LOCUS       NM_014053               5919 bp    mRNA    linear   PRI 24-JAN-2025
DEFINITION  Homo sapiens FLVCR choline and heme transporter 1 (FLVCR1), mRNA.
ACCESSION   NM_014053
VERSION     NM_014053.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5919)
  AUTHORS   Qu,Y., Meng,B., Cai,S., Yang,B., He,Y., Fu,C., Li,X., Li,P.,
            Cao,Z., Mao,X., Teng,W. and Shi,S.
  TITLE     Apoptotic metabolites ameliorate bone aging phenotypes via
            TCOF1/FLVCR1-mediated mitochondrial homeostasis
  JOURNAL   J Nanobiotechnology 22 (1), 549 (2024)
   PUBMED   39237990
  REMARK    GeneRIF: Apoptotic metabolites ameliorate bone aging phenotypes via
            TCOF1/FLVCR1-mediated mitochondrial homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5919)
  AUTHORS   Bertino,F., Mukherjee,D., Bonora,M., Bagowski,C., Nardelli,J.,
            Metani,L., Zanin Venturini,D.I., Chianese,D., Santander,N.,
            Salaroglio,I.C., Hentschel,A., Quarta,E., Genova,T., McKinney,A.A.,
            Allocco,A.L., Fiorito,V., Petrillo,S., Ammirata,G., De Giorgio,F.,
            Dennis,E., Allington,G., Maier,F., Shoukier,M., Gloning,K.P.,
            Munaron,L., Mussano,F., Salsano,E., Pareyson,D., di Rocco,M.,
            Altruda,F., Panagiotakos,G., Kahle,K.T., Gressens,P., Riganti,C.,
            Pinton,P.P., Roos,A., Arnold,T., Tolosano,E. and Chiabrando,D.
  TITLE     Dysregulation of FLVCR1a-dependent mitochondrial calcium handling
            in neural progenitors causes congenital hydrocephalus
  JOURNAL   Cell Rep Med 5 (7), 101647 (2024)
   PUBMED   39019006
  REMARK    GeneRIF: Dysregulation of FLVCR1a-dependent mitochondrial calcium
            handling in neural progenitors causes congenital hydrocephalus.
REFERENCE   3  (bases 1 to 5919)
  AUTHORS   Ri,K., Weng,T.H., Claveras Cabezudo,A., Josting,W., Zhang,Y.,
            Bazzone,A., Leong,N.C.P., Welsch,S., Doty,R.T., Gursu,G.,
            Lim,T.J.Y., Schmidt,S.L., Abkowitz,J.L., Hummer,G., Wu,D.,
            Nguyen,L.N. and Safarian,S.
  TITLE     Molecular mechanism of choline and ethanolamine transport in humans
  JOURNAL   Nature 630 (8016), 501-508 (2024)
   PUBMED   38778100
  REMARK    GeneRIF: Molecular mechanism of choline and ethanolamine transport
            in humans.
REFERENCE   4  (bases 1 to 5919)
  AUTHORS   Rajadhyaksha,A.M., Elemento,O., Puffenberger,E.G., Schierberl,K.C.,
            Xiang,J.Z., Putorti,M.L., Berciano,J., Poulin,C., Brais,B.,
            Michaelides,M., Weleber,R.G. and Higgins,J.J.
  TITLE     Mutations in FLVCR1 cause posterior column ataxia and retinitis
            pigmentosa
  JOURNAL   Am J Hum Genet 87 (5), 643-654 (2010)
   PUBMED   21070897
  REMARK    GeneRIF: These results suggest that aberrant FLVCR1 causes a
            selective degeneration of a subpopulation of neurons in the retina
            and the posterior columns of the spinal cord via dysregulation of
            heme or iron homeostasis.
REFERENCE   5  (bases 1 to 5919)
  AUTHORS   Rey,M.A., Duffy,S.P., Brown,J.K., Kennedy,J.A., Dick,J.E., Dror,Y.
            and Tailor,C.S.
