LOCUS       NM_002022               2303 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens flavin containing dimethylaniline monoxygenase 4
            (FMO4), mRNA.
ACCESSION   NM_002022
VERSION     NM_002022.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2303)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2303)
  AUTHORS   Howard,T.D., Hsu,F.C., Grzywacz,J.G., Chen,H., Quandt,S.A.,
            Vallejos,Q.M., Whalley,L.E., Cui,W., Padilla,S. and Arcury,T.A.
  TITLE     Evaluation of candidate genes for cholinesterase activity in
            farmworkers exposed to organophosphorus pesticides: association of
            single nucleotide polymorphisms in BCHE
  JOURNAL   Environ Health Perspect 118 (10), 1395-1399 (2010)
   PUBMED   20529763
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2303)
  AUTHORS   Ross,C.J., Katzov-Eckert,H., Dube,M.P., Brooks,B., Rassekh,S.R.,
            Barhdadi,A., Feroz-Zada,Y., Visscher,H., Brown,A.M., Rieder,M.J.,
            Rogers,P.C., Phillips,M.S., Carleton,B.C. and Hayden,M.R.
  CONSRTM   CPNDS Consortium
  TITLE     Genetic variants in TPMT and COMT are associated with hearing loss
            in children receiving cisplatin chemotherapy
  JOURNAL   Nat Genet 41 (12), 1345-1349 (2009)
   PUBMED   19898482
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Erratum:[Nat Genet. 2013 May;45(5):578]
REFERENCE   4  (bases 1 to 2303)
  AUTHORS   Novick,R.M., Mitzey,A.M., Brownfield,M.S. and Elfarra,A.A.
  TITLE     Differential localization of flavin-containing monooxygenase (FMO)
            isoforms 1, 3, and 4 in rat liver and kidney and evidence for
            expression of FMO4 in mouse, rat, and human liver and kidney
            microsomes
  JOURNAL   J Pharmacol Exp Ther 329 (3), 1148-1155 (2009)
   PUBMED   19307449
  REMARK    GeneRIF: Data show a compelling visual demonstration of the
            isoform-specific localization patterns of FMO1, -3, and -4 in the
            rat liver and kidney and the first evidence for expression of FMO4
            at the protein level in mouse and human liver and kidney
            microsomes.
REFERENCE   5  (bases 1 to 2303)
  AUTHORS   Furnes,B., Feng,J., Sommer,S.S. and Schlenk,D.
  TITLE     Identification of novel variants of the flavin-containing
            monooxygenase gene family in African Americans
  JOURNAL   Drug Metab Dispos 31 (2), 187-193 (2003)
   PUBMED   12527699
REFERENCE   6  (bases 1 to 2303)
  AUTHORS   Itagaki,K., Carver,G.T. and Philpot,R.M.
  TITLE     Expression and characterization of a modified flavin-containing
            monooxygenase 4 from humans
  JOURNAL   J Biol Chem 271 (33), 20102-20107 (1996)
   PUBMED   8702731
REFERENCE   7  (bases 1 to 2303)
  AUTHORS   Phillips,I.R., Dolphin,C.T., Clair,P., Hadley,M.R., Hutt,A.J.,
            McCombie,R.R., Smith,R.L. and Shephard,E.A.
  TITLE     The molecular biology of the flavin-containing monooxygenases of
            man
  JOURNAL   Chem Biol Interact 96 (1), 17-32 (1995)
   PUBMED   7720101
REFERENCE   8  (bases 1 to 2303)
  AUTHORS   Hines,R.N., Cashman,J.R., Philpot,R.M., Williams,D.E. and
            Ziegler,D.M.
  TITLE     The mammalian flavin-containing monooxygenases: molecular
            characterization and regulation of expression
  JOURNAL   Toxicol Appl Pharmacol 125 (1), 1-6 (1994)
   PUBMED   8128486
  REMARK    Review article
REFERENCE   9  (bases 1 to 2303)
  AUTHORS   Lawton,M.P., Cashman,J.R., Cresteil,T., Dolphin,C.T., Elfarra,A.A.,
            Hines,R.N., Hodgson,E., Kimura,T., Ozols,J., Phillips,I.R. et al.
