LOCUS       NM_024619               1822 bp    mRNA    linear   PRI 20-MAR-2024
DEFINITION  Homo sapiens fructosamine 3 kinase related protein (FN3KRP),
            transcript variant 1, mRNA.
ACCESSION   NM_024619
VERSION     NM_024619.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1822)
  AUTHORS   Torres,G.G., Nygaard,M., Caliebe,A., Blanche,H., Chantalat,S.,
            Galan,P., Lieb,W., Christiansen,L., Deleuze,J.F., Christensen,K.,
            Strauch,K., Muller-Nurasyid,M., Peters,A., Nothen,M.M.,
            Hoffmann,P., Flachsbart,F., Schreiber,S., Ellinghaus,D., Franke,A.,
            Dose,J. and Nebel,A.
  TITLE     Exome-Wide Association Study Identifies FN3KRP and PGP as New
            Candidate Longevity Genes
  JOURNAL   J Gerontol A Biol Sci Med Sci 76 (5), 786-795 (2021)
   PUBMED   33491046
  REMARK    GeneRIF: Exome-Wide Association Study Identifies FN3KRP and PGP as
            New Candidate Longevity Genes.
REFERENCE   2  (bases 1 to 1822)
  AUTHORS   Chen,P., Takeuchi,F., Lee,J.Y., Li,H., Wu,J.Y., Liang,J., Long,J.,
            Tabara,Y., Goodarzi,M.O., Pereira,M.A., Kim,Y.J., Go,M.J.,
            Stram,D.O., Vithana,E., Khor,C.C., Liu,J., Liao,J., Ye,X., Wang,Y.,
            Lu,L., Young,T.L., Lee,J., Thai,A.C., Cheng,C.Y., van Dam,R.M.,
            Friedlander,Y., Heng,C.K., Koh,W.P., Chen,C.H., Chang,L.C.,
            Pan,W.H., Qi,Q., Isono,M., Zheng,W., Cai,Q., Gao,Y., Yamamoto,K.,
            Ohnaka,K., Takayanagi,R., Kita,Y., Ueshima,H., Hsiung,C.A., Cui,J.,
            Sheu,W.H., Rotter,J.I., Chen,Y.D., Hsu,C., Okada,Y., Kubo,M.,
            Takahashi,A., Tanaka,T., van Rooij,F.J., Ganesh,S.K., Huang,J.,
            Huang,T., Yuan,J., Hwang,J.Y., Gross,M.D., Assimes,T.L., Miki,T.,
            Shu,X.O., Qi,L., Chen,Y.T., Lin,X., Aung,T., Wong,T.Y., Teo,Y.Y.,
            Kim,B.J., Kato,N. and Tai,E.S.
  CONSRTM   CHARGE Hematology Working Group
  TITLE     Multiple nonglycemic genomic loci are newly associated with blood
            level of glycated hemoglobin in East Asians
  JOURNAL   Diabetes 63 (7), 2551-2562 (2014)
   PUBMED   24647736
REFERENCE   3  (bases 1 to 1822)
  AUTHORS   Chen,P., Ong,R.T., Tay,W.T., Sim,X., Ali,M., Xu,H., Suo,C., Liu,J.,
            Chia,K.S., Vithana,E., Young,T.L., Aung,T., Lim,W.Y., Khor,C.C.,
            Cheng,C.Y., Wong,T.Y., Teo,Y.Y. and Tai,E.S.
