LOCUS       NM_015033               5420 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens formin binding protein 1 (FNBP1), transcript variant
            1, mRNA.
ACCESSION   NM_015033 XM_052666
VERSION     NM_015033.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5420)
  AUTHORS   Zeni,C., Komiya,Y. and Habas,R.
  TITLE     Formin Binding Protein 1 (FNBP1) regulates non-canonical Wnt
            signaling and vertebrate gastrulation
  JOURNAL   Dev Biol 515, 18-29 (2024)
   PUBMED   38945423
  REMARK    GeneRIF: Formin Binding Protein 1 (FNBP1) regulates non-canonical
            Wnt signaling and vertebrate gastrulation.
REFERENCE   2  (bases 1 to 5420)
  AUTHORS   Zhang,J., Li,X., Zhou,Y., Lin,M., Zhang,Q. and Wang,Y.
  TITLE     FNBP1 Facilitates Cervical Cancer Cell Survival by the Constitutive
            Activation of FAK/PI3K/AKT/mTOR Signaling
  JOURNAL   Cells 12 (15), 1964 (2023)
   PUBMED   37566043
  REMARK    GeneRIF: FNBP1 Facilitates Cervical Cancer Cell Survival by the
            Constitutive Activation of FAK/PI3K/AKT/mTOR Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5420)
  AUTHORS   Suman,P., Mehta,V., Craig,A.W.B. and Chander,H.
  TITLE     Wild-type p53 suppresses formin-binding protein-17 (FBP17) to
            reduce invasion
  JOURNAL   Carcinogenesis 43 (5), 494-503 (2022)
   PUBMED   35134126
  REMARK    GeneRIF: Wild-type p53 suppresses formin-binding protein-17 (FBP17)
            to reduce invasion.
REFERENCE   4  (bases 1 to 5420)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   5  (bases 1 to 5420)
  AUTHORS   Wang,Z., Tian,Z., Song,X. and Zhang,J.
  TITLE     Membrane tension sensing molecule-FNBP1 is a prognostic biomarker
            related to immune infiltration in BRCA, LUAD and STAD
  JOURNAL   BMC Immunol 23 (1), 1 (2022)
   PUBMED   34998385
  REMARK    GeneRIF: Membrane tension sensing molecule-FNBP1 is a prognostic
            biomarker related to immune infiltration in BRCA, LUAD and STAD.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5420)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein
            with FCH, FBH, RhoGAP and SH3 domains
  JOURNAL   Int J Mol Med 11 (6), 791-797 (2003)
   PUBMED   12736724
  REMARK    GeneRIF: FNBP1 family proteins (FNBP1 and TRIP10) consist of FCH,
            FBH and SH3 domains.
REFERENCE   7  (bases 1 to 5420)
  AUTHORS   Fujita,H., Katoh,H., Ishikawa,Y., Mori,K. and Negishi,M.
  TITLE     Rapostlin is a novel effector of Rnd2 GTPase inducing neurite
            branching
  JOURNAL   J Biol Chem 277 (47), 45428-45434 (2002)
   PUBMED   12244061
  REMARK    GeneRIF: Rat rapostlin protein has 93% aa identity to human FBP17.
REFERENCE   8  (bases 1 to 5420)
  AUTHORS   Ghadimi,M.P., Sanzenbacher,R., Thiede,B., Wenzel,J., Jing,Q.,
            Plomann,M., Borkhardt,A., Kabelitz,D. and Janssen,O.
  TITLE     Identification of interaction partners of the cytosolic polyproline
            region of CD95 ligand (CD178)
  JOURNAL   FEBS Lett 519 (1-3), 50-58 (2002)
   PUBMED   12023017
REFERENCE   9  (bases 1 to 5420)
  AUTHORS   Richnau,N. and Aspenstrom,P.
  TITLE     Rich, a rho GTPase-activating protein domain-containing protein
            involved in signaling by Cdc42 and Rac1
  JOURNAL   J Biol Chem 276 (37), 35060-35070 (2001)
   PUBMED   11431473
REFERENCE   10 (bases 1 to 5420)
  AUTHORS   Fuchs,U., Rehkamp,G., Haas,O.A., Slany,R., Konig,M., Bojesen,S.,
            Bohle,R.M., Damm-Welk,C., Ludwig,W.D., Harbott,J. and Borkhardt,A.
  TITLE     The human formin-binding protein 17 (FBP17) interacts with sorting
            nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous
            leukemia
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8756-8761 (2001)
   PUBMED   11438682
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW575478.1, AB011126.1,
            AL158207.15 and CK005680.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_015033.2.
