LOCUS       NM_001164473            4227 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens formin binding protein 1 like (FNBP1L), transcript
            variant 3, mRNA.
ACCESSION   NM_001164473
VERSION     NM_001164473.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4227)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 4227)
  AUTHORS   Miller,K.A., Garza-Mayers,A.C., Leung,Y. and Goldberg,M.B.
  TITLE     Identification of interactions among host and bacterial proteins
            and evaluation of their role early during Shigella flexneri
            infection
  JOURNAL   Microbiology (Reading) 164 (4), 540-550 (2018)
   PUBMED   29488864
  REMARK    GeneRIF: During Shigella flexneri infection host protein Toca-1
            precipitate not only the Shigella type 3 secreted effector protein
            IcsB, but also the type 3 secreted proteins OspC3, IpgD and IpaB.
            In infected cells, OspC3-mediated restriction of IL-18 production
            does not require the interaction with Toca-1.
REFERENCE   3  (bases 1 to 4227)
  AUTHORS   Watson,J.R., Fox,H.M., Nietlispach,D., Gallop,J.L., Owen,D. and
            Mott,H.R.
  TITLE     Investigation of the Interaction between Cdc42 and Its Effector
            TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS
            FACILITATED BY DIFFERENTIAL BINDING AFFINITIES
  JOURNAL   J Biol Chem 291 (26), 13875-13890 (2016)
   PUBMED   27129201
  REMARK    GeneRIF: This suggests that TOCA1 binding to Cdc42 is an early step
            in the Cdc42-dependent pathways that govern actin dynamics, and the
            differential binding affinities of the effectors facilitate a
            handover from TOCA1 to N-WASP, which can then drive recruitment of
            the actin-modifying machinery.
REFERENCE   4  (bases 1 to 4227)
  AUTHORS   Kleino,I., Jarviluoma,A., Hepojoki,J., Huovila,A.P. and Saksela,K.
  TITLE     Preferred SH3 domain partners of ADAM metalloproteases include
            shared and ADAM-specific SH3 interactions
  JOURNAL   PLoS One 10 (3), e0121301 (2015)
   PUBMED   25825872
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4227)
  AUTHORS   Chander,H., Brien,C.D., Truesdell,P., Watt,K., Meens,J., Schick,C.,
            Germain,D. and Craig,A.W.
  TITLE     Toca-1 is suppressed by p53 to limit breast cancer cell invasion
            and tumor metastasis
  JOURNAL   Breast Cancer Res 16 (6), 3413 (2014)
   PUBMED   25547174
  REMARK    GeneRIF: Loss of p53 tumor suppressor function in breast cancers
            leads to upregulation of Toca-1, and results in enhanced risk of
            developing metastatic disease.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4227)
  AUTHORS   Tsujita,K., Suetsugu,S., Sasaki,N., Furutani,M., Oikawa,T. and
            Takenawa,T.
  TITLE     Coordination between the actin cytoskeleton and membrane
            deformation by a novel membrane tubulation domain of PCH proteins
            is involved in endocytosis
  JOURNAL   J Cell Biol 172 (2), 269-279 (2006)
   PUBMED   16418535
REFERENCE   7  (bases 1 to 4227)
  AUTHORS   Itoh,T., Erdmann,K.S., Roux,A., Habermann,B., Werner,H. and De
            Camilli,P.
  TITLE     Dynamin and the actin cytoskeleton cooperatively regulate plasma
            membrane invagination by BAR and F-BAR proteins
  JOURNAL   Dev Cell 9 (6), 791-804 (2005)
   PUBMED   16326391
REFERENCE   8  (bases 1 to 4227)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
REFERENCE   9  (bases 1 to 4227)
  AUTHORS   Ho,H.Y., Rohatgi,R., Lebensohn,A.M., Le,Ma., Li,J., Gygi,S.P. and
            Kirschner,M.W.
  TITLE     Toca-1 mediates Cdc42-dependent actin nucleation by activating the
            N-WASP-WIP complex
  JOURNAL   Cell 118 (2), 203-216 (2004)
   PUBMED   15260990
  REMARK    GeneRIF: Toca-1 promotes actin nucleation by activating the
            N-WASP-WIP/CR16 complex, the predominant form of N-WASP in cells.
REFERENCE   10 (bases 1 to 4227)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FNBP1L gene in silico
  JOURNAL   Int J Mol Med 13 (1), 157-162 (2004)
   PUBMED   14654988
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC095034.2, DW423801.1,
            AY514449.1, AK299760.1 and AK000282.1.
            
            On Aug 13, 2020 this sequence version replaced NM_001164473.2.
            
            Summary: The protein encoded by this gene binds to both CDC42 and
            N-WASP. This protein promotes CDC42-induced actin polymerization by
            activating the N-WASP-WIP complex and, therefore, is involved in a
            pathway that links cell surface signals to the actin cytoskeleton.
