LOCUS       NM_001365522            7952 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens fibronectin 1 (FN1), transcript variant 17, mRNA.
ACCESSION   NM_001365522 XM_017003694
VERSION     NM_001365522.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7952)
  AUTHORS   Millapan,T., Gutierrez,A., Rosas,K., Buchegger,K., Ili,C.G. and
            Brebi,P.
  TITLE     In Silico Insights Reveal Fibronectin 1 as a Theranostic Marker in
            Gastric Cancer
  JOURNAL   Int J Mol Sci 25 (20), 11113 (2024)
   PUBMED   39456895
  REMARK    GeneRIF: In Silico Insights Reveal Fibronectin 1 as a Theranostic
            Marker in Gastric Cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7952)
  AUTHORS   Skoczynski,K., Kraus,A., Daniel,C., Buttner-Herold,M., Amann,K.,
            Schiffer,M., Hermann,K., Herrnberger-Eimer,L., Tamm,E.R. and
            Buchholz,B.
  TITLE     The extracellular matrix protein fibronectin promotes metanephric
            kidney development
  JOURNAL   Pflugers Arch 476 (6), 963-974 (2024)
   PUBMED   38563997
  REMARK    GeneRIF: The extracellular matrix protein fibronectin promotes
            metanephric kidney development.
REFERENCE   3  (bases 1 to 7952)
  AUTHORS   Bhattarai,P., Gunasekaran,T.I., Belloy,M.E., Reyes-Dumeyer,D.,
            Julich,D., Tayran,H., Yilmaz,E., Flaherty,D., Turgutalp,B.,
            Sukumar,G., Alba,C., McGrath,E.M., Hupalo,D.N., Bacikova,D., Le
            Guen,Y., Lantigua,R., Medrano,M., Rivera,D., Recio,P., Nuriel,T.,
            Ertekin-Taner,N., Teich,A.F., Dickson,D.W., Holley,S., Greicius,M.,
            Dalgard,C.L., Zody,M., Mayeux,R., Kizil,C. and Vardarajan,B.N.
  TITLE     Rare genetic variation in fibronectin 1 (FN1) protects against
            APOEepsilon4 in Alzheimer's disease
  JOURNAL   Acta Neuropathol 147 (1), 70 (2024)
   PUBMED   38598053
  REMARK    GeneRIF: Rare genetic variation in fibronectin 1 (FN1) protects
            against APOEepsilon4 in Alzheimer's disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 7952)
  AUTHORS   Sakai,T., Choo,Y.Y., Mitsuhashi,S., Ikebe,R., Jeffers,A., Idell,S.,
            Tucker,T.A. and Ikebe,M.
  TITLE     Myocardin regulates fibronectin expression and secretion from human
            pleural mesothelial cells
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (4), L419-L430 (2024)
   PUBMED   38349126
  REMARK    GeneRIF: Myocardin regulates fibronectin expression and secretion
            from human pleural mesothelial cells.
REFERENCE   5  (bases 1 to 7952)
  AUTHORS   England,J., McFarquhar,A. and Campeau,P.M.
  TITLE     Spondylometaphyseal Dysplasia, Corner Fracture Type
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   32200603
REFERENCE   6  (bases 1 to 7952)
  AUTHORS   Ruegg,C., Postigo,A.A., Sikorski,E.E., Butcher,E.C., Pytela,R. and
            Erle,D.J.
  TITLE     Role of integrin alpha 4 beta 7/alpha 4 beta P in lymphocyte
            adherence to fibronectin and VCAM-1 and in homotypic cell
            clustering
  JOURNAL   J Cell Biol 117 (1), 179-189 (1992)
   PUBMED   1372909
REFERENCE   7  (bases 1 to 7952)
  AUTHORS   Baron,M., Main,A.L., Driscoll,P.C., Mardon,H.J., Boyd,J. and
            Campbell,I.D.
  TITLE     1H NMR assignment and secondary structure of the cell adhesion type
            III module of fibronectin
  JOURNAL   Biochemistry 31 (7), 2068-2073 (1992)
   PUBMED   1311202
REFERENCE   8  (bases 1 to 7952)
  AUTHORS   Gutman,A., Yamada,K.M. and Kornblihtt,A.