            
            Summary: The protein encoded by this gene is a member of the
            formin-binding-protein family. The protein contains an N-terminal
            Fer/Cdc42-interacting protein 4 (CIP4) homology (FCH) domain
            followed by a coiled-coil domain, a proline-rich motif, a second
            coiled-coil domain, a Rho family protein-binding domain (RBD), and
            a C-terminal SH3 domain. This protein binds sorting nexin 2 (SNX2),
            tankyrase (TNKS), and dynamin; an interaction between this protein
            and formin has not been demonstrated yet in human. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB011126.1, BC101755.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000446176.7/ ENSP00000413625.1
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-41                AW575478.1         6-46
            42-1320             AB011126.1         1-1279
            1321-1321           AL158207.15        124960-124960       c
            1322-2208           AB011126.1         1281-2167
            2209-2362           AB011126.1         2170-2323
            2363-4914           AL158207.15        88746-91297         c
            4915-5420           CK005680.1         1-506
FEATURES             Location/Qualifiers
     source          1..5420
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..5420
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /note="formin binding protein 1"
                     /db_xref="GeneID:23048"
                     /db_xref="HGNC:HGNC:17069"
                     /db_xref="MIM:606191"
     exon            1..238
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2068
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /note="isoform 1 is encoded by transcript variant 1;
                     formin-binding protein 17"
                     /codon_start=1
                     /product="formin-binding protein 1 isoform 1"
                     /protein_id="NP_055848.1"
                     /db_xref="CCDS:CCDS48040.1"
                     /db_xref="GeneID:23048"
                     /db_xref="HGNC:HGNC:17069"
                     /db_xref="MIM:606191"
                     /translation="MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAK
                     QLRNLSKKYQPKKNSKEEEEYKYTSCKAFISNLNEMNDYAGQHEVISENMASQIIVDL
                     ARYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDA
                     DINVTKADVEKARQQAQIRHQMAEDSKADYSSILQKFNHEQHEYYHTHIPNIFQKIQE
                     MEERRIVRMGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVIEAYKSGF
                     EPPGDIEFEDYTQPMKRTVSDNSLSNSRGEGKPDLKFGGKSKGKLWPFIKKNKLMSLL
                     TSPHQPPPPPPASASPSAVPNGPQSPKQQKEPLSHRFNEFMTSKPKIHCFRSLKRGLS
                     LKLGATPEDFSNLPPEQRRKKLQQKVDELNKEIQKEMDQRDAITKMKDVYLKNPQMGD
                     PASLDHKLAEVSQNIEKLRVETQKFEAWLAEVEGRLPARSEQARRQSGLYDSQNPPTV
                     NNCAQDRESPDGSYTEEQSQESEMKVLATDFDDEFDDEEPLPAIGTCKALYTFEGQNE
                     GTISVVEGETLYVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVCLDKNAKDS"
     exon            239..354
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            355..411
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            412..559
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            560..622
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            623..727
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            728..856
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            857..1003
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1201
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..1384
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1385..1399
