LOCUS       NM_175736              12625 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens formin like 3 (FMNL3), transcript variant 1, mRNA.
ACCESSION   NM_175736
VERSION     NM_175736.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12625)
  AUTHORS   He,J., Chen,S., Wu,X., Jiang,D., Li,R. and Mao,Z.
  TITLE     Hsa_circ_0081534 facilitates malignant phenotypes by sequestering
            miR-874-3p and upregulating FMNL3 in nasopharyngeal carcinoma
  JOURNAL   Auris Nasus Larynx 49 (5), 822-833 (2022)
   PUBMED   35428519
  REMARK    GeneRIF: Hsa_circ_0081534 facilitates malignant phenotypes by
            sequestering miR-874-3p and upregulating FMNL3 in nasopharyngeal
            carcinoma.
REFERENCE   2  (bases 1 to 12625)
  AUTHORS   Chua-On,D., Proungvitaya,T., Techasen,A., Limpaiboon,T.,
            Roytrakul,S., Tummanatsakun,D., Araki,N. and Proungvitaya,S.
  TITLE     Bioinformatic Prediction of Novel Signaling Pathways of
            Apoptosis-inducing Factor, Mitochondrion-associated 3 (AIFM3) and
            Their Roles in Metastasis of Cholangiocarcinoma Cells
  JOURNAL   Cancer Genomics Proteomics 19 (1), 35-49 (2022)
   PUBMED   34949658
  REMARK    GeneRIF: Bioinformatic Prediction of Novel Signaling Pathways of
            Apoptosis-inducing Factor, Mitochondrion-associated 3 (AIFM3) and
            Their Roles in Metastasis of Cholangiocarcinoma Cells.
REFERENCE   3  (bases 1 to 12625)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 12625)
  AUTHORS   Kinoshita-Kikuta,E., Tanikawa,A., Hosokawa,T., Kiwado,A.,
            Moriya,K., Kinoshita,E., Koike,T. and Utsumi,T.
  TITLE     A strategy to identify protein-N-myristoylation-dependent
            phosphorylation reactions of cellular proteins by using Phos-tag
            SDS-PAGE
  JOURNAL   PLoS One 14 (11), e0225510 (2019)
   PUBMED   31751425
  REMARK    GeneRIF: Results demonstrated that N-myristoylation-dependent
            phosphorylation in FMNL3 occurs at a single Ser residue at position
            174, which is a Ser residue conserved between FMNL2 and FMNL3,
            corresponding to Ser-171 in FMNL2.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 12625)
  AUTHORS   Liu,J., Chen,S., Chen,Y., Geng,N. and Feng,C.
  TITLE     High expression of FMNL3 associates with cancer cell migration,
            invasion, and unfavorable prognosis in tongue squamous cell
            carcinoma
  JOURNAL   J Oral Pathol Med 48 (6), 459-467 (2019)
   PUBMED   30955218
  REMARK    GeneRIF: FMNL3 overexpression is related to the metastasis of
            tongue squamous cell carcinoma and poor prognosis.
REFERENCE   6  (bases 1 to 12625)
  AUTHORS   Hetheridge,C., Scott,A.N., Swain,R.K., Copeland,J.W., Higgs,H.N.,
            Bicknell,R. and Mellor,H.
  TITLE     The formin FMNL3 is a cytoskeletal regulator of angiogenesis
  JOURNAL   J Cell Sci 125 (Pt 6), 1420-1428 (2012)
   PUBMED   22275430
  REMARK    GeneRIF: Formin-like 3 (FMNL3) is a crucial regulator of
            endothelial cell elongation during angiogenesis.
REFERENCE   7  (bases 1 to 12625)
  AUTHORS   Bai,S.W., Herrera-Abreu,M.T., Rohn,J.L., Racine,V., Tajadura,V.,
            Suryavanshi,N., Bechtel,S., Wiemann,S., Baum,B. and Ridley,A.J.