  TITLE     Human fibronectin is synthesized as a pre-propolypeptide
  JOURNAL   FEBS Lett 207 (1), 145-148 (1986)
   PUBMED   3770189
REFERENCE   9  (bases 1 to 7952)
  AUTHORS   Kornblihtt,A.R., Vibe-Pedersen,K. and Baralle,F.E.
  TITLE     Isolation and characterization of cDNA clones for human and bovine
            fibronectins
  JOURNAL   Proc Natl Acad Sci U S A 80 (11), 3218-3222 (1983)
   PUBMED   6304699
REFERENCE   10 (bases 1 to 7952)
  AUTHORS   Zucker,M.B., Mosesson,M.W., Broekman,M.J. and Kaplan,K.L.
  TITLE     Release of platelet fibronectin (cold-insoluble globulin) from
            alpha granules induced by thrombin or collagen; lack of requirement
            for plasma fibronectin in ADP-induced platelet aggregation
  JOURNAL   Blood 54 (1), 8-12 (1979)
   PUBMED   444675
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012462.5 and AC073284.5.
            
            On Apr 15, 2020 this sequence version replaced NM_001365522.1.
            
            Summary: This gene encodes fibronectin, a glycoprotein present in a
            soluble dimeric form in plasma, and in a dimeric or multimeric form
            at the cell surface and in extracellular matrix. The encoded
            preproprotein is proteolytically processed to generate the mature
            protein. Fibronectin is involved in cell adhesion and migration
            processes including embryogenesis, wound healing, blood
            coagulation, host defense, and metastasis. The gene has three
            regions subject to alternative splicing, with the potential to
            produce 20 different transcript variants, at least one of which
            encodes an isoform that undergoes proteolytic processing. The
            full-length nature of some variants has not been determined.
            [provided by RefSeq, Jan 2016].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.17483.1,
                                           SRR14038192.1932122.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-414               AC012462.5         70138-70551         c
            415-543             AC012462.5         69179-69307         c
            544-681             AC012462.5         67807-67944         c
            682-813             AC012462.5         66316-66447         c
            814-951             AC012462.5         65198-65335         c
            952-1110            AC012462.5         62663-62821         c
            1111-1302           AC012462.5         59577-59768         c
            1303-1482           AC012462.5         58629-58808         c
            1483-1659           AC012462.5         57833-58009         c
            1660-1812           AC012462.5         56574-56726         c
            1813-1941           AC012462.5         55156-55284         c
            1942-2085           AC012462.5         53725-53868         c
            2086-2207           AC012462.5         49320-49441         c
            2208-2388           AC012462.5         44417-44597         c
            2389-2565           AC012462.5         44046-44222         c
            2566-2694           AC012462.5         42781-42909         c
            2695-2784           AC012462.5         42591-42680         c
            2785-2979           AC012462.5         41610-41804         c
            2980-3252           AC012462.5         40721-40993         c
            3253-3519           AC012462.5         38872-39138         c
            3520-3614           AC012462.5         33740-33834         c
            3615-3783           AC012462.5         32163-32331         c
            3784-3870           AC012462.5         31620-31706         c
            3871-4062           AC012462.5         29011-29202         c
            4063-4335           AC012462.5         27414-27686         c
            4336-4518           AC012462.5         26115-26297         c
