LOCUS       NM_052905               5630 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens formin like 2 (FMNL2), mRNA.
ACCESSION   NM_052905
VERSION     NM_052905.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5630)
  AUTHORS   Liu,J., Zhang,J.G., Sun,Y., Qiu,L., Yang,Y., Yang,R., Jin,Y.,
            Li,C.M. and Jiang,D.L.
  TITLE     [Effect of miR-22 Targeting FMNL2 on Cell Migration and Apoptosis
            in Childhood Acute Myeloid Leukemia]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 31 (6), 1617-1623 (2023)
   PUBMED   38071036
  REMARK    GeneRIF: [Effect of miR-22 Targeting FMNL2 on Cell Migration and
            Apoptosis in Childhood Acute Myeloid Leukemia].
REFERENCE   2  (bases 1 to 5630)
  AUTHORS   Lorenzen,L., Frank,D., Schwan,C. and Grosse,R.
  TITLE     Spatiotemporal Regulation of FMNL2 by N-Terminal Myristoylation and
            C-Terminal Phosphorylation Drives Rapid Filopodia Formation
  JOURNAL   Biomolecules 13 (3), 548 (2023)
   PUBMED   36979484
  REMARK    GeneRIF: Spatiotemporal Regulation of FMNL2 by N-Terminal
            Myristoylation and C-Terminal Phosphorylation Drives Rapid
            Filopodia Formation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5630)
  AUTHORS   Xie,Y., Lin,H., Wei,W., Kong,Y., Fang,Q., Chen,E., Liu,J. and Li,M.
  TITLE     LINC00839 promotes malignancy of liver cancer via binding FMNL2
            under hypoxia
  JOURNAL   Sci Rep 12 (1), 18757 (2022)
   PUBMED   36335129
  REMARK    GeneRIF: LINC00839 promotes malignancy of liver cancer via binding
            FMNL2 under hypoxia.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5630)
  AUTHORS   Lee,A.J., Raghavan,N.S., Bhattarai,P., Siddiqui,T., Sariya,S.,
            Reyes-Dumeyer,D., Flowers,X.E., Cardoso,S.A.L., De Jager,P.L.,
            Bennett,D.A., Schneider,J.A., Menon,V., Wang,Y., Lantigua,R.A.,
            Medrano,M., Rivera,D., Jimenez-Velazquez,I.Z., Kukull,W.A.,
            Brickman,A.M., Manly,J.J., Tosto,G., Kizil,C., Vardarajan,B.N. and
            Mayeux,R.
  TITLE     FMNL2 regulates gliovascular interactions and is associated with
            vascular risk factors and cerebrovascular pathology in Alzheimer's
            disease
  JOURNAL   Acta Neuropathol 144 (1), 59-79 (2022)
   PUBMED   35608697
  REMARK    GeneRIF: FMNL2 regulates gliovascular interactions and is
            associated with vascular risk factors and cerebrovascular pathology
            in Alzheimer's disease.
REFERENCE   5  (bases 1 to 5630)
  AUTHORS   Lee,S.W., Yang,C.C., Lai,H.Y., Tsai,H.H., Yeh,C.F., Kuo,Y.H.,
            Kang,N.W., Chen,T.J. and Chang,S.L.
  TITLE     Formin-Like 2 Is a Potential Biomarker of Poor Prognosis in
            Nasopharyngeal Carcinoma
  JOURNAL   Oncology 100 (9), 475-484 (2022)
   PUBMED   35772391
  REMARK    GeneRIF: Formin-Like 2 Is a Potential Biomarker of Poor Prognosis
            in Nasopharyngeal Carcinoma.
REFERENCE   6  (bases 1 to 5630)
  AUTHORS   Maestrini,E., Pagnamenta,A.T., Lamb,J.A., Bacchelli,E., Sykes,N.H.,
            Sousa,I., Toma,C., Barnby,G., Butler,H., Winchester,L.,
            Scerri,T.S., Minopoli,F., Reichert,J., Cai,G., Buxbaum,J.D.,
            Korvatska,O., Schellenberg,G.D., Dawson,G., de Bildt,A.,
            Minderaa,R.B., Mulder,E.J., Morris,A.P., Bailey,A.J. and
            Monaco,A.P.
