LOCUS       NM_001282693            2152 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens flavin containing dimethylaniline monoxygenase 1
            (FMO1), transcript variant 3, mRNA.
ACCESSION   NM_001282693 XM_005245034
VERSION     NM_001282693.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2152)
  AUTHORS   Cheropkina,H., Catucci,G., Marucco,A., Fenoglio,I., Gilardi,G. and
            Sadeghi,S.J.
  TITLE     Human flavin-containing monooxygenase 1 and its long-sought
            hydroperoxyflavin intermediate
  JOURNAL   Biochem Pharmacol 193, 114763 (2021)
   PUBMED   34509493
  REMARK    GeneRIF: Human flavin-containing monooxygenase 1 and its
            long-sought hydroperoxyflavin intermediate.
REFERENCE   2  (bases 1 to 2152)
  AUTHORS   Veeravalli,S., Phillips,I.R., Freire,R.T., Varshavi,D.,
            Everett,J.R. and Shephard,E.A.
  TITLE     Flavin-Containing Monooxygenase 1 Catalyzes the Production of
            Taurine from Hypotaurine
  JOURNAL   Drug Metab Dispos 48 (5), 378-385 (2020)
   PUBMED   32156684
REFERENCE   3  (bases 1 to 2152)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2152)
  AUTHORS   Perez-Paramo,Y.X., Chen,G., Ashmore,J.H., Watson,C.J.W., Nasrin,S.,
            Adams-Haduch,J., Wang,R., Gao,Y.T., Koh,W.P., Yuan,J.M. and
            Lazarus,P.
  TITLE     Nicotine-N'-Oxidation by Flavin Monooxygenase Enzymes
  JOURNAL   Cancer Epidemiol Biomarkers Prev 28 (2), 311-320 (2019)
   PUBMED   30381441
  REMARK    GeneRIF: Decreases in N'-oxidation activity (V (max)/K (m)) were
            observed for the FMO1(I303V), FMO3(N61S), FMO3(D132H), FMO3(V257M),
            and FMO3(E308G) variants in vitro when compared with their
            respective wild-type isoforms.
REFERENCE   5  (bases 1 to 2152)
  AUTHORS   Tabib,T., Morse,C., Wang,T., Chen,W. and Lafyatis,R.
  TITLE     SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in
            Human Skin
  JOURNAL   J Invest Dermatol 138 (4), 802-810 (2018)
   PUBMED   29080679
  REMARK    GeneRIF: Differential gene expression by SFRP2(+), FMO1(+), and
            COL11A1(+) fibroblasts suggests roles in matrix deposition,
            inflammatory cell retention, and connective tissue cell
            differentiation, respectively.
            Erratum:[J Invest Dermatol. 2018 Sep;138(9):2086. doi:
            10.1016/j.jid.2018.07.003.. PMID: 30143084]
REFERENCE   6  (bases 1 to 2152)
  AUTHORS   Phillips,I.R., Dolphin,C.T., Clair,P., Hadley,M.R., Hutt,A.J.,
            McCombie,R.R., Smith,R.L. and Shephard,E.A.
  TITLE     The molecular biology of the flavin-containing monooxygenases of
            man
  JOURNAL   Chem Biol Interact 96 (1), 17-32 (1995)
   PUBMED   7720101
REFERENCE   7  (bases 1 to 2152)
  AUTHORS   Hines,R.N., Cashman,J.R., Philpot,R.M., Williams,D.E. and
            Ziegler,D.M.
  TITLE     The mammalian flavin-containing monooxygenases: molecular
            characterization and regulation of expression
  JOURNAL   Toxicol Appl Pharmacol 125 (1), 1-6 (1994)
   PUBMED   8128486
  REMARK    Review article
REFERENCE   8  (bases 1 to 2152)
  AUTHORS   Lawton,M.P., Cashman,J.R., Cresteil,T., Dolphin,C.T., Elfarra,A.A.,
            Hines,R.N., Hodgson,E., Kimura,T., Ozols,J., Phillips,I.R. et al.
  TITLE     A nomenclature for the mammalian flavin-containing monooxygenase
            gene family based on amino acid sequence identities
  JOURNAL   Arch Biochem Biophys 308 (1), 254-257 (1994)
   PUBMED   8311461
REFERENCE   9  (bases 1 to 2152)
  AUTHORS   Shephard,E.A., Dolphin,C.T., Fox,M.F., Povey,S., Smith,R. and
            Phillips,I.R.
