LOCUS       NM_001460               5215 bp    mRNA    linear   PRI 16-SEP-2024
DEFINITION  Homo sapiens flavin containing dimethylaniline monoxygenase 2
            (FMO2), transcript variant 1, mRNA.
ACCESSION   NM_001460 NR_158621
VERSION     NM_001460.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5215)
  AUTHORS   Wu,L., Chu,J., Shangguan,L., Cao,M. and Lu,F.
  TITLE     Discovery and identification of the prognostic significance and
            potential mechanism of FMO2 in breast cancer
  JOURNAL   Aging (Albany NY) 15 (21), 12651-12673 (2023)
   PUBMED   37963835
  REMARK    GeneRIF: Discovery and identification of the prognostic
            significance and potential mechanism of FMO2 in breast cancer.
REFERENCE   2  (bases 1 to 5215)
  AUTHORS   Wang,L., Zha,H., Huang,J. and Shi,L.
  TITLE     Flavin containing monooxygenase 2 regulates renal tubular cell
            fibrosis and paracrine secretion via SMURF2 in AKI-CKD
            transformation
  JOURNAL   Int J Mol Med 52 (5) (2023)
   PUBMED   37800598
  REMARK    GeneRIF: Flavin containing monooxygenase 2 regulates renal tubular
            cell fibrosis and paracrine secretion via SMURF2 in AKI-CKD
            transformation.
REFERENCE   3  (bases 1 to 5215)
  AUTHORS   Yu,S., Yang,R., Xu,T., Li,X., Wu,S. and Zhang,J.
  TITLE     Cancer-associated fibroblasts-derived FMO2 as a biomarker of
            macrophage infiltration and prognosis in epithelial ovarian cancer
  JOURNAL   Gynecol Oncol 167 (2), 342-353 (2022)
   PUBMED   36114029
  REMARK    GeneRIF: Cancer-associated fibroblasts-derived FMO2 as a biomarker
            of macrophage infiltration and prognosis in epithelial ovarian
            cancer.
REFERENCE   4  (bases 1 to 5215)
  AUTHORS   Perez-Paramo,Y.X., Chen,G., Ashmore,J.H., Watson,C.J.W., Nasrin,S.,
            Adams-Haduch,J., Wang,R., Gao,Y.T., Koh,W.P., Yuan,J.M. and
            Lazarus,P.
  TITLE     Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes
  JOURNAL   Cancer Epidemiol Biomarkers Prev 28 (2), 311-320 (2019)
   PUBMED   30381441
  REMARK    GeneRIF: The functional FMO2(427Q) isoform was active against
            nicotine; the truncated FMO2(Q472stop) isoform exhibited no enzyme
            activity.
REFERENCE   5  (bases 1 to 5215)
  AUTHORS   Whetstine,J.R., Yueh,M.F., McCarver,D.G., Williams,D.E., Park,C.S.,
            Kang,J.H., Cha,Y.N., Dolphin,C.T., Shephard,E.A., Phillips,I.R. and
            Hines,R.N.
  TITLE     Ethnic differences in human flavin-containing monooxygenase 2
            (FMO2) polymorphisms: detection of expressed protein in
            African-Americans
  JOURNAL   Toxicol Appl Pharmacol 168 (3), 216-224 (2000)
   PUBMED   11042094
  REMARK    GeneRIF: Observational study of genotype prevalence. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 5215)
  AUTHORS   Dolphin,C.T., Beckett,D.J., Janmohamed,A., Cullingford,T.E.,
            Smith,R.L., Shephard,E.A. and Phillips,I.R.
  TITLE     The flavin-containing monooxygenase 2 gene (FMO2) of humans, but
            not of other primates, encodes a truncated, nonfunctional protein
  JOURNAL   J Biol Chem 273 (46), 30599-30607 (1998)
   PUBMED   9804831
REFERENCE   7  (bases 1 to 5215)
  AUTHORS   Phillips,I.R., Dolphin,C.T., Clair,P., Hadley,M.R., Hutt,A.J.,
            McCombie,R.R., Smith,R.L. and Shephard,E.A.