  TITLE     Identification and characterization of a set of conserved and new
            regulators of cytoskeletal organization, cell morphology and
            migration
  JOURNAL   BMC Biol 9, 54 (2011)
   PUBMED   21834987
  REMARK    Erratum:[BMC Biol. 2024 Oct 10;22(1):228. doi:
            10.1186/s12915-024-02036-3.. PMID: 39390519]
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 12625)
  AUTHORS   Harris,E.S., Gauvin,T.J., Heimsath,E.G. and Higgs,H.N.
  TITLE     Assembly of filopodia by the formin FRL2 (FMNL3)
  JOURNAL   Cytoskeleton (Hoboken) 67 (12), 755-772 (2010)
   PUBMED   20862687
  REMARK    GeneRIF: Data suggest that the FH2 domain of FRL2 possesses
            properties not shared by FRL1 that allow it to generate filopodia.
REFERENCE   9  (bases 1 to 12625)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FMNL1, FMNL2 and FMNL3
            genes in silico
  JOURNAL   Int J Oncol 22 (5), 1161-1168 (2003)
   PUBMED   12684686
REFERENCE   10 (bases 1 to 12625)
  AUTHORS   Bedford,M.T., Chan,D.C. and Leder,P.
  TITLE     FBP WW domains and the Abl SH3 domain bind to a specific class of
            proline-rich ligands
  JOURNAL   EMBO J 16 (9), 2376-2383 (1997)
   PUBMED   9171351
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB095934.2, BC090955.1 and AC020612.40.
            
            On Nov 22, 2018 this sequence version replaced NM_175736.4.
            
            Summary: The protein encoded by this gene contains a formin
            homology 2 domain and has high sequence identity to the mouse Wbp3
            protein. Two alternative transcripts encoding different isoforms
            have been described. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) lacks an alternate exon in the
            3' coding region, compared to variant 3. The encoded isoform (1),
            is shorter than isoform 3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC159100.1, AB095934.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000335154.10/ ENSP00000335655.5
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4018              AB095934.2         10-4027
            4019-4191           BC090955.1         3531-3703
            4192-11183          AB095934.2         4200-11191
            11184-12625         AC020612.40        110689-112130       c
FEATURES             Location/Qualifiers
     source          1..12625
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.12"
     gene            1..12625
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /note="formin like 3"
                     /db_xref="GeneID:91010"
                     /db_xref="HGNC:HGNC:23698"
                     /db_xref="MIM:616288"
     exon            1..351
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..3309
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /note="isoform 1 is encoded by transcript variant 1; WW
                     domain binding protein 3; formin-like protein 3; formin
                     homology 2 domain-containing protein 3"
                     /codon_start=1
                     /product="formin-like protein 3 isoform 1"
                     /protein_id="NP_783863.4"
                     /db_xref="CCDS:CCDS44874.1"
                     /db_xref="GeneID:91010"