  TITLE     Localization of genes encoding three distinct flavin-containing
            monooxygenases to human chromosome 1q
  JOURNAL   Genomics 16 (1), 85-89 (1993)
   PUBMED   8486388
REFERENCE   10 (bases 1 to 2152)
  AUTHORS   Dolphin,C., Shephard,E.A., Povey,S., Palmer,C.N., Ziegler,D.M.,
            Ayesh,R., Smith,R.L. and Phillips,I.R.
  TITLE     Cloning, primary sequence, and chromosomal mapping of a human
            flavin-containing monooxygenase (FMO1)
  JOURNAL   J Biol Chem 266 (19), 12379-12385 (1991)
   PUBMED   1712018
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA537896.1, AK315100.1 and
            M64082.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001282693.1.
            
            Summary: Metabolic N-oxidation of the diet-derived
            amino-trimethylamine (TMA) is mediated by flavin-containing
            monooxygenase and is subject to an inherited FMO3 polymorphism in
            man resulting in a small subpopulation with reduced TMA N-oxidation
            capacity resulting in fish odor syndrome Trimethylaminuria. Three
            forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult
            liver, and FMO3 are encoded by genes clustered in the 1q23-q25
            region. Flavin-containing monooxygenases are NADPH-dependent
            flavoenzymes that catalyzes the oxidation of soft nucleophilic
            heteroatom centers in drugs, pesticides, and xenobiotics. Several
            transcript variants encoding different isoforms have been found for
            this gene. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (3) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b) is
            shorter at the N-terminus compared to isoform a. Variants 2 and 3
            both encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK290113.1, AK315100.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000617670.6/ ENSP00000481732.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                DA537896.1         25-51
            28-556              AK315100.1         1-529
            557-2152            M64082.1           519-2114
FEATURES             Location/Qualifiers
     source          1..2152
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..2152
                     /gene="FMO1"
                     /note="flavin containing dimethylaniline monoxygenase 1"
                     /db_xref="GeneID:2326"
                     /db_xref="HGNC:HGNC:3769"
                     /db_xref="MIM:136130"
     exon            1..130
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            131..268
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1735
                     /gene="FMO1"
                     /EC_number="1.14.13.8"
                     /EC_number="1.14.13.148"
                     /note="isoform b is encoded by transcript variant 3;
                     Flavin-containing monooxygenase 1 (fetal liver); flavin
                     containing monooxygenase 1; dimethylaniline monooxygenase
                     [N-oxide-forming] 1; FMO 1; dimethylaniline oxidase 1;
                     fetal hepatic flavin-containing monooxygenase 1;
                     trimethylamine monooxygenase"
                     /codon_start=1
                     /product="flavin-containing monooxygenase 1 isoform b"
                     /protein_id="NP_001269622.1"
                     /db_xref="CCDS:CCDS1294.1"
                     /db_xref="GeneID:2326"
                     /db_xref="HGNC:HGNC:3769"
                     /db_xref="MIM:136130"
                     /translation="MAKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSDDLGGLWRFT
                     EHVEEGRASLYKSVVSNSCKEMSCYSDFPFPEDYPNYVPNSQFLEYLKMYANHFDLLK
                     HIQFKTKVCSVTKCSDSAVSGQWEVVTMHEEKQESAIFDAVMVCTGFLTNPYLPLDSF
                     PGINAFKGQYFHSRQYKHPDIFKDKRVLVIGMGNSGTDIAVEASHLAEKVFLSTTGGG