  TITLE     The molecular biology of the flavin-containing monooxygenases of
            man
  JOURNAL   Chem Biol Interact 96 (1), 17-32 (1995)
   PUBMED   7720101
REFERENCE   8  (bases 1 to 5215)
  AUTHORS   Hines,R.N., Cashman,J.R., Philpot,R.M., Williams,D.E. and
            Ziegler,D.M.
  TITLE     The mammalian flavin-containing monooxygenases: molecular
            characterization and regulation of expression
  JOURNAL   Toxicol Appl Pharmacol 125 (1), 1-6 (1994)
   PUBMED   8128486
  REMARK    Review article
REFERENCE   9  (bases 1 to 5215)
  AUTHORS   Dolphin,C.T., Shephard,E.A., Povey,S., Smith,R.L. and Phillips,I.R.
  TITLE     Cloning, primary sequence and chromosomal localization of human
            FMO2, a new member of the flavin-containing mono-oxygenase family
  JOURNAL   Biochem J 287 (Pt 1) (Pt 1), 261-267 (1992)
   PUBMED   1417778
REFERENCE   10 (bases 1 to 5215)
  AUTHORS   Lomri,N., Gu,Q. and Cashman,J.R.
  TITLE     Molecular cloning of the flavin-containing monooxygenase (form II)
            cDNA from adult human liver
  JOURNAL   Proc Natl Acad Sci U S A 89 (5), 1685-1689 (1992)
   PUBMED   1542660
  REMARK    Erratum:[Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9910. doi:
            10.1073/pnas.92.21.9910. PMID: 7568243]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB224311.1, BC005894.1,
            KF459607.1, AL833218.1, R95468.1, AK098145.1, AI821378.1 and
            AL021026.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001460.4.
            
            Summary: This gene encodes a flavin-containing monooxygenase family
            member. It is an NADPH-dependent enzyme that catalyzes the
            N-oxidation of some primary alkylamines through an N-hydroxylamine
            intermediate. However, some human populations contain an allele
            (FMO2*2A) with a premature stop codon, resulting in a protein that
            is C-terminally-truncated, has no catalytic activity, and is likely
            degraded rapidly. This gene is found in a cluster with other
            related family members on chromosome 1. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2014].
            
            Transcript Variant: This variant (1), which represents the
            functional FMO2*1 allele, is the longer transcript and encodes the
            longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.258376.1,
                                           SRR1803612.81140.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000209929.10/ ENSP00000209929.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DB224311.1         54-55
            3-1479              BC005894.1         1-1477
            1480-1480           KF459607.1         175-175
            1481-2806           AL833218.1         1462-2787
            2807-3246           AL833218.1         2789-3228
            3247-3336           R95468.1           61-150
            3337-4937           AK098145.1         669-2269
            4938-5212           AI821378.1         1-275               c
            5213-5215           AL021026.1         125740-125742
FEATURES             Location/Qualifiers
     source          1..5215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..5215
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /note="flavin containing dimethylaniline monoxygenase 2"