  CONSRTM   IMGSAC
  TITLE     High-density SNP association study and copy number variation
            analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4
            gene region in autism susceptibility
  JOURNAL   Mol Psychiatry 15 (9), 954-968 (2010)
   PUBMED   19401682
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5630)
  AUTHORS   Kitzing,T.M., Wang,Y., Pertz,O., Copeland,J.W. and Grosse,R.
  TITLE     Formin-like 2 drives amoeboid invasive cell motility downstream of
            RhoC
  JOURNAL   Oncogene 29 (16), 2441-2448 (2010)
   PUBMED   20101212
  REMARK    GeneRIF: a novel regulatory and functional interaction between RhoC
            and FMNL2 for modulating cell shape and invasiveness and provide
            mechanistic insight into RhoC-specific signalling events.
REFERENCE   8  (bases 1 to 5630)
  AUTHORS   Zhu,X.L., Liang,L. and Ding,Y.Q.
  TITLE     Overexpression of FMNL2 is closely related to metastasis of
            colorectal cancer
  JOURNAL   Int J Colorectal Dis 23 (11), 1041-1047 (2008)
   PUBMED   18665374
  REMARK    GeneRIF: FMNL2 may play an important role in the metastasis of CRC
            and may be a useful marker for metastasis of CRC.
REFERENCE   9  (bases 1 to 5630)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 5630)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human FMNL1, FMNL2 and FMNL3
            genes in silico
  JOURNAL   Int J Oncol 22 (5), 1161-1168 (2003)
   PUBMED   12684686
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC012066.10, AB067489.1,
            AC093794.2 and AC012443.8.
            
            On Nov 22, 2018 this sequence version replaced NM_052905.3.
            
            Summary: This gene encodes a formin-related protein. Formin-related
            proteins have been implicated in morphogenesis, cytokinesis, and
            cell polarity. Alternatively spliced transcript variants encoding
            different isoforms have been described but their full-length nature
            has yet to be determined. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC167159.1, AB067489.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000288670.14/ ENSP00000288670.9
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AC012066.10        25811-25873
            64-295              AC012066.10        25874-26105
            296-549             AB067489.1         1-254
            550-568             AC093794.2         26035-26053
            569-771             AB067489.1         274-476
            772-789             AC012443.8         23744-23761
            790-2103            AB067489.1         495-1808
            2104-2165           AC012443.8         94219-94280
            2166-5630           AB067489.1         1874-5338
FEATURES             Location/Qualifiers
     source          1..5630
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q23.3"
     gene            1..5630
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /note="formin like 2"
                     /db_xref="GeneID:114793"
                     /db_xref="HGNC:HGNC:18267"
                     /db_xref="MIM:616285"
     exon            1..547
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..3709
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /note="formin homology 2 domain containing 2; formin
                     homology 2 domain-containing protein 2"
                     /codon_start=1
                     /product="formin-like protein 2"
                     /protein_id="NP_443137.2"
                     /db_xref="CCDS:CCDS46429.1"