            4519-4608           AC012462.5         22695-22784         c
            4609-4878           AC012462.5         21172-21441         c
            4879-4995           AC012462.5         19343-19459         c
            4996-5160           AC012462.5         18503-18667         c
            5161-5316           AC012462.5         17811-17966         c
            5317-5430           AC012462.5         16695-16808         c
            5431-5618           AC012462.5         13613-13800         c
            5619-5706           AC012462.5         12658-12745         c
            5707-5883           AC012462.5         10981-11157         c
            5884-5973           AC012462.5         10112-10201         c
            5974-6153           AC012462.5         9697-9876           c
            6154-6243           AC012462.5         7805-7894           c
            6244-6435           AC012462.5         6592-6783           c
            6436-6542           AC012462.5         6392-6498           c
            6543-6681           AC012462.5         4777-4915           c
            6682-6846           AC012462.5         2346-2510           c
            6847-6959           AC012462.5         1-113               c
            6960-6972           AC073284.5         94615-94627         c
            6973-7079           AC073284.5         93989-94095         c
            7080-7190           AC073284.5         91079-91189         c
            7191-7952           AC073284.5         89975-90736         c
FEATURES             Location/Qualifiers
     source          1..7952
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q35"
     gene            1..7952
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /note="fibronectin 1"
                     /db_xref="GeneID:2335"
                     /db_xref="HGNC:HGNC:3778"
                     /db_xref="MIM:135600"
     exon            1..414
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     CDS             267..7262
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /note="isoform 17 precursor is encoded by transcript
                     variant 17; cold-insoluble globulin; migration-stimulating
                     factor; lnc-ABCA12-8; epididymis secretory sperm binding
                     protein"
                     /codon_start=1
                     /product="fibronectin isoform 17 precursor"
                     /protein_id="NP_001352451.1"
                     /db_xref="GeneID:2335"
                     /db_xref="HGNC:HGNC:3778"
                     /db_xref="MIM:135600"
                     /translation="MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVA
                     VSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYT
                     GNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHET
                     GGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGE
                     GSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSV
                     QTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCT
                     CLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNY
                     EQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQ
                     NYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC
                     IAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSET
                     GTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPN
                     SHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLI
                     SIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSW
                     VSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGE
                     QSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTEL
                     NLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQ
