wang,L., Yang,X., Jiang,Q., Ji,F., Xu,Y., Fan,X.,
            Zhou,Z. and Fu,C.
  TITLE     Up-regulated FNDC1 accelerates stemness and chemoradiation
            resistance in colorectal cancer cells
  JOURNAL   Biochem Biophys Res Commun 602, 84-90 (2022)
   PUBMED   35255438
  REMARK    GeneRIF: Up-regulated FNDC1 accelerates stemness and chemoradiation
            resistance in colorectal cancer cells.
REFERENCE   4  (bases 1 to 6548)
  AUTHORS   Yunwen,C., Shanshan,G., Zhifei,B., Saijun,C. and Hua,Y.
  TITLE     The silencing of FNDC1 inhibits the tumorigenesis of breast cancer
            cells via modulation of the PI3K/Akt signaling pathway
  JOURNAL   Mol Med Rep 23 (6) (2021)
   PUBMED   33899120
  REMARK    GeneRIF: The silencing of FNDC1 inhibits the tumorigenesis of
            breast cancer cells via modulation of the PI3K/Akt signaling
            pathway.
REFERENCE   5  (bases 1 to 6548)
  AUTHORS   Liu,Y.P., Chen,W.D., Li,W.N. and Zhang,M.
  TITLE     Overexpression of FNDC1 Relates to Poor Prognosis and Its Knockdown
            Impairs Cell Invasion and Migration in Gastric Cancer
  JOURNAL   Technol Cancer Res Treat 18, 1533033819869928 (2019)
   PUBMED   31530096
  REMARK    GeneRIF: The findings elaborated the biological role of fibronectin
            type III domain containing 1 in gastric cancer and potential
            mechanism of action, possibly providing a new insight for future
            clinical diagnosis or even molecular therapy
REFERENCE   6  (bases 1 to 6548)
  AUTHORS   Hayashi,H., Al Mamun,A., Sakima,M. and Sato,M.
  TITLE     Activator of G-protein signaling 8 is involved in VEGF-mediated
            signal processing during angiogenesis
  JOURNAL   J Cell Sci 129 (6), 1210-1222 (2016)
   PUBMED   26826188
  REMARK    GeneRIF: Knockdown of AGS8 inhibited vascular endothelial growth
            factor (VEGF)-induced tube formation, as well as VEGF-stimulated
            cell growth and migration.
REFERENCE   7  (bases 1 to 6548)
  AUTHORS   Wild,P.S., Zeller,T., Schillert,A., Szymczak,S., Sinning,C.R.,
            Deiseroth,A., Schnabel,R.B., Lubos,E., Keller,T.,
            Eleftheriadis,M.S., Bickel,C., Rupprecht,H.J., Wilde,S.,
            Rossmann,H., Diemert,P., Cupples,L.A., Perret,C., Erdmann,J.,
            Stark,K., Kleber,M.E., Epstein,S.E., Voight,B.F., Kuulasmaa,K.,
            Li,M., Schafer,A.S., Klopp,N., Braund,P.S., Sager,H.B.,
            Demissie,S., Proust,C., Konig,I.R., Wichmann,H.E., Reinhard,W.,
            Hoffmann,M.M., Virtamo,J., Burnett,M.S., Siscovick,D.,
            Wiklund,P.G., Qu,L., El Mokthari,N.E., Thompson,J.R., Peters,A.,
            Smith,A.V., Yon,E., Baumert,J., Hengstenberg,C., Marz,W.,
            Amouyel,P., Devaney,J., Schwartz,S.M., Saarela,O., Mehta,N.N.,
            Rubin,D., Silander,K., Hall,A.S., Ferrieres,J., Harris,T.B.,
            Melander,O., Kee,F., Hakonarson,H., Schrezenmeir,J., Gudnason,V.,
            Elosua,R., Arveiler,D., Evans,A., Rader,D.J., Illig,T.,
            Schreiber,S., Bis,J.C., Altshuler,D., Kavousi,M., Witteman,J.C.,
            Uitterlinden,A.G., Hofman,A., Folsom,A.R., Barbalic,M.,
            Boerwinkle,E., Kathiresan,S., Reilly,M.P., O'Donnell,C.J.,
            Samani,N.J., Schunkert,H., Cambien,F., Lackner,K.J., Tiret,L.,
            Salomaa,V., Munzel,T., Ziegler,A. and Blankenberg,S.
