LOCUS       NM_054034               2388 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens fibronectin 1 (FN1), transcript variant 7, mRNA.
ACCESSION   NM_054034
VERSION     NM_054034.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2388)
  AUTHORS   Millapan,T., Gutierrez,A., Rosas,K., Buchegger,K., Ili,C.G. and
            Brebi,P.
  TITLE     In Silico Insights Reveal Fibronectin 1 as a Theranostic Marker in
            Gastric Cancer
  JOURNAL   Int J Mol Sci 25 (20), 11113 (2024)
   PUBMED   39456895
  REMARK    GeneRIF: In Silico Insights Reveal Fibronectin 1 as a Theranostic
            Marker in Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2388)
  AUTHORS   Skoczynski,K., Kraus,A., Daniel,C., Buttner-Herold,M., Amann,K.,
            Schiffer,M., Hermann,K., Herrnberger-Eimer,L., Tamm,E.R. and
            Buchholz,B.
  TITLE     The extracellular matrix protein fibronectin promotes metanephric
            kidney development
  JOURNAL   Pflugers Arch 476 (6), 963-974 (2024)
   PUBMED   38563997
  REMARK    GeneRIF: The extracellular matrix protein fibronectin promotes
            metanephric kidney development.
REFERENCE   3  (bases 1 to 2388)
  AUTHORS   Bhattarai,P., Gunasekaran,T.I., Belloy,M.E., Reyes-Dumeyer,D.,
            Julich,D., Tayran,H., Yilmaz,E., Flaherty,D., Turgutalp,B.,
            Sukumar,G., Alba,C., McGrath,E.M., Hupalo,D.N., Bacikova,D., Le
            Guen,Y., Lantigua,R., Medrano,M., Rivera,D., Recio,P., Nuriel,T.,
            Ertekin-Taner,N., Teich,A.F., Dickson,D.W., Holley,S., Greicius,M.,
            Dalgard,C.L., Zody,M., Mayeux,R., Kizil,C. and Vardarajan,B.N.
  TITLE     Rare genetic variation in fibronectin 1 (FN1) protects against
            APOEepsilon4 in Alzheimer's disease
  JOURNAL   Acta Neuropathol 147 (1), 70 (2024)
   PUBMED   38598053
  REMARK    GeneRIF: Rare genetic variation in fibronectin 1 (FN1) protects
            against APOEepsilon4 in Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2388)
  AUTHORS   Sakai,T., Choo,Y.Y., Mitsuhashi,S., Ikebe,R., Jeffers,A., Idell,S.,
            Tucker,T.A. and Ikebe,M.
  TITLE     Myocardin regulates fibronectin expression and secretion from human
            pleural mesothelial cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (4), L419-L430 (2024)
   PUBMED   38349126
  REMARK    GeneRIF: Myocardin regulates fibronectin expression and secretion
            from human pleural mesothelial cells.
REFERENCE   5  (bases 1 to 2388)
  AUTHORS   England,J., McFarquhar,A. and Campeau,P.M.
  TITLE     Spondylometaphyseal Dysplasia, Corner Fracture Type
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   32200603
REFERENCE   6  (bases 1 to 2388)
  AUTHORS   Ruegg,C., Postigo,A.A., Sikorski,E.E., Butcher,E.C., Pytela,R. and
            Erle,D.J.
  TITLE     Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte
            adherence to fibronectin and VCAM-1 and in homotypic cell
            clustering
  JOURNAL   J Cell Biol 117 (1), 179-189 (1992)
   PUBMED   1372909
REFERENCE   7  (bases 1 to 2388)
  AUTHORS   Baron,M., Main,A.L., Driscoll,P.C., Mardon,H.J., Boyd,J. and
            Campbell,I.D.
  TITLE     1H NMR assignment and secondary structure of the cell adhesion type
            III module of fibronectin
  JOURNAL   Biochemistry 31 (7), 2068-2073 (1992)
   PUBMED   1311202
REFERENCE   8  (bases 1 to 2388)
  AUTHORS   Gutman,A., Yamada,K.M. and Kornblihtt,A.