                     /db_xref="GeneID:2327"
                     /db_xref="HGNC:HGNC:3770"
                     /db_xref="MIM:603955"
     exon            1..60
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     exon            61..198
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1674
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /EC_number="1.14.13.8"
                     /note="isoform a is encoded by transcript variant 1; FMO,
                     pulmonary; pulmonary flavin-containing monooxygenase 2;
                     dimethylaniline oxidase 2; dimethylaniline monooxygenase
                     [N-oxide-forming] 2; flavin containing monooxygenase 2
                     (non-functional)"
                     /codon_start=1
                     /product="flavin-containing monooxygenase 2 isoform a"
                     /protein_id="NP_001451.2"
                     /db_xref="CCDS:CCDS1293.2"
                     /db_xref="GeneID:2327"
                     /db_xref="HGNC:HGNC:3770"
                     /db_xref="MIM:603955"
                     /translation="MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFK
                     ENVEDGRASIYQSVVTNTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLK
                     YIQFQTTVLSVRKCPDFSSSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSF
                     PGMERFKGQYFHSRQYKHPDGFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGT
                     WVMSRISEDGYPWDSVFHTRFRSMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNK
                     YIMKEPVLNDDVPSRLLCGAIKVKSTVKELTETSAIFEDGTVEENIDVIIFATGYSFS
                     FPFLEDSLVKVENNMVSLYKYIFPAHLDKSTLACIGLIQPLGSIFPTAELQARWVTRV
                     FKGLCSLPSERTMMMDIIKRNEKRIDLFGESQSQTLQTNYVDYLDELALEIGAKPDFC
                     SLLFKDPKLAVRLYFGPCNSYQYRLVGPGQWEGARNAIFTQKQRILKPLKTRALKDSS
                     NFSVSFLLKILGLLAVVVAFFCQLQWS"
     exon            199..387
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     exon            388..550
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..693
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..893
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     exon            894..1249
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1322
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..5215
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3655..3660
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /note="hexamer: AATAAA"
     polyA_site      3676
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /note="major polyA site"
     regulatory      3740..3745
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /note="hexamer: AATAAA"
     polyA_site      3759
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /note="major polyA site"
     regulatory      4914..4919
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /note="hexamer: AATAAA"
     polyA_site      4939
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
     regulatory      5117..5122
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /note="hexamer: AATAAA"
     polyA_site      5138
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
     regulatory      5186..5191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
                     /note="hexamer: AATAAA"
     polyA_site      5215