                     /db_xref="GeneID:114793"
                     /db_xref="HGNC:HGNC:18267"
                     /db_xref="MIM:616285"
                     /translation="MGNAGSMDSQQTDFRAHNVPLKLPMPEPGELEERFAIVLNAMNL
                     PPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLDPAVTRKKFRRRVQE
                     STQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLSFAQYAVTFDFESVESTVES
                     SVDKSKPWSRSIEDLHRGSNLPSPVGNSVSRSGRHSALRYNTLPSRRTLKNSRLVSKK
                     DDVHVCIMCLRAIMNYQYGFNMVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLV
                     RGGHEIILSAFDNFKEVCGEKQRFEKLMEHFRNEDNNIDFMVASMQFINIVVHSVEDM
                     NFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQAYLDNVFDVGALLEDAETKNAAL
                     ERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKELDVVREIYKDANTQVHT
                     LRKMVKEKEEAIQRQSTLEKKIHELEKQGTIKIQKKGDGDIAILPVVASGTLSMGSEV
                     VAGNSVGPTMGAASSGPLPPPPPPLPPSSDTPETVQNGPVTPPMPPPPPPPPPPPPPP
                     PPPPPPPLPGPAAETVPAPPLAPPLPSAPPLPGTSSPTVVFNSGLAAVKIKKPIKTKF
                     RMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFKTKAQGPAIDLSSSKQK
                     IPQKGSNKVTLLEANRAKNLAITLRKAGKTADEICKAIHVFDLKTLPVDFVECLMRFL
                     PTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFAESIQML
                     TPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKS
                     TDRKQTLLHYISNVVKEKYHQVSLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTK
                     REYTMHDHNTLLKEFILNNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFP
                     VFVRFVKAYKQAEEENELRKKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIA
                     ELRRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQNLRSVNGA
                     EITM"
     exon            548..631
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..712
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            713..789
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..873
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1026
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1135
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1212
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1306
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1381
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1492
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1493..1642
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1744
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..2057
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2267
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2268..2392
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2595
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2596..2830
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2831..2899
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2900..2980
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            2981..3110
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3111..3274
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3275..3376
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3475
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3476..3599
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     exon            3600..5630
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5610..5615
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /note="hexamer: AATAAA"
     polyA_site      5630
                     /gene="FMNL2"
                     /gene_synonym="FHOD2"