  TITLE     Human fibronectin is synthesized as a pre-propolypeptide
  JOURNAL   FEBS Lett 207 (1), 145-148 (1986)
   PUBMED   3770189
REFERENCE   9  (bases 1 to 2388)
  AUTHORS   Kornblihtt,A.R., Vibe-Pedersen,K. and Baralle,F.E.
  TITLE     Isolation and characterization of cDNA clones for human and bovine
            fibronectins
  JOURNAL   Proc Natl Acad Sci U S A 80 (11), 3218-3222 (1983)
   PUBMED   6304699
REFERENCE   10 (bases 1 to 2388)
  AUTHORS   Zucker,M.B., Mosesson,M.W., Broekman,M.J. and Kaplan,K.L.
  TITLE     Release of platelet fibronectin (cold-insoluble globulin) from
            alpha granules induced by thrombin or collagen; lack of requirement
            for plasma fibronectin in ADP-induced platelet aggregation
  JOURNAL   Blood 54 (1), 8-12 (1979)
   PUBMED   444675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012462.5.
            
            On Apr 15, 2020 this sequence version replaced NM_054034.2.
            
            Summary: This gene encodes fibronectin, a glycoprotein present in a
            soluble dimeric form in plasma, and in a dimeric or multimeric form
            at the cell surface and in extracellular matrix. The encoded
            preproprotein is proteolytically processed to generate the mature
            protein. Fibronectin is involved in cell adhesion and migration
            processes including embryogenesis, wound healing, blood
            coagulation, host defense, and metastasis. The gene has three
            regions subject to alternative splicing, with the potential to
            produce 20 different transcript variants, at least one of which
            encodes an isoform that undergoes proteolytic processing. The
            full-length nature of some variants has not been determined.
            [provided by RefSeq, Jan 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ849445.1, BX538045.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467147, SAMEA2467148
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               AC012462.5         70138-70551         c
            415-543             AC012462.5         69179-69307         c
            544-681             AC012462.5         67807-67944         c
            682-813             AC012462.5         66316-66447         c
            814-951             AC012462.5         65198-65335         c
            952-1110            AC012462.5         62663-62821         c
            1111-1302           AC012462.5         59577-59768         c
            1303-1482           AC012462.5         58629-58808         c
            1483-1659           AC012462.5         57833-58009         c
            1660-1812           AC012462.5         56574-56726         c
            1813-1941           AC012462.5         55156-55284         c
            1942-2085           AC012462.5         53725-53868         c
            2086-2388           AC012462.5         49139-49441         c
FEATURES             Location/Qualifiers
     source          1..2388
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..2388
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /note="fibronectin 1"
                     /db_xref="GeneID:2335"
                     /db_xref="HGNC:HGNC:3778"
                     /db_xref="MIM:135600"
     exon            1..414
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..2240
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /note="isoform 7 preproprotein is encoded by transcript
                     variant 7; cold-insoluble globulin; migration-stimulating
                     factor; lnc-ABCA12-8; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="fibronectin isoform 7 preproprotein"
                     /protein_id="NP_473375.2"
                     /db_xref="CCDS:CCDS46512.1"
                     /db_xref="GeneID:2335"
                     /db_xref="HGNC:HGNC:3778"
                     /db_xref="MIM:135600"
                     /translation="MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVA
                     VSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYT
                     GNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHET
                     GGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGE
                     GSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSV
                     QTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCT
                     CLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNY
                     EQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQ
                     NYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC
                     IAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSET
                     GTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPN
                     SHPIQWNAPQPSHISKYILRWRPVSIPPRNLGY"
     exon            415..543
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            544..681
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            682..813
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            814..951
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1110
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1302
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1482
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1659
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1812
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1941
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2085
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2388
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2362..2367
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /note="hexamer: ATTAAA"
     polyA_site      2388
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcgccg gctgtgctgc acagggggag gagagggaac cccaggcgcg agcgggaaga
       61 ggggacctgc agccacaact tctctggtcc tctgcatccc ttctgtccct ccacccgtcc
      121 ccttccccac cctctggccc ccaccttctt ggaggcgaca acccccggga ggcattagaa
      181 gggatttttc ccgcaggttg cgaagggaag caaacttggt ggcaacttgc ctcccggtgc
      241 gggcgtctct cccccaccgt ctcaacatgc ttaggggtcc ggggcccggg ctgctgctgc
      301 tggccgtcca gtgcctgggg acagcggtgc cctccacggg agcctcgaag agcaagaggc
      361 aggctcagca aatggttcag ccccagtccc cggtggctgt cagtcaaagc aagcccggtt
      421 gttatgacaa tggaaaacac tatcagataa atcaacagtg ggagcggacc tacctaggca
      481 atgcgttggt ttgtacttgt tatggaggaa gccgaggttt taactgcgag agtaaacctg
      541 aagctgaaga gacttgcttt gacaagtaca ctgggaacac ttaccgagtg ggtgacactt
      601 atgagcgtcc taaagactcc atgatctggg actgtacctg catcggggct gggcgaggga
      661 gaataagctg taccatcgca aaccgctgcc atgaaggggg tcagtcctac aagattggtg
      721 acacctggag gagaccacat gagactggtg gttacatgtt agagtgtgtg tgtcttggta
      781 atggaaaagg agaatggacc tgcaagccca tagctgagaa gtgttttgat catgctgctg
      841 ggacttccta tgtggtcgga gaaacgtggg agaagcccta ccaaggctgg atgatggtag
      901 attgtacttg cctgggagaa ggcagcggac gcatcacttg cacttctaga aatagatgca
      961 acgatcagga cacaaggaca tcctatagaa ttggagacac ctggagcaag aaggataatc
     1021 gaggaaacct gctccagtgc atctgcacag gcaacggccg aggagagtgg aagtgtgaga
     1081 ggcacacctc tgtgcagacc acatcgagcg gatctggccc cttcaccgat gttcgtgcag
     1141 ctgtttacca accgcagcct cacccccagc ctcctcccta tggccactgt gtcacagaca
     1201 gtggtgtggt ctactctgtg gggatgcagt ggctgaagac acaaggaaat aagcaaatgc
     1261 tttgcacgtg cctgggcaac ggagtcagct gccaagagac agctgtaacc cagacttacg
     1321 gtggcaactc aaatggagag ccatgtgtct taccattcac ctacaatggc aggacgttct
     1381 actcctgcac cacagaaggg cgacaggacg gacatctttg gtgcagcaca acttcgaatt
     1441 atgagcagga ccagaaatac tctttctgca cagaccacac tgttttggtt cagactcgag
     1501 gaggaaattc caatggtgcc ttgtgccact tccccttcct atacaacaac cacaattaca
     1561 ctgattgcac ttctgagggc agaagagaca acatgaagtg gtgtgggacc acacagaact
     1621 atgatgccga ccagaagttt gggttctgcc ccatggctgc ccacgaggaa atctgcacaa
     1681 ccaatgaagg ggtcatgtac cgcattggag atcagtggga taagcagcat gacatgggtc
     1741 acatgatgag gtgcacgtgt gttgggaatg gtcgtgggga atggacatgc attgcctact
     1801 cgcagcttcg agatcagtgc attgttgatg acatcactta caatgtgaac gacacattcc
     1861 acaagcgtca tgaagagggg cacatgctga actgtacatg cttcggtcag ggtcggggca
     1921 ggtggaagtg tgatcccgtc gaccaatgcc aggattcaga gactgggacg ttttatcaaa
     1981 ttggagattc atgggagaag tatgtgcatg gtgtcagata ccagtgctac tgctatggcc
     2041 gtggcattgg ggagtggcat tgccaacctt tacagaccta tccaagctca agtggtcctg
     2101 tcgaagtatt tatcactgag actccgagtc agcccaactc ccaccccatc cagtggaatg
     2161 caccacagcc atctcacatt tccaagtaca ttctcaggtg gagacctgtg agtatcccac
     2221 ccagaaacct tggatactga gtctcctaat cttatcaatt ctgatggttt ctttttttcc
     2281 cagcttttga gccaacaact ctgattaact attcctatag catttactat atttgtttag
     2341 tgaacaaaca atatgtggtc aattaaattg acttgtagac tgagggga
//