  TITLE     A study assessing the association of glycated hemoglobin A1C
            (HbA1C) associated variants with HbA1C, chronic kidney disease and
            diabetic retinopathy in populations of Asian ancestry
  JOURNAL   PLoS One 8 (11), e79767 (2013)
   PUBMED   24244560
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1822)
  AUTHORS   Soranzo,N., Sanna,S., Wheeler,E., Gieger,C., Radke,D., Dupuis,J.,
            Bouatia-Naji,N., Langenberg,C., Prokopenko,I., Stolerman,E.,
            Sandhu,M.S., Heeney,M.M., Devaney,J.M., Reilly,M.P., Ricketts,S.L.,
            Stewart,A.F., Voight,B.F., Willenborg,C., Wright,B., Altshuler,D.,
            Arking,D., Balkau,B., Barnes,D., Boerwinkle,E., Bohm,B.,
            Bonnefond,A., Bonnycastle,L.L., Boomsma,D.I., Bornstein,S.R.,
            Bottcher,Y., Bumpstead,S., Burnett-Miller,M.S., Campbell,H.,
            Cao,A., Chambers,J., Clark,R., Collins,F.S., Coresh,J., de
            Geus,E.J., Dei,M., Deloukas,P., Doring,A., Egan,J.M., Elosua,R.,
            Ferrucci,L., Forouhi,N., Fox,C.S., Franklin,C., Franzosi,M.G.,
            Gallina,S., Goel,A., Graessler,J., Grallert,H., Greinacher,A.,
            Hadley,D., Hall,A., Hamsten,A., Hayward,C., Heath,S., Herder,C.,
            Homuth,G., Hottenga,J.J., Hunter-Merrill,R., Illig,T.,
            Jackson,A.U., Jula,A., Kleber,M., Knouff,C.W., Kong,A., Kooner,J.,
            Kottgen,A., Kovacs,P., Krohn,K., Kuhnel,B., Kuusisto,J., Laakso,M.,
            Lathrop,M., Lecoeur,C., Li,M., Li,M., Loos,R.J., Luan,J.,
            Lyssenko,V., Magi,R., Magnusson,P.K., Malarstig,A., Mangino,M.,
            Martinez-Larrad,M.T., Marz,W., McArdle,W.L., McPherson,R.,
            Meisinger,C., Meitinger,T., Melander,O., Mohlke,K.L., Mooser,V.E.,
            Morken,M.A., Narisu,N., Nathan,D.M., Nauck,M., O'Donnell,C.,
            Oexle,K., Olla,N., Pankow,J.S., Payne,F., Peden,J.F.,
            Pedersen,N.L., Peltonen,L., Perola,M., Polasek,O., Porcu,E.,
            Rader,D.J., Rathmann,W., Ripatti,S., Rocheleau,G., Roden,M.,
            Rudan,I., Salomaa,V., Saxena,R., Schlessinger,D., Schunkert,H.,
            Schwarz,P., Seedorf,U., Selvin,E., Serrano-Rios,M., Shrader,P.,
            Silveira,A., Siscovick,D., Song,K., Spector,T.D., Stefansson,K.,
            Steinthorsdottir,V., Strachan,D.P., Strawbridge,R., Stumvoll,M.,
            Surakka,I., Swift,A.J., Tanaka,T., Teumer,A., Thorleifsson,G.,
            Thorsteinsdottir,U., Tonjes,A., Usala,G., Vitart,V., Volzke,H.,
            Wallaschofski,H., Waterworth,D.M., Watkins,H., Wichmann,H.E.,
            Wild,S.H., Willemsen,G., Williams,G.H., Wilson,J.F., Winkelmann,J.,
            Wright,A.F., Zabena,C., Zhao,J.H., Epstein,S.E., Erdmann,J.,
            Hakonarson,H.H., Kathiresan,S., Khaw,K.T., Roberts,R., Samani,N.J.,
            Fleming,M.D., Sladek,R., Abecasis,G., Boehnke,M., Froguel,P.,
            Groop,L., McCarthy,M.I., Kao,W.H., Florez,J.C., Uda,M.,
            Wareham,N.J., Barroso,I. and Meigs,J.B.
  CONSRTM   WTCCC
  TITLE     Common variants at 10 genomic loci influence hemoglobin A(C) levels
            via glycemic and nonglycemic pathways
  JOURNAL   Diabetes 59 (12), 3229-3239 (2010)
   PUBMED   20858683
  REMARK    Erratum:[Diabetes. 2011 Mar;60(3):1050-1. multiple author names
            added]
REFERENCE   5  (bases 1 to 1822)
  AUTHORS   Payne,L.S., Brown,P.M., Middleditch,M., Baker,E., Cooper,G.J. and
            Loomes,K.M.
  TITLE     Mapping of the ATP-binding domain of human fructosamine
            3-kinase-related protein by affinity labelling with
            5'-[p-(fluorosulfonyl)benzoyl]adenosine
  JOURNAL   Biochem J 416 (2), 281-288 (2008)
   PUBMED   18637789
  REMARK    GeneRIF: Studies provide evidence that Fn3KRP possesses an
            ATP-binding domain that is structurally related to that of both the
            aminoglycoside kinases and eukaryotic protein kinases.
REFERENCE   6  (bases 1 to 1822)
  AUTHORS   Szwergold,B.S.
  TITLE     Fructosamine-6-phosphates are deglycated by phosphorylation to
            fructosamine-3,6-bisphosphates catalyzed by fructosamine-3-kinase
            (FN3K) and/or fructosamine-3-kinase-related-protein (FN3KRP)
  JOURNAL   Med Hypotheses 68 (1), 37-45 (2007)
   PUBMED   16920277
  REMARK    GeneRIF: In this paper we propose a resolution of both these
            quandaries by proposing that fructosamine-6-phosphates are
            deglycated by phosphorylation to fructosamine-3,6-bisphosphates
            catalyzed by FN3KRP and/or possibly FN3K.