  TITLE     Enhanced alternative splicing of the FLVCR1 gene in Diamond
            Blackfan anemia disrupts FLVCR1 expression and function that are
            critical for erythropoiesis
  JOURNAL   Haematologica 93 (11), 1617-1626 (2008)
   PUBMED   18815190
  REMARK    GeneRIF: Alternative splicing of FLVCR1 transcripts and subsequent
            FLVCR1 insufficiency is an additional contributing factor to the
            erythropoietic defect observed in Diamond-Blackfan anemia.
REFERENCE   6  (bases 1 to 5919)
  AUTHORS   Quigley,J.G., Yang,Z., Worthington,M.T., Phillips,J.D., Sabo,K.M.,
            Sabath,D.E., Berg,C.L., Sassa,S., Wood,B.L. and Abkowitz,J.L.
  TITLE     Identification of a human heme exporter that is essential for
            erythropoiesis
  JOURNAL   Cell 118 (6), 757-766 (2004)
   PUBMED   15369674
REFERENCE   7  (bases 1 to 5919)
  AUTHORS   Quigley,J.G., Burns,C.C., Anderson,M.M., Lynch,E.D., Sabo,K.M.,
            Overbaugh,J. and Abkowitz,J.L.
  TITLE     Cloning of the cellular receptor for feline leukemia virus subgroup
            C (FeLV-C), a retrovirus that induces red cell aplasia
  JOURNAL   Blood 95 (3), 1093-1099 (2000)
   PUBMED   10648427
  REMARK    Erratum:[Blood 2000 Jul 1;96(1):8]
REFERENCE   8  (bases 1 to 5919)
  AUTHORS   Tailor,C.S., Willett,B.J. and Kabat,D.
  TITLE     A putative cell surface receptor for anemia-inducing feline
            leukemia virus subgroup C is a member of a transporter superfamily
  JOURNAL   J Virol 73 (8), 6500-6505 (1999)
   PUBMED   10400745
REFERENCE   9  (bases 1 to 5919)
  AUTHORS   Higgins,J.J., Morton,D.H. and Loveless,J.M.
  TITLE     Posterior column ataxia with retinitis pigmentosa (AXPC1) maps to
            chromosome 1q31-q32
  JOURNAL   Neurology 52 (1), 146-150 (1999)
   PUBMED   9921862
REFERENCE   10 (bases 1 to 5919)
  AUTHORS   Higgins,J.J., Morton,D.H., Patronas,N. and Nee,L.E.
  TITLE     An autosomal recessive disorder with posterior column ataxia and
            retinitis pigmentosa
  JOURNAL   Neurology 49 (6), 1717-1720 (1997)
   PUBMED   9409377
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF118637.1, AK314481.1,
            AC104333.2, AK090739.1 and GD138340.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014053.3.
            
            Summary: This gene encodes a member of the major facilitator
            superfamily of transporter proteins. The encoded protein is a heme
            transporter that may play a critical role in erythropoiesis by
            protecting developing erythroid cells from heme toxicity. This gene
            may play a role in posterior column ataxia with retinitis
            pigmentosa and the hematological disorder Diamond-Blackfan
            syndrome. [provided by RefSeq, Jan 2011].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.55135.1,
                                           SRR1803617.202383.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366971.9/ ENSP00000355938.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-332               AF118637.1         21-352
            333-1808            AK314481.1         329-1804
            1809-4977           AC104333.2         125680-128848
            4978-5917           AK090739.1         863-1802
            5918-5919           GD138340.1         89-90
FEATURES             Location/Qualifiers
     source          1..5919
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.3"