                     /db_xref="HGNC:HGNC:23698"
                     /db_xref="MIM:616288"
                     /translation="MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSS
                     MNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRR
                     VQESTKVLRELEISLRTNHIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESG
                     DDGAFDKLRSWSRSIEDLQPPSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLV
                     SQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAV
                     CLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSV
                     EDMNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKN
                     VALEKVEELEEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQ
                     VHTLRRLIKEKEEAFQRRCHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAP
                     APPPEEVLPLPPPPAPPLPPPPPPLPDKCPPAPPLPGAAPSVVLTVGLSAIRIKKPIK
                     TKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFKTKAQGPALDLICS
                     KNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLM
                     RFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNL
                     QMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLD
                     TKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGME
                     LIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVF
                     FPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIA
                     ELRRRQAKEHRPVYEGKDGTIEDIITGLHCQPMVVRHQARSAAPPSGPPRAPGPH"
     exon            352..435
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..516
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            517..593
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            594..677
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            678..830
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            831..939
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            940..1016
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1017..1110
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1111..1185
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1296
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1297..1446
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1548
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1549..1828
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..1897
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1898..2022
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..2225
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2460
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2529
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2530..2610
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2740
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2741..2901
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2902..3003
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3004..3096
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3220
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     exon            3221..12625
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8381..8386