REFERENCE   7  (bases 1 to 1822)
  AUTHORS   Conner,J.R., Beisswenger,P.J. and Szwergold,B.S.
  TITLE     Some clues as to the regulation, expression, function, and
            distribution of fructosamine-3-kinase and
            fructosamine-3-kinase-related protein
  JOURNAL   Ann N Y Acad Sci 1043, 824-836 (2005)
   PUBMED   16037310
  REMARK    GeneRIF: Enzyme is a constitutive 'housekeeping' gene and that ig
            plays an important role in cell metabolism, possibly as a
            deglycating enzyme.
REFERENCE   8  (bases 1 to 1822)
  AUTHORS   Conner,J.R., Beisswenger,P.J. and Szwergold,B.S.
  TITLE     The expression of the genes for fructosamine-3-kinase and
            fructosamine-3-kinase-related protein appears to be constitutive
            and unaffected by environmental signals
  JOURNAL   Biochem Biophys Res Commun 323 (3), 932-936 (2004)
   PUBMED   15381090
  REMARK    GeneRIF: These data suggest that FN3K and FN3KRP act as protein
            repair enzymes and are expressed constitutively in human cells
            independently of some of the variables altered in the diabetic
            state.
REFERENCE   9  (bases 1 to 1822)
  AUTHORS   Collard,F., Wiame,E., Bergans,N., Fortpied,J., Vertommen,D.,
            Vanstapel,F., Delpierre,G. and Van Schaftingen,E.
  TITLE     Fructosamine 3-kinase-related protein and deglycation in human
            erythrocytes
  JOURNAL   Biochem J 382 (Pt 1), 137-143 (2004)
   PUBMED   15137908
REFERENCE   10 (bases 1 to 1822)
  AUTHORS   Collard,F., Delpierre,G., Stroobant,V., Matthijs,G. and Van
            Schaftingen,E.
  TITLE     A mammalian protein homologous to fructosamine-3-kinase is a
            ketosamine-3-kinase acting on psicosamines and ribulosamines but
            not on fructosamines
  JOURNAL   Diabetes 52 (12), 2888-2895 (2003)
   PUBMED   14633848
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC024361.21.
            
            On Nov 23, 2018 this sequence version replaced NM_024619.3.
            
            Summary: A high concentration of glucose can result in
            non-enzymatic oxidation of proteins by reaction of glucose and
            lysine residues (glycation). Proteins modified in this way are less
            active or functional. This gene encodes an enzyme which catalyzes
            the phosphorylation of psicosamines and ribulosamines compared to
            the neighboring gene which encodes a highly similar enzyme,
            fructosamine-3-kinase, which has different substrate specificity.
            The activity of both enzymes may result in deglycation of proteins
            to restore their function. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Mar 2012].
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005624.1, SRR3476690.81538.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000269373.11/ ENSP00000269373.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-191               AC024361.21        67871-68061
            192-343             AC024361.21        70071-70222
            344-435             AC024361.21        71437-71528
            436-518             AC024361.21        73969-74051
            519-641             AC024361.21        77645-77767
            642-1822            AC024361.21        77998-79178
FEATURES             Location/Qualifiers
     source          1..1822
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1822
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /note="fructosamine 3 kinase related protein"
                     /db_xref="GeneID:79672"
                     /db_xref="HGNC:HGNC:25700"
                     /db_xref="MIM:611683"
     exon            1..191
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..980
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /EC_number="2.7.1.172"
                     /note="protein-psicosamine 3-kinase FN3KRP; FN3K-related
                     protein; testis secretory sperm-binding protein Li 211a;
                     protein-ribulosamine 3-kinase"
                     /codon_start=1
                     /product="ketosamine-3-kinase"
                     /protein_id="NP_078895.2"