                     /gene="FMO2"
                     /gene_synonym="FMO1B1"
ORIGIN      
        1 acacaaccaa gggagaaaac tattctgtca aagagacggt gccaaaaggc aaaaacaaag
       61 gagctgatgg caaagaaggt agctgtgatt ggagctgggg tcagtggcct aatttctctg
      121 aagtgctgtg tggatgaggg acttgagccc acttgctttg agagaactga agatattgga
      181 ggagtgtgga ggttcaaaga gaatgtggaa gatggccgag caagtatcta tcaatctgtc
      241 gttaccaaca ccagcaaaga aatgtcctgt ttcagtgact ttccaatgcc tgaagatttt
      301 ccaaacttcc tgcataattc taaacttctg gaatatttca ggatttttgc taaaaaattt
      361 gatctgctaa aatatattca gttccagaca actgtcctta gtgtgagaaa atgtccagat
      421 ttctcatcct ctggccaatg gaaggttgtc actcagagca acggcaagga gcagagtgct
      481 gtctttgacg cagttatggt ttgcagtggc caccacattc tacctcatat cccactgaag
      541 tcatttccag gtatggagag gttcaaaggc caatatttcc atagccgcca atacaagcat
      601 ccagatggat ttgagggaaa acgcatcctg gtgattggaa tgggaaactc aggctcagat
      661 attgctgttg agctgagtaa gaatgctgct caggttttta tcagcaccag gcatggcacc
      721 tgggtcatga gccgtatctc tgaagatggc tatccttggg actcagtgtt ccacacccgg
      781 tttcgttcta tgctccgcaa tgtactgcca cgaacagctg taaaatggat gatagaacaa
      841 cagatgaatc ggtggttcaa ccatgaaaat tatggccttg agcctcaaaa caaatacatt
      901 atgaaggaac ctgtactaaa tgatgatgtc ccaagtcgtc tactctgtgg agccatcaag
      961 gtgaaatcta cagtgaaaga gctcacagaa acttctgcca tctttgagga tggaacagtg
     1021 gaggagaaca ttgatgtcat catttttgca acaggatata gtttctcttt tcccttcctt
     1081 gaagattcac tcgttaaagt agagaataat atggtctcac tgtataaata catattcccc
     1141 gctcacctgg acaagtcaac cctcgcgtgc attggtctca tccagcccct aggttccatt
     1201 ttcccaactg ctgaacttca agctcgttgg gtgacaagag ttttcaaagg cttgtgtagc
     1261 ctgccctcag agagaactat gatgatggac attatcaaaa ggaatgaaaa aagaattgac
     1321 ctgtttggag aaagccagag ccagacgttg cagaccaatt atgttgacta cttggacgag
     1381 ctcgccttag agataggtgc gaagccagat ttctgctctc tcttgttcaa agatcctaaa
     1441 ctggctgtga gactctattt cggaccctgc aactcctatc agtatcgcct ggttgggcct
     1501 gggcaatggg aaggagccag aaatgccatc ttcacccaga aacaaagaat actgaagcca
     1561 ctcaagactc gggccctgaa ggattcatct aatttctcag tttcttttct gttgaaaatc
     1621 ctgggccttc ttgctgttgt tgtggccttt ttttgccaac ttcaatggtc ctagtcagca
     1681 taatgctttg ggctttatta tcttgtcagt cactacctcc taaagaaaaa aaaaaaggct
     1741 agaagaaaaa acattacatt catgttctaa ttatagattt tagagttagg tagtacaggt
     1801 aagggggaaa ttgtaaagaa ttagcagaat taggcatatg tacaaaacca aaattttgtc
     1861 atgaaatttt gcctttccac gcttccctca gttcaccaaa gttaccaaaa tgtaaaataa
     1921 aataagactg gctcaggtaa gtagtgctgc caaccctgat ataggggagt tgtatggaaa
     1981 aatagtagaa ttacacagca tgaaaagcag cccatggttt aaattattgg acaatttaaa
     2041 ttgtgggtaa atatttaaaa ctcctgaaca atgtttctga tggtcttcta tccaccctac
     2101 ttggtaacaa agttctcaga tgttaggtca tgtttcattt gctcagtcgg ggatcactca
     2161 aaactactag acaaaaaagt gagaggatag atttagaaaa catcagtgat gctcagataa
     2221 acttttagga cctcatatta agagctaagc aaatggccac atttcctata ttttgacaga
     2281 gatactgctg gaaaaattaa aattaaaatg ccataatagc tacctaacaa atatatatgt
     2341 ttaatgttta tcataggcca gacattgtgc tatgtgcata tcatatgtat tatttcattt
     2401 aattctcaca acaattctgt gaaatggtta cagctattat agtcatttca cagatgatga
     2461 aactaagatt cagagcagct gatcttgtga ggcagctgga attggaactc agatttgttg
     2521 aactctagaa ctaaagatca taatgttgtc ttgtaatata tttatttaca aaacacttca