                     /note="major polyA site"
ORIGIN      
        1 gtctgctcca ggtgctagcc aggcaggcgc agccgtggcc ggctagggct ggaagtgtca
       61 gcggcggccg cgggcccggc agaaggccga gtaggaggga ccacgcgccg ggggccgcga
      121 tctctggcag ggggcggtgt gccagcggag caccatgcac ataggcgccc agcgccccaa
      181 ctacccctcc cgaggaaaag aggccggggc cgcgctgggg cggcggagag catgagggag
      241 gccggggggc ggctcggctt ggagcgctgc tagggagcgg tgcgcgccgc acacccgcct
      301 gggcgcggcg gagggcgggg agccgggcag gtcgcgcctg cgggcggcag ccgaccgccg
      361 ggagctgttc tgatttccga cgcgcacgct aggggcccgg agcagccccc ggccccggcg
      421 cgccgccgac atgggcaacg cagggagcat ggattcgcag cagaccgatt tcagggcgca
      481 caacgtgcct ttgaagctgc cgatgccaga gccaggtgaa ctggaggagc gatttgccat
      541 cgtgctgaat gctatgaacc tacctcctga caaagccagg ttactgcggc agtatgataa
      601 tgagaaaaaa tgggaactga tttgtgatca ggaacgattc caggtgaaga atcctcccca
      661 tacatacatt caaaagctca aaggctatct ggatccagct gtaaccagga agaaattcag
      721 acggcgtgtt caagaatcta cacaagtgct aagagaactg gaaatttctt tgagaactaa
      781 ccacattgga tgggtcagag aatttctgaa tgaagaaaac aaaggtcttg atgttctagt
      841 ggaatatctc tcatttgcac agtacgcggt aacttttgac tttgaaagtg tggagagtac
      901 tgtggagagc tcggtggaca aatcaaagcc ctggagtagg tccatcgagg acctgcacag
      961 agggagcaac ctgccctcac ctgtgggcaa cagtgtctcc cgctctggaa gacattctgc
     1021 actgcgatat aatacattgc caagcagaag aactctgaaa aattcaagat tagtgagtaa
     1081 gaaagatgat gtgcatgtct gtatcatgtg tttacgtgcc atcatgaatt atcagtatgg
     1141 tttcaacatg gtcatgtctc atccacacgc tgtcaatgag attgcactaa gcctgaacaa
     1201 caagaatccc agaacaaaag cccttgtctt agaactgttg gcagccgttt gtcttgtcag
     1261 aggcgggcat gaaatcattt tatcagcatt tgataacttt aaagaggttt gtggagaaaa
     1321 acagcgcttt gagaagttga tggaacattt caggaatgaa gacaataaca tagattttat
     1381 ggtggcttct atgcagttta ttaatattgt agtccattca gtagaagata tgaatttcag
     1441 agttcacctg cagtatgaat ttaccaaatt aggcctggac gaatacttgg acaagctgaa
     1501 acacactgag agtgacaagc ttcaagtcca gatccaggct tacctggaca atgtttttga
     1561 tgtaggagct ctactggaag atgctgaaac taagaatgct gccttggaga gggtggaaga
     1621 actggaagaa aacatttctc atttatctga aaaactgcaa gacacagaga atgaagccat
     1681 gtccaagatt gtggaactgg aaaagcaact catgcagagg aacaaggagc tggatgtcgt
     1741 tcgggaaatc tacaaagatg caaatactca agttcacaca ttaagaaaaa tggtcaaaga
     1801 aaaagaagaa gcaattcaaa gacagtctac cctggaaaaa aagattcatg agctagagaa
     1861 acaagggacc attaaaattc agaagaaagg ggatggggat atcgccatac tgccagttgt
     1921 ggcttctggc acattgtcca tggggtcaga agtggtagca ggtaactctg tgggacccac
     1981 aatgggggcc gcttcctcag gacccttgcc ccctcctcca ccaccactgc ctccctcatc
     2041 agacacacct gaaacagtgc aaaatggtcc agtaacacca cctatgccac cgccgccgcc
     2101 gccccctcct ccacctcctc ctcccccacc gccccctccg cctcctcctc tcccaggccc
     2161 tgcagctgag actgtaccag ctcctccctt agcacctccc cttccctctg cacctccgct
     2221 gcctggaaca tcttcaccca cagtggtttt caactcagga ttagcagctg tgaaaattaa
     2281 gaagccaatc aagacgaagt tcagaatgcc agtgtttaac tgggttgctc tgaagcccaa
     2341 tcagatcaat ggcacagtct tcaatgaaat tgatgatgag cgaattctgg aggatttaaa
     2401 tgtggatgaa tttgaggaaa tattcaagac aaaagcccaa ggacctgcca ttgatctttc
     2461 ttcaagcaaa cagaagatac cacagaaggg atcaaacaaa gtgacattac tagaagcaaa
     2521 cagggccaaa aatcttgcca taactttaag gaaagctgga aagactgctg atgaaatatg
     2581 taaagctatt catgtatttg acttgaagac actgcctgtg gactttgtgg aatgcttgat
     2641 gcggttccta ccaactgaga atgaagtgaa agtgcttcgg ctctacgagc gggaaaggaa
     2701 gcctctggaa aacttgtcag atgaagatcg gttcatgatg cagtttagta aaatcgagag