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /note="hexamer: AATAAA"
     polyA_site      8403
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /note="major polyA site"
     regulatory      12606..12611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /note="hexamer: AATAAA"
     polyA_site      12625
                     /gene="FMNL3"
                     /gene_synonym="FHOD3; FRL2; WBP-3; WBP3"
                     /note="major polyA site"
ORIGIN      
        1 gcctccgtcc gccttgcttc ggtgcggctg tccgctacgc tgcctccgcc ctcgccgcgc
       61 gcccccgcca gcgggactcc agggaacccc cggcgccctc gacggggccg aggagtcggg
      121 actcggggag ccggcgctga gggaggagcc tggtcggagc cgcggagccg aaagctccgg
      181 agcgtggagg tggggggccg aggcccctga gggggccccg ccgcgatggg caacctggag
      241 agcgccgagg gggtcccggg agagcccccc tctgtcccgt tgttgctgcc gcccggcaag
      301 atgccgatgc ctgagccctg tgagctggag gaaaggttcg ccctggtgct gagctccatg
      361 aacctgcctc cagacaaggc ccggctcctg cggcagtatg acaatgagaa gaaatgggat
      421 ctgatctgtg accaggaacg attccaggtg aagaatcctc cccacactta cattcagaaa
      481 ctccagagct tcttggaccc cagtgtaact cggaagaagt tcaggaggag ggtgcaggag
      541 tcaaccaaag tactaaggga gctggagatc tctcttcgca ccaaccacat tgggtgggtg
      601 cgggaatttc tgaatgatga aaacaaaggc ctggatgtac tggtggatta cctgtccttt
      661 gcccagtgtt ctgtcatgtt tgactttgag ggtctggaaa gtggtgacga tggtgcattt
      721 gacaaactcc ggtcctggag caggtcaatc gaggacctgc agccacccag cgccctgtcg
      781 gcccccttca ccaacagcct cgctcgctct gcgcgccagt ctgtgctccg gtatagcact
      841 ctccctgggc gcagggccct gaagaactcc cgcctagtga gccagaagga tgacgtccac
      901 gtctgtatcc tttgtctcag agccatcatg aactatcagt acggattcaa cctggtcatg
      961 tcccaccccc atgctgtcaa tgagattgca cttagcctca ataacaagaa tccaaggacc
     1021 aaagcccttg tcttagagct tctggcagct gtgtgtttgg tgcgaggagg tcacgaaatc
     1081 atccttgctg cctttgacaa tttcaaagag gtatgcaagg agctgcaccg ctttgagaag
     1141 ctgatggagt atttccggaa tgaggacagc aatattgact tcatggtggc ctgcatgcag
     1201 ttcatcaaca tcgtggtgca ctcggtggag gacatgaact tccgggtcca cctgcagtat
     1261 gagtttacca agctggggct agaggagttc ctgcagaagt caaggcacac agagagcgag
     1321 aagctgcagg tgcagattca ggcatatctg gacaacgtgt ttgatgtcgg gggtttgttg
     1381 gaggatgctg agaccaagaa tgtagccctg gagaaggtgg aggagttgga ggagcatgtg
     1441 tcccatctca cagagaagct tctggaccta gagaatgaaa acatgatgcg ggtggcagaa
     1501 ctagagaagc agctgctaca gcgggagaag gaactagaga gcatcaagga gacatatgag
     1561 aacacaagcc accaggtgca caccctgcgg aggctcatta aagagaagga ggaggccttt
     1621 cagcgtcgat gtcatttgga gccaaatgtc cggggcctgg agtctgtgga cagtgaggcc
     1681 ctggccagag taggccctgc agagctgagt gagggcatgc caccctccga cctggacctt
     1741 ctggctccag ccccaccccc tgaggaggtc ctgcctcttc ctccaccacc agctccgccc
     1801 ttgccccctc cacctccccc attaccagac aagtgtcccc cagccccacc tctccctggt
     1861 gctgcaccct ctgtggtgtt gacagtgggc ctgtcagcca ttcgaattaa gaaacctatc
     1921 aagaccaagt tccggctgcc tgtcttcaac tggacagcac tgaaacccaa ccagatcagt
     1981 ggcactgtct tcagcgaact tgatgatgag aagatcttgg aggacctgga tcttgataag
     2041 tttgaagaat tattcaagac aaaagcgcag ggccctgccc ttgacctcat ctgctccaaa
     2101 aacaagacag cgcaaaaagc tgccagcaag gtgactctgt tggaagccaa tcgtgccaag
     2161 aacctggcca tcaccctacg caaggctggc cgctcggctg aggagatctg cagggccatt
     2221 catacgtttg acttgcagac actacctgtg gacttcgtgg agtgcctgat gcgcttcctg