  TITLE     A genome-wide association study identifies LIPA as a susceptibility
            gene for coronary artery disease
  JOURNAL   Circ Cardiovasc Genet 4 (4), 403-412 (2011)
   PUBMED   21606135
REFERENCE   8  (bases 1 to 6548)
  AUTHORS   Anderegg,U., Breitschwerdt,K., Kohler,M.J., Sticherling,M.,
            Haustein,U.F., Simon,J.C. and Saalbach,A.
  TITLE     MEL4B3, a novel mRNA is induced in skin tumors and regulated by
            TGF-beta and pro-inflammatory cytokines
  JOURNAL   Exp Dermatol 14 (9), 709-718 (2005)
   PUBMED   16098131
  REMARK    GeneRIF: MEL4B3 is a novel mRNA induced in skin tumors and
            regulated by TGF-beta and pro-inflammatory cytokines
REFERENCE   9  (bases 1 to 6548)
  AUTHORS   Gao,M., Craig,D., Lequin,O., Campbell,I.D., Vogel,V. and
            Schulten,K.
  TITLE     Structure and functional significance of mechanically unfolded
            fibronectin type III1 intermediates
  JOURNAL   Proc Natl Acad Sci U S A 100 (25), 14784-14789 (2003)
   PUBMED   14657397
  REMARK    GeneRIF: mechanical stretching of FN-III1 may induce
            fibrillogenesis through a partially unfolded intermediate
REFERENCE   10 (bases 1 to 6548)
  AUTHORS   Seki,T., Selby,J., Haupl,T. and Winchester,R.
  TITLE     Use of differential subtraction method to identify genes that
            characterize the phenotype of cultured rheumatoid arthritis
            synoviocytes
  JOURNAL   Arthritis Rheum 41 (8), 1356-1364 (1998)
   PUBMED   9704633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ009660.1, AL356417.17 and AL590551.8.
            
            On Nov 23, 2018 this sequence version replaced NM_032532.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ009660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA2144120
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000297267.14/ ENSP00000297267.9
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               DQ009660.1         4-305
            303-303             AL356417.17        97014-97014
            304-4632            DQ009660.1         307-4635
            4633-4650           AL590551.8         10795-10812
            4651-4707           DQ009660.1         4636-4692
            4708-4708           AL590551.8         10870-10870
            4709-6548           DQ009660.1         4694-6533
FEATURES             Location/Qualifiers
     source          1..6548
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q25.3"
     gene            1..6548
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /note="fibronectin type III domain containing 1"
                     /db_xref="GeneID:84624"
                     /db_xref="HGNC:HGNC:21184"
                     /db_xref="MIM:609991"
     exon            1..306
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..5882
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /note="fibronectin type III domain containing 2;
                     fibronectin type III domain-containing protein 1;
                     activation-associated cDNA protein; expressed in synovial
                     lining protein"
                     /codon_start=1
                     /product="fibronectin type III domain-containing protein 1
                     precursor"