     2761 gctcatgcag aagatgacca tcatggcctt cattgggaac tttgctgaaa gcattcagat
     2821 gctgactcct caactacatg cgattatagc agcatctgtc tctataaagt cgtcccaaaa
     2881 actcaagaaa attctggaga tcatcttagc ccttggaaac tacatgaata gcagtaaaag
     2941 aggagcagtt tatggattta aacttcagag tttagatctg ctcttagata caaagtcaac
     3001 agacagaaag caaacactgt tgcactatat atccaatgtg gtgaaagaaa aatatcacca
     3061 agtgtccctg ttttataatg agcttcatta tgtggaaaaa gctgctgcag tctcccttga
     3121 gaatgttttg ctggatgtca aggagctcca gaggggaatg gacttgacca agagagagta
     3181 caccatgcat gaccataaca cgctgctgaa ggagttcatc ctcaacaatg aggggaagct
     3241 gaagaagctg caggatgatg ccaagatcgc acaggatgcc tttgatgatg ttgtgaagta
     3301 ttttggagaa aaccccaaga caacaccacc ctctgtcttc tttcctgtct ttgtccggtt
     3361 tgtgaaagca tataagcaag cagaagagga aaatgagctg aggaaaaagc aggaacaagc
     3421 tctcatggaa aaactcctag agcaagaagc tctgatggag cagcaggatc caaagtctcc
     3481 ttctcataaa tcaaagaggc agcagcaaga gttaattgca gaattaagaa gacgacaagt
     3541 taaagataac agacatgtat atgagggaaa agatggtgcc attgaagata ttatcacaga
     3601 tcttagaaac caaccataca gacgagccga tgcggtgagg agaagcgtca ggcggcgctt
     3661 tgatgatcag aacttgcgtt ctgttaatgg tgccgaaata acaatgtgaa cctgagactg
     3721 gcctgcatga atacagggtg tgcgtgaatg aaactgccca catgaacttt atgtgctacg
     3781 atttaactgc agccttgaac acacacaaaa atattcttaa gggctcagat ttagcaaaca
     3841 cggaagaatt ttaaaatgag ctctcctttc aacccttgtt aacaagtgcc taaaaatgga
     3901 agtacctgtt cagattaatc aaagcaatag gatttgattt gattaggtat ctttttacac
     3961 cagtatgtta tttttaacca aaatgtaaag ttcttattaa actcattacc tgccattgtg
     4021 attgtcccat catggcccac ctggtttcct gatgttgtaa ataacatcaa tgcatctgct
     4081 gtgggtcctt tgctgagatg tcttcgaagg aattttgttt tagccatatc catcaacttt
     4141 gtattttact tgcaatttgg aagaaggaaa gtcacatgat gaaactcctt ttgtctataa
     4201 ccaggccctg gcaaagtgca aacaggatgc aactgcagtg gcacaaaggt cactcaatcc
     4261 tttgtttcca gtttcacatt ctactacttc tgcgctagag aacgatgctc tgtgagaggc
     4321 attcactagt atgaatgtgg ggatatagtg tataagactt atttgcagta ctgtgttctt
     4381 cagctagagg cagcttttta aataatgcaa gtgtatttat tagcattaaa attaacatct
     4441 cagtaatcag cattagcatt tctgaggacc attattaatt ctgagaacag aaattggtgc
     4501 cttgcaagga agtttactag ctctatcaac aagcattcaa ggttacatct gctagcagag
     4561 tagtgttagg aacctggcct tactctcctc tgacaatcgc aattttttct tattttttat
     4621 aaattcaaga agatacactt ggcatcgtgt atcgaggcta agtttttcat gcatttccca
     4681 gactacttat ggagaattgc agtttaagtt gctgaaaagt attaacatgg tattaagctt
     4741 aaataatacg taatgggact agatggccca ctaagccact gttattttcc ttcctctctg
     4801 gcagggcact tgatccattc caaagtcaaa aactggactg aagctaaatt tgtacttttc
     4861 ataatataca ttctgcttct ggcttatctt cttggtacat caatatatta attgtaaagt
     4921 ttattgtata gtatttaacc gctgaagttc ctattttatg ttgtgcttat gtgaacccct
     4981 tggtgaaggt cccttttcct tggatgtgta gttatatgat ctttttaaat gtacagatat
     5041 tttgctataa aatcggtgca gttttttatg gtttttacac ttctctttaa ttcccaccta
     5101 agcctctggg taatattgta aatattgttt taaaatgcat cagcctatgc tatacaatct
     5161 gaatgttatt ttaacttata gtttttttta atatatatat ttaactataa ggacagttta
     5221 gggaacaagt tacctaccac atttcacttt agtgtaccta tttacagaaa gattaaactg
     5281 ccacctgcgg gcacattccc ataaatgtgt actttacttt aaaaagaaca tgccacgatt
     5341 ttgtctttct gtggactcaa cattcacttc gattaaaaat agcaatttga ccaagttgga
     5401 cttccactac aaagcagctg ttttccaaag ttcaatgctg acatatatgt atattaaaat
     5461 aattgcctat ttattaatct acaaatagac aacgttggca tgttcttttc tgtttgtcta
     5521 ttaatgggcc tgcttcttag caatattaga atgttttata aaagcaattc atgttacttt
     5581 tctggtcttt tcatggcata tgagcaaata ataaactatt tacactacta
//