     2281 cccacagagg ctgaggtaaa gctgctgcgg caatatgagc gggagcggca gcccctggag
     2341 gagttggcag ctgaggaccg cttcatgctg ctcttcagca aggtggaacg gttgacccag
     2401 cgaatggctg gcatggcctt cctggggaac ttccaggata acctgcagat gctcacaccg
     2461 caactcaatg ccatcattgc ggcgtccgct tccgtcaagt cttcacagaa gctgaagcag
     2521 atgttggaga tcatacttgc actggggaac tacatgaaca gcagcaagcg gggagctgtg
     2581 tatggcttca agctccagag cctggatctg ctgctggata ccaagtccac tgaccggaag
     2641 atgacactgc ttcatttcat cgccttgaca gtgaaggaga aatacccaga cctggctaac
     2701 ttctggcatg agctgcactt tgttgagaag gctgcagcag tgtccctgga gaacgtgctg
     2761 ctggacgtga aggagctggg ccggggcatg gagctgattc ggcgtgagtg cagcatccat
     2821 gacaacagcg tcctccggaa cttcctcagt accaatgaag gcaaactaga caagctccag
     2881 cgggacgcca agacggctga ggaggcctac aatgcagttg tgcgctactt tggcgagagt
     2941 cccaagacta cacctccttc tgtattcttc ccagtatttg tccgattcat tcgttcttac
     3001 aaggaagcag aacaagagaa tgaagcccgc aagaagcagg aggaggtaat gcgggagaag
     3061 cagctggctc aggaagccaa gaaactggat gccaagaccc catcccagcg gaacaagtgg
     3121 caacagcagg agttaatagc agagttgagg cggcgccagg ccaaggaaca ccggcctgtt
     3181 tatgagggga aggatggtac catcgaggac atcatcacag gcctccactg ccagcctatg
     3241 gttgttcgcc accaagccag gagtgctgca ccgcccagtg gtccccctcg ggctccaggc
     3301 ccccactgag accctctcgg aggcagaagc acttcacccc tcagagtcct acaagtccaa
     3361 ccagtggacc tggaattggc caagggctca ggagagggct gtgttgctct ctcaaccatg
     3421 tccgccccag ctcttgaggc tggatctttc tacttgtgcc actatgggca ctaggtctgt
     3481 aggtccctgg tgcttccagt actgcacttt gcccccaagg tctttgactt catttcctga
     3541 agggtcacca agggtcagct cagggctagg aaaaaccatt tccagcctta gcctaaacag
     3601 ggcacataga tctctcccac tagagcccag agggatgaga ggagagagca actgttcttt
     3661 cttttttttt cccttccttt ttgcaggccc atggtcagct ctggtctaga tgtatctagg
     3721 cttagggagc cctgggaccc tgccagtctc agttcatctc ttaccaggag caaggccctc
     3781 tgaagcatgg gccgtgccag ctgtgcccta gtgataaggg taagaggaga gatgtcaggc
     3841 tcactgccct tatttctctg cccatttcat tctaggctca cactgtcctt gtcaaggtgg
     3901 gcagaagagc agaggtcttc tctgcaccaa ccactctctg cagatggctg gagaaagggt
     3961 gtgccaactc ttcaccttct ttcctcagct acggtttttt tttttttttt tttttttttg
     4021 gcaggggaca aggagcatgg tggtcttggc tatttgctta ccttcccgtt tctcctctgc
     4081 ccctggaagg gaatgtgggg gcccactttt ttgtacatgt accacctccc tttcctctta
     4141 ctgtacataa acctcagact ctccccctct caacaaaggc ttgatgcacc aggcctgact
     4201 ttgtctcctc tttctgagct tagggggcta gggtggccat ttagtctgac ctgggctatg
     4261 gggatagaaa agaaatcttt ggggcactgc atctgttttg gaggagatga gatcagaact
     4321 ctggggaaag gagaaccggc taggtgggct ctagccacac aaagggaagc aggcctgcca
     4381 tgagacacta gtgccctctg ctgggcatgt gtccagtccc cagcctgccc cagtagcaca
     4441 tggaaaagag tcactggcca tgttataaat attgttattt aaaaaacaaa aaacaaaaca
     4501 cacgtacatt aggtcctggg tggaggaaga agtggtggag cctcagggcc agggcaggca
     4561 ggagcaggca ctgatgctag agggtgatga ccctgccctc tgccacccag gctgcgtcca
     4621 acagcctgtg actcttccct ggagacccct tctctcacac ttttatctac tggcatcacc
     4681 caccccacat ggcatatacc acccatctct ggtctggggc tgagggcaag gactgcacta
     4741 gtccagggag taggggaccc ttgaacacca agagcaacct tgagaggtgc caacaatggt
     4801 gtgctggggg tggggttact ttagaaaaag tggacacaga ccagactaag gaagaagtct