                     /protein_id="NP_115921.2"
                     /db_xref="CCDS:CCDS47512.1"
                     /db_xref="GeneID:84624"
                     /db_xref="HGNC:HGNC:21184"
                     /db_xref="MIM:609991"
                     /translation="MAPEAGATLRAPRRLSWAALLLLAALLPVASSAAASVDHPLKPR
                     HVKLLSTKMGLKVTWDPPKDATSRPVEHYNIAYGKSLKSLKYIKVNAETYSFLIEDVE
                     PGVVYFVLLTAENHSGVSRPVYRAESPPGGEWIEIDGFPIKGPGPFNETVTEKEVPNK
                     PLRVRVRSSDDRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDERTHE
                     IKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRVMSSQSV
                     LVSWVDPVLEKQKKVVASRQYTVRYREKGELARWDYKQIANRRVLIENLIPDTVYEFA
                     VRISQGERDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPTVVAASWDALPETEGKV
                     KEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFKIRATNRRGLGPHSKAF
                     IVAMPTTSKADVEQNTEDNGKPEKPEPSSPSPRAPASSQHPSVPASPQGRNAKDLLLD
                     LKNKILANGGAPRKPQLRAKKAEELDLQSTEITGEEELGSREDSPMSPSDTQDQKRTL
                     RPPSRHGHSVVAPGRTAVRARMPALPRREGVDKPGFSLATQPRPGAPPSASASPAHHA
                     STQGTSHRPSLPASLNDNDLVDSDEDERAVGSLHPKGAFAQPRPALSPSRQSPSSVLR
                     DRSSVHPGAKPASPARRTPHSGAAEEDSSASAPPSRLSPPHGGSSRLLPTQPHLSSPL
                     SKGGKDGEDAPATNSNAPSRSTMSSSVSSHLSSRTQVSEGAEASDGESHGDGDREDGG
                     RQAEATAQTLRARPASGHFHLLRHKPFAANGRSPSRFSIGRGPRLQPSSSPQSTVPSR
                     AHPRVPSHSDSHPKLSSGIHGDEEDEKPLPATVVNDHVPSSSRQPISRGWEDLRRSPQ
                     RGASLHRKEPIPENPKSTGADTHPQGKYSSLASKAQDVQQSTDADTEGHSPKAQPGST
                     DRHASPARPPAARSQQHPSVPRRMTPGRAPQQQPPPPVATSQHHPGPQSRDAGRSPSQ
                     PRLSLTQAGRPRPTSQGRSHSSSDPYTASSRGMLPTALQNQDEDAQGSYDDDSTEVEA
                     QDVRAPAHAARAKEAAASLPKHQQVESPTGAGAGGDHRSQRGHAASPARPSRPGGPQS
                     RARVPSRAAPGKSEPPSKRPLSSKSQQSVSAEDDEEEDAGFFKGGKEDLLSSSVPKWP
                     SSSTPRGGKDADGSLAKEEREPAIALAPRGGSLAPVKRPLPPPPGSSPRASHVPSRLP
                     PRSAATVSPVAGTHPWPQYTTRAPPGHFSTTPMLSLRQRMMHARFRNPLSRQPARPSY
                     RQGYNGRPNVEGKVLPGSNGKPNGQRIINGPQGTKWVVDLDRGLVLNAEGRYLQDSHG
                     NPLRIKLGGDGRTIVDLEGTPVVSPDGLPLFGQGRHGTPLANAQDKPILSLGGKPLVG
                     LEVIKKTTHPPTTTMQPTTTTTPLPTTTTPRPTTATTRRTTTTRRTTTRRPTTTVRTT
                     TRTTTTTTPTPTTPIPTCPPGTLERHDDDGNLIMSSNGIPECYAEEDEFSGLETDTAV
                     PTEEAYVIYDEDYEFETSRPPTTTEPSTTATTPRVIPEEGAISSFPEEEFDLAGRKRF
                     VAPYVTYLNKDPSAPCSLTDALDHFQVDSLDEIIPNDLKKSDLPPQHAPRNITVVAVE
                     GCHSFVIVDWDKATPGDVVTGYLVYSASYEDFIRNKWSTQASSVTHLPIENLKPNTRY
                     YFKVQAQNPHGYGPISPSVSFVTESDNPLLVVRPPGGEPIWIPFAFKHDPSYTDCHGR
                     QYVKRTWYRKFVGVVLCNSLRYKIYLSDNLKDTFYSIGDSWGRGEDHCQFVDSHLDGR
                     TGPQSYVEALPTIQGYYRQYRQEPVRFGNIGFGTPYYYVGWYECGVSIPGKW"
     exon            307..501
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            502..588
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            589..657
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            658..864
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            865..963
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1081