            Alternative splicing results in multiple transcript variants
            encoding different isoforms. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.275921.1,
                                           SRR1803614.187.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271234.13/ ENSP00000271234.7
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC095034.2         90262-90274
            14-164              DW423801.1         18-168
            165-1154            AY514449.1         1-990
            1155-2145           AK299760.1         528-1518
            2146-4227           AK000282.1         1211-3292
FEATURES             Location/Qualifiers
     source          1..4227
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.1"
     gene            1..4227
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /note="formin binding protein 1 like"
                     /db_xref="GeneID:54874"
                     /db_xref="HGNC:HGNC:20851"
                     /db_xref="MIM:608848"
     exon            1..188
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1982
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transducer of Cdc42-dependent actin assembly 1; toca-1;
                     transducer of Cdc42-dependent actin assembly protein 1"
                     /codon_start=1
                     /product="formin-binding protein 1-like isoform 3"
                     /protein_id="NP_001157945.1"
                     /db_xref="CCDS:CCDS53343.1"
                     /db_xref="GeneID:54874"
                     /db_xref="HGNC:HGNC:20851"
                     /db_xref="MIM:608848"
                     /translation="MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAK
                     QLRNLVKKYCPKRSSKDEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELM
                     RYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDND
                     TNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEM
                     DERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFE
                     PPGDFPFEDYSQHIYRTISDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKPQSP
                     PLTPTSLFTSSTPNGSQFLTFSIEPVHYCMNEIKTGKPRIPSFRSLKRGWSVKMGPAL
                     EDFSHLPPEQRRKKLQQRIDELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPK
                     LAETMNNIDRLRMEIHKNEAWLSEVEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTD
                     DANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLY
                     IIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEKNSKGS"
     exon            189..304
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            305..358
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            359..506
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            507..569
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            570..674
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            675..803
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            804..950
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1154
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1313
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1328
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1329..1438
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1571
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1666
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1815
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1816..1974
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..4227
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4199..4204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /note="hexamer: AATAAA"
     polyA_site      4227
                     /gene="FNBP1L"
                     /gene_synonym="C1orf39; TOCA1"
                     /note="major polyA site"
ORIGIN      
        1 agtcgcgtct ttctcactca ctggggagcc cggcggtggc ggcacctttc gaggtagacc
       61 cgctgagctg ctagcccgcc ggccagcgag tgagaggtcg gacagactgt ggagccgaca
      121 gactgaagga cagcggcacc gccagacggc cagaaagttc cgccatgagc tggggcacgg
      181 agctgtggga tcagttcgac agcttagaca agcatacaca atggggaatt gacttcttgg
      241 aaagatatgc caaatttgtt aaagagagga tagaaattga acagaactat gcgaaacaat
      301 tgagaaatct ggttaagaag tactgcccca aacgttcatc caaagatgaa gagccacggt
      361 ttacctcgtg tgtagccttt tttaatatcc ttaatgagtt aaatgactat gcaggacagc
      421 gagaagttgt agcagaagaa atggcgcaca gagtgtatgg tgaattaatg agatatgctc
      481 atgatctgaa aactgaaaga aaaatgcatc tgcaagaagg acgaaaagct caacaatatc