     4861 gaggcagacg gtgagggtgg cccaggagcc atggcctcac acagacccga ggcagagaac
     4921 agctcattgg gtcactggtg atcatccagc tgctgtagga gtgtccgccg ccgcctctcc
     4981 agctcaccct cactcagctc actttctgac gtgtcccagc ctgtctgttg gagcaaaggc
     5041 acagttcacc cttagcctgc actaagggcc gtggaagctt gaccagcgtg ctgactggcc
     5101 tagggcccct gcccctcacc ttctccttct tgattccaaa gcctggggaa cggttaggga
     5161 gctctgcctg ttggagctcc ctgtccttgt cctgttcttg ttctttctca tcgctctcct
     5221 tgccagcttt ctcctcaggg tctgtctcac tctcaggact attctgtaag agtccagagc
     5281 ccacctcctc agttcctgtg gatagcctgg gaggcaggta gaacagaact cacaaaatag
     5341 caggggctta ggtagaagtt ccttcactca ccgacttgtg tcttctcttc ttagttttct
     5401 tttttggttt cttggctttc cgaaggccat gatctagaga tagaaaaatc cctactaagt
     5461 cccaacagga gaaagacagg ctctttttct ttgttctagc ccctctgttc attcttcaca
     5521 ggcaggaacc tcatgctctg aggaagtcta agtccagttt tccttctcca gcttcttgct
     5581 tgggcaggta gaggaagttc tttctacttc cacaggtgca gccctcccaa tccagtctac
     5641 cctcaaagga gctggggctt gtggagggca tcctctcagt ctgggacaac agttctccag
     5701 cttctacgct cacagcaact gcttacctgc tccaagaaga tgggaggaag gggagccccg
     5761 tcctccaagg gcagcacccc cactttcaac tgaatcaagt gaggaagagg gctcagagcc
     5821 tgactctgag gggttccgcc tcctccgctt ggggggccgg agagatggtg ggggcagctc
     5881 ctcttcttct gactcagagc cctgggcaga tcagcagata catgtcagtg cagaggttct
     5941 ctgccctcca gaagccctcg tctgggaatt cgagagagga ggaggaccca gggccaaagg
     6001 aatcctcaaa cttccctcca agggagatat tgtaagggga aaacaaagtg tttatttccc
     6061 caaaacaacc cagcttcacc ccatgtccct tctacacgct tactcactga gggtgagtgg
     6121 gaacgcttgt gatggtgctt cttgcctttc ctgccatgct ttcggccttt ggtgtggagg
     6181 tgctggcatt cagtctgcta gaggcagagg aagaagggtg aggacagcac cagacttagc
     6241 cccaggaagg atcctacttc ctaaaatctg gctttgcctc cctttctcag actagagcct
     6301 tctgcctatc ccagggatcc tcaggcctcc ccttccttag ctggccagga gtgccctaag
     6361 ggtaagaggg aggccactga ggtctctgtt gaactggtct aatgagttca agggcctgag
     6421 gcagatccag aggacaagcc tgcctcacct ccagcacctg taggaactcc cggaagagcc
     6481 ggatccgctc cgactccagg gtgatctgct caaaggctga gtcacacaca aaacgctcac
     6541 ggaccttgaa cgaggagagc actgctgatc agactaggcc ccactcagcc tggcctggac
     6601 accgccatga gcacagggca gggctggggc agagaaagga agggaactgg agctggccca
     6661 gggctgtgac gtgactgggg tgggccctca gtggtgaagc accgctgccc tcaggcttga
     6721 ggggtgcttg gggccaggct acgctcctga cctcttccca ggcagtgcct agctccagag
     6781 caggcacagc ctgcctcagc atgcttcgaa aggcagcttc cctgcgccgc atcctgcgtg
     6841 cctcctcctt ctcccgctcc ctctcccgtg cctctgcttt ctccagcagc tgaggaaaga
     6901 agggacacgg aacagggtca cccaggaggg tggatgccag gtcccactca ggcatacctt
     6961 aggaggtgga aagttagggt ctgggcttct accaccatcc cctgaattgg gaatatagtc
     7021 agtgggacag tgagtgagaa ggaatggagc aagacacaga tgaattagag aacttcccac
     7081 gccccgccca gcccctcaca ctattgaagg tcagcttgat gttgcctgcg tccagtgcgg
     7141 cagccctctt gtcaaagctt atgacgtggg cgaagtcctc aaaggccgtg ttcacctcca
     7201 cgcagaagcc ccggtcctgt gggtacagca gtgcatgaag caggggcacc acgtgcctga
     7261 ggccaaagct ggcaggcaga gtggtcacat tacagatggt caagaaggcc cttgcctctg
     7321 gaagagatcc acaggactgt ggtctgcatt agaaaccaag ttatccaagt cctcatcact
     7381 tgacaattaa gcccccatgc ctacccttgg tttggatgtc acacagagct gaaggggttg