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1269
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1270..1377
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1566
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..4164
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            4165..4265
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4377
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            4378..4818
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            4819..4887
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            4888..5031
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            5032..5262
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            5263..5371
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            5372..5451
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            5452..5481
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            5482..5643
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            5644..5766
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     exon            5767..6548
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6515..6520
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /note="hexamer: ATTAAA"
     polyA_site      6548
                     /gene="FNDC1"
                     /gene_synonym="AGS8; bA243O10.1; dJ322A24.1; FNDC2;
                     MEL4B3"
                     /note="major polyA site"
ORIGIN      
        1 agtggcggag cgcggctgcc ggtgtgcggc cgggagcgat cgccgcgggg caggggcgcg
       61 gcgggcaccg cgcagagcgc gcagaacaga cggacggcgg cggggacccg acggcggcgc
      121 ctcggcactc cccagactcc ggccagcgcc cccctgccag ccgcaagcac ccagccccgg
      181 cccaccccgg gctctcgatg gcccccgagg ccggggcgac cctgcgcgcg ccgcgccggc
      241 tgtcctgggc ggcgctgctg ctcttggccg cgctgctccc cgtcgcctcc tcggcggcgg
      301 cctcagttga ccacccactg aagccaaggc atgtgaaact gctgtccact aaaatgggcc
      361 tgaaagtcac gtgggaccca cccaaagatg ctaccagtag acctgtggag cattacaaca
      421 ttgcctatgg gaagtcactg aaaagtctta aatacatcaa ggtgaatgcg gagacatact
      481 ccttccttat tgaggatgtg gagccggggg tagtgtactt tgtgctgctt actgcagaaa
      541 accacagtgg agtgagccgt cctgtttaca gagctgaaag cccacctgga ggtgaatgga
      601 tcgagattga tggttttccc attaagggtc caggaccatt taatgaaacc gtcacagaaa
      661 aggaagtgcc caacaagccc ttgcgtgtgc gtgtccggtc ctcagatgac aggctgtccg
      721 ttgcgtggaa ggcaccacgc ctgtctggag ccaagagtcc acgcagatca cggggttttc
      781 tcctgggcta cggggagagt ggccggaaga tgaattatgt tccactgaca agagatgaac
      841 ggacacacga aattaaaaag ctagcctcgg aatccgtgta tgtggtctcc ctgcagtcca
      901 tgaactctca gggccggagc caaccagtct acagggctgc cctaacaaag cgaaagattt
      961 cagaagagga cgaattggat gtacctgacg acatcagcgt ccgggttatg tcatctcagt
     1021 ctgtgcttgt gtcctgggtg gatcctgttc tggaaaaaca gaagaaagtt gttgcatcaa
     1081 gacagtacac cgtgcgctat cgagagaagg gggaattggc caggtgggat tataagcaga
     1141 tcgctaacag gcgtgtgctg attgagaacc tgattccaga cactgtgtat gaatttgcag
     1201 tccgtatttc acagggtgaa agagatggca aatggagtac gtcagtcttc caaagaacac
     1261 cagaatctgc ccctaccaca gctcctgaaa acttgaacgt ctggccagtc aatggcaaac
     1321 ctacagttgt cgctgcatct tgggatgcgc taccagagac tgaggggaaa gtgaaagaat
