LOCUS       NM_197964               1014 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens formation of mitochondrial complex V assembly factor 1
            homolog (FMC1), transcript variant 1, mRNA.
ACCESSION   NM_197964 XM_088045
VERSION     NM_197964.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1014)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1014)
  AUTHORS   Li,Y., Jourdain,A.A., Calvo,S.E., Liu,J.S. and Mootha,V.K.
  TITLE     CLIC, a tool for expanding biological pathways based on
            co-expression across thousands of datasets
  JOURNAL   PLoS Comput Biol 13 (7), e1005653 (2017)
   PUBMED   28719601
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1014)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1014)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   5  (bases 1 to 1014)
  AUTHORS   Lefebvre-Legendre,L., Vaillier,J., Benabdelhak,H., Velours,J.,
            Slonimski,P.P. and di Rago,J.P.
  TITLE     Identification of a nuclear gene (FMC1) required for the
            assembly/stability of yeast mitochondrial F(1)-ATPase in heat
            stress conditions
  JOURNAL   J Biol Chem 276 (9), 6789-6796 (2001)
   PUBMED   11096112
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB125801.1, BC008467.1 and AC083880.5.
            
            On Nov 23, 2018 this sequence version replaced NM_197964.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the supproted protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.159667.1,
                                           SRR1803612.37763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000297534.7/
                                                  ENSP00000297534.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                CB125801.1         187-256
            71-712              BC008467.1         79-720
            713-943             AC083880.5         12217-12447
            944-1005            BC008467.1         953-1014
            1006-1014           AC083880.5         12510-12518
FEATURES             Location/Qualifiers
     source          1..1014
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q34"
     gene            1..1014
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
                     /note="formation of mitochondrial complex V assembly
                     factor 1 homolog"
                     /db_xref="GeneID:154791"
                     /db_xref="HGNC:HGNC:26946"
                     /db_xref="MIM:620766"
     exon            1..186
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..390
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
                     /note="formation of mitochondrial complexes 1 homolog;
                     UPF0562 protein C7orf55; ATP synthase assembly factor
                     FMC1, mitochondrial"
                     /codon_start=1
                     /product="protein FMC1 homolog"
                     /protein_id="NP_932068.2"
                     /db_xref="CCDS:CCDS5853.1"
                     /db_xref="GeneID:154791"
                     /db_xref="HGNC:HGNC:26946"
                     /db_xref="MIM:620766"
                     /translation="MAALGSPSHTFRGLLRELRYLSAATGRPYRDTAAYRYLVKAFRA
                     HRVTSEKLCRAQHELHFQAATYLCLLRSIRKHVALHQEFHGKGERSVEESAGLVGLKL
                     PHQPGGKGWEP"
     exon            187..1014
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
                     /inference="alignment:Splign:2.1.0"
     regulatory      460..465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
                     /note="hexamer: ATTAAA"
     polyA_site      481
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
                     /note="major polyA site"
     regulatory      979..984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
                     /note="hexamer: TATAAA"
     regulatory      990..995
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
                     /note="hexamer: AATAAA"
     polyA_site      1000
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
     polyA_site      1014
                     /gene="FMC1"
                     /gene_synonym="C7orf55; HSPC268"
ORIGIN      
        1 agggtcgtag gacgccgttg ggcaccacgc tcggagaagg acaggacaat ggcggcctta
       61 gggtccccgt cgcacacttt tcgaggactt ctgcgggagt tgcgctacct gagcgcggcc
      121 accggccgac cctatcgcga caccgcggcc tatcggtacc ttgtgaaggc tttccgtgca
      181 catcgggtca ccagtgaaaa gttgtgcaga gcccaacatg agcttcattt ccaagctgcc
      241 acctatctct gcctcctgcg tagcatccgg aaacatgtgg ccctacatca ggaatttcat
      301 ggcaagggtg agcgctcggt ggaggagtct gctggcttgg tgggtctcaa gttgccccat
      361 cagcctggag ggaagggctg ggagccatga acatggagaa tatccttgga tgctgcattc
      421 ataggagaat tgaataattt ctatcaatat gtatttatca ttaaattttt tttaagttta
      481 aggtttttct ctgtaatttt gtttactagt tcttagggga attaactgga catttcatct
      541 ttactctcag tgaatttact gaactttttg cactagactg atgttgtttt tctacttaaa
      601 aaaatttttt tatattttat tttaaaagta gtacaagcct tagccaggca cggtggctca
      661 cgcctgtaat cccagcactt tgggaggcca aggcaggcgg atcacctgag gttgggagtt
      721 cgcgaccagc ctgaccaaca tggaaaaacc ccgtctctac taaaaataca aaattagcca
      781 ggcgtggtgg cacatgcctg taatcccagc tactcaggag gctgggacag gagaatcgct
      841 tgaacccggg aggtggaggt tgcgatgagc tgagatcgcg ccatggcact cactccagcc
      901 tgggcaacaa gagcaaaact ctgtctcaaa aaaaaaaaaa aaattagtat aagccttttg
      961 tttaaggaat tcaaatgtta taaacataaa ataaaagaaa ccctcttttc cttt
//