     gene            1..5919
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /note="FLVCR choline and heme transporter 1"
                     /db_xref="GeneID:28982"
                     /db_xref="HGNC:HGNC:24682"
                     /db_xref="MIM:609144"
     exon            1..916
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1846
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /note="feline leukemia virus subgroup C receptor-related
                     protein 1; feline leukemia virus subgroup C cellular
                     receptor 1; heme transporter FLVCR1; FLVCR heme
                     transporter 1"
                     /codon_start=1
                     /product="choline/ethanolamine transporter FLVCR1"
                     /protein_id="NP_054772.1"
                     /db_xref="CCDS:CCDS1510.1"
                     /db_xref="GeneID:28982"
                     /db_xref="HGNC:HGNC:24682"
                     /db_xref="MIM:609144"
                     /translation="MARPDDEEGAAVAPGHPLAKGYLPLPRGAPVGKESVELQNGPKA
                     GTFPVNGAPRDSLAAASGVLGGPQTPLAPEEETQARLLPAGAGAETPGAESSPLPLTA
                     LSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPL
                     IFPATWLLDTRGLRLTALLGSGLNCLGAWIKCGSVQQHLFWVTMLGQCLCSVAQVFIL
                     GLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQNDTNLLACNIST
                     MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPF
                     VLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWL
                     DYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLGFFMTGYLPLGFEFA
                     VEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILT
                     ALIKSDLRRHNINIGITNVDVKAIPADSPTDQEPKTVMLSKQSESAI"
     exon            917..1061
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1202
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1270
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1374
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1485
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1486..1591
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1592..1703
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1704..1771
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..5919
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1946..1951
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /note="hexamer: AATAAA"
     polyA_site      1970
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /note="major polyA site"
     regulatory      5896..5901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /note="hexamer: AATAAA"
     polyA_site      5919
                     /gene="FLVCR1"
                     /gene_synonym="AXPC1; FLVCR; MFSD7B; NEDMISH; PCA; PCARP;
                     RETSNS; SLC49A1"
                     /note="major polyA site"
ORIGIN      
        1 agaccttcat ctgttcacgc ggtagcgcgg attgcggttc gcggcgcgcg ccaccgggga
       61 aggagcggtg ggccgagggg ttggaggtgg ggccccagga ggacctcggg ctgtgggccg
      121 ggagagcgga gtcggggagt ggggcggggg agcgaggtgg cgccggggag cctgggatat
      181 ggcgcggcca gacgatgagg agggggcggc ggtggcgccc ggacacccgc tcgcgaaagg
      241 atacctcccg ttgccgaggg gcgcgcccgt tgggaaggag agcgtggagc tgcagaacgg
      301 gcccaaagcg ggcaccttcc cggtgaatgg ggccccccgg gacagcctcg ctgccgcctc
      361 gggagttctg ggcgggcctc agactccact ggccccagaa gaggagaccc aggcccggct
      421 gctgcctgcg ggcgcgggag ctgagacccc gggggccgag agcagcccgc tgccccttac