      541 ttgacatgtg ctggaaacag atggataata gtaaaaagaa gtttgaaaga gaatgtagag
      601 aggcagaaaa ggcacaacag agttatgaaa gattggataa tgatactaat gcaaccaagg
      661 cagatgttga aaaggccaaa cagcagttga atctgcgtac gcatatggcc gatgaaaata
      721 aaaatgaata tgctgcacaa ttacaaaact ttaatggaga acaacataaa catttttatg
      781 tagtgattcc tcagatttac aagcaactac aagaaatgga cgaacgaagg actattaaac
      841 tcagtgagtg ttacagagga tttgctgact cagaacgcaa agttattccc atcatttcaa
      901 aatgtttgga aggaatgatt cttgcagcaa aatcagttga tgaaagaaga gactctcaaa
      961 tggtggtaga ctccttcaaa tctggttttg aacctccagg agactttcca tttgaagatt
     1021 acagtcaaca tatatataga accatttctg atgggactat cagtgcatcc aaacaggaga
     1081 gtgggaagat ggatgccaaa accacagtag gaaaggccaa gggcaaattg tggctctttg
     1141 gaaagaagcc aaagccacag tccccaccct taacccctac tagtttattc acatccagta
     1201 ctcctaatgg gtcccagttt ctcacattct ccattgagcc cgtgcattat tgtatgaatg
     1261 aaataaaaac agggaagccc agaattcctt ctttcagaag cctcaaaaga gggtggtcgg
     1321 tgaagatggg cccagcacta gaagatttca gtcatctgcc accagaacag agacgtaaaa
     1381 aactacagca gcgcattgat gaacttaaca gagaactaca gaaagaatca gaccaaaaag
     1441 atgcactcaa caaaatgaaa gatgtatatg agaagaatcc acaaatgggg gatccaggga
     1501 gtttgcagcc taaattagca gagaccatga ataacattga ccgcctacga atggaaatcc
     1561 ataagaatga ggcttggctc tctgaagtcg aaggcaaaac aggtgggaga ggagacagaa
     1621 gacatagcag tgacataaat catcttgtaa cacagggacg agaaagtcct gagggaagtt
     1681 acactgatga tgcaaaccag gaagtccgtg ggccacccca gcagcatggt caccacaatg
     1741 agtttgatga tgaatttgag gatgatgatc ccttgcctgc tattggacac tgcaaagcta
     1801 tctacccttt tgatggacat aatgaaggta ctctagcaat gaaagaaggt gaagttctct
     1861 acattataga ggaggacaaa ggtgacggat ggacaagagc tcggagacag aacggtgaag
     1921 aaggctacgt tcccacgtca tacatagatg taactctaga gaaaaacagt aaaggttcct
     1981 gaagagggtt tctgaggaaa tgggcaagat gttgaaggag gttacatgca gctgcttttg
     2041 ggggagggta ttagagttgt caggctcaaa gagagtgaga gaagcaagtt gcatgagtgc
     2101 atgcagacat gatttttttt ttactaactt cattagcatt tccatacatt gtttttaaaa
     2161 atcataatac caacccttaa gttcctagtt cacagttatt cccacaaaag aaaaagccaa
     2221 caatagtgta ccatttttct atttatttta ttgctgtcta atcaataaag aatgcagagc
     2281 tgtcaaaaaa tgtgtcttac attagctgtc ccaacaggat tgtcttccct cccagctctg
     2341 ttttaattgg cttttagacc cactatctgt cagatccttg ccatctgtca gtgtctgcct
     2401 gcgccacctc cgtgcttgct taacatcctg ttgcatgtct agcgtgattg agctagattt
     2461 ttcaggcatg tctttagatt cccttgttct tgtcaaagcc ttgttttgtt ttacatttgt
     2521 agtgcaaatc actttgtcaa acatctccag cactaatgtt tccatcttag tatttgtgca
     2581 cactgctata acttccccac tgcaaacatt ccagttttgg cattacgaag aagtagctgt
     2641 gaacctgaag tatttatgat aagaaaaaga aaacatctct gctgtagcct acagcccagt
     2701 tgaaagaact ctttgaaacg tgatacatct tcagcacctc agtctgggaa gaatctagtc
     2761 agcactgaaa tcctggcata ataaacacag aagatattca ccacctcaag acaaaggact
     2821 attgtcaaaa gtcagctgct tccattcaaa tgctgcctta aacttgagtg cctaaatctg
     2881 ttgattgcca acactaccac tacagtatcc cacaaagggc tttatgtgtc agctcagtgc
     2941 gacctgcttt aactctgcag caccgctgca gctgccgatg tagcctcggt aggtggctat
     3001 tagagctcta ccatatacag tggtgcatct tcaaatttat gcatcaaact aaagacatgt
     3061 ccaagtccat tttaatttcc tcagtggttt tatgagaagt tttatgggcc tcccccaatt
     3121 gtctttttat tttgggttat gacgatcatg tttgataatt acaatgatag tctctttcca
     3181 cgtgatgctt ttgtttgaac ctgataaaat ttagtgaaac tttgtaatga tctatgtgca
     3241 cttttacttg taaaatggaa tttctgtatg tttatacttg taaatatgat tgttgttagt
     3301 gctcctgttg ctcatggtgt cctgcctcgc atttgtgatt ctgttaatga catgtatctt
     3361 aactaatttc ttagtggtgt tgtaataggg agatggggca ggtggggggt tatttgtacc
     3421 actgaatctt cattaatttg gttctttact gttttgaggg gagaaagaac gtgaaatggt
     3481 ttgtgtatta ttgaatttta agcaatattt tagaagctgt gtgactgctt taataacttt
     3541 ttcccagtgt tatttgaatc atactacccg ttatactaaa gctgaatgac aattgtgtga
     3601 aagttactgc cttcataaga tcaagtcacc actgttacac agctgacata tagtgtatta
     3661 cctttgcagc tagtaaacta taaagtttag atattgaatc tcgttacagg gttatttata
     3721 taatgtgaca ttattcagta ctgacagact acatgaagta gttttaaaat ctagtgctat
     3781 ttttatttta aaggttagca atgaggagga aatgtgatct ggctgtgttt gtcttctgta
     3841 caaagcctga agtgcttatg gttttttggc taacagccac agagggcaaa gtttaagact
     3901 ttcttgtaag gactaactgt tcttttcaag ctactgtttg tttttctaaa agcaggattt
     3961 gcttccgtag gaggcaagtt ccttgatgtg gaatagtgca acctgtatat gggttattat
     4021 aataggaaag acatttgtac ttgcacagtt taaatcattc ttaaattttg aacatgtgaa
     4081 ttgtcccaaa aaatctttaa ttttttggta atttttactc tttttgtgca catgttgatt
     4141 tcttaatggt aaatccttca tttaaagata gtgttctctg ttgagaatat ttacatggaa
     4201 taaaacaatc ttttcatggc ctgttaa
//