  TITLE     A nomenclature for the mammalian flavin-containing monooxygenase
            gene family based on amino acid sequence identities
  JOURNAL   Arch Biochem Biophys 308 (1), 254-257 (1994)
   PUBMED   8311461
REFERENCE   10 (bases 1 to 2303)
  AUTHORS   Dolphin,C.T., Shephard,E.A., Povey,S., Smith,R.L. and Phillips,I.R.
  TITLE     Cloning, primary sequence and chromosomal localization of human
            FMO2, a new member of the flavin-containing mono-oxygenase family
  JOURNAL   Biochem J 287 (Pt 1) (Pt 1), 261-267 (1992)
   PUBMED   1417778
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX495448.1 and BC002780.2.
            
            On Nov 23, 2018 this sequence version replaced NM_002022.2.
            
            Summary: Metabolic N-oxidation of diet-derived amino-trimethylamine
            (TMA) is mediated by flavin-containing monooxygenase and is subject
            to an inherited FMO3 polymorphism in man. This results in a small
            subpopulation with reduced TMA N-oxidation capacity and causes fish
            odor syndrome (Trimethylaminuria). Three forms of the enzyme are
            encoded by genes clustered in the 1q23-q25 region.
            Flavin-containing monooxygenases are NADPH-dependent flavoenzymes
            that catalyzes the oxidation of soft nucleophilic heteroatom
            centers in drugs, pesticides, and xenobiotics. [provided by RefSeq,
            Jan 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002780.2, SRR1803616.201813.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367749.4/ ENSP00000356723.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                BX495448.1         2-52
            52-2303             BC002780.2         1-2252
FEATURES             Location/Qualifiers
     source          1..2303
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..2303
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /note="flavin containing dimethylaniline monoxygenase 4"
                     /db_xref="GeneID:2329"
                     /db_xref="HGNC:HGNC:3772"
                     /db_xref="MIM:136131"
     exon            1..231
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     exon            232..373
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     exon            374..513
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     CDS             382..2058
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /EC_number="1.14.13.8"
                     /note="FMO 4; dimethylaniline oxidase 4; hepatic
                     flavin-containing monooxygenase 4; flavin containing
                     monooxygenase 4"
                     /codon_start=1
                     /product="dimethylaniline monooxygenase [N-oxide-forming]
                     4"
                     /protein_id="NP_002013.1"
                     /db_xref="CCDS:CCDS1295.1"
                     /db_xref="GeneID:2329"
                     /db_xref="HGNC:HGNC:3772"
                     /db_xref="MIM:136131"
                     /translation="MAKKVAVIGAGVSGLSSIKCCVDEDLEPTCFERSDDIGGLWKFT
                     ESSKDGMTRVYKSLVTNVCKEMSCYSDFPFHEDYPNFMNHEKFWDYLQEFAEHFDLLK
                     YIQFKTTVCSITKRPDFSETGQWDVVTETEGKQNRAVFDAVMVCTGHFLNPHLPLEAF
                     PGIHKFKGQILHSQEYKIPEGFQGKRVLVIGLGNTGGDIAVELSRTAAQVLLSTRTGT
                     WVLGRSSDWGYPYNMMVTRRCCSFIAQVLPSRFLNWIQERKLNKRFNHEDYGLSITKG
                     KKAKFIVNDELPNCILCGAITMKTSVIEFTETSAVFEDGTVEENIDVVIFTTGYTFSF
                     PFFEEPLKSLCTKKIFLYKQVFPLNLERATLAIIGLIGLKGSILSGTELQARWVTRVF
                     KGLCKIPPSQKLMMEATEKEQLIKRGVFKDTSKDKFDYIAYMDDIAACIGTKPSIPLL
                     FLKDPRLAWEVFFGPCTPYQYRLMGPGKWDGARNAILTQWDRTLKPLKTRIVPDSSKP