                     FVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVT
                     YYFKVFAVSHGRESKPLTAQQTTKLDAPTNLQFVNETDSTVLVRWTPPRAQITGYRLT
                     VGLTRRGQPRQYNVGPSVSKYPLRNLQPASEYTVSLVAIKGNQESPKATGVFTTLQPG
                     SSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVSGLTPG
                     VEYVYTIQVLRDGQERDAPIVNKVVTPLSPPTNLHLEANPDTGVLTVSWERSTTPDIT
                     GYRITTTPTNGQQGNSLEEVVHADQSSCTFDNLSPGLEYNVSVYTVKDDKESVPISDT
                     IIPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSV
                     GYYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTW
                     APPPSIDLTNFLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYVVSVSSVYEQH
                     ESTPLRGRQKTGLDSPTGIDFSDITANSFTVHWIAPRATITGYRIRHHPEHFSGRPRE
                     DRVPHSRNSITLTNLTPGTEYVVSIVALNGREESPLLIGQQSTVSDVPRDLEVVAATP
                     TSLLISWDAPAVTVRYYRITYGETGGNSPVQEFTVPGSKSTATISGLKPGVDYTITVY
                     AVTGRGDSPASSKPISINYRTEIDKPSQMQVTDVQDNSISVKWLPSSSPVTGYRVTTT
                     PKNGPGPTKTKTAGPDQTEMTIEGLQPTVEYVVSVYAQNPSGESQPLVQTAVTTIPAP
                     TDLKFTQVTPTSLSAQWTPPNVQLTGYRVRVTPKEKTGPMKEINLAPDSSSVVVSGLM
                     VATKYEVSVYALKDTLTSRPAQGVVTTLENVSPPRRARVTDATETTITISWRTKTETI
                     TGFQVDAVPANGQTPIQRTIKPDVRSYTITGLQPGTDYKIYLYTLNDNARSSPVVIDA
                     STAIDAPSNLRFLATTPNSLLVSWQPPRARITGYIIKYEKPGSPPREVVPRPRPGVTE
                     ATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTVQKTPFVTHPGYDTGNGIQLPGTS
                     GQQPSVGQQMIFEEHGFRRTTPPTTATPIRHRPRPYPPNVGQEALSQTTISWAPFQDT
                     SEYIISCHPVGTDEEPLQFRVPGTSTSATLTGLTRGATYNVIVEALKDQQRHKVREEV
                     VTVGNSVNEGLNQPTDDSCFDPYTVSHYAVGDEWERMSESGFKLLCQCLGFGSGHFRC
                     DSSRWCHDNGVNYKIGEKWDRQGENGQMMSCTCLGNGKGEFKCDPHEATCYDDGKTYH
                     VGEQWQKEYLGAICSCTCFGGQRGWRCDNCRRPGGEPSPEGTTGQSYNQYSQRYHQRT
                     NTNVNCPIECFMPLDVQADREDSRE"
     exon            415..543
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            544..681
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            682..813
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            814..951
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1110
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1302
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1482
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1659
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1812
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1813..1941
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            1942..2085
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            2086..2207
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2388
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            2389..2565
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2694
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            2695..2784
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2979
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            2980..3252
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            3253..3519
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3614
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            3615..3783
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3870
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4062
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            4063..4335
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            4336..4518
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            4519..4608
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            4609..4878
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            4879..4995
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            4996..5160