      481 ggcgctctcc ccgcggcgct tcgtggtgct cctgatcttc agcctgtact cgctggtcaa
      541 cgcctttcag tggatccagt acagcatcat tagcaacgtc ttcgagggct tctacggtgt
      601 caccttgctg cacatcgact ggctgtccat ggtgtacatg ctggcctacg tgcccctcat
      661 cttcccggcc acctggctgc tggacaccag aggcctgcgg ctcaccgccc tgctgggctc
      721 cggcctcaac tgcctgggtg cctggatcaa gtgcggcagt gtgcagcagc atctcttctg
      781 ggtcaccatg ttgggccagt gcttgtgctc ggtggcccag gtgttcatcc tgggcttgcc
      841 ctcccgcatc gcctcagtgt ggtttgggcc caaagaggtg tccacagctt gtgccaccgc
      901 cgtgctgggc aatcagcttg gaactgcagt tggctttttg ctaccaccag ttttagtacc
      961 caacacacag aatgacacaa atctcctggc ttgtaatatc agcaccatgt tttatggaac
     1021 atcagctgtt gccacacttt tatttatttt aacagcaatt gccttcaaag aaaaacctcg
     1081 gtatccacca agtcaggctc aagcagctct tcaagacagt ccccctgaag agtactccta
     1141 taagaaatca ataagaaacc tgtttaaaaa cattcctttt gtccttctgt tgatcactta
     1201 tggtatcatg actggtgcct tttattcagt ctcaacgtta ttaaatcaaa tgatattgac
     1261 atattatgag ggagaagaag tcaatgctgg aaggattggg ctaacgctag tagtagctgg
     1321 aatggtgggc tctattcttt gtggcttatg gctggattat actaaaacat acaaacagac
     1381 tactctgata gtttatattt tgtcttttat tggaatggtt atctttactt tcacattgga
     1441 ccttagatat attatcatcg tgtttgttac tggaggggtg cttggcttct tcatgactgg
     1501 ttacctccct ttgggttttg aatttgctgt tgaaatcact taccctgaat ctgaaggtac
     1561 ttcatctggt cttcttaatg cttctgcaca gatatttgga attttgttca cattggctca
     1621 aggaaagctc acatcagact atggtcctaa ggcagggaac atttttctct gtgtctggat
     1681 gtttataggc atcatattaa cagcattaat caagtctgat ctgcgaagac acaacataaa
     1741 tataggaatt acaaatgttg atgttaaagc tataccagct gacagtccca cagaccaaga
     1801 accaaaaacg gttatgttgt ccaagcagtc agaatcagca atttgaagag aaaggcaaag
     1861 ttactgtcct gtagtaattg gggacaatgt gatcatcctt ggagagagat gtgagcacca
     1921 aggctgggtt tgtatgtggt gggggaataa acacacttac ttgaaaatta ccatatgaac
     1981 tctaaatgca taattattat tttgcttaat tgttaaatta agggaaattt tcttaaaatt
     2041 cttctgttta catcatgtta acactactgt ttatctaatt agtatccggt ttttagtctc
     2101 atattgtatc tgaaagtaag cttcttgacg tttacttttt aaaagtcgat gtttttcttt
     2161 tttgtagaaa atggaagctt agaatacttt ttaaagtgat aatatggggt gttcagtccc
     2221 cataagatat aatagttcat gcagtttata tattaaagta tccagtggaa ctaaatgtac
     2281 aatatattcc taattggctg cctttttcac tgtgctgacc agctgttcaa gccacttcag
     2341 tttgagtaca acataccaac atgacactac tcacccacaa aggacagcat tgggatcagg
     2401 ctttcagatg acctctaaga tttttcccat ttattgtact cttgttacaa agtacttttt
     2461 aacacatgca gtcaatggct ataaaaacta ttctgtgtac agattctacc cagactttgg
     2521 tcttagaatt atgttctaat taaggagcct ggttacaggt tcattctgtc ttgagttctt
     2581 ttctgtgctg cctttctatc atggataaat gctaacgctg tattttttca ctccaacttg
     2641 agatagagta gttttgtacc cattgccttt tttttctttt aaactctctt tttttttttt
     2701 tcctgatgtg taactttcta gtaagataat ttcatcatgt atgttactgg ctatttcatg
     2761 atttcatgta tcacatcgta tattttgcct tgaagattcc tgaaataagg aaatctataa
     2821 taacttcaga tagcctacat gtccccattt agtggagacc tcttgaatgc tatttgaatt
     2881 ctgcagtatc atttttatga ccattctcct ttgaggaata ctatgcccag gtacatgctc
     2941 tatcagtgtg ccgggagagt ggattctttt cttcactgca gagtcatcac actgttagaa
     3001 tagtctgctc ttttacatgc tcaggtaggg aaaataggac caaatatatt tccacagtgc
     3061 ctaccactgt gtcatgttta cagtgagagt ttaaatattg ttgatgtcct gactctgtga
     3121 gctcataggg agtatcttca tagtaatgac atttgatcag ccataaaatt tacattatgt