                     ASMSHYLKAWGAPVLLASLLLICKSSLFLKLVRDKLQDRMSPYLVSLWRG"
     exon            514..702
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     exon            703..865
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1008
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1208
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1561
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1631
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..2303
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2280..2285
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /note="hexamer: AATAAA"
     polyA_site      2303
                     /gene="FMO4"
                     /gene_synonym="FMO2"
                     /note="major polyA site"
ORIGIN      
        1 acacaacttt ttttccttag tctgtatact ttctgctgtc actagcataa cagaaaagac
       61 gaatggcttt tgttttaaac tgagggcact tttacaaaag tcatctttcc atttattttt
      121 ctttcagaaa aaagaatttg ggttttgagc ttttttaaaa aaaaaagaca aacactttcc
      181 ttgactttga gaaataattt aagtcaaaga atctgctcta tgctaaccaa gagatagagc
      241 acagcaaaga tctgccagcc ccaggcctct acctagtggc ctggaaattc aagtattctt
      301 attggtggag gccatttgtt tctgattaga agctgtctaa acctcctact cctcaactca
      361 aaggaaaaca cagagcatac catggccaag aaagttgcag tgattggagc tggtgtgagt
      421 ggcctctcct ccatcaaatg ctgtgtggat gaggacctgg agcccacctg ctttgagaga
      481 agtgatgaca ttgggggatt atggaagttt actgaatctt ccaaagatgg gatgaccagg
      541 gtctataagt cattagtgac aaatgtctgt aaggaaatgt catgttacag tgacttccct
      601 ttccacgaag attatcctaa tttcatgaac catgaaaaat tttgggacta tctccaagaa
      661 tttgctgagc actttgacct cctgaaatac attcagttta agaccactgt gtgcagcata
      721 acgaagcgtc cagacttctc cgaaactggt cagtgggatg ttgtcacaga gacagagggc
      781 aagcaaaata gagctgtctt tgatgctgtt atggtttgca ctggacattt cctgaatccc
      841 catttacctt tggaagcctt tcctggaatt cataagttta aaggtcagat cctgcatagt
      901 caagagtaca agatcccaga aggctttcag ggcaaacgcg tcttggtgat tggtcttggg
      961 aacactggag gagacattgc tgtggaactc agtcgaacgg cagctcaggt acttctcagt
     1021 actagaactg gtacctgggt tcttgggcgc tcttcagatt ggggctatcc ttataatatg
     1081 atggttacaa gaagatgctg tagttttatt gcacaagttc tgccttcacg ttttctaaac
     1141 tggattcaag aaaggaagtt gaataagaga tttaatcatg aggattatgg attaagtatt
     1201 accaaaggga aaaaagcaaa attcattgtg aatgatgagc tgccaaactg tatcctctgt
     1261 ggggcaatca ctatgaaaac cagcgtgatt gaatttacag aaacctctgc tgtctttgaa
     1321 gatgggacag tggaagaaaa cattgatgtt gtgatcttca ctacaggata tacattttct
     1381 tttccatttt ttgaagaacc tcttaaaagc ctctgtacaa agaagatatt tctatacaag
     1441 caagtctttc ccttaaacct agagagagcg acattagcca tcatcggcct tatcggcctt
     1501 aaaggatcca tcttatcagg cacagagctc caagcacgat gggtcacaag agtattcaaa
     1561 ggactctgta agatacctcc atcccaaaaa ttgatgatgg aggctactga aaaggaacag
     1621 ctcattaaaa ggggagtgtt taaagacacc agcaaagaca aatttgacta cattgcctac
     1681 atggatgata tcgctgcctg cataggcaca aagcccagca tcccacttct gttcctcaag
     1741 gatcccagac tagcttggga agttttcttt ggaccatgta ctccttatca gtaccgcctc
     1801 atgggccctg gaaaatggga tggagccaga aatgccatcc tgacccagtg ggacagaaca
     1861 ttgaaacctt taaaaactcg aattgtccct gattcctcca agcctgcctc catgtcacat
     1921 tatttaaaag cctggggggc acctgtccta cttgcctctc ttctacttat ctgtaaatct
     1981 tcacttttct tgaaattggt gagagataaa ctacaggaca gaatgtcccc ttacctagta
     2041 agtctttggc gaggatgaac ctgattgtta caagggttac acaaagtcat gctaattcta
     2101 tctccaagta tcttgtgcat ccctcctctg ctctccatca taactgctat tagccaaatt
     2161 caggcccagt catctcctat ctgaattatt gtattatctt cttctttgtt ttcagtaccc
     2221 tctttcttgc caccctttcc aatgcatctt ctaccctgct acctcagtga ttattctaaa
     2281 ataaatatat atgatatggt tta
//