                     /db_xref="CCDS:CCDS11817.1"
                     /db_xref="GeneID:79672"
                     /db_xref="HGNC:HGNC:25700"
                     /db_xref="MIM:611683"
                     /translation="MEELLRRELGCSSVRATGHSGGGCISQGRSYDTDQGRVFVKVNP
                     KAEARRMFEGEMASLTAILKTNTVKVPKPIKVLDAPGGGSVLVMEHMDMRHLSSHAAK
                     LGAQLADLHLDNKKLGEMRLKEAGTVGRGGGQEERPFVARFGFDVVTCCGYLPQVNDW
                     QEDWVVFYARQRIQPQMDMVEKESGDREALQLWSALQLKIPDLFRDLEIIPALLHGDL
                     WGGNVAEDSSGPVIFDPASFYGHSEYELAIAGMFGGFSSSFYSAYHGKIPKAPGFEKR
                     LQLYQLFHYLNHWNHFGSGYRGSSLNIMRNLVK"
     exon            192..343
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /inference="alignment:Splign:2.1.0"
     exon            344..435
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /inference="alignment:Splign:2.1.0"
     exon            436..518
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /inference="alignment:Splign:2.1.0"
     exon            519..641
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /inference="alignment:Splign:2.1.0"
     exon            642..1822
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1691..1696
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /note="hexamer: ATTAAA"
     polyA_site      1712
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /note="major polyA site"
     regulatory      1773..1778
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /note="hexamer: AATAAA"
     polyA_site      1793
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /note="major polyA site"
     regulatory      1798..1803
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /note="hexamer: AATAAA"
     polyA_site      1822
                     /gene="FN3KRP"
                     /gene_synonym="FN3KL"
                     /note="major polyA site"
ORIGIN      
        1 ctctcgagtc tccgccagat ccggggcggg tccgcggccg cggcgggaac atggaggagc
       61 tcctgaggcg cgagctgggc tgcagctctg tcagggccac gggccactcg gggggcgggt
      121 gcatcagcca gggccggagc tacgacacgg atcaaggacg agtgttcgtg aaagtgaacc
      181 ccaaggcgga ggccagaaga atgtttgaag gtgagatggc aagtttaact gccatcctga
      241 aaacaaacac ggtgaaagtg cccaagccca tcaaggttct ggatgcccca ggcggcggga
      301 gcgtgctggt gatggagcac atggacatga ggcatctgag cagtcatgct gcaaagcttg
      361 gagcccagct ggccgattta caccttgata acaagaagct tggagagatg cgcctgaagg
      421 aggcgggcac agtggggaga ggaggtgggc aggaggaacg gccctttgtg gcccggtttg
      481 gatttgacgt ggtgacgtgc tgtggatacc tcccccaggt gaatgactgg caggaggact
      541 gggtcgtgtt ctatgcccgg cagcgcattc agccccagat ggacatggtg gagaaggagt
      601 ctggggacag ggaggccctc cagctttggt ctgctctgca gttaaagatc cctgacctgt
      661 tccgtgacct ggagatcatc ccagccttac tccacgggga cctctggggt ggaaacgtag
      721 cagaggattc ctctgggccg gtgatttttg acccagcttc tttctacggc cactcggaat
      781 atgagctggc aatagctggc atgtttgggg gctttagcag ctccttttac tccgcctacc
      841 acggcaaaat ccccaaggcc ccaggattcg agaagcgcct tcagttgtat cagctctttc
      901 actacttgaa ccactggaat cattttggat cggggtacag aggatcctcc ctgaacatca
      961 tgaggaatct ggtcaagtga gcgggcctta ctctggaagg aggcctcaga ggtttctcca
     1021 cagtcctctt ctgggcaaat tcttgtttct tcacatgctg gactagctta agaccaatgc
     1081 agtagcttat ttccaagcct tgcaaagtat ataatatcta agaggaaagg ttttgtcatc
     1141 ccagcgttgt ccactttgtg gggctttgta ggtagacgga gccacactac aggcagggta
     1201 tgagcagagg gatgtatgga gtgtgggtga ctctgagcct cactgctgct gcaaggtggg
     1261 gaaactgtaa gtgaacccct gtgggtgcgg gggagggtat ccggtgcgca gggaggtggc
     1321 cagcgccccc gggcactgct gctcataggt acctttccac tgcctcctcc ctgctctcct
     1381 gtgcaggaat gtctctgagc tgttcacgtt gatgcttctt ggttggcaag acttgggtgt
     1441 agacatgaaa ccatcttact aaaagcgtct taaaatgacc aattccagaa tcaagcgtat
     1501 tccgttttct tcctgcatga tccctgggcc ctcccgcagg ctgagcaagt ctgtaaactg
     1561 attctgggag aaaccaagct gctggccata gggtgtcctt gggtacatcc aggagtcttc
     1621 attgcttctg ttattacccc gtctcctctg ccattttcta cagcttgctg agttgtcatt
     1681 cctttgcaac attaaaatac atgctgaact catatttttc cttccttcac tgttgtagta
     1741 aagagacata tttcatgaat ggcattgatg ctaataaatc ctttgcacaa aaatttgaat
     1801 aaacttccag tggtttcgat aa
//