     7441 ggagatgtct cccaactgct gattaatgct gagtttctca aaattaactt ttgttccttt
     7501 ggcttaaagc tctggcccca gctgggccct cctgctgctc agcagtgctt ccatgcattc
     7561 tcaatcaaca tttgctggcc cctacccttt gggtctattt attgagtgct tactatgtac
     7621 caggtaccat gatgagtgtt tcacacatta tctcatttaa tcctcttggt tctacattta
     7681 agaataggtc ctagtatcct aattttacac agaaggagaa accaaggttc agagaaacta
     7741 gagcacttgc ccaaggtctc acagctgata tacggctggg caagaaccct accctggggg
     7801 ggctctctat ccccaaagtg tctgctttca agcaccacac ccacccagat gacttagtcc
     7861 atgggagaaa cggaggccac caggtgtgca gctccccacc aatactaaaa acatgtccac
     7921 aggccaggct ctatgcttct catttaggcc tcacaacatt ccagtgaagc agaggcttag
     7981 aaaagtgatc tcagttggcc caagatgaca tgagtggtaa atgaagccac tggagttcaa
     8041 agtctggctc tcacgtcagt taagcacagg ccagattccc tttctctccc tccacatagc
     8101 tctcacctcc tctggccttt ttgctgatgg cagaggtgtg ctcctctttc ttctttccaa
     8161 gggtacttcc tcaaccctgc tacagtcctt atcaacacag cattcattct cagggaattg
     8221 aaagctccaa gtcacccttg ttactggctc cttccatcaa gcagacacct cacctaacct
     8281 ggaacatcct ttccaccatg ctctcccctt catcaagcta actacctctg ctcttttcca
     8341 ttgtttcaaa acctcttgaa atgcagcaga aaggaaaagg aataaacatt tattgagaac
     8401 ctattagaca ctttacagat gttatttaat tctcacaacc ttacctatga attatccctg
     8461 atttacaggt gagcaaacag gctcagagac acggaactta cggaggtctc agagccaata
     8521 agcaaccagg agtaatctga ctctaaaaca tgtgctgccc ccatgccacc tccatgactc
     8581 tactctccca aaggttgctt gtgtctacta gccaaatcca aggccgcctt ctttgtcctc
     8641 actcatctgg tcctcagtgc ctctaccact tacttcttca acactcccct ctccaggtca
     8701 caccctctct gaccttttat tctcttgcat atgcatgttc ctgagaacag cacttagtcc
     8761 tctttcacta cccaatctgt actccctcgc aatctcatcc ttcatctctc ctgattttca
     8821 aacatcctag actggatatt tcagacactt aaaattcaac agatctcaag agaatatatt
     8881 tctcatgagc atcctccatg gatctccctg acccggatct gtctgcctgt tctaagtcca
     8941 gggctctttg cattatccta tgggatgaaa ggcaccatca tggtctgcct ggctgtggaa
     9001 agcaagaggg actcctgggc tcatctgccc tccataggca ggaacccaaa tggggaaaga
     9061 ggaagggaac tgtctaaaaa agttgctttc tcaggttgtg tggagagaca ggactcagtg
     9121 aggataggcc cctacaggcc tatcaaccag ccactctgtg gctaaaagtt aattgtccaa
     9181 taaaatttag ctatcccagg ataaggcatt tctactttat acgattattc tgttttaaaa
     9241 tatatttgct ttgagagtaa ttccccaaat agaattccta ttttctacag ccttgctctt
     9301 cttgttttat ccttatcaat agtgccatca tccactgccc tgacacctct gattccttcc
     9361 tttccctcca tttcacaaaa tctatcaatt ctacttagtg actctatccc actggtgttg
     9421 aattctccct ttttttttta aacagcagaa acagtttatt aaaatagaaa tcttatgtag
     9481 aacctttatg cataaaaaag attcaagctg cttcacttga aaacaggaag cagcaccaaa
     9541 tccccccata ctcaactcca acccttgctt gtctcaaggc acctacatag aaacccagag
     9601 tgtctcagaa gaacagctgg agcgctacag cctgctctct tctgctgtcc ccactgcccc
     9661 cggctaggat cacctcctac aagattcctg cacagcctac tgacttttct ccctgctcac
     9721 cctcttccat ccctctaacc cagctcctag catctagtgc ttcttggact tttgtaccaa
     9781 gtagccccaa cagtaggaga gaggtctggg gataagtgaa atgaatatga ctatttgaat
     9841 taccactatc agttttagta tcttgaggct tcaagaactg ctctacctag caccaccacc
     9901 ttccctaagg acataagtac gtactctaga ctgaaaggtt ctactataca ccatctaatc
     9961 tgatcattcc ccggttcctc attacttacg agagaaaaat ccaaatttct tattttagca