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1509
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1642
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1764
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1901
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2060
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     exon            2061..5420
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5403..5408
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /note="hexamer: AATAAA"
     polyA_site      5420
                     /gene="FNBP1"
                     /gene_synonym="FBP17"
                     /note="major polyA site"
ORIGIN      
        1 gcggctgctg cttcctcggg ccattttgct gtggagcggc ggggaggagg agccgccgag
       61 gagaccccgg gcgaggagct gcgagccgga ggaggccgcg cggactccgg gctttccgcc
      121 gtcgcgggga tctcgggggg caaagggatc gccggggagg gggaccagag agccgcgccc
      181 gccgcgcgga gcgccccttc gcgtcccctg caccatgagc tggggcaccg agctctggga
      241 tcagtttgac aacttagaaa aacacacaca gtggggaatt gatattcttg agaaatatat
      301 caagtttgtg aaagaaagga cagagattga actcagctat gcaaagcaac tcaggaatct
      361 ttcaaagaag taccaaccta aaaagaactc gaaggaggaa gaagaataca agtatacgtc
      421 atgtaaagct ttcatttcca acctgaacga aatgaatgat tacgcagggc agcatgaagt
      481 tatctccgag aacatggcat cacagatcat tgtggacttg gcacgctatg ttcaggaact
      541 gaaacaggag aggaaatcaa actttcacga tggccgtaaa gcacagcagc acatcgagac
      601 ttgctggaag cagcttgaat ctagtaaaag gcgatttgaa cgcgattgca aagaggcgga
      661 cagggcgcag cagtactttg agaaaatgga cgctgacatc aatgtcacaa aagcggatgt
      721 tgaaaaggcc cgacaacaag ctcaaatacg tcaccaaatg gcagaggaca gcaaagcaga
      781 ttactcatcc attctccaga aattcaacca tgagcagcat gaatattacc atactcacat
      841 ccccaacatc ttccagaaaa tacaagagat ggaggaaagg aggattgtga gaatgggaga
      901 gtccatgaag acatatgcag aggttgatcg gcaggtgatc ccaatcattg ggaagtgcct
      961 ggatggaata gtaaaagcag ccgaatcaat tgatcagaaa aatgattcac agctggtaat
     1021 agaagcttat aaatcagggt ttgagcctcc tggagacatt gaatttgagg attacactca
     1081 gccaatgaag cgcactgtgt cagataacag cctttcaaat tccagaggag aaggcaaacc
     1141 agacctcaaa tttggtggca aatccaaagg aaagttatgg ccgttcatca aaaaaaataa
     1201 gcttatgtcc cttttaacat ccccccatca gcctccccct ccccctcctg cctctgcctc
     1261 accctctgct gttcccaacg gcccccagtc tcccaagcag caaaaggaac ccctctccca
     1321 tcgcttcaac gagttcatga cctccaaacc caaaatccac tgcttcagga gcctaaagcg
     1381 tgggctttct ctcaagctgg gtgcaacacc ggaggatttc agcaacctcc cacctgaaca
     1441 aagaaggaaa aagctgcagc agaaagtcga tgagttaaat aaagaaattc agaaggagat
     1501 ggatcaaaga gatgccataa caaaaatgaa agatgtctac ctaaagaatc ctcagatggg
     1561 agacccagcc agtttggatc acaaattagc agaagtcagc caaaatatag agaaactgcg
     1621 agtagagacc cagaaatttg aggcctggct ggctgaggtt gaaggccggc tcccagcacg
     1681 cagcgagcag gcgcgccggc agagcggact gtacgacagc cagaacccac ccacagtcaa
     1741 caactgcgcc caggaccgtg agagcccaga tggcagttac acagaggagc agagtcagga
     1801 gagtgagatg aaggtgctgg ccacggattt tgacgacgag tttgatgatg aggagcccct
     1861 ccctgccata gggacgtgca aagctctcta cacatttgaa ggtcagaatg aaggaacgat
     1921 ttccgtagtt gaaggagaaa cattgtatgt catagaggaa gacaaaggcg atggctggac
     1981 ccgcattcgg agaaatgaag atgaagaggg ttatgtcccc acttcatatg tcgaagtctg
     2041 tttggacaaa aatgccaaag attcctagag gggagtgcct gcgagcctcg ggtgagcctt
     2101 cctggaggag cctccgtctg cttgttccca caggcctcca gcgccctgcc ctgtggacag
     2161 cccacccctc cgcagcccca tccctgcggg gcggtctctc tctctctcca gcatgctccc
     2221 tgcggccctg ccctcccgcc cagcccgggc cacctcgtgg gggacaagtc tcgccagcgc
     2281 ccacccccat ggctcgggtc agtcctcatc gctccccctc cccaccccgc gcaggccact
     2341 gagacggtgg gacacacgcc cctacctgct ccttcctggg ccctcagtcc acccgggctc
     2401 gtcctggcag cccttccgcg cttcacacag tgccttttgt gaaagtgtca tcacgggtcc