                     WVISRIFDSGYPWDMVFMTRFQNMLRNSLPTPIVTWLMERKINNWLNHANYGLIPEDR
                     TQLKEFVLNDELPGRIITGKVFIRPSIKEVKENSVIFNNTSKEEPIDIIVFATGYTFA
                     FPFLDESVVKVEDGQASLYKYIFPAHLQKPTLAIIGLIKPLGSMIPTGETQARWAVRV
                     LKGVNKLPPPSVMIEEINARKENKPSWFGLCYCKALQSDYITYIDELLTYINAKPNLF
                     SMLLTDPHLALTVFFGPCSPYQFRLTGPGKWEGARNAIMTQWDRTFKVIKARVVQESP
                     SPFESFLKVFSFLALLVAIFLIFL"
     exon            269..457
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            458..620
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            621..763
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            764..963
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1319
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1392
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..2152
                     /gene="FMO1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2139..2144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMO1"
                     /note="hexamer: AATAAA"
     polyA_site      2152
                     /gene="FMO1"
                     /note="major polyA site"
ORIGIN      
        1 agaccaggtt tatccactgt gctggggact cccaagccag cactggctca tactgattca
       61 ttttgatctc tgctaatacc agagtcctgc gtggcagagc cattggcacc agaaattaca
      121 agtacgtaaa gagaacatgg ccaagcgagt tgccattgtg ggagctgggg tcagcggcct
      181 ggcctccatc aagtgctgtc tggaagaagg actggagccc acctgctttg agaggagcga
      241 tgaccttggg gggctgtgga gattcaccga acatgttgaa gaaggcagag ccagtctcta
      301 caagtctgtg gtttccaaca gctgcaagga gatgtcttgt tactcagact ttccattccc
      361 agaagattat ccaaactatg tgccaaattc tcaattcctg gaatatctca aaatgtatgc
      421 aaaccacttt gaccttctga aacacattca attcaagacc aaagtctgca gtgtaacaaa
      481 atgctcagat tctgctgtct ctggccaatg ggaggtggtc actatgcatg aagagaagca
      541 agagtcagcc atctttgatg ctgtcatggt ctgcactggc tttcttacta atccttattt
      601 gccactggat tcctttccag gtattaatgc ctttaaaggc cagtactttc atagccggca
      661 atataagcat ccagatatat ttaaggacaa gagagtcctt gtgattggaa tgggaaattc
      721 tggcacagac attgctgtgg aggccagcca cctggcggaa aaggtgttcc tcagcaccac
      781 cggaggggga tgggtgatca gccgaatctt tgactcgggc tacccatggg acatggtgtt
      841 catgacacgc tttcagaaca tgttgagaaa ttccctccca accccaattg tgacttggtt
      901 gatggagcga aagataaaca actggctcaa tcatgcaaat tacggcttaa taccagaaga
      961 caggactcag ctgaaagagt ttgtgctaaa tgatgagctc ccaggacgca tcatcactgg
     1021 gaaagtgttc atcaggccaa gcataaaaga ggtaaaggaa aactctgtca tatttaacaa
     1081 tacttcaaag gaagagccta ttgacatcat tgtctttgcc actggataca catttgcttt
     1141 ccccttcctt gatgagtctg tagtgaaagt tgaagatggc caggcctcac tgtacaagta
     1201 tatcttccct gcacatctgc aaaagccaac cctggccatt attggcctca tcaaaccctt
     1261 gggctccatg atacctacag gagaaacaca agctcggtgg gctgttcgag tcctgaaagg
     1321 tgtaaataag ttaccaccac caagtgtcat gatagaggaa attaatgcaa ggaaagaaaa
     1381 caagcccagt tggtttggct tgtgctactg caaggcttta caatcagatt atatcacata
     1441 catagatgaa ctcctgacct atatcaatgc aaaacccaac ctgttctcta tgctcctaac
     1501 ggatccacat ctggctctga ccgtcttctt tggcccatgc tcaccatacc agttccgctt
     1561 gactggccca ggaaaatggg aaggagccag aaatgccatc atgacccagt gggaccgaac
     1621 attcaaggtc atcaaagctc gagttgtaca agagtctcca tctccctttg aaagttttct
     1681 taaagtcttt agctttctgg ctttgcttgt ggctattttt ctgattttcc tataagtaaa
     1741 agatctccta aatggaagat gcacagagta gatttacaat gctccaattc ctctcttaca
     1801 gcaatattgc cttcacagtt ataaactgta ttcaaatagt aaaggccacc ctctcgcttc
     1861 cctggctggc cccagggcta ccactggtat tcctgagcct ctcccagctc cacttctaat
     1921 gctagagaat gataactaag acttctgtgc atttgaaggt tgttggaaag ttacaggttc
     1981 attttagaaa gaaagctgtt cttgacagca ctctgagcca tcatacctct ttcccatata
     2041 aactattttc acagatctca actaaaaccc cttacttcac aaatgattgt gttgtgctga
     2101 aatggtgctc ttatagtact ggcttattaa aagtaaaaaa taaacctaaa aa
//