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            5161..5316
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            5317..5430
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            5431..5618
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            5619..5706
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            5707..5883
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            5884..5973
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            5974..6153
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            6154..6243
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            6244..6435
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            6436..6542
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            6543..6681
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            6682..6846
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            6847..6972
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            6973..7079
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            7080..7190
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     exon            7191..7952
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7933..7938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /note="hexamer: AATAAA"
     polyA_site      7952
                     /gene="FN1"
                     /gene_synonym="CIG; ED-B; FINC; FN; FNZ; GFND; GFND2;
                     LETS; MSF; SMDCF"
                     /note="major polyA site"
ORIGIN      
        1 gcccgcgccg gctgtgctgc acagggggag gagagggaac cccaggcgcg agcgggaaga
       61 ggggacctgc agccacaact tctctggtcc tctgcatccc ttctgtccct ccacccgtcc
      121 ccttccccac cctctggccc ccaccttctt ggaggcgaca acccccggga ggcattagaa
      181 gggatttttc ccgcaggttg cgaagggaag caaacttggt ggcaacttgc ctcccggtgc
      241 gggcgtctct cccccaccgt ctcaacatgc ttaggggtcc ggggcccggg ctgctgctgc
      301 tggccgtcca gtgcctgggg acagcggtgc cctccacggg agcctcgaag agcaagaggc
      361 aggctcagca aatggttcag ccccagtccc cggtggctgt cagtcaaagc aagcccggtt
      421 gttatgacaa tggaaaacac tatcagataa atcaacagtg ggagcggacc tacctaggca
      481 atgcgttggt ttgtacttgt tatggaggaa gccgaggttt taactgcgag agtaaacctg
      541 aagctgaaga gacttgcttt gacaagtaca ctgggaacac ttaccgagtg ggtgacactt
      601 atgagcgtcc taaagactcc atgatctggg actgtacctg catcggggct gggcgaggga
      661 gaataagctg taccatcgca aaccgctgcc atgaaggggg tcagtcctac aagattggtg
      721 acacctggag gagaccacat gagactggtg gttacatgtt agagtgtgtg tgtcttggta
      781 atggaaaagg agaatggacc tgcaagccca tagctgagaa gtgttttgat catgctgctg
      841 ggacttccta tgtggtcgga gaaacgtggg agaagcccta ccaaggctgg atgatggtag
      901 attgtacttg cctgggagaa ggcagcggac gcatcacttg cacttctaga aatagatgca
      961 acgatcagga cacaaggaca tcctatagaa ttggagacac ctggagcaag aaggataatc
     1021 gaggaaacct gctccagtgc atctgcacag gcaacggccg aggagagtgg aagtgtgaga
     1081 ggcacacctc tgtgcagacc acatcgagcg gatctggccc cttcaccgat gttcgtgcag
     1141 ctgtttacca accgcagcct cacccccagc ctcctcccta tggccactgt gtcacagaca
     1201 gtggtgtggt ctactctgtg gggatgcagt ggctgaagac acaaggaaat aagcaaatgc
     1261 tttgcacgtg cctgggcaac ggagtcagct gccaagagac agctgtaacc cagacttacg
     1321 gtggcaactc aaatggagag ccatgtgtct taccattcac ctacaatggc aggacgttct
     1381 actcctgcac cacagaaggg cgacaggacg gacatctttg gtgcagcaca acttcgaatt
     1441 atgagcagga ccagaaatac tctttctgca cagaccacac tgttttggtt cagactcgag
     1501 gaggaaattc caatggtgcc ttgtgccact tccccttcct atacaacaac cacaattaca
     1561 ctgattgcac ttctgagggc agaagagaca acatgaagtg gtgtgggacc acacagaact
     1621 atgatgccga ccagaagttt gggttctgcc ccatggctgc ccacgaggaa atctgcacaa
     1681 ccaatgaagg ggtcatgtac cgcattggag atcagtggga taagcagcat gacatgggtc
     1741 acatgatgag gtgcacgtgt gttgggaatg gtcgtgggga atggacatgc attgcctact