     2461 cctgaggaga caaggcaggt ccagcgcaca tcaggcggac tgagcactcg atgtcatccg
     2521 tgtcgatgtc atccgtgtgt cccagactgt ctgctgtaga aaacacttcc tcctctcctg
     2581 agtctgtgaa gtcctcagtg gtcctttttg gattctaggc ttgcacctca tactaaacat
     2641 tgaccctttc actatgccct caacctggga gcatctggca ggcagggggg caggtacaca
     2701 cacacccaca ggcacaccca ccagtacaca cgcgtgcgca tacacacatt ttggtttgac
     2761 gccctgtttt cagtggcctg gggaggtcca cactggaagt cgaattccag ctcgccttgt
     2821 tgactcgcct gtgtccaccg gccatgagga gcccacgcct gtcctcccca tcactttcct
     2881 gtccctgaga actgtagatc atgcgcttgt gagcgaggcc ctcccctctg caccagctca
     2941 ttgcaaagcg aacatcctct cctttccagg agccccagga ttagcatctg aaaagggtag
     3001 cacttccttt tttgttgttg tttttttttt ttttttgaga cgggagtctc gctctattgt
     3061 tcagactgga gtgcagtggc atgatctcgg ctcactacaa cctccacctc ctgggttcca
     3121 gcgattctcc tgcctcagcc tcccaaatag ctgtgattac aggcgtgcac caccacgccc
     3181 ggctaatgtt tgtattttta gtagagacag ggtttcaccg tgttggtcag gctggtctca
     3241 aactcctgac ctcaggtgat ccgcccgcct cagcctccca aagtgctgag attacaggtg
     3301 tgagctaccg caccccgccg aggttagcac tttcatcacc aaagaccccg tgcctctcgt
     3361 ggtcctttga gggatcccgc cgccaccacc cttgtatttt atcacgtgct cttcagggca
     3421 tgtggaattc gttgagtttg cttttagagc caagtttctt tccctgtgtg ggtttttgag
     3481 gaaaacctga ggtcccctaa tctgtggcca ccaccccccc cccccgccac gccttagagc
     3541 agagcagccc ctcctctcat ttggtgcaga aacagtcaag aggaaccatt ggcctagagc
     3601 tcctgtgacc gagagcgcca cggaagcctg gggatgacgt cgggcagctt tattctttgc
     3661 ttggctttgg taactaggtg gtcccctcaa gcatcctcag ttcctcttgc tgtttatgaa
     3721 tctaagacaa ggaagtccta tagaagccaa agggacaggg acggaaagga caggtcccaa
     3781 gggatggggc tgtctttact tgtggaaacc aggaaattgc tcctctcagc caaccaaggt
     3841 tgaccacaca ccacccttcc ggagcagctc agtcagccct cggggacgag aaaccacaag
     3901 cgcagagacg ctgaggccca ggcaggtgaa gaggaagtgg ctttgggttt ttaaagtagg
     3961 tgagcgtgag cctctctgac tgcttcttcc ccggggggga ctgcaaaccg ctcagggttg
     4021 cggcagagcc atggacttcc ggtccctgca acgggtgacc taagcgtggt gcacccatca
     4081 gtcacgcagg aggactgact tgacagacga aagacaagcc cggatgacac agggtgagaa
     4141 gagtcagggc cgcacctctg tccctgcaaa ccaacaggtg catggtgagt gtggcagtcc
     4201 ccacagctcc acaatgggct cccccgccaa cggggacgac agggatcttc aggaacttct
     4261 gacctcacca agtcaagtgg accactctcc actccacgag gatgtgaaac ggttctttaa
     4321 aatgggattt tagagcctcg ggaatgcatg tgcgtcacat ctttcatatt atgggtcagg
     4381 atagattcat ttcttgcaac atagtggaaa agatataagc tgcagtaatt tgctctttga
     4441 atgaccgtca cccccagtat aggatatgct tgtatccccc cgtcactcct ccgcctgttt
     4501 tttaaacttt tccaccacct gcgtccaaaa agaatgttat agcgagtgct cttaaatgtt
     4561 gaacctgggt gttgcttccg ggccagtctg cgtggctcca tgaaaagctc actgctgccc
     4621 cagccgggct tcttagagga ggtcagttgt cctatgtatc atcatttact ctgggaatcc
     4681 tactgtgaaa tcatgtctgt atttttctgg agcagttcac atagagtaga atgtggaatt
     4741 tcccgtgaac gtctccttcc tcccccgtat ctgccgcctg tcacttcgcc accgtgctag
     4801 aatactgttg tgttgtaaga tgactaattt taaaagaacc tgccctgaaa agttcttaga
     4861 aacgcagtga aagggaggaa cttgtccttt acccagtttt tcctttgtag gatgggaaag
     4921 tataaaaagg cacagaaggt tgtcatgggc tgttccttgg gggtttttat cctgctcacc
     4981 gtggagataa gcctgcggct tgtctaacca gcgcagcgca aaggtctcga tgccttttgg
     5041 taacatccgt cattgcagaa gaaagtttac acgacgtcaa aaagtgacgt tcatgctaag
     5101 tgtttttcca gaaatattgg tttcatgttt cttattggct ctgcctcctg tgcttatatc
     5161 atccaaaaac tttttaaaaa ggtccagaat tctattttaa cctgatgttg agcaccttta
     5221 aaatgttcgt atgtgtgttg cactaattct aaactttgga ggcattttgc tgtgtgaggc
     5281 cgatcgccac tgtaaaggtc ctagagttgc ctgtttgtct ctggagatgg aattaaacca
     5341 aataaagagc ttccactgga ggcttgtatt gaccttgtaa ctatatgtta atctcgtgtt
     5401 aaaataaaat ataacttgtg
//