     1381 acattctttc atacgccccg gctctcaaac catttggagc aaagtccctc acctatcctg
     1441 gagacactac ttctgccctg gtggatggtc tgcagcctgg ggaacgctat cttttcaaaa
     1501 tccgggccac aaacaggaga ggcctgggac ctcactccaa agccttcatt gtcgctatgc
     1561 caacaaccag taaggcggat gttgagcaga acacggagga caatgggaaa cccgaaaaac
     1621 ctgagccttc ctcaccttct cccagagctc cagcttcctc ccaacacccc tctgtgcctg
     1681 cttctcccca agggagaaat gccaaggacc ttcttcttga cttgaagaac aaaatattgg
     1741 ctaatggtgg ggcgccccga aaaccccagc ttcgcgccaa gaaggcagag gagctggatc
     1801 ttcagtcgac agaaatcact ggggaggagg agctgggttc ccgggaggac tcgcccatgt
     1861 caccctcaga cacccaagac cagaaacgga ccctgaggcc gccaagtaga cacggccact
     1921 cggtggttgc tcccggcagg actgcagtga gggcccggat gccagcgctg ccccgaaggg
     1981 aaggcgtaga taagcctggc ttttccctgg ccacgcagcc ccgcccaggg gcgcccccct
     2041 cggcttcggc ctctcctgcc caccacgcgt ccacccaggg cacctctcat cgtccttccc
     2101 tgcctgccag cttgaatgac aacgacttgg tggactcaga cgaagatgag cgcgctgtgg
     2161 gctccctcca ccccaagggc gccttcgccc agccccggcc agccctgtcc cccagccgcc
     2221 agtccccgtc cagcgttctc cgcgacagaa gctctgtgca ccccggcgca aagccagcct
     2281 cgccggcccg gaggaccccc cattcagggg ccgcagagga agattccagt gcctcagccc
     2341 caccctcaag actttctcca ccccatgggg gatcatctcg gctgctgccc acccagccac
     2401 acctgagctc tccactttcc aagggcggga aggatggtga ggacgcccca gccaccaact
     2461 ccaatgcgcc atcacggtcc accatgtcct cctccgtctc ttctcatctc tcgtccagga
     2521 cgcaggtctc tgagggagcg gaggcttctg atggtgaaag ccacggtgac ggcgataggg
     2581 aagacggcgg aaggcaggcg gaggccacgg cccagacgct gcgggcccgg cctgcctctg
     2641 gacacttcca tttgctcaga cacaaaccct ttgctgccaa cgggaggtct ccaagcaggt
     2701 tcagcattgg gcggggacct cggctgcagc cctccagctc cccacagtcg actgtgccct
     2761 cccgagccca ccccagggtt ccctctcact ctgattccca ccctaagctt agctcaggta
     2821 tccatggaga cgaggaggat gagaagccgc ttcctgccac cgttgtcaat gaccacgtgc
     2881 cttcctcctc caggcagccc atctcccggg gctgggagga cttaaggaga agcccgcaga
     2941 gaggggccag cctgcatcgg aaggaaccca tcccagagaa ccccaaatcc acaggggcag
     3001 atacacatcc tcagggcaag tactcctccc tggcctccaa ggctcaggat gttcaacaga
     3061 gcacagacgc ggacacggag ggtcattctc ccaaagcaca gccagggtcc acagaccgcc
     3121 acgcgtcccc tgctcgtccg cccgcagcac ggtcacagca gcatcccagt gttcccagaa
     3181 ggatgacacc cggccgggcc ccacaacagc agccccctcc tcccgtcgcc acgtcccagc
     3241 accacccggg accccagagc agagacgcgg gtcggtcacc ttcccagccc aggctctcac
     3301 tgacccaggc cgggcggccc cgccccacgt cgcagggccg ctcccactcc tcctcggacc
     3361 cttacacggc gagctccaga gggatgctcc ccacggccct ccagaaccag gacgaggatg
     3421 cccagggcag ctacgacgac gacagcacag aagtcgaggc ccaggatgtg cgggcccccg
     3481 cgcacgccgc gcgcgccaag gaggcagctg cgtcccttcc caagcaccag caggtggagt
     3541 ctcccacagg cgcaggggca ggtggcgacc acaggtccca gcgcggacat gcggcctccc
     3601 ccgccaggcc cagccgaccc ggcggccccc agtcccgcgc ccgggtaccc agcagggcag
     3661 cgccggggaa gtcggagcct ccttccaagc ggcccctgtc ctccaagtcc cagcagtcgg
     3721 tctcagccga ggacgacgag gaggaggacg cgggattttt taaaggcggg aaagaagacc
     3781 ttctgtcttc ctctgtgcca aagtggccct cttcctccac tcccaggggc ggcaaagacg
     3841 ccgatgggag cctcgccaag gaagagaggg agcctgccat cgcgcttgcc cctcgcggag
     3901 ggagcctggc tcctgtgaag cgacctctcc ccccacctcc aggcagctcc cccagggcct