    10021 ttcaaggcac tttacatgca gggctctact tccaagctgg ggcatgtggt tccagagaaa
    10081 gagaggatac ctcaggacag tatgatacat cttacctaat ggtaagtaat ttaaaatatt
    10141 aaatttatat taaataggta atatggtgtt aaaatgcaac acctacgtga atttgtaagg
    10201 caaaacagta cttcaaagaa atgtatatgc agtgagacat ttctagcttt atttccagat
    10261 ccctttcaac ccaggtacca tttaatctct gtaattaggt gtactctggt ggaacactca
    10321 ccatttttta gatgaggaaa cagggtcaga aaggtcaagt gacctatcca aggtcacaca
    10381 actagcaagc agttaagcta gacttttact gtaggcagtc tgcctccagt cccgctccta
    10441 accactgtac tgtattatct cctcaaatgc attagaatct tcacttccat aaagaaatat
    10501 gctctttgtt tttttctttt ggaacacaag gtttagtcca tcactcactc acttttccac
    10561 ttttgataag atgtaaatat tgagaactat ttctcttctc cagtagaaga agagcaacag
    10621 gccatgtgtg atggtaaatg gcagctgaca cttgcgacag tatcaagaag gcactaagga
    10681 atggtgagaa ggatgacttg ccctttctaa agtggcatct cagcttgagt ctgcagaatg
    10741 ccttgcaaat ccagctcagt actgctagat aatccatatt gacaagagaa gctaaagatt
    10801 cagattttct atgtgaagtt tcctggtttt aaaatgttag caacaaattc caaattttta
    10861 cagaacactg tacaggccag aaagaacaat ctgtgtgcta ccagtttaca attagctatg
    10921 cttcttcctc ctcagacctg gcatgccctt tccaccccct tgcctttgct cttagtaccc
    10981 cgtgtacact ccaacctctt ccacctacaa atttctaaat gcacagttca aatgttagtt
    11041 cttcagattc ctgtctctgt aataacactt gcccctttgt ataacagttc tcatgtatat
    11101 cttcctatta gaccatgagc tcctgtggta gaaattgtgt attcattact gtatccctag
    11161 tgtgcagtaa aggatcacag tagatatctg ctgaaccaag ctgtaatgct tctgcaaaac
    11221 aggacttatc agggagtcct ctgcagggag tgtgccctgc atccatcctg tatccatcca
    11281 taaccccagc ctccctcacc ttaaggatgt ccttaatgat cttcttttca tcatggaatc
    11341 gtgccttcaa ctcctccaca tagaacttga ataagtccag aggggtggag cctgtaagga
    11401 gggagggagg ggggcctggc gggcggcagc ttcccaaggc ctgggggctg ggccgaggac
    11461 aggagccggt agtagggggt gcagagaggc tggcagggca ggaagccagg ccagagaagg
    11521 gggagcctgg ctgccttacc cggctggccc agcatgttgg caaagcggac atcagtgctg
    11581 actgctggat atagctccat ccaggtggac atagagtgca gctgccctgt ctcatgcagc
    11641 tcgtccagga aggtctgagc agggagaggc cagttatagg gagagtgaga cagggaggca
    11701 gagccacaga ctgaggggga agagagggaa tggcagagga agaggcaggg acaatcaaga
    11761 ttgaggaaat gcaggcaaga gaggcagaga tgaagagatg cagatggaag gctgagaaca
    11821 atgcaaaaag agagaaagta aatacacaga gagggacaga acaaaaaggt gagaacaagc
    11881 cagtcccggg atgcaaagaa acagaaacct gcctgcagta acccctagca ctaccaccac
    11941 cactgccacc cccaagctga gggaataaac tctgcctgtc gggtgcccca ccaagggaaa
    12001 taaacatggc ctagctgcca agtcatgcct gtagggtgct ctctactggc agtttctggg
    12061 tggtgcatac atctagtctc cctagaagag cacagtccag aattgaggag gtacagcaga
    12121 aacagactgc aggcagagag aggtctcata gagcttggac agggctaggc acagaaagaa
    12181 caggcagcgt atccagaagg gggcagggaa tgggtgaaga ggttgtgctc tagggcagag
    12241 ctgagctctg atctagaaag gacagcaaag atacctggaa ggcctcccga ttcttgcgtt
    12301 gttggcgtcg ctcccgaagc cgggcccgct cccgttcctc ctcctcttcc ctctccaaag
    12361 ctcggatgtg ctcctcaaaa cagatcagtg catcttcctt gtccatgtct aaagacaggc
    12421 aggaggttcc gcgggcattg tcccagcagg ataccctctc agaccccagc acccctaatg
    12481 tttcaacgat gctgtcctac aggtgctagg gatacccagg gtggtggggg aagggcctgg
    12541 agggggctct gtgggagcag ccactgcaat ggtagttctt aagaggggat cattaattgt
    12601 ataagaataa ataagcaagt attca
//