     3181 tcatatgcac ccaaaaaagc tagtcaggta atgaataccc ttgaagtgaa tagcaatttt
     3241 gatttaggca gtgtgttagg ccatccttgc attgctataa agaaatattt aggctgggcg
     3301 tggtggctca cgcctgtaat cccagcactt tgggaggctg aagcgtgtgg atcacctgag
     3361 gtcaggagtt caagaccagc ctggccaaca tggtaaaacc ccatctctac taaaaaaaaa
     3421 aaaaaaaaaa aaaaaaaaaa aaaaggccag gcgcagtgct gtggctcatg cctgtaatct
     3481 cagcactttg ggaggccaag gcaggtggat cacaaagtca ggagttcaaa accagcctgg
     3541 ccaagatggt gaaaccccat ctctactaaa aatacaaaaa ttagcgcagt ggcaggcgcc
     3601 tgtaatccca gctactcagg aggctgaggc aggagaatcg cttgaatgcg aatggcagag
     3661 gttgcagtga gcgaaaatca cactactgca ctccagcctg ggagataaag tgagactgtc
     3721 tcaaataaat aaataaataa ataaataaat aaataaataa ataaataaaa cctgaggttg
     3781 agcacgatgg ctcacaccta tagtcccagc actttgggag gctgaggtgg gtggatcatt
     3841 tgaggccagg agttgaagac cagtctggcc aacatggcaa aaccccatct ctactaaaaa
     3901 tacatacaca cacacacaca cacacaaatt agccgggcat ggtggcacac gcctgtagtc
     3961 ccagcttctt gggaagctga ggcatgagaa ttgcctgaac ctggaaggcg gaggctacag
     4021 tgagctgaga ttgcgccact gcactccagc ctgggtgaca gagcgagact ctgtttcagg
     4081 aaaaaaagaa cagaaatacc tgagactggg taatttataa ataaaagagg tttaagtggc
     4141 tcacagttct gcaggctgtg taagcatggc accagtgtct gctcggcttc tggggagccc
     4201 tcagggagct ttactcatgg tgaaaggcta agtgggagca gagatgtcac atggcgaagc
     4261 aggagcaaga gagcagggag gtgccacaca ccttcaaaca accagatttt gtgaaaactc
     4321 actcattact gcaaggacag caccaagcca tgagggatcc acccgcagga cccaaacacc
     4381 ttctattagg gccaaccttc aacattgggg attacatttc aatgtgagat tggagggaca
     4441 agtatcccaa ctatatcagg cagaatatat gcattgatat atattgaaat tataacattc
     4501 tctataatca agtgactgta aattatgtcg aatctgaccc tggggaatgt gttatctaaa
     4561 gaatttgact aagaatcagg aactctgtgt ccatgtcctg gatgtatttc tgtatgttcc
     4621 tataactctg gacaaatcat taaacctctc tgggcagcgt tttcctcatc catgaaatga
     4681 atgtgttcaa tttgatctca aagatctttc caaaatatta aatgccatta atcatggaat
     4741 agaccaaatt attgtatcac aggaacttga atccagccag agaaaaattc cctggacaat
     4801 tggataaaca aatgtgattg ctaccttatg gatacaacgg acttttacat ttctttttag
     4861 cctttttagt cagttgaggg taactcaagc agagtatgtc caatcattag cttcctttga
     4921 tatttacatt acaggtaaaa acggccaaaa atatatttta aggtctctcc ccaaatgttt
     4981 ttatttttaa actatcaatg ttgtttaaaa taatcatgta cttgttgagt tcctgaggtt
     5041 tggaacaaat tacacataaa atttagaata ctttatttct gaaaagcata tacatatatg
     5101 ttatgtttat ttttccttgt tgattagaaa ggtgatggaa tatgtgacaa tgcaaaatga
     5161 attgataatt tttctgtatt ttgagtgaaa gttgtctgta atatgtcaag caagaatgtt
     5221 ataattctac agtaatgtgt gacttcatga cagagctaca ttctgagaaa tttgtcatta
     5281 ggtgatttca tcattgtgtg aacatcatga agtgtactta cacaaaccta ggtggtagag
     5341 cctactgcac acctgggcta gatggcaaag tctgtcgctt ctgggctaca gacctgtaca
     5401 gcatggtact gtattgaata ctgtaggcaa ctgtaacaca atggtatctg tgtaatctaa
     5461 acatagaaca gataatacat tgtgctacaa tgtaacaatg gctgtggcat cactaggtga
     5521 taggaatttt tcagttccat tataatctta taggatctct gtcatatgtg gtcaattgtt
     5581 gatcgaaaca tgactgtatg tcgtattttc agaaaatgga ataggtaatc atcacttgtg
     5641 tgaattttaa tcaaatgact taggaaagaa actggatgtt tcaaaagctg ttgcatttat
     5701 tacaaatgtc acaaatacag ctcttgcctt ttgagaatgt tggagagatg tctttaaaaa
     5761 atatgtttgt gtgtaaaaat gtgtctgtat gcaatagcta gaaaaatgcc tgtgtcttaa
     5821 gtcattactc atgttctaat ttttgttctt tgtactattt atctgtatgc ttgttcttca
     5881 gtatttcaga ctcaaaataa atttattttt ttatgttaa
//