     3961 cccacgtccc ttcccgactg ccgcctcgca gcgctgccac cgtgagcccc gtcgcgggca
     4021 cccacccctg gccgcagtac accacgcgcg ccccacctgg ccacttctcc accaccccga
     4081 tgctgtcctt gcgccagagg atgatgcatg ccagattccg taaccctctc tcccgacagc
     4141 ctgccagacc ctcttacaga caaggttata atggcagacc aaatgtagaa gggaaagtcc
     4201 ttcctggtag taatggaaaa ccgaatggac agagaattat caatggccct caaggaacaa
     4261 agtgggttgt ggaccttgat cgtgggttag tattgaatgc agaaggaagg tacctccaag
     4321 attcacatgg aaatcctctt cggattaaac taggaggaga tggtcgaacc attgtagatc
     4381 tggaagggac ccccgtggtg agtcctgacg gcctcccact ctttgggcag gggcgacatg
     4441 gcacacctct ggccaatgcc caagataagc caattttgag tcttggagga aagccgctgg
     4501 tgggcttgga ggtcatcaaa aaaaccaccc atccccctac cactaccatg cagcccacca
     4561 ctactacgac gcccctgcct accactacaa ccccgaggcc caccactgcc accacccgcc
     4621 gcacgaccac cacccgccgc acgaccacca ggcgtccaac aaccacagtc cgaaccacta
     4681 cgcggacaac caccaccacc acccccacac ccaccactcc catccccacc tgtccccctg
     4741 ggaccttgga acggcacgac gatgatggca acctgataat gagctccaat gggatcccag
     4801 agtgctacgc tgaagaagat gagttctcag gcttggagac tgacactgca gtacctacgg
     4861 aagaggccta cgttatatat gatgaagatt atgaatttga gacgtcaagg ccaccaacca
     4921 ccactgagcc ttcgaccact gctaccacac cgagggtgat cccagaggaa ggcgccatca
     4981 gttcctttcc tgaagaagaa tttgatctgg ctggaaggaa acgatttgtt gctccttacg
     5041 tgacgtacct aaataaagac ccatcagccc cgtgctctct gactgatgca ctggatcact
     5101 tccaagtgga cagcctggat gaaatcatcc ccaatgacct gaagaagagt gacctgcctc
     5161 cccagcatgc tccccgcaac atcaccgtgg tggccgtgga aggttgccac tcatttgtca
     5221 ttgtggactg ggacaaagcc accccaggag atgtggtcac aggttacttg gtttacagtg
     5281 catcctatga agacttcatc aggaacaagt ggtccactca agcttcatca gtaactcact
     5341 tgcccattga gaacctaaag cccaacacga ggtattattt taaagtgcaa gcacaaaatc
     5401 ctcatggcta cggacctatc agcccttcgg tctcatttgt caccgaatca gataatcctc
     5461 tgcttgttgt gaggccccca ggcggtgagc ctatctggat cccattcgct ttcaaacatg
     5521 atcccagcta cacggactgc catggacggc aatatgtgaa gcgcacgtgg tatcgaaagt
     5581 tcgtgggagt tgttctttgt aattcactga ggtataaaat ctacctcagt gacaacctga
     5641 aagatacatt ctacagcatt ggagacagct ggggaagagg tgaagaccat tgccaatttg
     5701 tggattcaca ccttgatgga agaacagggc ctcagtccta tgtagaagcc ctccctacta
     5761 ttcaaggcta ctatcgccag tatcgtcagg agcctgtcag gtttgggaac atcggcttcg
     5821 gaacccccta ctactatgtg ggctggtacg agtgtggggt ctccatccct ggaaagtggt
     5881 aatcacagga ccgtcatgct gcaagcttgc cctgcccagc cccaccaact aagtcgcact
     5941 aggggctgtg agcaaagaca gccagcgtgc tcagccccgc tgccctaggt gccaggaagg
     6001 tcatagatgg acactggcca ttctggtcat ctcagtctgg aactcagtcc cacttcttgg
     6061 cctggacaat gaacaggatt cagttttgct gttaactttg cttctctact tttttttgtt
     6121 tgtttgtaat agcacatccc agagacatca gaaaccagca actgattcag tgtgatttcc
     6181 agacttttta ggcatgaaat tcggacactt cagtatttcc aggaatagca tatgcacgct
     6241 gttcttgctt catggaatgc tacatgcttt ctgtttttct cattttggat ttctccaaaa
     6301 ctaactgaat ttaagcttca ggtccctttg tatgcagtag aaaggaatta ttaaaaacac
     6361 caccaaagaa aataaatata tcctacttga aatttactct atggacttac ccactgctag
     6421 aataaatgta tcaaatctta tttgtaaatt ctcaattttg atatatatat gtatatatgc
     6481 atatacatat ccacacttgt ctgcaagaat attgattaaa attgctaaat ttgtacttgt
     6541 tcaccaga
//