     1801 cgcagcttcg agatcagtgc attgttgatg acatcactta caatgtgaac gacacattcc
     1861 acaagcgtca tgaagagggg cacatgctga actgtacatg cttcggtcag ggtcggggca
     1921 ggtggaagtg tgatcccgtc gaccaatgcc aggattcaga gactgggacg ttttatcaaa
     1981 ttggagattc atgggagaag tatgtgcatg gtgtcagata ccagtgctac tgctatggcc
     2041 gtggcattgg ggagtggcat tgccaacctt tacagaccta tccaagctca agtggtcctg
     2101 tcgaagtatt tatcactgag actccgagtc agcccaactc ccaccccatc cagtggaatg
     2161 caccacagcc atctcacatt tccaagtaca ttctcaggtg gagacctaaa aattctgtag
     2221 gccgttggaa ggaagctacc ataccaggcc acttaaactc ctacaccatc aaaggcctga
     2281 agcctggtgt ggtatacgag ggccagctca tcagcatcca gcagtacggc caccaagaag
     2341 tgactcgctt tgacttcacc accaccagca ccagcacacc tgtgaccagc aacaccgtga
     2401 caggagagac gactcccttt tctcctcttg tggccacttc tgaatctgtg accgaaatca
     2461 cagccagtag ctttgtggtc tcctgggtct cagcttccga caccgtgtcg ggattccggg
     2521 tggaatatga gctgagtgag gagggagatg agccacagta cctggatctt ccaagcacag
     2581 ccacttctgt gaacatccct gacctgcttc ctggccgaaa atacattgta aatgtctatc
     2641 agatatctga ggatggggag cagagtttga tcctgtctac ttcacaaaca acagcgcctg
     2701 atgcccctcc tgacacgact gtggaccaag ttgatgacac ctcaattgtt gttcgctgga
     2761 gcagacccca ggctcccatc acagggtaca gaatagtcta ttcgccatca gtagaaggta
     2821 gcagcacaga actcaacctt cctgaaactg caaactccgt caccctcagt gacttgcaac
     2881 ctggtgttca gtataacatc actatctatg ctgtggaaga aaatcaagaa agtacacctg
     2941 ttgtcattca acaagaaacc actggcaccc cacgctcaga tacagtgccc tctcccaggg
     3001 acctgcagtt tgtggaagtg acagacgtga aggtcaccat catgtggaca ccgcctgaga
     3061 gtgcagtgac cggctaccgt gtggatgtga tccccgtcaa cctgcctggc gagcacgggc
     3121 agaggctgcc catcagcagg aacacctttg cagaagtcac cgggctgtcc cctggggtca
     3181 cctattactt caaagtcttt gcagtgagcc atgggaggga gagcaagcct ctgactgctc
     3241 aacagacaac caaactggat gctcccacta acctccagtt tgtcaatgaa actgattcta
     3301 ctgtcctggt gagatggact ccacctcggg cccagataac aggataccga ctgaccgtgg
     3361 gccttacccg aagaggacag cccaggcagt acaatgtggg tccctctgtc tccaagtacc
     3421 cactgaggaa tctgcagcct gcatctgagt acaccgtatc cctcgtggcc ataaagggca
     3481 accaagagag ccccaaagcc actggagtct ttaccacact gcagcctggg agctctattc
     3541 caccttacaa caccgaggtg actgagacca ccattgtgat cacatggacg cctgctccaa
     3601 gaattggttt taagctgggt gtacgaccaa gccagggagg agaggcacca cgagaagtga
     3661 cttcagactc aggaagcatc gttgtgtccg gcttgactcc aggagtagaa tacgtctaca
     3721 ccatccaagt cctgagagat ggacaggaaa gagatgcgcc aattgtaaac aaagtggtga
     3781 caccattgtc tccaccaaca aacttgcatc tggaggcaaa ccctgacact ggagtgctca
     3841 cagtctcctg ggagaggagc accaccccag acattactgg ttatagaatt accacaaccc
     3901 ctacaaacgg ccagcaggga aattctttgg aagaagtggt ccatgctgat cagagctcct
     3961 gcacttttga taacctgagt cccggcctgg agtacaatgt cagtgtttac actgtcaagg
     4021 atgacaagga aagtgtccct atctctgata ccatcatccc agaggtgccc caactcactg
     4081 acctaagctt tgttgatata accgattcaa gcatcggcct gaggtggacc ccgctaaact
     4141 cttccaccat tattgggtac cgcatcacag tagttgcggc aggagaaggt atccctattt
     4201 ttgaagattt tgtggactcc tcagtaggat actacacagt cacagggctg gagccgggca
     4261 ttgactatga tatcagcgtt atcactctca ttaatggcgg cgagagtgcc cctactacac
     4321 tgacacaaca aacggctgtt cctcctccca ctgacctgcg attcaccaac attggtccag
     4381 acaccatgcg tgtcacctgg gctccacccc catccattga tttaaccaac ttcctggtgc
     4441 gttactcacc tgtgaaaaat gaggaagatg ttgcagagtt gtcaatttct ccttcagaca
     4501 atgcagtggt cttaacaaat ctcctgcctg gtacagaata tgtagtgagt gtctccagtg
     4561 tctacgaaca acatgagagc acacctctta gaggaagaca gaaaacaggt cttgattccc
     4621 caactggcat tgacttttct gatattactg ccaactcttt tactgtgcac tggattgctc
     4681 ctcgagccac catcactggc tacaggatcc gccatcatcc cgagcacttc agtgggagac
     4741 ctcgagaaga tcgggtgccc cactctcgga attccatcac cctcaccaac ctcactccag
     4801 gcacagagta tgtggtcagc atcgttgctc ttaatggcag agaggaaagt cccttattga