     2581 ttatttataa agaatttact aacagtttat cttatttata cccatacatc tgctactttg
     2641 ggaggccctt tacatagaaa acagcattct ttttgccaaa tatgaccaaa ttacttttat
     2701 ttataatttt tgatttatat ttcagctaga tctaaaaagc atctgaagga atttacaatg
     2761 aaagatacct atgcaataac atttaggata atctttgaca ttttggaaaa ataagaattg
     2821 aggaaaaaaa gtgtatcttt caagtagatg caaagcatta taatgactga cacttgtatc
     2881 taactccagt cttacagata actaaggcaa aaagctaaat aaacaatatg taacctctaa
     2941 catttggtaa aaggaagtat actggtctgt tagcagagac aaactttttt tagaattgaa
     3001 gtctgaaaca aacaaaagca attcaatgtc aatagacatt aagcaacata atagacaaac
     3061 atctcctaag ggaacatttg ttacagctgc tccttccctg aactgtgctt tggaagataa
     3121 gctctgtcct gagtccaaac caagcccttc caagagagaa caaaggtcag agatgttgaa
     3181 gattccagca aatttctcct cttatttcta ccaagccttt gtgaacattg ctcttcattt
     3241 tggcctgtac ttctccctca gggacgtaga acaatggaat gtcagtcagt ctctgtagtt
     3301 aaaacttttt ctttaaaatt caattaaggt acttctccct cagggacgta gaacaatgga
     3361 atgtcagtca gtctctgtag ttaaaacttt ttctttaaaa ttcaattaag gtacttctcc
     3421 ctcagggacg tagaacaatg gaatgtcagt cagtctctgt agttaaaact ttttctttaa
     3481 aattcaatta agttacacca gaatttacag gcaagatttt ttttttcatt gctcccataa
     3541 gcaaatttgt tttaaaataa ttgtaaatga ggtatatact tagttcttgg ttaaaaaata
     3601 tattgctttg ttaagtatta aagattattt gtaagtcatt gtattaataa tactaataaa
     3661 atttatcaag cctttatagc aagggtcagt gaattaccac tgcctgtggg ccaaatctag
     3721 ctcactatct gtttttgtaa ataaaatttt ataatagtac acagccacac tcattcattt
     3781 attttctgtg gttgctttca agctacaatt gtagagttgg gtagtcgcaa cagaatctct
     3841 gtggcccaca aggctaaaat atttacattc tcacccatta cagaaaaagt ttgataattc
     3901 ctgctttata atatgtaagg cattgtccca ttttgcataa cttgccttat ttcatcatta
     3961 tcactaccca tttagtagct atggttgtta tcttacttct acagtggaag agattgaaaa
     4021 gcatttgtca ggttaatgct aaatcagtgc ggaaatatag ctccactagg aaaatattat
     4081 taaatttata tccctaaaat ttttagaaat ctctcaaaat ctttccaaat gttctggtat
     4141 ctttgaaaaa tgtaaatagt ttatttatag agaaccctac ctctgaggtt gactcaaagg
     4201 ttaaagaagg ctcatcagtc tatccttctg cctccatata tcctgaacat caaactatcc
     4261 caggaaaacc atctagagta gtttgtttca aaatattagc cacagaccac ctacatcaca
     4321 ataactcagg gagcttatag aagtgaagat tcctgaatat aaacatagta ataattcaac
     4381 ctactgaatg gaaatctctg ctgaaatcca cagttttcat aagctcccca gatgattcct
     4441 gtgtacatta aatctagaaa ccattagttt gagatctctc aaaaataaaa ataaaaattg
     4501 ctttcagaga gtagcccatg aaatttccca ttcttcaagg acaaattcct tctgttcagc
     4561 cttggtcctc caactgcagt ttacaatttt tgttcttctc ctgtaaagaa tgtcaatggt
     4621 tatcaccttc aatagtttca atatgtcccc caaagttatg tgtttgaaac ttgcaatagt
     4681 attgggagat ggggcctaat gaggtgatta ggtgaagtct ctgccctcat gaaaagatta
     4741 atcccattat ctcaggagtg tgttggttat aaaagcaagt ttggctccct cttttcctca
     4801 cacactcttt ttcccttctg ccttcacctt tgccgtgggt ggacacagca agaaggccct
     4861 catcagatgc tggccccttg gtcttgaatt tcctagcctc tacaactaag ccaaataaat
     4921 ttctgtttat tataaataac ccagtctcag atattctgtt acagaaacac aaaatggact
     4981 aagacaccac ccttttccaa aatctctcct tgtgatggct ccctttacta acctttcttt
     5041 tagctattcc ctttatgata gtttcttaat tttttctatc aaaagctaaa tatggcacac
     5101 ttgttcttta cagaaaaata aagatatttt aaacaaaata ctagggccat ggtatgtaat
     5161 aaaatttgaa acaataattt caaataataa agattgaaaa tgcttaaccc agaaa
//