     4861 ttggccaaca atcaacagtt tctgatgttc cgagggacct ggaagttgtt gctgcgaccc
     4921 ccaccagcct actgatcagc tgggatgctc ctgctgtcac agtgagatat tacaggatca
     4981 cttacggaga gacaggagga aatagccctg tccaggagtt cactgtgcct gggagcaagt
     5041 ctacagctac catcagcggc cttaaacctg gagttgatta taccatcact gtgtatgctg
     5101 tcactggccg tggagacagc cccgcaagca gcaagccaat ttccattaat taccgaacag
     5161 aaattgacaa accatcccag atgcaagtga ccgatgttca ggacaacagc attagtgtca
     5221 agtggctgcc ttcaagttcc cctgttactg gttacagagt aaccaccact cccaaaaatg
     5281 gaccaggacc aacaaaaact aaaactgcag gtccagatca aacagaaatg actattgaag
     5341 gcttgcagcc cacagtggag tatgtggtta gtgtctatgc tcagaatcca agcggagaga
     5401 gtcagcctct ggttcagact gcagtaacca ctattcctgc accaactgac ctgaagttca
     5461 ctcaggtcac acccacaagc ctgagcgccc agtggacacc acccaatgtt cagctcactg
     5521 gatatcgagt gcgggtgacc cccaaggaga agaccggacc aatgaaagaa atcaaccttg
     5581 ctcctgacag ctcatccgtg gttgtatcag gacttatggt ggccaccaaa tatgaagtga
     5641 gtgtctatgc tcttaaggac actttgacaa gcagaccagc tcagggagtt gtcaccactc
     5701 tggagaatgt cagcccacca agaagggctc gtgtgacaga tgctactgag accaccatca
     5761 ccattagctg gagaaccaag actgagacga tcactggctt ccaagttgat gccgttccag
     5821 ccaatggcca gactccaatc cagagaacca tcaagccaga tgtcagaagc tacaccatca
     5881 caggtttaca accaggcact gactacaaga tctacctgta caccttgaat gacaatgctc
     5941 ggagctcccc tgtggtcatc gacgcctcca ctgccattga tgcaccatcc aacctgcgtt
     6001 tcctggccac cacacccaat tccttgctgg tatcatggca gccgccacgt gccaggatta
     6061 ccggctacat catcaagtat gagaagcctg ggtctcctcc cagagaagtg gtccctcggc
     6121 cccgccctgg tgtcacagag gctactatta ctggcctgga accgggaacc gaatatacaa
     6181 tttatgtcat tgccctgaag aataatcaga agagcgagcc cctgattgga aggaaaaaga
     6241 cagttcaaaa gacccctttc gtcacccacc ctgggtatga cactggaaat ggtattcagc
     6301 ttcctggcac ttctggtcag caacccagtg ttgggcaaca aatgatcttt gaggaacatg
     6361 gttttaggcg gaccacaccg cccacaacgg ccacccccat aaggcatagg ccaagaccat
     6421 acccgccgaa tgtaggacaa gaagctctct ctcagacaac catctcatgg gccccattcc
     6481 aggacacttc tgagtacatc atttcatgtc atcctgttgg cactgatgaa gaacccttac
     6541 agttcagggt tcctggaact tctaccagtg ccactctgac aggcctcacc agaggtgcca
     6601 cctacaacgt catagtggag gcactgaaag accagcagag gcataaggtt cgggaagagg
     6661 ttgttaccgt gggcaactct gtcaacgaag gcttgaacca acctacggat gactcgtgct
     6721 ttgaccccta cacagtttcc cattatgccg ttggagatga gtgggaacga atgtctgaat
     6781 caggctttaa actgttgtgc cagtgcttag gctttggaag tggtcatttc agatgtgatt
     6841 catctagatg gtgccatgac aatggtgtga actacaagat tggagagaag tgggaccgtc
     6901 agggagaaaa tggccagatg atgagctgca catgtcttgg gaacggaaaa ggagaattca
     6961 agtgtgaccc tcatgaggca acgtgttatg atgatgggaa gacataccac gtaggagaac
     7021 agtggcagaa ggaatatctc ggtgccattt gctcctgcac atgctttgga ggccagcggg
     7081 gctggcgctg tgacaactgc cgcagacctg ggggtgaacc cagtcccgaa ggcactactg
     7141 gccagtccta caaccagtat tctcagagat accatcagag aacaaacact aatgttaatt
     7201 gcccaattga gtgcttcatg cctttagatg tacaggctga cagagaagat tcccgagagt
     7261 aaatcatctt tccaatccag aggaacaagc atgtctctct gccaagatcc atctaaactg
     7321 gagtgatgtt agcagaccca gcttagagtt cttctttctt tcttaagccc tttgctctgg
     7381 aggaagttct ccagcttcag ctcaactcac agcttctcca agcatcaccc tgggagtttc
     7441 ctgagggttt tctcataaat gagggctgca cattgcctgt tctgcttcga agtattcaat
     7501 accgctcagt attttaaatg aagtgattct aagatttggt ttgggatcaa taggaaagca
     7561 tatgcagcca accaagatgc aaatgttttg aaatgatatg accaaaattt taagtaggaa
     7621 agtcacccaa acacttctgc tttcacttaa gtgtctggcc cgcaatactg taggaacaag
     7681 catgatcttg ttactgtgat attttaaata tccacagtac tcactttttc caaatgatcc
     7741 tagtaattgc ctagaaatat ctttctctta cctgttattt atcaattttt cccagtattt
     7801 ttatacggaa aaaattgtat tgaaaacact tagtatgcag ttgataagag gaatttggta
     7861 taattatggt gggtgattat tttttatact gtatgtgcca aagctttact actgtggaaa
     7921 gacaactgtt ttaataaaag atttacattc ca
//
